Conserved Protein Domain Family
Ax_dynein_light

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pfam10211: Ax_dynein_light 
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Statistics
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PSSM-Id: 337669
View PSSM: pfam10211
Aligned: 83 rows
Threshold Bit Score: 83.7512
Threshold Setting Gi: 574972050
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124474610  59 DEILNKFFP--PRRf--eHEGHFFK-QVVSVNDVKRDELNQLEAELDQRLI---ERQARKSGI-CPVRE----------- 118
gi 74864271   68 NDPIYYIFP--SKCi--kVKKAEHI--SYVSRVTNDEDIVLCLKRIYEVLSnmySKNM-------IIKE----------- 123
gi 122123760 155 ETLLYTLLP--PQRivceETGETIV-KSVSLEQPSRVEVAKLHERTLQQLQ---QRRAREWGI-CPLRR----------- 216
gi 122042697 146 ERVLYTLLP--PRRtvckETGNTIL-QCVSTEPSSRVEVADLHERLTERLR---QRRARDSGI-CPIRR----------- 207
gi 641673525  14 NKVFEYIYP--PEEw--mEDGVKWR-RVASTEPADRNHVLALAEDLKSNLS---YWHARMHGV-CLVRR----------- 73
gi 154418524  42 RDVLNSLFP--PIEf--eQDEIKYT-RSISTAPISKTDVTKLRTELDTLLH---KNKTKPKGI-DIIRS----------- 101
gi 358339104  20 lqaLSKFFP--PVRy--kEMGTKWV-KHVSAKQATPIEMTHVKQEVDRVLK---VRCSRKAPL-CVIRE----------- 79
gi 901859105  68 NEPLYNMFP--LKCv--rDKKVDQI-SYV-CRVTSEEDATACLKKIQDIVS---KMYAQNM----LIEK----------- 123
gi 398017019 268 SRVLSSATAaaARSa----aSTPVMwRRADVAHLSRLDVVLLYKHLERRCA---CESARPRGVvCPNRE----------- 329
gi 574972050   4 ffnLSLLFP--IKVf--kKTDKTLI--QLISEDTNLSDL----ELIQAVLK--------------NIENnnmdklnffyv 59
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124474610 119 -DLHSQL---FE---EIIRQSAINCPERGLLLMRVYDNLKLTFAAYQTLYAGSVVFGNRKAA--ESE----IGKSEQDSK 185
gi 74864271  124 -EYLNEL---LNiltELCRQISVTCFQRGLLLKQLFNYNIMLLFEYHKLVKSSLAFNLKKQM--KQNdilnNFHKEIEKK 197
gi 122123760 217 -EIYTEL---FD---ELIREITLEEPARGVLLLRIRDEMNQTLAAHRALAERTLLFASKQRM--EPP----EDISALRQR 283
gi 122042697 208 -EVYAEV---FD---ELIRQITLEEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQRE--EAG----EGMDELKRR 274
gi 641673525  74 -ELYTQC---FN---ELIRQVCVNSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTT--LDD----HKDDVTEKD 140
gi 154418524 102 -ELYSQC---FE---EVIRQVTIDSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNI--QVT----LGMDQLLDY 168
gi 358339104  80 -DVLSDL---IR---EILRQVTIDCPEQGLLLRRILDHNEMEFNAYETLLRFTDAFVGRKWA--EWQ----HWKADRTRQ 146
gi 901859105 124 -DFLEDLlsvFM---ELCRQVSVTCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEI--KRS----HTMSELRQE 193
gi 398017019 330 -CIYNDG---LR---ELIRQVTLLCPERGLLLDELARRMRQAIETYDVLLDSANQYAVRKST--ERD----LHQYLFAEK 396
gi 574972050  60 eNIIFEL---LD---EIIRQVICEYPKRGFALLLITNELQKNINYYKNLID----------IieHNNemntQGFKEMNEK 123
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124474610 186 ----IADYDKKKIYLENQKILLENELDAIQRSFKEIRELEEKRMESEMQFLKQQTKHLEHFLKQ 245
gi 74864271  198 nn--------siNSLTKEIINTEEMMEQEKINSEKEIAEVNIIYQNKIDKLKKNNQRKKDEFTR 253
gi 122123760 284 ----IKELEEEREELLVKRRMATVREEQIQSALLDENTARVKLWQDETCYYRRANRQVSQRIKT 343
gi 122042697 275 ----IHELEEKRLELIVRKKAVQVREEQILRAIEQENNTRSKLRQDELGYYRRANRQLTQRIKS 334
gi 641673525 141 ----IQDIEDAHVKLKKKLVDANNKYNKLKTDLKNELNNLKDANQHELSFFNRNHEALKDQLKl 200
gi 154418524 169 ----NKKLREKRRELELEANNLQIQLDGLEKRIQENKQIREKEFADEIAFLKKQGQSIKMIYDQ 228
gi 358339104 147 ----IYELEDTKRILEFQATELKHKVDQLEKKNQEMKIKWDAARMEEVKYYKKTGEHLRAQMDv 206
gi 901859105 194 ----MERKKEAINSLRSEILDTDRLIEEERANAEREMSEVNIIYQNKIDKLKKNNQRKRDEFTR 253
gi 398017019 397 -----TDLETEVRRREHRVNEWRAKYAGLQKRFQEQQEADRKLHAEEIAYAKRANQQLVSEIKR 455
gi 574972050 124 nnliLQDLLVEENKLKEKLIDVQTRLELLKEENKKKLQENKNKKEIQYDLLKHNESLLDkikei 187
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