Conserved Protein Domain Family
Ax_dynein_light

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pfam10211: Ax_dynein_light 
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Statistics
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PSSM-Id: 337669
View PSSM: pfam10211
Aligned: 83 rows
Threshold Bit Score: 83.7512
Threshold Setting Gi: 574972050
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A0C8X4        59 DEILNKFFP--PRRf--eHEGHFFK-QVVSVNDVKRDELNQLEAELDQRLI---ERQARKSGI-CPVRE----------- 118 Paramecium tetr...
Q8ILP2        68 NDPIYYIFP--SKCi--kVKKAEHI--SYVSRVTNDEDIVLCLKRIYEVLSnmySKNM-------IIKE----------- 123 Plasmodium falc...
Q389G1       155 ETLLYTLLP--PQRivceETGETIV-KSVSLEQPSRVEVAKLHERTLQQLQ---QRRAREWGI-CPLRR----------- 216 Trypanosoma brucei
Q4DPW6       146 ERVLYTLLP--PRRtvckETGNTIL-QCVSTEPSSRVEVADLHERLTERLR---QRRARDSGI-CPIRR----------- 207 Trypanosoma cruzi
XP_008186366  14 NKVFEYIYP--PEEw--mEDGVKWR-RVASTEPADRNHVLALAEDLKSNLS---YWHARMHGV-CLVRR----------- 73  pea aphid
XP_001582280  42 RDVLNSLFP--PIEf--eQDEIKYT-RSISTAPISKTDVTKLRTELDTLLH---KNKTKPKGI-DIIRS----------- 101 Trichomonas vag...
GAA47226      20 lqaLSKFFP--PVRy--kEMGTKWV-KHVSAKQATPIEMTHVKQEVDRVLK---VRCSRKAPL-CVIRE----------- 79  Clonorchis sine...
KMZ78213      68 NEPLYNMFP--LKCv--rDKKVDQI-SYV-CRVTSEEDATACLKKIQDIVS---KMYAQNM----LIEK----------- 123 Plasmodium viva...
XP_003861697 268 SRVLSSATAaaARSa----aSTPVMwRRADVAHLSRLDVVLLYKHLERRCA---CESARPRGVvCPNRE----------- 329 Leishmania dono...
ETW34298       4 ffnLSLLFP--IKVf--kKTDKTLI--QLISEDTNLSDL----ELIQAVLK--------------NIENnnmdklnffyv 59  Plasmodium falc...
A0C8X4       119 -DLHSQL---FE---EIIRQSAINCPERGLLLMRVYDNLKLTFAAYQTLYAGSVVFGNRKAA--ESE----IGKSEQDSK 185 Paramecium tetr...
Q8ILP2       124 -EYLNEL---LNiltELCRQISVTCFQRGLLLKQLFNYNIMLLFEYHKLVKSSLAFNLKKQM--KQNdilnNFHKEIEKK 197 Plasmodium falc...
Q389G1       217 -EIYTEL---FD---ELIREITLEEPARGVLLLRIRDEMNQTLAAHRALAERTLLFASKQRM--EPP----EDISALRQR 283 Trypanosoma brucei
Q4DPW6       208 -EVYAEV---FD---ELIRQITLEEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQRE--EAG----EGMDELKRR 274 Trypanosoma cruzi
XP_008186366  74 -ELYTQC---FN---ELIRQVCVNSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTT--LDD----HKDDVTEKD 140 pea aphid
XP_001582280 102 -ELYSQC---FE---EVIRQVTIDSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNI--QVT----LGMDQLLDY 168 Trichomonas vag...
GAA47226      80 -DVLSDL---IR---EILRQVTIDCPEQGLLLRRILDHNEMEFNAYETLLRFTDAFVGRKWA--EWQ----HWKADRTRQ 146 Clonorchis sine...
KMZ78213     124 -DFLEDLlsvFM---ELCRQVSVTCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEI--KRS----HTMSELRQE 193 Plasmodium viva...
XP_003861697 330 -CIYNDG---LR---ELIRQVTLLCPERGLLLDELARRMRQAIETYDVLLDSANQYAVRKST--ERD----LHQYLFAEK 396 Leishmania dono...
ETW34298      60 eNIIFEL---LD---EIIRQVICEYPKRGFALLLITNELQKNINYYKNLID----------IieHNNemntQGFKEMNEK 123 Plasmodium falc...
A0C8X4       186 ----IADYDKKKIYLENQKILLENELDAIQRSFKEIRELEEKRMESEMQFLKQQTKHLEHFLKQ 245 Paramecium tetraurelia
Q8ILP2       198 nn--------siNSLTKEIINTEEMMEQEKINSEKEIAEVNIIYQNKIDKLKKNNQRKKDEFTR 253 Plasmodium falciparum 3D7
Q389G1       284 ----IKELEEEREELLVKRRMATVREEQIQSALLDENTARVKLWQDETCYYRRANRQVSQRIKT 343 Trypanosoma brucei
Q4DPW6       275 ----IHELEEKRLELIVRKKAVQVREEQILRAIEQENNTRSKLRQDELGYYRRANRQLTQRIKS 334 Trypanosoma cruzi
XP_008186366 141 ----IQDIEDAHVKLKKKLVDANNKYNKLKTDLKNELNNLKDANQHELSFFNRNHEALKDQLKl 200 pea aphid
XP_001582280 169 ----NKKLREKRRELELEANNLQIQLDGLEKRIQENKQIREKEFADEIAFLKKQGQSIKMIYDQ 228 Trichomonas vaginalis G3
GAA47226     147 ----IYELEDTKRILEFQATELKHKVDQLEKKNQEMKIKWDAARMEEVKYYKKTGEHLRAQMDv 206 Clonorchis sinensis
KMZ78213     194 ----MERKKEAINSLRSEILDTDRLIEEERANAEREMSEVNIIYQNKIDKLKKNNQRKRDEFTR 253 Plasmodium vivax India VII
XP_003861697 397 -----TDLETEVRRREHRVNEWRAKYAGLQKRFQEQQEADRKLHAEEIAYAKRANQQLVSEIKR 455 Leishmania donovani
ETW34298     124 nnliLQDLLVEENKLKEKLIDVQTRLELLKEENKKKLQENKNKKEIQYDLLKHNESLLDkikei 187 Plasmodium falciparum Tanzania ...
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