4D18,6EPC


Conserved Protein Domain Family
CSN8_PSD8_EIF3K

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pfam10075: CSN8_PSD8_EIF3K 
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CSN8/PSMD8/EIF3K family
This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.
Statistics
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Aligned: 35 rows
Threshold Bit Score: 97.3413
Threshold Setting Gi: 224495933
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4D18_H    35 IATPPVYGQLLALYLLHNDM-NNARYLWKRIPPAIKSA-------------------NSELGGIWSVGQRIWQRDFPGIY 94  human
A7F080    64 LTKDETITNILVKSLTVFPS-PDFSLALHLLPPHILTPissssalp----aagdaplSEAVQKLAVLNTLLSSANYSQFW 138 Sclerotinia sclerot...
Q7S2R9    62 RIKDEVITNILVKAMTQFPS-PQFDLALHLLSPSQSNPgpns-----------sselTEAVSKLRALNAQLEGAEYARFW 129 Neurospora crassa O...
Q4WXE9    64 LLQPETVTNILAKALTVFPS-PAFSLCLALLPAHTQPFptadtda------sqtsdfVESIQKLARLSTLLESAQYAQFW 136 Aspergillus fumigat...
EDN08903  63 LLHTETTTNILAKALTVFPS-PAFSLALALLPAYTQPFsastsssl----pmqtsdfIESIQKLARLNTLLESAQYTLFW 137 Histoplasma capsula...
Q5CU68    90 RTNLEIVQDILLLSIIRGPLsSDFLSCTYQIPLSVQND--------------------PNIKQIIQLNDLLTSCRYANMW 149 Cryptosporidium parvum
Q9W2D9    64 MLNFDITYTILLKSLTSLPH-TDFVMAKCLLLPQQMKD--------------------ENVQTIIDLADILERADFTLFW 122 fruit fly
Q1HPS4    62 KFNADITCQILLKALTNFPH-TDFTLCKCLLLESVVEN--------------------ETISQIKYLADILEQCDFAQFG 120 domestic silkworm
Q567V6    61 YFQTTVTAQILLKALTNLPH-TDFTLCKCMIDQTHQEE--------------------RPIRQILYLGNLLETCHFQSFW 119 zebrafish
Q1E6D3    63 LLNAETVTNILAKALTVFPS-PAFSLSLALLPAYTQPYatsstqattanlpmqtadfVEAVQKLTHLSTLLESAQYTAFW 141 Coccidioides immiti...
4D18_H    95 TTINAhQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLP--VEEAVKGILEQ-GWQAD--------STT 163 human
A7F080   139 STLDSdDLYADLIADVSGFEELIRIRIASTISQSVREIPSSELENWLGMN--GEAFEKFIKEVcGWTIE--------NGS 208 Sclerotinia sclerot...
Q7S2R9   130 ATLDSdDLYADLTTDIAGFEDMIRVRIAQLVGQSYREIQFPVLESWLGLNn-SEATTQFITETcGWKVE--------GDV 200 Neurospora crassa O...
Q4WXE9   137 STLNSdDLYADLVADVAGFEELVRIRIAIEVGKAFREINAEVLEQWLDLRs-REALEKFVTEVcSWEVDktg---pnGTV 212 Aspergillus fumigat...
EDN08903 138 STLNSdDLYADLVADVAGFEELVRVRIAVEVGKAFREIGADVLAQWLDLNg-LEALEKFVVDVcGWEVDknagsdltSAV 216 Histoplasma capsula...
Q5CU68   150 NLLKTnDQLRSKVEKIQGFYDSIRDIIIYSVNCSHSCISTAVLSELLDFPkdSTELKNIIEKN-KWILD--------SAC 220 Cryptosporidium parvum
Q9W2D9   123 QRAEVn---RNMFRHITGFHDSIRKFVSHVVGTTFQTIRKDLLKELLGGIe-DSTLESWIKRN-GWKNQ--------GQG 189 fruit fly
Q1HPS4   121 NRVHQm---PELCSRISGFHDSIRKFVCHVVGITFQTIDKNNLANLLGGId-DVTLKHWVKKY-GWRD---------DGS 186 domestic silkworm
Q567V6   120 ASLEEn---RDLIDGITGFEESVRKFICHVVGITYQNIEYRLLAEMLGDPl-DTQVKVWMNKY-GWTEN--------EDG 186 zebrafish
Q1E6D3   142 STLNSdDLYADLTADVAGFEELIRIRIAVEVGKAFREIGADVLMGWLDMRg-METLEKFVVDVcGWEVDkskaegenGVI 220 Coccidioides immiti...
4D18_H   164 RMVLprK 170 human
A7F080   209 VIVPlnK 215 Sclerotinia sclerotiorum 1980 UF-70
Q7S2R9   201 VQIPknA 207 Neurospora crassa OR74A
Q4WXE9   213 VKVPtnK 219 Aspergillus fumigatus Af293
EDN08903 217 IRVPknK 223 Histoplasma capsulatum NAm1
Q5CU68   221 EIIRipl 227 Cryptosporidium parvum
Q9W2D9   190 LVIVamQ 196 fruit fly
Q1HPS4   187 LIFIanQ 193 domestic silkworm
Q567V6   187 QIFIhnQ 193 zebrafish
Q1E6D3   221 VRVPrnK 227 Coccidioides immitis RS
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