Conserved Protein Domain Family
Mitofilin

?
pfam09731: Mitofilin 
Mitochondrial inner membrane protein
Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.
Statistics
?
PSSM-Id: 337494
View PSSM: pfam09731
Aligned: 18 rows
Threshold Bit Score: 368.675
Threshold Setting Gi: 74858195
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q6PFS4        39 GSSAGKivaasLLTVGGGLGGTILYAKWDPKFRSSIEKS-VPYSDQLFDMVLGAPPSPPVpi----------qkK----- 102 zebrafish
Q9ASV5        69 KGNSSK-----VVIGGVAIAGAFLVAYQTGYLDQYLGKEqQKLSERIHSDALTEKLEEAHhlnvpsgvedstekD----- 138 thale cress
P91928        68 EAGFGKvv--lFVSPLAAVGGVITYAKYDDDFRKLVEKN-VPGAGSVIKVALQEEPPFKGitknvndqidkvksG----- 139 fruit fly
Q16U68        37 EAGFGKvl--vvLSPFLVGGGVVAYAKYDNEFRKTLVTN-VPALEPVLKALLQEENPLDEvs-----------kK----- 97  yellow fever mo...
Q9XXN2        20 SSGGLKfvgatVGAVTAGAAGVAGYASYDNEFRKKLEGV-IPGSRTILNYTIGEEEPPAP--------------R----- 79  Caenorhabditis ...
Q22505        37 KSGGGKgl-alVGATVVGAGGVVGYAYVDPEFRHKVEST-VPPVKQVFDAVLGES-SLQK--------------T----- 94  Caenorhabditis ...
Q5K8K8        77 PRRFRRvfvytALGVAGFYALSGYVGTKSDAYRDLFTQY-VPGGEAVADYADDNDWD----------------------- 132 Cryptococcus ne...
NP_001006462  41 gvSVGKiigasVLFVGGGVGGTVLYASYDPRFRENVEKA-IPYSDKLFEMALGPAPYSVPip-----------kK----- 103 chicken
XP_312591     42 EAGFGKvl--vVLSPILIGGGVVTYAKYDNEFRKTLITN-VPALEPVLKTLLQETNPLDEvs-----------kK----- 102 Anopheles gambi...
XP_011386449  40 RSGLGRlfvysTVGATVFYGISTVAALNNDRYNHFFVES-IPGGERIIDYLDTHDVGQEI--------------Ksinlh 104 Ustilago maydis...
Q6PFS4       103 ---------PETVKPLQISSLSEATKDSKQPKAKAKKSDpapppsveeapapapalqsleeasaeaAHI-ISAISEVP-- 170 zebrafish
Q9ASV5       139 ---------GKVETQPQVTHSEASEGVQSDIELQPESDLs-------------------------sDRF-TYISSNQE-- 181 thale cress
P91928       140 ---------IETVTSTVDSVTSKVTGLFGGGSGDDKSKKskvepv---------------katpaeEKR-PSKPSEVS-- 192 fruit fly
Q16U68        98 ---------LDEISSTISGYTSTVTGFFTGVSKEEEKKPektkp-----------------skpvaK---PAAPAAPS-- 146 yellow fever mo...
Q9XXN2        80 ---------LKDLRPLQYSADPKVPPKPFEPKPVKKELIg--------------------------VKEnLKETTEPK-- 122 Caenorhabditis ...
Q22505        95 ---------KQQIGDLKDAVVNAVPKKKEVLPPLELAPLppv----------------------lpR---EPTHVDPV-- 138 Caenorhabditis ...
Q5K8K8       133 -----------NVSGKAVRAWQSITGARPETRTEKVERKi------------------------------GEVRQEAA-- 169 Cryptococcus ne...
NP_001006462 104 ---------PVQQGPLKISSVAEVMKESKQPVPKP---------------------------------Q-TSKTEAVA-- 138 chicken
XP_312591    103 ---------MDDISKTIGEYTSTITGFFGGGDEEKKQEKk--------------------------PDL-PPITRAKSvh 146 Anopheles gambi...
XP_011386449 105 gygdkaidvTKTAYDSVSGAVSRVFSGDAGASESAGDERd---------------------------AR-LRVSEARA-- 154 Ustilago maydis...
Q6PFS4       171 ------------------SVPAPGTSDESPSGhsaaaeecckectepep-------avkerpaeevtarlaqQDKAELDA 225 zebrafish
Q9ASV5       182 ------------------ETPQETVIDRAEIN----------------------------------------LPISASED 203 thale cress
P91928       193 ------------------KTEAKPVSKPAAAAapapaa----------------------------kpkdnpLPRDVVEL 226 fruit fly
Q16U68       147 ------------------PAPASKAAPAKATApaaaatvpk----------------------piapkpaeeVPKSISDL 186 yellow fever mo...
Q9XXN2       123 ------------------KIEKKPENPYIGAK----------------------------------------TPLNPQER 144 Caenorhabditis ...
Q22505       139 ------------------DVRKDVTPMIPKPS-----------------------------------------PDVVFAK 159 Caenorhabditis ...
Q5K8K8       170 ------------------KVPAQVKDKADEAKdhv-----------------------------------vgKHTASQKI 196 Cryptococcus ne...
NP_001006462 139 ------------------PSEEKEDKEHEGSHaikerspd------------------------evaarlaqQDKEEQEK 176 chicken
XP_312591    147 vpvpspplpkpepinlsdKVPEQPKKKPEAAApkvttatatkaaaaataaapaksapaapskpaplasggetVPKSISDL 226 Anopheles gambi...
XP_011386449 155 ------------------TAKAEADKLAQRAKv--------------------------------------aAEKAEHQA 178 Ustilago maydis...
Q6PFS4       226 LAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKL----------------------------REAMDSETPpde 277 zebrafish
Q9ASV5       204 SGAKPDMPSEIISEAESVKLEAVPKPGDSPIIVNAQSSSV----------------------------HRESETESA--- 252 thale cress
P91928       227 EKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDKAVENG----------------------------ENSLWTTLKnra 278 fruit fly
Q16U68       187 ERQIDVAAATAIKEYGKAVQVLKDYTNEVKKVVDESVDKL----------------------------DSSSWVLLRnrt 238 yellow fever mo...
Q9XXN2       145 NEKLTESLKNHLTQAEKATKVATSAKLETIRAIEHHVQTI----------------------------REAIEAGKDgdw 196 Caenorhabditis ...
Q22505       160 NQQLEEKLKIAIHSAEGKVRLATEAKLKTINAINEHASIL----------------------------KQTVDDAKHanw 211 Caenorhabditis ...
Q5K8K8       197 HERAEELRKAVEQKTHEAEARLKELTGEAKHKVQEATKDA----------------------------PFNFSEGVEgiv 248 Cryptococcus ne...
NP_001006462 177 ISALAATLEGALSSTARITLQAITAQESAVQAVNAHLQILkeamddsetagekksaqwrtleealkdrRRAVDEAADvll 256 chicken
XP_312591    227 EQQVEVAATIAIKEYGHAVDVLKSYTNEVRKVVDESVDKL----------------------------DSSSWTTLR--- 275 Anopheles gambi...
XP_011386449 179 ESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTEASKDG----------------------------RNIIQRAVD--- 227 Ustilago maydis...
Q6PFS4       278 kstqalnealneraravddagea--------lfkakgeleklrsvidkakqskidsaR---------------------- 327 zebrafish
Q9ASV5       253 ---------------------------------------------------------S---------------------- 253 thale cress
P91928       279 sardtavataeraar-------------------------eaqekivaceialsaaaT---------------------- 311 fruit fly
Q16U68       239 sardtalkaaedaaeda---------------------renieklhrlldsrdikcsD---------------------- 275 yellow fever mo...
Q9XXN2       197 dsvtvahlkakrlaekdekaek-----------larnavadlvteanlggqgettqlN---------------------- 243 Caenorhabditis ...
Q22505       212 envtsalqraeaearvdsgqev-----------dgrnyidnlrkivndgkrdsttatN---------------------- 258 Caenorhabditis ...
Q5K8K8       249 raaesalhktehkaaeaadkvkpaearpsspfpdtqrprelkpetvtpqvpsyegkkL---------------------- 306 Cryptococcus ne...
NP_001006462 257 kakeelektkg---------------------------------vienakksqipgaK---------------------- 281 chicken
XP_312591    276 ---------------------------------------------------------Nrtsardtalqaaedaadkargn 298 Anopheles gambi...
XP_011386449 228 ---------------------------------------------------------Svqvmtdi--------------- 235 Ustilago maydis...
Q6PFS4       328 -----------------PQILAAEEN----------LHS-------------------------------MIVDLDKVVT 349 zebrafish
Q9ASV5       254 -----------------PKDPAALKT----------PED-------------------------------GIEREVQLPG 275 thale cress
P91928       312 -----------------AQNAKKVEAvr------dkIKK-------------------------------LVDHIGNVKD 337 fruit fly
Q16U68       276 -----------------ELKDKAREN----------IAS-------------------------------YLEHLKKAKE 297 yellow fever mo...
Q9XXN2       244 -----------------PLVPISKAT----------AEK-------------------------------LSNELDEMIS 265 Caenorhabditis ...
Q22505       259 -----------------PLLLNAQET----------ANK-------------------------------LSHQLDEINA 280 Caenorhabditis ...
Q5K8K8       307 -----------------YTGPPLPLGhepppgyylpPPP-------------------------------STKKEKVEEK 338 Cryptococcus ne...
NP_001006462 282 -----------------SHIIAAEEN----------LHH-------------------------------MIVDLDNVVK 303 chicken
XP_312591    299 ieklhallnsreikcsdELKDKARQN----------IAA-------------------------------YLDHLKKAKE 337 Anopheles gambi...
XP_011386449 236 ----------gantkaaPSKSAAPGN----------GPKeevketyigelpvnheapvgyaaprrdrglqAPDHPTARLR 295 Ustilago maydis...
Q6PFS4       350 KVQTAQSEAKIVSQYSELVNEAKAQfqqelaNITPEIQANWKGLSGkLSADDLNSLIAHAHRRIDQLNRELAEQRVREQI 429 zebrafish
Q9ASV5       276 SLLKEYNLEGSDTESTGSSSIGEQI------TKETEAFPNSTEGLKdSYMTEDGKLVLDFLAAIHAAEKQQAHLDAQVFA 349 thale cress
P91928       338 ELYRHKDTASVSDKYWRNVEKARNYfideieSIFPGLSLADKKLNL--SKEDLDLFILHAYTHVLAYQKELQRLQTDGEL 415 fruit fly
Q16U68       298 DVYKARNLATLGEKYWKKVETARNFfideieSLFPGI--NLSEKKLdLSKDDLDLFILHAFTQVVAHQKELQKLQIEGDQ 375 yellow fever mo...
Q9XXN2       266 NVKHVDSERIFVHDYSDRVAESRRKfqmelkAVHPNLN---YEDGMkIKKADLHTILAHAHLRIDQLSQKLIDSKLNEEK 342 Caenorhabditis ...
Q22505       281 LVNKSRQESAVLNQYKDLIEKSRQQfalemkSILPNVDIHAKDKNL--NEDELNALIAHAHLKVDQLRCQLSDQQVREEL 358 Caenorhabditis ...
Q5K8K8       339 VEEIKERLPLLVPKVKEFASEEPIIsq--laSTIDSLTSSLSTPSK-ALSSDATGILNKAQDDLTALNARLQEVKKAEKA 415 Cryptococcus ne...
NP_001006462 304 KVQAAQSEAKIVAQYHELVATAREEfqreldSITPDVQPGWKGLTGqLSTDDLNSLIAHAHRRIDQLNKELAEQRVREQQ 383 chicken
XP_312591    338 EVYAARDLASLGEKYWKRVESARNYfveemeSLFPGINLAERKLN--LSKDELDLFILHAYTQVIAHQKELQKLQIEGDQ 415 Anopheles gambi...
XP_011386449 296 PDPEAPKLPLLAPSIKSLSASEPMIaq--laGTIDELTVFLKETP--SSGAKAKGVLESAQIDLEQLSQRLETIKRQEAK 371 Ustilago maydis...
Q6PFS4       430 HIEVALEQQKLEdQKAQERAVISALEHSRE------DMRLEQEKKVQEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQE 503 zebrafish
Q9ASV5       350 EELRALKEKYENeLRDLRARELMRIEEAAIldkelkRERTKAAAAIKAIQERMEDKLKAELEQKETEAQLALSKAEELAK 429 thale cress
P91928       416 RLKRAIDSVR---GDNDSEALRAQLEYHLEae--rrKLAVENQKKIFHIHAESDKLLRLQLKKQAEAHADHIKDIVAQRE 490 fruit fly
Q16U68       376 QLKRALEAVR---GTDQSEAVKAQLEYEIAke--krELNLRNQRKLLAIRAELERNLRSQMKRQSEAHTDHLADALAQKE 450 yellow fever mo...
Q9XXN2       343 RIQSIIAKKKEDlLEKLRLETNAKQAAVIPefd-kkKLDAELARATAEIQKKYDEKLK---------------EVVRTQK 406 Caenorhabditis ...
Q22505       359 HISKALEEQRLAdERIASEKLSIEMSrv------grQNELEIERALVESRSSWEGELENQLKRTASAHSEHLEQVIRTQR 432 Caenorhabditis ...
Q5K8K8       416 KLEQSISEKKKE-----FEALLKSMEAEKAks--eeGLKQTWQHERQTMVEDWRKELEGELEQQRQSIEQRLREEVVSQG 488 Cryptococcus ne...
NP_001006462 384 HIELALEKQKLEdKKALEAAVAKALEHHKS------EIEIEQEKKVEEVREVMESEMRTQLRRQAAAHTDHLRDVLKIQE 457 chicken
XP_312591    416 NLRRALEAVR---GSDQSEEVKARLEYEIAke--krQLNLLNQKKLLLTRAELEQQMREQLKRQTEAHVDHLKDALTQKE 490 Anopheles gambi...
XP_011386449 372 RVEDSLAAQAKR-YETQISKQSQEAADKLSsr--esDWQKSFEEEHAKQTQQFKEKLEKELATQSQIINERLKEEVIAQG 448 Ustilago maydis...
Q6PFS4       504 QELreeaqeilNSKMMEQEthyrrltqeqlDTFTLDMNAAYARLKGIEEAIDS-------HVIAEEEARKAHQLWLSVEA 576 zebrafish
Q9ASV5       430 AEM--------ISTIAKEK-----------AAQIEKMAEADLNIKALSMAFYA-------RSEEARQSHSVHKLALGALA 483 thale cress
P91928       491 TDLtrsfkrelEDKLATEK-----------ANYKLQLAGMLGKLRGMDAALAE-------RADAERTANQAQALWAACQA 552 fruit fly
Q16U68       451 VEMkrkfqrelDEKITTEQ-----------AAYKLQLAAMLGKLKGMDAALKEiddemkgRADAEKSAHQAQALWGACQS 519 yellow fever mo...
Q9XXN2       407 QLYdiehakdvDEAVLKER-----------NLHSSAVGKALAQLAGIEKALSG-------HLQMDIENRKSKQMWLATQN 468 Caenorhabditis ...
Q22505       433 QLFeieqnqkvEEAVLQER-----------NLHSKQVGAALSRLEGIEEALGS-------RVALDNENRRAKQFWIACHN 494 Caenorhabditis ...
Q5K8K8       489 IELqrrwlrsiKTQVETER-----------GGRLAKLDSLTTSLKQLERITLD-------NSATLDDNVRLHKIWSALRA 550 Cryptococcus ne...
NP_001006462 458 QELkvefeqnlSEKLSEQEmqfrrltqeqlDNFTLDINTAYARLKGIEQAVES-------HAVAEEEARKAHQLWLSVEA 530 chicken
XP_312591    491 LEMkrkfqrelDEKITTEQ-----------ASYKLQLAAMLGKLKGIHNALVE-------HADAEKSAHQAQALWGACQS 552 Anopheles gambi...
XP_011386449 449 IELqrrwmkdiKAKVEEER-----------GGRLSKLDELATDLKSLEKVSLD-------NSSVLDENLSVHTLWTAVRA 510 Ustilago maydis...
Q6PFS4       577 LNYTLKSAgad-----sptEPLEGAVRAIKES-----CAENEFAQALAIAIPEESLNR-GIYSEASLRARF-YDIRRLAR 644 zebrafish
Q9ASV5       484 LDDTLSKG-----------LPVQKEIDTLQTYle--gTHKDSILGLVLSSLPEEARSN-GTDTVLQLNQKF-DTLKGTLR 548 thale cress
P91928       553 LWASVRAAtpgvh-ykdrlRPLKNEINAIAKV-----AKGDDLVAAVLESVPKEAQER-GVYPEDALRERF-LNVERVAR 624 fruit fly
Q16U68       520 LWSSIRSGqpgks-wreqlRPLKDEIGAVARA-----AEGDELVGVVLKGLPETAKNR-GVYPEDALRERF-IKVEQVSR 591 yellow fever mo...
Q9XXN2       469 LKGTVIFGnrasccmegrrAPLGDQMKTLLSCcg--gGNSDEFVKTINTAMSKTSKVR-GEYTEQDLNTRF-NKVCRIGR 544 Caenorhabditis ...
Q22505       495 LIDTLKHGnkagnniderrLPLNESLNLLKEV-----NPEDEFVNAIIDSFPKQATTV-GTYTEQDLKNRF-EQLYKIGR 567 Caenorhabditis ...
Q5K8K8       551 VQSKVDSGd----------LAFDDELRALKSLstptaSSGEGVVRSALEQIEKSGIPQtGVKSFAALSSWFtNTVAPRIQ 620 Cryptococcus ne...
NP_001006462 531 LKYCMKTAsgd-----sptEPLESAVKAIKAS-----CSDNAFTEALTAALPQESLTR-GVYSEEALRARF-YTVQKLAK 598 chicken
XP_312591    553 LWSSIRSGqpgks-wrdqlRPLKDEIAAVARS-----AEGDELVTVVLKGLPETAVKR-GVYPEDALRERF-LKVEEVSR 624 Anopheles gambi...
XP_011386449 511 VQHALDDAsa-------tkRPFAEQLRVLKGTs---kARDDPVLSAAIEALDASGAADtGVETFTTLKQWFdDKVGPRVR 580 Ustilago maydis...
Q6PFS4       645 RVALI-D-ETRNSLYQYFLSYLQSVLLFERD----Qeapp-----aklaPEDLDTFKLLAYATYSIERGDLELAAKFVNQ 713 zebrafish
Q9ASV5       549 HFSLI-P-PGGGGILAHSLAHVASSLKFKEV----D-------------QANGGIESVIKKVDNYLAEGKLAEAAATLEE 609 thale cress
P91928       625 RLALV-P-EEGAGLPIYFLSYLQSLFILRPD----NpiskdelenkpfdYSKLDTYDILNRARYHVDRSDFLQALKYMNL 698 fruit fly
Q16U68       592 RLALV-P-AEGARLPLYFLSFLQAALIAKPD----VpiskdeledkpfdFNKLDTYDILNRARYWLDRGDLVKTVQYMNL 665 yellow fever mo...
Q9XXN2       545 RVAYV----NEGGALAHLYSWLKSSLTIELV----Pkkgan----esltPAVENNFTLLTRAEQLWKSGKKSDAIRVLQL 612 Caenorhabditis ...
Q22505       568 KTASI-D-ENGGTLGAYFWSYVKSLFLVDMP----Qqygnl----daidVNNTDNYEILSRAKQYVHNGDLDKAIRVVQL 637 Caenorhabditis ...
Q5K8K8       621 SSSLVpA-PEEATVISHLASAGLSKIMFRPQ----Agr-----------vPGDSVGAVLARAEWCLAEKDLDGAAREINS 684 Cryptococcus ne...
NP_001006462 599 RVAMI-D-ETRNSLYQYFLSYLQSLLVFHPQ----Qlkpp-----aelsPDDLDTFKLLSYASYCIEHGDLELAAKFVNQ 667 chicken
XP_312591    625 RLALV-P-AEGARLPMYVLSYLQAALIARPDkpisQdelen----kpfdFSKLDTYDILNRARYWLDRGDLVKTVQYVNL 698 Anopheles gambi...
XP_011386449 581 QVSLV-PsPETSGVLSHLASAALSPILFHKK----Gl------------VPGQDVPSVLARAEYYLDRKDLDSATRELNQ 643 Ustilago maydis...
Q6PFS4       714 -LRG-ESQRVAQDWLKEARLTLETKQVISLLSAYAN 747 zebrafish
Q9ASV5       610 gVKGsKAEEIVSDWVRRARNRAITEQALTLLQSYAT 645 thale cress
P91928       699 -LQG-ASRKIAGEWMKEARLMLETQQAANTLMAHAA 732 fruit fly
Q16U68       666 -LQG-ASRKAAMDWLNEARLLLETQQAASTLMAHAS 699 yellow fever mosquito
Q9XXN2       613 -TDG-ATRRVAADFIADARRQHEALLLSRLLLAHAA 646 Caenorhabditis elegans
Q22505       638 -LKG-QPAHLARDWIVDTRSYLESRLLAQLLVAHAA 671 Caenorhabditis elegans
Q5K8K8       685 -LTG-WPAKLANDWLQQARRKLEVQQALEVVATEAT 718 Cryptococcus neoformans
NP_001006462 668 -LRG-ESRRVAHDWLTEARMTLETKQIVDILTAYAS 701 chicken
XP_312591    699 -LQG-APRKAALDWLNEARLLLETQQAASTLMAHAA 732 Anopheles gambiae str. PEST
XP_011386449 644 -LKG-WPKLLASDWLAASRKRLEVQQALDVVQTEAS 677 Ustilago maydis 521
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap