Conserved Protein Domain Family
Mitofilin

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pfam09731: Mitofilin 
Mitochondrial inner membrane protein
Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.
Statistics
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PSSM-Id: 337494
View PSSM: pfam09731
Aligned: 18 rows
Threshold Bit Score: 368.675
Threshold Setting Gi: 74858195
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230   39 GSSAGKivaasLLTVGGGLGGTILYAKWDPKFRSSIEKS-VPYSDQLFDMVLGAPPSPPVpi----------qkK----- 102
gi 75167734   69 KGNSSK-----VVIGGVAIAGAFLVAYQTGYLDQYLGKEqQKLSERIHSDALTEKLEEAHhlnvpsgvedstekD----- 138
gi 251757495  68 EAGFGKvv--lFVSPLAAVGGVITYAKYDDDFRKLVEKN-VPGAGSVIKVALQEEPPFKGitknvndqidkvksG----- 139
gi 121955331  37 EAGFGKvl--vvLSPFLVGGGVVAYAKYDNEFRKTLVTN-VPALEPVLKALLQEENPLDEvs-----------kK----- 97
gi 75029364   20 SSGGLKfvgatVGAVTAGAAGVAGYASYDNEFRKKLEGV-IPGSRTILNYTIGEEEPPAP--------------R----- 79
gi 74966123   37 KSGGGKgl-alVGATVVGAGGVVGYAYVDPEFRHKVEST-VPPVKQVFDAVLGES-SLQK--------------T----- 94
gi 74682304   77 PRRFRRvfvytALGVAGFYALSGYVGTKSDAYRDLFTQY-VPGGEAVADYADDNDWD----------------------- 132
gi 57530041   41 gvSVGKiigasVLFVGGGVGGTVLYASYDPRFRENVEKA-IPYSDKLFEMALGPAPYSVPip-----------kK----- 103
gi 158291084  42 EAGFGKvl--vVLSPILIGGGVVTYAKYDNEFRKTLITN-VPALEPVLKTLLQETNPLDEvs-----------kK----- 102
gi 758972780  40 RSGLGRlfvysTVGATVFYGISTVAALNNDRYNHFFVES-IPGGERIIDYLDTHDVGQEI--------------Ksinlh 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  103 ---------PETVKPLQISSLSEATKDSKQPKAKAKKSDpapppsveeapapapalqsleeasaeaAHI-ISAISEVP-- 170
gi 75167734  139 ---------GKVETQPQVTHSEASEGVQSDIELQPESDLs-------------------------sDRF-TYISSNQE-- 181
gi 251757495 140 ---------IETVTSTVDSVTSKVTGLFGGGSGDDKSKKskvepv---------------katpaeEKR-PSKPSEVS-- 192
gi 121955331  98 ---------LDEISSTISGYTSTVTGFFTGVSKEEEKKPektkp-----------------skpvaK---PAAPAAPS-- 146
gi 75029364   80 ---------LKDLRPLQYSADPKVPPKPFEPKPVKKELIg--------------------------VKEnLKETTEPK-- 122
gi 74966123   95 ---------KQQIGDLKDAVVNAVPKKKEVLPPLELAPLppv----------------------lpR---EPTHVDPV-- 138
gi 74682304  133 -----------NVSGKAVRAWQSITGARPETRTEKVERKi------------------------------GEVRQEAA-- 169
gi 57530041  104 ---------PVQQGPLKISSVAEVMKESKQPVPKP---------------------------------Q-TSKTEAVA-- 138
gi 158291084 103 ---------MDDISKTIGEYTSTITGFFGGGDEEKKQEKk--------------------------PDL-PPITRAKSvh 146
gi 758972780 105 gygdkaidvTKTAYDSVSGAVSRVFSGDAGASESAGDERd---------------------------AR-LRVSEARA-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  171 ------------------SVPAPGTSDESPSGhsaaaeecckectepep-------avkerpaeevtarlaqQDKAELDA 225
gi 75167734  182 ------------------ETPQETVIDRAEIN----------------------------------------LPISASED 203
gi 251757495 193 ------------------KTEAKPVSKPAAAAapapaa----------------------------kpkdnpLPRDVVEL 226
gi 121955331 147 ------------------PAPASKAAPAKATApaaaatvpk----------------------piapkpaeeVPKSISDL 186
gi 75029364  123 ------------------KIEKKPENPYIGAK----------------------------------------TPLNPQER 144
gi 74966123  139 ------------------DVRKDVTPMIPKPS-----------------------------------------PDVVFAK 159
gi 74682304  170 ------------------KVPAQVKDKADEAKdhv-----------------------------------vgKHTASQKI 196
gi 57530041  139 ------------------PSEEKEDKEHEGSHaikerspd------------------------evaarlaqQDKEEQEK 176
gi 158291084 147 vpvpspplpkpepinlsdKVPEQPKKKPEAAApkvttatatkaaaaataaapaksapaapskpaplasggetVPKSISDL 226
gi 758972780 155 ------------------TAKAEADKLAQRAKv--------------------------------------aAEKAEHQA 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  226 LAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKL----------------------------REAMDSETPpde 277
gi 75167734  204 SGAKPDMPSEIISEAESVKLEAVPKPGDSPIIVNAQSSSV----------------------------HRESETESA--- 252
gi 251757495 227 EKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDKAVENG----------------------------ENSLWTTLKnra 278
gi 121955331 187 ERQIDVAAATAIKEYGKAVQVLKDYTNEVKKVVDESVDKL----------------------------DSSSWVLLRnrt 238
gi 75029364  145 NEKLTESLKNHLTQAEKATKVATSAKLETIRAIEHHVQTI----------------------------REAIEAGKDgdw 196
gi 74966123  160 NQQLEEKLKIAIHSAEGKVRLATEAKLKTINAINEHASIL----------------------------KQTVDDAKHanw 211
gi 74682304  197 HERAEELRKAVEQKTHEAEARLKELTGEAKHKVQEATKDA----------------------------PFNFSEGVEgiv 248
gi 57530041  177 ISALAATLEGALSSTARITLQAITAQESAVQAVNAHLQILkeamddsetagekksaqwrtleealkdrRRAVDEAADvll 256
gi 158291084 227 EQQVEVAATIAIKEYGHAVDVLKSYTNEVRKVVDESVDKL----------------------------DSSSWTTLR--- 275
gi 758972780 179 ESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTEASKDG----------------------------RNIIQRAVD--- 227
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  278 kstqalnealneraravddagea--------lfkakgeleklrsvidkakqskidsaR---------------------- 327
gi 75167734  253 ---------------------------------------------------------S---------------------- 253
gi 251757495 279 sardtavataeraar-------------------------eaqekivaceialsaaaT---------------------- 311
gi 121955331 239 sardtalkaaedaaeda---------------------renieklhrlldsrdikcsD---------------------- 275
gi 75029364  197 dsvtvahlkakrlaekdekaek-----------larnavadlvteanlggqgettqlN---------------------- 243
gi 74966123  212 envtsalqraeaearvdsgqev-----------dgrnyidnlrkivndgkrdsttatN---------------------- 258
gi 74682304  249 raaesalhktehkaaeaadkvkpaearpsspfpdtqrprelkpetvtpqvpsyegkkL---------------------- 306
gi 57530041  257 kakeelektkg---------------------------------vienakksqipgaK---------------------- 281
gi 158291084 276 ---------------------------------------------------------Nrtsardtalqaaedaadkargn 298
gi 758972780 228 ---------------------------------------------------------Svqvmtdi--------------- 235
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  328 -----------------PQILAAEEN----------LHS-------------------------------MIVDLDKVVT 349
gi 75167734  254 -----------------PKDPAALKT----------PED-------------------------------GIEREVQLPG 275
gi 251757495 312 -----------------AQNAKKVEAvr------dkIKK-------------------------------LVDHIGNVKD 337
gi 121955331 276 -----------------ELKDKAREN----------IAS-------------------------------YLEHLKKAKE 297
gi 75029364  244 -----------------PLVPISKAT----------AEK-------------------------------LSNELDEMIS 265
gi 74966123  259 -----------------PLLLNAQET----------ANK-------------------------------LSHQLDEINA 280
gi 74682304  307 -----------------YTGPPLPLGhepppgyylpPPP-------------------------------STKKEKVEEK 338
gi 57530041  282 -----------------SHIIAAEEN----------LHH-------------------------------MIVDLDNVVK 303
gi 158291084 299 ieklhallnsreikcsdELKDKARQN----------IAA-------------------------------YLDHLKKAKE 337
gi 758972780 236 ----------gantkaaPSKSAAPGN----------GPKeevketyigelpvnheapvgyaaprrdrglqAPDHPTARLR 295
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  350 KVQTAQSEAKIVSQYSELVNEAKAQfqqelaNITPEIQANWKGLSGkLSADDLNSLIAHAHRRIDQLNRELAEQRVREQI 429
gi 75167734  276 SLLKEYNLEGSDTESTGSSSIGEQI------TKETEAFPNSTEGLKdSYMTEDGKLVLDFLAAIHAAEKQQAHLDAQVFA 349
gi 251757495 338 ELYRHKDTASVSDKYWRNVEKARNYfideieSIFPGLSLADKKLNL--SKEDLDLFILHAYTHVLAYQKELQRLQTDGEL 415
gi 121955331 298 DVYKARNLATLGEKYWKKVETARNFfideieSLFPGI--NLSEKKLdLSKDDLDLFILHAFTQVVAHQKELQKLQIEGDQ 375
gi 75029364  266 NVKHVDSERIFVHDYSDRVAESRRKfqmelkAVHPNLN---YEDGMkIKKADLHTILAHAHLRIDQLSQKLIDSKLNEEK 342
gi 74966123  281 LVNKSRQESAVLNQYKDLIEKSRQQfalemkSILPNVDIHAKDKNL--NEDELNALIAHAHLKVDQLRCQLSDQQVREEL 358
gi 74682304  339 VEEIKERLPLLVPKVKEFASEEPIIsq--laSTIDSLTSSLSTPSK-ALSSDATGILNKAQDDLTALNARLQEVKKAEKA 415
gi 57530041  304 KVQAAQSEAKIVAQYHELVATAREEfqreldSITPDVQPGWKGLTGqLSTDDLNSLIAHAHRRIDQLNKELAEQRVREQQ 383
gi 158291084 338 EVYAARDLASLGEKYWKRVESARNYfveemeSLFPGINLAERKLN--LSKDELDLFILHAYTQVIAHQKELQKLQIEGDQ 415
gi 758972780 296 PDPEAPKLPLLAPSIKSLSASEPMIaq--laGTIDELTVFLKETP--SSGAKAKGVLESAQIDLEQLSQRLETIKRQEAK 371
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  430 HIEVALEQQKLEdQKAQERAVISALEHSRE------DMRLEQEKKVQEVREVMEAEMRTQLRRQAAAHTDHLRDVLKVQE 503
gi 75167734  350 EELRALKEKYENeLRDLRARELMRIEEAAIldkelkRERTKAAAAIKAIQERMEDKLKAELEQKETEAQLALSKAEELAK 429
gi 251757495 416 RLKRAIDSVR---GDNDSEALRAQLEYHLEae--rrKLAVENQKKIFHIHAESDKLLRLQLKKQAEAHADHIKDIVAQRE 490
gi 121955331 376 QLKRALEAVR---GTDQSEAVKAQLEYEIAke--krELNLRNQRKLLAIRAELERNLRSQMKRQSEAHTDHLADALAQKE 450
gi 75029364  343 RIQSIIAKKKEDlLEKLRLETNAKQAAVIPefd-kkKLDAELARATAEIQKKYDEKLK---------------EVVRTQK 406
gi 74966123  359 HISKALEEQRLAdERIASEKLSIEMSrv------grQNELEIERALVESRSSWEGELENQLKRTASAHSEHLEQVIRTQR 432
gi 74682304  416 KLEQSISEKKKE-----FEALLKSMEAEKAks--eeGLKQTWQHERQTMVEDWRKELEGELEQQRQSIEQRLREEVVSQG 488
gi 57530041  384 HIELALEKQKLEdKKALEAAVAKALEHHKS------EIEIEQEKKVEEVREVMESEMRTQLRRQAAAHTDHLRDVLKIQE 457
gi 158291084 416 NLRRALEAVR---GSDQSEEVKARLEYEIAke--krQLNLLNQKKLLLTRAELEQQMREQLKRQTEAHVDHLKDALTQKE 490
gi 758972780 372 RVEDSLAAQAKR-YETQISKQSQEAADKLSsr--esDWQKSFEEEHAKQTQQFKEKLEKELATQSQIINERLKEEVIAQG 448
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  504 QELreeaqeilNSKMMEQEthyrrltqeqlDTFTLDMNAAYARLKGIEEAIDS-------HVIAEEEARKAHQLWLSVEA 576
gi 75167734  430 AEM--------ISTIAKEK-----------AAQIEKMAEADLNIKALSMAFYA-------RSEEARQSHSVHKLALGALA 483
gi 251757495 491 TDLtrsfkrelEDKLATEK-----------ANYKLQLAGMLGKLRGMDAALAE-------RADAERTANQAQALWAACQA 552
gi 121955331 451 VEMkrkfqrelDEKITTEQ-----------AAYKLQLAAMLGKLKGMDAALKEiddemkgRADAEKSAHQAQALWGACQS 519
gi 75029364  407 QLYdiehakdvDEAVLKER-----------NLHSSAVGKALAQLAGIEKALSG-------HLQMDIENRKSKQMWLATQN 468
gi 74966123  433 QLFeieqnqkvEEAVLQER-----------NLHSKQVGAALSRLEGIEEALGS-------RVALDNENRRAKQFWIACHN 494
gi 74682304  489 IELqrrwlrsiKTQVETER-----------GGRLAKLDSLTTSLKQLERITLD-------NSATLDDNVRLHKIWSALRA 550
gi 57530041  458 QELkvefeqnlSEKLSEQEmqfrrltqeqlDNFTLDINTAYARLKGIEQAVES-------HAVAEEEARKAHQLWLSVEA 530
gi 158291084 491 LEMkrkfqrelDEKITTEQ-----------ASYKLQLAAMLGKLKGIHNALVE-------HADAEKSAHQAQALWGACQS 552
gi 758972780 449 IELqrrwmkdiKAKVEEER-----------GGRLSKLDELATDLKSLEKVSLD-------NSSVLDENLSVHTLWTAVRA 510
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  577 LNYTLKSAgad-----sptEPLEGAVRAIKES-----CAENEFAQALAIAIPEESLNR-GIYSEASLRARF-YDIRRLAR 644
gi 75167734  484 LDDTLSKG-----------LPVQKEIDTLQTYle--gTHKDSILGLVLSSLPEEARSN-GTDTVLQLNQKF-DTLKGTLR 548
gi 251757495 553 LWASVRAAtpgvh-ykdrlRPLKNEINAIAKV-----AKGDDLVAAVLESVPKEAQER-GVYPEDALRERF-LNVERVAR 624
gi 121955331 520 LWSSIRSGqpgks-wreqlRPLKDEIGAVARA-----AEGDELVGVVLKGLPETAKNR-GVYPEDALRERF-IKVEQVSR 591
gi 75029364  469 LKGTVIFGnrasccmegrrAPLGDQMKTLLSCcg--gGNSDEFVKTINTAMSKTSKVR-GEYTEQDLNTRF-NKVCRIGR 544
gi 74966123  495 LIDTLKHGnkagnniderrLPLNESLNLLKEV-----NPEDEFVNAIIDSFPKQATTV-GTYTEQDLKNRF-EQLYKIGR 567
gi 74682304  551 VQSKVDSGd----------LAFDDELRALKSLstptaSSGEGVVRSALEQIEKSGIPQtGVKSFAALSSWFtNTVAPRIQ 620
gi 57530041  531 LKYCMKTAsgd-----sptEPLESAVKAIKAS-----CSDNAFTEALTAALPQESLTR-GVYSEEALRARF-YTVQKLAK 598
gi 158291084 553 LWSSIRSGqpgks-wrdqlRPLKDEIAAVARS-----AEGDELVTVVLKGLPETAVKR-GVYPEDALRERF-LKVEEVSR 624
gi 758972780 511 VQHALDDAsa-------tkRPFAEQLRVLKGTs---kARDDPVLSAAIEALDASGAADtGVETFTTLKQWFdDKVGPRVR 580
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187230  645 RVALI-D-ETRNSLYQYFLSYLQSVLLFERD----Qeapp-----aklaPEDLDTFKLLAYATYSIERGDLELAAKFVNQ 713
gi 75167734  549 HFSLI-P-PGGGGILAHSLAHVASSLKFKEV----D-------------QANGGIESVIKKVDNYLAEGKLAEAAATLEE 609
gi 251757495 625 RLALV-P-EEGAGLPIYFLSYLQSLFILRPD----NpiskdelenkpfdYSKLDTYDILNRARYHVDRSDFLQALKYMNL 698
gi 121955331 592 RLALV-P-AEGARLPLYFLSFLQAALIAKPD----VpiskdeledkpfdFNKLDTYDILNRARYWLDRGDLVKTVQYMNL 665
gi 75029364  545 RVAYV----NEGGALAHLYSWLKSSLTIELV----Pkkgan----esltPAVENNFTLLTRAEQLWKSGKKSDAIRVLQL 612
gi 74966123  568 KTASI-D-ENGGTLGAYFWSYVKSLFLVDMP----Qqygnl----daidVNNTDNYEILSRAKQYVHNGDLDKAIRVVQL 637
gi 74682304  621 SSSLVpA-PEEATVISHLASAGLSKIMFRPQ----Agr-----------vPGDSVGAVLARAEWCLAEKDLDGAAREINS 684
gi 57530041  599 RVAMI-D-ETRNSLYQYFLSYLQSLLVFHPQ----Qlkpp-----aelsPDDLDTFKLLSYASYCIEHGDLELAAKFVNQ 667
gi 158291084 625 RLALV-P-AEGARLPMYVLSYLQAALIARPDkpisQdelen----kpfdFSKLDTYDILNRARYWLDRGDLVKTVQYVNL 698
gi 758972780 581 QVSLV-PsPETSGVLSHLASAALSPILFHKK----Gl------------VPGQDVPSVLARAEYYLDRKDLDSATRELNQ 643
                        890       900       910
                 ....*....|....*....|....*....|....*.
gi 82187230  714 -LRG-ESQRVAQDWLKEARLTLETKQVISLLSAYAN 747
gi 75167734  610 gVKGsKAEEIVSDWVRRARNRAITEQALTLLQSYAT 645
gi 251757495 699 -LQG-ASRKIAGEWMKEARLMLETQQAANTLMAHAA 732
gi 121955331 666 -LQG-ASRKAAMDWLNEARLLLETQQAASTLMAHAS 699
gi 75029364  613 -TDG-ATRRVAADFIADARRQHEALLLSRLLLAHAA 646
gi 74966123  638 -LKG-QPAHLARDWIVDTRSYLESRLLAQLLVAHAA 671
gi 74682304  685 -LTG-WPAKLANDWLQQARRKLEVQQALEVVATEAT 718
gi 57530041  668 -LRG-ESRRVAHDWLTEARMTLETKQIVDILTAYAS 701
gi 158291084 699 -LQG-APRKAALDWLNEARLLLETQQAASTLMAHAA 732
gi 758972780 644 -LKG-WPKLLASDWLAASRKRLEVQQALDVVQTEAS 677
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