Conserved Protein Domain Family
ETRAMP

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pfam09716: ETRAMP 
Malarial early transcribed membrane protein (ETRAMP)
These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.
Statistics
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PSSM-Id: 313012
View PSSM: pfam09716
Aligned: 42 rows
Threshold Bit Score: 33.7659
Threshold Setting Gi: 74881962
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Y781         1 MKVPKVsAIFLVFLLSVCFLSSPSLCDANAGnkipnasnpavngnsae------------------naqgpagsktnngp 62  Plasmodium chab...
Q7RL79         1 MKVPKVsALFLVFLLSVSFLPSSSLCDPNAAntkipnipnptanaqsptvsgnsie---qtaeepnaatkvnnvpvpekk 77  Plasmodium yoel...
Q4YK90         1 MKVPKVsALFFVFLLSVCFLPSPSLCDASTGntkipnipnipnssgnaqsptvsgnsieqtaetsnvatranhvpapekt 80  Plasmodium berghei
Q7RSZ7         1 MKTTYV-SLFFIILLICGIFECKASSVDETNd------------------------------------------------ 31  Plasmodium yoel...
Q4YNP1         1 MNTLNV-FFVFYVLYITTFFFNPCFCEDTDYy------------------------------------------------ 31  Plasmodium berghei
Q7RK90        27 MNTLKV-FFVFYVLYITTFFFNPCFCEDADYy------------------------------------------------ 57  Plasmodium yoel...
Q8IEU1         1 MKVSKL-VLFAHIFFIINILCQYICLNASKVnkkg--------------------------------------------k 35  Plasmodium falc...
XP_001612702   1 MKIAKL-LALFAILPIVCLLGQEEVKAVSPS------------------------------------------------- 30  Plasmodium viva...
XP_002261684   1 MKITKL-LALFAILPIVCLCGNEEVDVISQN------------------------------------------------- 30  Plasmodium know...
XP_001616488   1 MKATNHlSVFALFLFIIAIIPCLAVYSDIPI------------------------------------------------- 31  Plasmodium viva...
Q4Y781        63 aseKKDSKDIAKIDDKITAK-KSAKPVIIGTISTIAALAIASALG-YGMYTKNKA 115 Plasmodium chabaudi
Q7RL79        78 ndaPVENKDIEKVNDQINAK-SKTKPLLISAISAVVAIAIASALG-YGIYTKKNS 130 Plasmodium yoelii yoelii
Q4YK90        81 ngaPVENKDIAKVNDKICAK-NKNKPLLISAISAVVAIAVASALG-YGIYTKKNL 133 Plasmodium berghei
Q7RSZ7        32 --pKPNNVKLTDKINSIFKNkRNGKIAAIAASIAGSTIAIALALAcMHpevrekf 84  Plasmodium yoelii yoelii
Q4YNP1        32 --sETNDNSLKNIDTAIGKK-KGKKSVAIALLSSGL---VASIIG-VLYYMYKSh 79  Plasmodium berghei
Q7RK90        58 --sEIDDGALDSIDTAIKKK-KKRKSVAIALLSSGL---VASVIG-VLYYMYKSH 105 Plasmodium yoelii yoelii
Q8IEU1        36 iaeEKKRKNIKNIDKAIEEHnKRKKLIYYSLIASGAIASVAAILG-LGYYGYKKS 89  Plasmodium falciparum 3D7
XP_001612702  31 ---DKLKKDDLDVDDRIRRLlQKRKLIMLSVIAATVLAAGGILGG-VGYGIVKHR 81  Plasmodium vivax Sal-1
XP_002261684  31 ---DKLKKEDLDVDTKIKKHlQKRKLMMMSMIAAAVLAVGGILGG-VGYGIAKQR 81  Plasmodium knowlesi strain H
XP_001616488  32 ---EKLDYETIKANEKIRSKsRKDELIMLSLVCGSILLAFASLWG-IRIHHTlky 82  Plasmodium vivax Sal-1
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