Conserved Protein Domain Family
ETRAMP

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pfam09716: ETRAMP 
Malarial early transcribed membrane protein (ETRAMP)
These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.
Statistics
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PSSM-Id: 313012
View PSSM: pfam09716
Aligned: 42 rows
Threshold Bit Score: 33.7659
Threshold Setting Gi: 74881962
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74981589    1 MKVPKVsAIFLVFLLSVCFLSSPSLCDANAGnkipnasnpavngnsae------------------naqgpagsktnngp 62
gi 74881962    1 MKVPKVsALFLVFLLSVSFLPSSSLCDPNAAntkipnipnptanaqsptvsgnsie---qtaeepnaatkvnnvpvpekk 77
gi 74986120    1 MKVPKVsALFFVFLLSVCFLPSPSLCDASTGntkipnipnipnssgnaqsptvsgnsieqtaetsnvatranhvpapekt 80
gi 74884082    1 MKTTYV-SLFFIILLICGIFECKASSVDETNd------------------------------------------------ 31
gi 74987309    1 MNTLNV-FFVFYVLYITTFFFNPCFCEDTDYy------------------------------------------------ 31
gi 74881657   27 MNTLKV-FFVFYVLYITTFFFNPCFCEDADYy------------------------------------------------ 57
gi 74843057    1 MKVSKL-VLFAHIFFIINILCQYICLNASKVnkkg--------------------------------------------k 35
gi 156093325   1 MKIAKL-LALFAILPIVCLLGQEEVKAVSPS------------------------------------------------- 30
gi 221053873   1 MKITKL-LALFAILPIVCLCGNEEVDVISQN------------------------------------------------- 30
gi 156101590   1 MKATNHlSVFALFLFIIAIIPCLAVYSDIPI------------------------------------------------- 31
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 74981589   63 aseKKDSKDIAKIDDKITAK-KSAKPVIIGTISTIAALAIASALG-YGMYTKNKA 115
gi 74881962   78 ndaPVENKDIEKVNDQINAK-SKTKPLLISAISAVVAIAIASALG-YGIYTKKNS 130
gi 74986120   81 ngaPVENKDIAKVNDKICAK-NKNKPLLISAISAVVAIAVASALG-YGIYTKKNL 133
gi 74884082   32 --pKPNNVKLTDKINSIFKNkRNGKIAAIAASIAGSTIAIALALAcMHpevrekf 84
gi 74987309   32 --sETNDNSLKNIDTAIGKK-KGKKSVAIALLSSGL---VASIIG-VLYYMYKSh 79
gi 74881657   58 --sEIDDGALDSIDTAIKKK-KKRKSVAIALLSSGL---VASVIG-VLYYMYKSH 105
gi 74843057   36 iaeEKKRKNIKNIDKAIEEHnKRKKLIYYSLIASGAIASVAAILG-LGYYGYKKS 89
gi 156093325  31 ---DKLKKDDLDVDDRIRRLlQKRKLIMLSVIAATVLAAGGILGG-VGYGIVKHR 81
gi 221053873  31 ---DKLKKEDLDVDTKIKKHlQKRKLMMMSMIAAAVLAVGGILGG-VGYGIAKQR 81
gi 156101590  32 ---EKLDYETIKANEKIRSKsRKDELIMLSLVCGSILLAFASLWG-IRIHHTlky 82
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