Conserved Protein Domain Family
ETRAMP

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pfam09716: ETRAMP 
Malarial early transcribed membrane protein (ETRAMP)
These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.
Statistics
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Aligned: 42 rows
Threshold Bit Score: 33.3784
Threshold Setting Gi: 74881962
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Y781         1 MKVPKVsAIFLVFLLSVCFLSSPSLCDANAGnkipnasnpavngnsae-naqgpagsktnngpaseKKDSKDIAKIDDKI 79  Plasmodium chab...
CAQ41779       1 MKISNV-YIFIFIFFFNILFEPHLCNAVIQ------------------------------------RNESHLIKSPIDEL 43  Plasmodium know...
CAX64167       1 MKVFIF-FAFVNFLFVLNLFSPCTCKKDYGK-----------------------------------EWVKDKLSLVNLKL 44  Plasmodium falc...
EDL45140       1 MKIFCI-FILINFLFIINLLAPCMCSENVVK-----------------------------------KKVLDMFNTVNDRL 44  malaria parasit...
XP_001613359   4 KNLMASfSLILLLCVLLNLAIVQVNANENNKikggkvpppsvptgnnsdnnvpkkdggennpppdaENALQELKNFTKNL 83  Plasmodium viva...
Q8I2F9         1 MRILKV-LTLLVFLLCINVFSPCYTKNGFL------------------------------------SRIKDRFTKFEKKM 43  Plasmodium falc...
XP_001608327   1 MKVTKV-LVTLAVLVALNLLTPCTCKNLFL------------------------------------EKVKAKLDAFDKNM 43  malaria parasit...
XP_004221879   1 MKITKV-LLTMAVFVALDSLTPCTCKNLFL------------------------------------EKVKENLDAFDKNM 43  Plasmodium cyno...
SOV83825       1 MKIIKL-YFFLFIMLMIELLGCGNVCN-ELT-----------------------------------EKKNMLLKESPEKL 43  Plasmodium sp. ...
XP_002258025   1 MRISCI-FLLLNFLFIINLLAPCMCSENVVK-----------------------------------KKVLNAFNTVSEKL 44  Plasmodium know...
Q4Y781        80 TAK-KSAKPVIIGTISTIAALAIASALG-YGMYTKNKA 115 Plasmodium chabaudi
CAQ41779      44 NRK--RKKKVLYAIIGVTLGMLAVVAGG-LGMIHKRKK 78  Plasmodium knowlesi strain H
CAX64167      45 EKYdKKKKFALISGAAIGALALI-TLIG--GIYMTKGR 79  Plasmodium falciparum 3D7
EDL45140      45 NSYdKKKKNAIMAGAATTAIALISTLIG--GVYLFKPK 80  malaria parasite P. vivax
XP_001613359  84 EKKtTTNRNIIISTTVINMVLLV-LLSGlIGYNTKKgf 120 Plasmodium vivax Sal-1
Q8I2F9        44 KDKeNKKK-LLISASIVGLSLLTNLIVG-FAYYNYRKN 79  Plasmodium falciparum 3D7
XP_001608327  44 KKKdFKKK-VLISSAILGAAILANVLAG-IGYYSYKKK 79  malaria parasite P. vivax
XP_004221879  44 KKKdFKK-KVIISSAILGAAILANVLAG-IGYYNYKKK 79  Plasmodium cynomolgi strain B
SOV83825      44 LNNkRRKKLV-YSVIGTLSAILGIAIIG-MGINSHFKe 79  Plasmodium sp. gorilla clade G3
XP_002258025  45 NGSdKTKKNVALAGAATTAIALISTLIG--GAYLLKPK 80  Plasmodium knowlesi strain H
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