Conserved Protein Domain Family
Med15

?
pfam09606: Med15 
ARC105 or Med15 subunit of Mediator complex non-fungal
The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Statistics
?
PSSM-Id: 312941
View PSSM: pfam09606
Aligned: 5 rows
Threshold Bit Score: 416.717
Threshold Setting Gi: 82188674
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q17BA4  14 QSVVNKINEAIQQSGMTS-----SKNGLEMENHVFQKARNKDEYLGYVARLILHVREMNTKNKNQQNPAGGSQ----DGG 84  yellow fever mosquito
Q9Y149  12 QNVISKIHDLLPPNAQDQ-----TKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQGgpppNAE 86  fruit fly
Q5TP13  14 QSVVNKINEAIQQTGMTS-----SKNGIEMENHVFHKARNKDEYLGFVARLILHVREMTAAAQQAQQDGGGNSsq-qGGG 87  African malaria mosquito
Q61L47  13 EHVIQRLEPELARNRQNApnlpvPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVL------------ 80  Caenorhabditis briggsae
Q7ZVN7  17 QKVVAQIEEAMRKAGTGH-----TKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIH-KKAQGG-P------------ 77  zebrafish
Q17BA4  85 NPNQQGGMPDPINALQTLATQGTR-PQMMggQM--GPGGPMGnqmGG-GNASNLLNTL-------------N--RPQMPM 145 yellow fever mosquito
Q9Y149  87 MGGGQNMMQDPLNALQNLASQGNRnPQMM--PMgaGGGAPVP---GGpGTASNLLQSLnqqrpgqqqmqpmSniRGQMPM 161 fruit fly
Q5TP13  88 GGGGGSGMPDPINALQNLASQGTR-PQMMg-QMgvGPGGPMGgqmGGaGQASNLLHSL----------------RPQMQM 149 African malaria mosquito
Q61L47  81 --QPSQFHSPPCTTAVLGTGVg---TPGYraPVppDPQPTSAqarNPpVTTATTQASTtpsa-----pavtGtvSASAAV 150 Caenorhabditis briggsae
Q7ZVN7  78 ---------DPINALQNLPGg----VP----GVi-GP-RPPGaqmGGmGQMS---------------------------- 110 zebrafish
Q17BA4 146 ---TGGmANMQGRVGTMGGPNQMGGMMpgqmpqgmpgmpNQMGGAMGPG-GMSGGkIVGQMNPMGQMNPMQMGVSGMPqg 221 yellow fever mosquito
Q9Y149 162 gagGAG-AQQMMQVQQMQQGGNAPGVM------------NVMGAGGGQNqGQIVG-NPGQQMGVGVGMPNQMVGPGPNs- 226 fruit fly
Q5TP13 150 g--GMGgPMQGNRVG-MGPGNQMGGMMgg---------pNQM---QGPGaGMVGG------------MPGQMGVGMGPgg 202 African malaria mosquito
Q61L47 151 aaaVASfPSPDSAALRAAPGGQTTPGSqpssgapgsttpNAPFPNGAGAqPGAPTmNGGAGGPPMGQPPPQMGAPNMGmn 230 Caenorhabditis briggsae
Q7ZVN7 111 ----MG-PHAMQGVAGGQQGAGAAGPMqqmiqqqqqqqqQQQ--QQQSIqFQTFQpQQQQQATMQSQQPSAMFQQIRLqq 183 zebrafish
Q17BA4 222 agqqqpqqpqgqqggpggpnqmnp-----mggmgmqvnpgghmnqnainqqmnqvGMSSGGNQMGNL-GGNSPMNPGNMG 295 yellow fever mosquito
Q9Y149 227 -------------------------------------------------------GPAVGGAGGPNAaPGAGGPGPNQMQ 251 fruit fly
Q5TP13 203 msggkiqmgvgpggpnqmnpmv----------mgqiqaqlqnqnamggqqmgtvgGTMNAGNQMGQMvGANAGMNPQAMG 272 African malaria mosquito
Q61L47 231 gpggyggygmmngppgag-----------------gpmggnpygqpmkkemdqsrGPWDPQGHMYQQqQPWGGMPPQQGH 293 Caenorhabditis briggsae
Q7ZVN7 184 lqqhhqnqqmqhqnqqqqqaqnqqqqnqlhqtrmqqqlqlqqlqqqqqqqlhqqqVHAQAQAQAQAQaQAQAQAQAQAQA 263 zebrafish
Q17BA4 296 IAPNQV-IRQQMPPGMNPNQQQLGMAGGQMNQM---------NQGVGG--------PGGNLGPVQqqQQPgqvgmAG--- 354 yellow fever mosquito
Q9Y149 252 GGPMNVnAMQQMPPMQQIQQNQLGMGMNPMMRM---------GQGNGMggp--qgmPGQGMQGMP--QGP-----HNvvg 313 fruit fly
Q5TP13 273 MASNQV-VRQQQLQQQGMGQVQMGLGPGQMGQL---------SAGVQGgvg--hggPAM--------------------- 319 African malaria mosquito
Q61L47 294 GGYPNR-PMNGQQTTPTGTSSVLESLINQPQQYpghhnqmapPGGDRNaaggragvPGNPGGVPGapQRPgampv----- 367 Caenorhabditis briggsae
Q7ZVN7 264 QAQAQ--AQAQAQAQAQAQ-AQAQAQAQSIQQMqqqqqlqvqAQGQPQvqg--qggAVQ-MPPHS--QQQqv-lvPQmvq 334 zebrafish
Q17BA4 355 --------MGPGGPGNL------------QQQNNPQQQSQGG--PNAAP-------------GQMN--QVGGPGGNMqa- 396 yellow fever mosquito
Q9Y149 314 gpagqqqvGGAGLPPNAv-----------QQGGMNPMGGMGVnmPPNLQ-------------QKPN--MPMGQAGQM--- 364 fruit fly
Q5TP13 320 ----------------------------------QQQQQAGGmgPGAGP-------------NQMNpgVAMGPGGVVgpa 352 African malaria mosquito
Q61L47 368 ----nqgvMSIEDQNVYqmklrnmrgscdSLRTRARQCRQEGnhEAAHK-------------LEVM--LSVLEGRRVvsl 428 Caenorhabditis briggsae
Q7ZVN7 335 gqhsqmsaLS-QQQQLKlqqamqarmqqqQQQQQQQQQQQQQqqQQQQQqqqqqqqqqqqhqQQQV--QQVQQASQLtav 411 zebrafish
Q17BA4 397 -------------------------mgNQGNFVPIGANPMVRKQ-DMMSGGQVYPGG--VVRSVTPNQFLRQSPSPSVPS 448 yellow fever mosquito
Q9Y149 365 ---------------------------FPGNRGGVGVGGQQPGQpFMRSSPSPADAQ--QLQQQAQLQQMQQQQQQLVVG 415 fruit fly
Q5TP13 353 ggggvmgpgpn--qmlgaggaggpgagQQGNFVGMGANAMVRKPpEMMPGGNVYPGSggAVRSVTPNNFLRQSPSPSVPS 430 African malaria mosquito
Q61L47 429 eyl------------------nhletwIARKQDFLNINPMGGGNpGHMGMNDPV---------MNGDHGMMSNGQVHNPY 481 Caenorhabditis briggsae
Q7ZVN7 412 pgqmmprpgmqipprlpratpnsaipqNPVAIGGQQMPQAQQ----MMSSPSPV--------QVQTPQSMPPPPQPQ-PS 478 zebrafish
Q17BA4 449 PAGPGSIG--PQSHPGQMIPSP-ALIPSPSPQVSSNIPAPRNIGQ------SPGQSL-------NTPGQ--AAAPSPLNP 510 yellow fever mosquito
Q9Y149 416 NQTPTQQPptPQMPTPNMIPSP-ALVPQSSPQMMQMQNSQRNIRQq-----SPSASI-------NTPGQ--VTGNSPFNP 480 fruit fly
Q5TP13 431 PVGPGAHG--PPSHPGQMIPSP-ALIPSPNPHMG-GVAQRSTIGQ------SPGGSL-------NTPGQpgGAVPSPLNP 493 African malaria mosquito
Q61L47 482 -GHPGYNH--GQYGMGG--PPPpHHMQMHQQQMWQQPQQQRMMPTdpm-mmGGGGPMhggpmyrGDMGH---EMNSPVNS 552 Caenorhabditis briggsae
Q7ZVN7 479 PQPPSSQP--NS-VSSGPTPSPgGFQPSPSPQPSQSPASSRTPQSyplqvpSPG-PL-------NTPGNp-SSVMSPAGA 546 zebrafish
Q17BA4 511 Q--EEHLYKEKYRSLQKYIEP--LKRMIAKMEHD--DV-DKMGKMKRLLDILCNPTCRIPLETLYKCEAALT-------- 575 yellow fever mosquito
Q9Y149 481 Q--EEALYREKYKQLTKYIEP--LKRMLAKISNDgtNV-EKMTKMSKLLEILCNPTQRVPLETLLKCEKALEkmdlisys 555 fruit fly
Q5TP13 494 Q--DEQLYREKYRALTKYIEP--LKRMIAKMEND--DI-DKIAKMKRLLEILSNPSVRIPLETLHKCEAALT-------- 558 African malaria mosquito
Q61L47 553 H------------RHNPYPSPaaMRNNMRGMQNGpgPIgRDRNSMSGS---MSGPSSGAPSL------------------ 599 Caenorhabditis briggsae
Q7ZVN7 547 SqsEDQLYMDKLRQLSKYIEP--LRRMINKIDKNedRK-KDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEkl------ 617 zebrafish
Q17BA4 576 -SQLGTire----------ppLNNPLVEAVSANLQSPLGNHTLQR---TFRPCLEALFGPDIkNLPTPAKQPRLAIDEPs 641 yellow fever mosquito
Q9Y149 556 gQQFGK---------------SSNPLLEVINTTLQSPVANHTLYR---TFRPTLELLFGTDI-TAPVPAKRPRVEEKST- 615 fruit fly
Q5TP13 559 -SQLGSire----------tpTNNPLVEAVSSSLQAATGNHTLQR---TFRPCLEALFGPDIkNLPPPAKQSRLALDDTg 624 African malaria mosquito
Q61L47 600 -NTMGTp-------------kMGAPGSIGGLSNLDDFTYDDFLPNpidALQPTLHIGPGSSMgGGP------RVNLND-- 657 Caenorhabditis briggsae
Q7ZVN7 618 kNDMAVptpppppvpctkkqyLCQPILDAVLANIRSPVFNHSLYR---TFAPAMTAIHGPQItGPSIPSRKRKLEDDE-- 692 zebrafish
Q17BA4 642 tsgsTGSQEIPHILQGEIARLDQKFKVSLDPCAIGDT-KTIKLICWLDDKHLPCVPPVAVTIPEEYPFTSPSCSLIEQEY 720 yellow fever mosquito
Q9Y149 616 ----SFEQEVPHVLQGEIARLDTKFKVKLDTTSQINN-KAIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEY 690 fruit fly
Q5TP13 625 aavgTGGGEIPHILQGEIARLDQKFKVSLDQCAISGT-RTIKLICWLDDKNLPCVPPVAVTIPEDYPSTAPSCSLIEQEY 703 African malaria mosquito
Q61L47 658 ------------AARKELQAMEGRF--EIEPNHQRHDaNHIIVSAKMRNQ---PVPPLRLVVPITYP--SGNVTVDRTAI 718 Caenorhabditis briggsae
Q7ZVN7 693 ------RQAIPNILQGEVARLNSKFLVNLDPSFCSNN-GMVHLICKLDDKNLPSVPPLQLSIPADYPDQSPHWEDDGQQY 765 zebrafish
Q17BA4 721 NATPFLIQ-VQKSFLARICKLPEMFSLSHLLDTWEMSVRQACSPNPSLVAPSA--------TSVLLGM 779 yellow fever mosquito
Q9Y149 691 SATPFLQT-VQQALIARISKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAVCE--------LSTLLGV 749 fruit fly
Q5TP13 704 NATPFLIL-VQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTG--------TSVLLGM 762 African malaria mosquito
Q61L47 719 DLDAYLYDdLQNVVHERLSR-PGLSSLTDYLNAWEEQVNQYMQQNQTNGGMDAafgvgndfFYDNLNL 785 Caenorhabditis briggsae
Q7ZVN7 766 EANPFLRT-VHKNMTSKLLQLPDKHSVTALLNTWAQSVRQAC-----------------------LSA 809 zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap