Conserved Protein Domain Family
Ndc1_Nup

?
pfam09531: Ndc1_Nup 
Nucleoporin protein Ndc1-Nup
Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.
Statistics
?
Aligned: 125 rows
Threshold Bit Score: 179.473
Threshold Setting Gi: 198423796
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_015210884         13 KVICWRAAASiAWSVLLLPVITALFVFLsHLDLfhpvqwisdslsvlggsyvifsvvlLCLvvLVVGFFDLQYYTVVPSI 92  spotted gar
EGI69334             11 eLLIQRMTLAvITSVILQLFVVCCVVLLtHLSTdyahwleetwti-vmsprmwtyiivLTLvtFLQSFFCSKNYLHPPLY 89  Panamani...
WGS:AAQB:GK22549-PA  12 llLLGRCVRAvVFSVMIQFLLLTIFLLFvNFQLfhplnwlantfglvcsfytwfasipLIIaiVVYGVILCQEHLVERRY 91  Drosophi...
EDV91575             11 QLLFSRCIHAgLLSVGVQLVMLITLLLCvNFQLwhpldwaadslrqvcscypwlasmpLIVavAFYVITLSKQRLSERRY 90  Drosophi...
WGS:AANI:GJ24406-PA  11 llLFGRCVRAvLLSVGVQFLLLTVFLLLvNFQLlhpldwvmgslrlvcsfytwfacipLLGavVFYGMTLSHQHLAERRY 90  Drosophi...
Q298S5               12 lLLFRRCLQAvLLTVGIQFLLLTIFLLFvNFQLlrplhwisvtlslvcsmytwfasipLVGavVLYGMILCQQHLAERLY 91  Drosophi...
WGS:AAPP:GF17021-PA  12 llLLGRCLRAvLLSAGIQFQLLLVFLLLvNFQLlspldwvsgtvglicswytwfasipLLAavVVYGVSLCQQHLVERPY 91  Drosophi...
Q9VCG4               12 llLLGRCLRAvLLSVAIQFLLLTVFLLFvNFQLlhplawvtgtlrlvaswytwfasipLVAsvVLYGVILCQQHLSERRY 91  fruit fly
Q7Q9X0               11 KICTERFVTSiYYCLLQQYLLVTIFLLFiNFSIlhpinwivgtvrllvsfypwiasvpLAIavVVHGIVLAKSCLLETRY 90  Anophele...
Q17BS7               17 KICVERFIYAiVYSVAVQFVLLTVFLLLvNFSLlhpvawimgsfrlvislstwmwilpLVSavIVHGIFLAKSYLAGIRY 96  yellow f...
XP_015210884         93 PCTKIALIGKVLHPQ--QFIHSLAHCLMGLLvswCAAVMIGgrYhvfakpchsEESHQMCLNEYHLFFLLAGAFMGYSYS 170 spotted gar
EGI69334             90 YKSRFAKLYMTLRIQ--SLFQRALYIVIGGIvvwLQLSLKKgsYssltt--dcsivYGTCSMEEYYFLLFSGLWSGLYFS 165 Panamani...
WGS:AAQB:GK22549-PA  92 HPSR---YRWLQHHGlrKLVFLVAHLMVGYLtvwLYTGYLHtdYrhlkykcygSD----CLSGYHIFLLGMGTTAGCYYF 164 Drosophi...
EDV91575             91 CPTR---YRWLIHHGprKLLFLIAHVFVGYLtawLYTTYLHtdYrhlvyksfgQD----CLNSYHVFLLGMGITSGCYYF 163 Drosophi...
WGS:AANI:GJ24406-PA  91 CPTR---YRWLLQNGprKLLFLFAHLVVGYLtawLYTGYLHtdYrhfvhkcygQD----CLNSYHIFLLGMGLSAGCYYF 163 Drosophi...
Q298S5               92 CPTR---FRWLVHYAprKLLFLAAHLLVGYLtawLYTGYMHtdYrhlwykcydQE----CISAYHVYLLGMGIFAGCYYF 164 Drosophi...
WGS:AAPP:GF17021-PA  92 CPTR---YRWILHYGprKLFFLGAHLLVGFLtawLYTGYLQtdYrhlsykcygED----CISGYHVYMLGMGLTAGCYYF 164 Drosophi...
Q9VCG4               92 CPTR---YRWLLHYGprKVLFLFAHLLVGLLtawLYTGYLHtdYqhlkykcygQD----CISAYNVYLLGIGMTAGCYYF 164 fruit fly
Q7Q9X0               91 HSTY---CQQLYRNLiqRSILLLTNGTIGCLtawLYTRFLRdeYrllflpsvqDDTv--fLNDRFVYLVMSGVFGGCYF- 164 Anophele...
Q17BS7               97 CPTR---FQQIYRSSitQSILLVVNCVVGFLtawLYTRFLRddYrvmfl---pkadGGSILNEKYLFLLLGGTFAGVYY- 169 yellow f...
XP_015210884        171 LLSVVKNMNYVSFQTIQQYKYLrFKGtLPVVIKHSAVQSLYSVRNYCITyLFLgy-iPRAWICTT-MNLSRDSTLhaldT 248 spotted gar
EGI69334            166 FKTGNFAEKYFQFPIIAQSKFLqLRRrFYTMFPTLMISSMWSTLYFMAIyYFMgs-yFREALL----PISMQVEVkpldT 240 Panamani...
WGS:AAQB:GK22549-PA 165 VSVYLNREVRIEFPVVSQSRSHkMRElLYGTLLNSLTRSLVPTLGFTLVfWLCgs-lVGHKLSQ---LLGVDTDErlegF 240 Drosophi...
EDV91575            164 AANYMRQEVAMEFPIIEQKRIEnLRGvLYETLLKSPLKSLWVTLVYSIGfWLFgg-lVRHRLTH---LIGVDADDrllgI 239 Drosophi...
WGS:AANI:GJ24406-PA 164 ATEYMHEEASIDFDFAEQSRPEkLRElLYGTLLKAPISSVMPTLCYTFIfWLFga-fLKYRLSV---LVNVDTDDrllgI 239 Drosophi...
Q298S5              165 VSVHMRQEVEIEFPIVNHLWGEkLREvLYSSLARSLIKSLLPTLAYTLLfWLFgg-vVCHKLSH---IFAVDLDErlegF 240 Drosophi...
WGS:AAPP:GF17021-PA 165 VSVHKRQEVSIKFPIVEQTLGEkLRElLYATLARSLVRSILPTLSYTMVfWILgr-lVCQRLCH---ILDVNMDErmdgF 240 Drosophi...
Q9VCG4              165 VSVHMRKEISIEFPIVEQSRAEkMRElLYASLAKSLLSSLLPTISYTAVfCLFgp-mVCHRLSH---ILSVDMDErldgF 240 fruit fly
Q7Q9X0              165 FLREQQNPDAVDFPIILLPKVAqYWNnLSSVLTKSMRKSVIGMFIYFSFyYTFsc-lFRHKLASVlGGARLQEEStlysF 243 Anophele...
Q17BS7              170 FIRNQSEKLILSFPVIQQPRYLqIRAhLYSVIYRSLFKSFVPTLTYVSFyYTFncfyFRYKLANMfQSVSLADESslgaL 249 yellow f...
XP_015210884        249 LAGllDFSLMFHLWITGTFLLVMWYITWLLFRIYITEMYWFPVQSTf----SENASQCLPKVLTGqQPPILKFLALQDLA 324 spotted gar
EGI69334            241 VSRllNLSLIWQLWLYQFIFMLITNNTNMLFEIYLTEWAPFKFGLSga-ytPDSSETTLIDVLSMdKIPIMQHLGYLDLV 319 Panamani...
WGS:AAQB:GK22549-PA 241 FGVvtSIRLLFYAWLLTAQILSNMHLMRRFYAILLSEDLPLTVSKNrt-afAQDQEVTMVAGLGVfHIYVVQCLSARFLF 319 Drosophi...
EDV91575            240 LDVasNGRLLFYAWLLTTQIVSNMHLMQRFNHVLLSERLPLVIARSrmsanASEQELTVASVLGLfDMYVAQCLAARFLY 319 Drosophi...
WGS:AANI:GJ24406-PA 240 LDVitNGRLLFYGWLLSAQIVSNMHLMRCFYATLLSEKLPMVVARNrv-slGSEQEVTVVAGLGVlNVYVVQCLAANFLY 318 Drosophi...
Q298S5              241 FGVatNGRLLFYGWLLTSQILSNMHLMRCFYSMFLSEEFPLAITKNra-afVQEKEVTVVAALGLsNVYVVQCLAAKYLY 319 Drosophi...
WGS:AAPP:GF17021-PA 241 FGVvsNVKLLFYGWLLTAQILSNMHLMRSFYGILLCEDLPLVITKQka-afASEQEITLVSCLGVfNVYVVQCLAANYFY 319 Drosophi...
Q9VCG4              241 FGVvtNVRLLFYGYLLTAQILSNMHLMRCFYGILLSEDLPLVVTKPra-afAHEQDITLVAGLGVfNVYVVQCLAAHHFY 319 fruit fly
Q7Q9X0              244 CSIvmDIRLLVYTWLFSALILSNINLMHVLFGIFLAEPQNFRIETSa---fQANDEPLLADALAYkQIPIVQQLAVEDLF 320 Anophele...
Q17BS7              250 YSVlmDVRLILYCWILSSQILSNMNLMQVLFHIFLTEYRKFPVEKSt---lANDSQVTLVEALACeKIPIIQQLAALDLF 326 yellow f...
XP_015210884        325 LLSQNSP-SRRQEVFSLSQPGGhPhNWTAISGECLGLLSDLTRRLVAYHEavasngrvkqqsagsdkkssssssssssse 403 spotted gar
EGI69334            320 TLAQKEK-MRRSILFTLSQPGGhPyNWNCVVQKSTKLLEKFSLDLNA--------------------------------- 365 Panamani...
WGS:AAQB:GK22549-PA 320 KLAHRKDsVHRQELFQLTEPGNrPaNWRAFCDQSLSIIGGFTDELMDSMQqismlkvaqnp-------------fpvinn 386 Drosophi...
EDV91575            320 EHALCNNsTIRLEIFQLTEPGNhPaNWRALCDQCLSIVATFTEELIESMQhislikgnesh------------lattaaf 387 Drosophi...
WGS:AANI:GJ24406-PA 319 EEARRKNsSVRAEIFQLTEPGNrPaNWRALCDQCVSIVGSFTEELSDSMRqislmkgneq--------------nfasih 384 Drosophi...
Q298S5              320 NLVTAGDaEKRSELFQLTEPGNrPaNWRSLCDQCLSLFGNFTDELIDSMQkisvlkgspss------------ppltpis 387 Drosophi...
WGS:AAPP:GF17021-PA 320 KLAMRKDsKQRAEIFQLTEPGNrPaNWRALCDQCLVILNSFTDDLVESMQkisvlkgaqnl-------------plpqti 386 Drosophi...
Q9VCG4              320 KLALRKNsPQRAEIFQLTEPGNrPaSWRSLCDQCLSILGSFTEELTESMQkisilkcaqsl-------------pmpkit 386 fruit fly
Q7Q9X0              321 AIAEAQClNRRKQLFSLTVPGGhPnNWRKLYDVCMKLIGDFTQELDQSIGgielkpappm--------------vlmggv 386 Anophele...
Q17BS7              327 TIAESCDpSRRARLYALSVPGGhPyNWRLVSGECIRLIKDYTGQLAKSIEgatlkpvp------------------dvak 388 yellow f...
XP_015210884        404 pSGLGelagwpvqtprAGAGLRTPGSvlARSSLGGLRSPLTAPFTPDLGSpfGspaiqrfartldpaspwygsvqsphvm 483 spotted gar
EGI69334            366 -ISIKsqdq---scysTLTARVPPVQ--QSKYIYHMRKLVSDTAPISVSEd-Vreapysgsfiqkfikqk---------- 428 Panamani...
WGS:AAQB:GK22549-PA 387 dsvsA-----------ALLAEKVLLR--QYNHLHGIRPIVSPGREQQSDQpvLggirhmpnwcervslql---------- 443 Drosophi...
EDV91575            388 idkkG-----------PLRTEKLLIR--QYNQLHGIRPASAEPTQQWDATdsvrhvpnrcerafikl------------- 441 Drosophi...
WGS:AANI:GJ24406-PA 385 sdssA-----------ALLAEKLLLR--QYNQMHGIRPVVSLPRDVPNQEwdTkamdsirhvpnwcertsmk-------- 443 Drosophi...
Q298S5              388 enasA-----------SLMAERVLTR--QYNQMHGIRAIVSPRSNAVIDRp-Vdrihrvpdwcertsmql---------- 443 Drosophi...
WGS:AAPP:GF17021-PA 387 dstsT-----------SIMAERLLLR--QYNQLHGIRQIASPPRNVAMDQp-Adgirhmpnwcervstql---------- 442 Drosophi...
Q9VCG4              387 esltT-----------SLMAEKVLLR--QYNQKHGIRPIVSPSREVAVESp-Adgirhfpnwcervstql---------- 442 fruit fly
Q7Q9X0              387 lrptA-----------SMDKDRFLKK--QYNQNFGIRSLSTPTLPGTPSsesnkqeaksegkresk-------------- 439 Anophele...
Q17BS7              389 lrptA-----------SMDAEKLLMK--QYNESFGIRSLSTSALPAesnpkqpdvickavdrr----------------- 438 yellow f...
XP_015210884        484 rrgpklwtsstdtlangspavspapeprvspaehkpsffslwlqnrreqvktflakrvlvmylFNKLPEASSQALFA-DS 562 spotted gar
EGI69334            429 ----------------------------------------------kdaftayllskplinyiFGEQDDNKIRYALQ-NG 461 Panamani...
WGS:AAQB:GK22549-PA 444 ----------------------------------------------gqalkrllhripgivylFSEPEGAKAAFLLA-NS 476 Drosophi...
EDV91575            442 ----------------------------------------------etmflgllprlpgivylFAESDGAKTVFLVD-NA 474 Drosophi...
WGS:AANI:GJ24406-PA 444 ---------------------------------------------lekllqqllrripgivyfFSEPEGAKTEFLLE-NA 477 Drosophi...
Q298S5              444 ----------------------------------------------eqslqllinripgivymFTEPEGAKTAFLLT-HS 476 Drosophi...
WGS:AAPP:GF17021-PA 443 ----------------------------------------------eealhrlvkrvpgilylFSEPEGSKTNFLLV-NS 475 Drosophi...
Q9VCG4              443 ----------------------------------------------eqslqrllqrvpgivylFNEPEGAKTTFLLA-NS 475 fruit fly
Q7Q9X0              440 ----------------------------------------------amlfasmlkripgydflFTESKSAKSHYLLSvQS 473 Anophele...
Q17BS7              439 ----------------------------------------------ldalresirnipgiyylFGEPKTAKTCHLLAtQS 472 yellow f...
XP_015210884        563 QAHIWALEGLSNLVAASYTEDRFGVVQTTFPNILSTMLTLLEAVDKHfklphAsskpvqssgsledttyktlRFALRASL 642 spotted gar
EGI69334            462 QLVIWAAEAISSLTVFSLSEDSYGIVQKDVPVIINTLLSVKQALDKL-----SksamlarkmqaddklireiFTSLRSAI 536 Panamani...
WGS:AAQB:GK22549-PA 477 LHIVWLSEGLAQICVASIKEDRYGVVQNDLPAIIKALSTLKDNLDKLgnvvgnl-----------rgshtshFSMLRGSI 545 Drosophi...
EDV91575            475 LHVIWLTQALAHLCVASIKQDRYGVVQDDLTAIIRALHRLKCELDKLhsalpsl-----------rpshssnYIVLRGAI 543 Drosophi...
WGS:AANI:GJ24406-PA 478 LPVIWLTQALAHICVASINEDSYGVVQDDLPGIIKALHRLKCELDRLsngmpnf------------rttsnsFNHLRYAV 545 Drosophi...
Q298S5              477 LPLVFVIQALSQICVFSLKEDRYGVVQTDLPDIIRSMSRLKGELDKLssvasnl------------rgpgssFSVLRGAV 544 Drosophi...
WGS:AAPP:GF17021-PA 476 QPLVYVTQALAQICAASLNEDRYGVVQNDLPAIVKAINKLRGELDKLnsvmgnl------------rapsseFNVLRSAV 543 Drosophi...
Q9VCG4              476 LPVVYMTQALAQVCAASLKEDPYGVVQNDLPAIIKAINKLRNELDKLssvigni------------rissssFNVLRCAV 543 fruit fly
Q7Q9X0              474 QLIVKVVQSLVAIACRSLYEDSYGVLQNDLPCIVHALLELKKVVDKIgsinldv------------kkvdrnYIALKGAV 541 Anophele...
Q17BS7              473 QQIVWIAQALASLAAHSIREDQFGVVQNDLPLVIRTLLQLKQVVDKVgsiqldv------------kkidrnYVALKAAT 540 yellow f...
XP_015210884        643 KTAIYRITVTFGEHLNAVEVSAEHR 667 spotted gar
EGI69334            537 KRSLYRIVTNFEPYINDLSLELSII 561 Panamanian leafcutter ant
WGS:AAQB:GK22549-PA 546 RRSLYNVVNCFNEYLGDLVDSPEEL 570 Drosophila willistoni
EDV91575            544 RRSLYNICISFHDYLGEVIPNGEEL 568 Drosophila grimshawi
WGS:AANI:GJ24406-PA 546 RRSLYNICTSFYKYLGELSSSGEEL 570 Drosophila virilis
Q298S5              545 RRSLFHICVAFGEYLSELIPSGEEL 569 Drosophila pseudoobscura pseudoobscura
WGS:AAPP:GF17021-PA 544 RRSLYTICNAFCDYLGDLLPPGEEL 568 Drosophila ananassae
Q9VCG4              544 RRSLYAICLSFCDYLDDLLPPGEEL 568 fruit fly
Q7Q9X0              542 KKSLYRFTTAFGPYIKHLVIEPEDI 566 Anopheles gambiae str. PEST
Q17BS7              541 KRSLYRIAAAFADYLNDIVLEPNDV 565 yellow fever mosquito
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap