Conserved Protein Domain Family
CDC27

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pfam09507: CDC27 
DNA polymerase subunit Cdc27
This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterized by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.
Statistics
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Aligned: 10 rows
Threshold Bit Score: 257.055
Threshold Setting Gi: 74617202
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS68186      20 KLITYRLLSRELRIHVDEAKQALAAFFDSHKDK---SQLDATYILIGRSAFRETQpdadkiardkdeqsegdklvgpssm 96  Ustilago maydis...
Q6CE56        16 LSVSYAMLSRKFDIAPKQAREVLTEYVESNKSD---NSLHVTYCLRGVKRHGVST------------------------- 67  Yarrowia lipoly...
EDO32210      21 RIVTYKWLSRTLTVTANQAKQMLYAFLTAQQEKknkPQLSVTYLVGGRILQHGEMcs----------------------- 77  starlet sea ane...
XP_003447500  18 KIVTYKWLSLTLGVHVNTAKQMLYHYLDHKRKEs-sAQLHATYLVSGKFVDNGQTsh----------------------- 73  Nile tilapia
P84798        19 KIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKEnsgAQLHVTYLVSGSLIQNGHSch----------------------- 75  cattle
Q7SAP2        17 KVVTYRLLSRALRVHPNVAKQMLYDFHKTQSSKk-pGTVYATYMLYGIKKSVQnqngnamdidlpssl------------ 83  Neurospora crassa
EDN09345      18 EIVTHRALSRALKVHSNLAKRMLYEFHRLENSKk-pQSVNATYLISGTPALAQRHalngcakdgddeimqsspft----- 91  Histoplasma cap...
Q2UB13        19 RTVTFRSLSRALRVHSTLAKQMLYDFHHNENNKk-pQSVNATYIITGVQKAPA-Patnghtngednrddvfpssp----- 91  Aspergillus oryzae
XP_756008     19 RTVTYRSLGRALKVHCNLAKRMLYEFHRTENKKk-pQSVNATYIITGIQRPSE-Katnsihaeshddgddimqgsp---- 92  Aspergillus fum...
CAG31915      19 riVTYKWLSYTLGVHVNQAKQMLYDYVERKRKEnsgAQLHVTYLVAGNLIQNGHTch----------------------- 75  chicken
KIS68186      97 sssstaparsfldsrvtqrqtkanverqvIRLVSAADLEKARSSFEQISSCHIYSVSPGRLLdAAQLTAVQHDLHTQ-QK 175 Ustilago maydis...
Q6CE56        68 -----------------------------IELCDGSEIATKRSEFNEPVSQLIYSVSASPTT-TTILYNMALEASSMgPN 117 Yarrowia lipoly...
EDO32210      78 ----------------------------qYVLTTDDRLEETKSQFDPVTSVHIYSIQKQTLKdSNSLYMVDYDISRE-HK 128 starlet sea ane...
XP_003447500  74 ----------------------------kVSVVREEQLEDFKAKMSLVVSVHVYSVQKALLKdSGPLYAVDYDAVKD-NL 124 Nile tilapia
P84798        76 ----------------------------kVAVVREDKLEAVKSKLAVTASVHVYSIQKAMLKdSGPLFNTDYDILKS-NL 126 cattle
Q7SAP2        84 --------------pdadpvddeevpsytLVLVQEERLADVLKEYETITSIHVYSVGPHPAKdLTLLVDAAQSALAI--- 146 Neurospora crassa
EDN09345      92 ---------ssqaarqedgdgnddipttsITLVREEDLLEAKSRYQTVFSIFIYSVEPTRLQdLNVLGDIGHDIMQH--- 159 Histoplasma cap...
Q2UB13        92 ---------ylsssmpnqdsapdtvatasVLLVREEDLEGRAPLVSHA----GLDLQQTVLQdLNVLTDVSRETVSN--- 155 Aspergillus oryzae
XP_756008     93 ---------flpssmpnqdaasdevpttsIILAREEDLDGKCLRLARS------NLQPAVLQdLNVLTDVHREMLAA--- 154 Aspergillus fum...
CAG31915      76 ----------------------------kVAVVREDKLEAMKSKLATVTSVHVYSIQKALLKdSGPLYNTDYDIIKA-NL 126 chicken
KIS68186     176 YVDSWQQTHRGAQLGViVNPNIKDNYdpskgiPSLGAPSGPALPVSKDS------------------KTAN-SSSSSSSS 236 Ustilago maydis...
Q6CE56       118 KFAIVSELVEGVDLTP-TKPVIKDDS------PPVAAAASKPLITTAPAkkpaakqkpkldffggkkKEAK-ETTPAKHE 189 Yarrowia lipoly...
EDO32210     129 HEDNRWSHIYCKEAARlGDGGESRAAag---rSALGKENSHPGLKTANGhskclsnil-icvlicieAGSS-TTDVQKNK 203 starlet sea ane...
XP_003447500 125 KNCSRYSAIRCASAVPmSSVELQQARe----vQQAPTPEPENKKAGMNGdtsp----------vlksSAKP-PKGIMG-M 188 Nile tilapia
P84798       127 QNCSKFSAIQCAAAVPrAPAESSSSEkleqsdPPVSPEMQASDELTTNGhgpp----------vpkqSSQQ-PKGIMG-M 194 cattle
Q7SAP2       147 -----KDDAKKPQPRPiVNSHVRRRErkglglKAAAPAKQESKTKTAPTkt---------------aPAKP-SPAPAPAA 205 Neurospora crassa
EDN09345     160 --QPNDPLEYGKQYGMiLNRNVKRRSg-----lPPAPPAPDPVETVKKQkveka--------neapiTTKP-EEPTQPQA 223 Histoplasma cap...
Q2UB13       156 -HSQEDPLEYGGQWSMiQNKNVKRRTg----sRPPPAPAATKSKPTIPSkr---------------pS-EA-TSSQIKPE 213 Aspergillus oryzae
XP_756008    155 -HAHEDPLEYGKQWGMiQNKDVKRRTg----vRPPPPAPTPAQEAAAPSkr---------------pSQDE-ATQKVKSE 213 Aspergillus fum...
CAG31915     127 HNCSKFSAIRCADAVPrTPAEVAQARtlarssSQTPSDTSAVSTPPLNGhg---------------pTAAKpEAHSPPRG 191 chicken
KIS68186     237 STV-TSALGTRPLSTTTTI-AKATTAAS-----SAPVGGRKSGLDWSRAKPKGSDSKPAAAKIKAQSSIQSVPDHktllg 309 Ustilago maydis...
Q6CE56       190 KKD-DHKEAVKDVKKETTP-IKEEKAAP-----VKEERKETKAPKGKSVLDAVKEGKKNEPKPKEPAPKSKKQLE----- 257 Yarrowia lipoly...
EDO32210     204 APP-QKSKKGQLPTMGMFA-VKTEKKPEpkaepVKPPETKKQDKSNSGGMLSFFGKPTAGQSKKTEAKQEKIEKK----- 276 starlet sea ane...
XP_003447500 189 FAN-KSAPKSQDNSKEMKP-EKKEDAHD-----IEAPKSK--PVAKVNPVANFFGTQTSKKPEKTVKEEEAPQSS----- 254 Nile tilapia
P84798       195 FAS-KAASKAQDANKETKT-EAKE-VMN-----SEKNNENLLLSGYWESMIVLFQAQCINKLKVNLDSEQEVKEE----- 261 cattle
Q7SAP2       206 APA-KPQEESKSTAPAMEP-EAPTATTK-----KPAPSLKRNTSAASGIMQAFSKAASLPKKAKTSEKSTTAAEE----- 273 Neurospora crassa
EDN09345     224 KTQ-TPQASSAASSRPSSG-GNNKGGTS-----DKPSSLKR---DSSNIFKAFAKVKPKVKKDDVLERPSGREVE----- 288 Histoplasma cap...
Q2UB13       214 PKK-EETAASEQASTREST-PSTASKPT-----EKAAPLKR---EKSNLFSSFAKAKPKQKKE-----ESATPAE----- 273 Aspergillus oryzae
XP_756008    214 SKK-AEHAAMTSQTKAEEK-PPVK--PS-----EKTAPLKR---EKSDLFSSFAKAKSKQKKDGS-ATPAVSGAE----- 275 Aspergillus fum...
CAG31915     192 IHGeCLQPKLLPKPRMQIKkPKAKEAPS-----VSAASSK--PSAKGNIMNNFFGKAAMNKLKVNSVPGQ-PKEE----- 258 chicken
KIS68186     310 SDDEDEDDDDDEDDDKPaklgyadEDDHNQDVTKAelvrgt-------apqgtGKRADARSQTE---------------- 366 Ustilago maydis...
Q6CE56       258 AEEAEKKRQRELEEALF-------ADEDEDFDIPV------------------KQPVKKEEPEK---------------- 296 Yarrowia lipoly...
EDO32210     277 SQEQKPKKEKIHEKESAtsnekkeQEKERKKSEGKpkprsekekqptrkrvkkFESSDEEEDEQpiksksekksrkksnd 356 starlet sea ane...
XP_003447500 255 SRAAQQHERSKPEEKQEt-----vAPVEPQKDTKKdsrs----------ktkrLEDSDGEEE------------------ 301 Nile tilapia
P84798       262 KKVEQPPLSVT-EPKLAapv-dlkKSSKKAEPVRMqqkek--------krrkqMELSD-DETKEt--------------- 315 cattle
Q7SAP2       274 -------TPAALSDDGE-------DDDDVPLPKPD------------------------AQSTR---------------- 299 Neurospora crassa
EDN09345     289 SAEHSGPEDVVLDDAS--------EEEREDLFLDT--------------------GTRRSNSKR---------------- 324 Histoplasma cap...
Q2UB13       274 SAEPSGAEDVFGDDDDA-------DEEPEELFPDS------------------GKSASSAAATR---------------- 312 Aspergillus oryzae
XP_756008    276 SAEPSGAEDVVLGDASD-------EEEPEELFPDS--------------------GKSSTANNR---------------- 312 Aspergillus fum...
CAG31915     259 KEAVKTSVPAT-EPESSpns-iveKPGRKTEPTKIqqkdkk-------skmkrMDKSDNEEEREp--------------- 314 chicken
KIS68186     367 -------AKEAAQ-RKELEAMMDTD--DEDN-DVQIVEPSGVSTSGNNTGQGKDLd------PDVDMADSTVTDTMDgse 429 Ustilago maydis...
Q6CE56       297 -------ETIKEElQEDLEKAEKDT--LTDA-QMIAGGELDVTTEDVEMGDDDNG-------NKEDVEMTDVHMTNDged 359 Yarrowia lipoly...
EDO32210     357 nkhepagEKTKQK-RKRAKNVLSDE--STDD-------ESPQASEQSVISETPV---------AEQQTKPRVSES----- 412 starlet sea ane...
XP_003447500 302 -------KMEKKK-RRRIKKPEPDS--SDED----VIPDSPQPVVTREPSSPSP---------KKEVEPDRHSHPSSs-- 356 Nile tilapia
P84798       316 -------ENMKKK-RRRIKLPESDS--SEDE----VIPDSP-GAYEAESPSPPPPspspepvLKTEPEPPPVKGSDG--- 377 cattle
Q7SAP2       300 -------KSKKER-EEELRRMMEDD--EDED--MEETADSP-APEEEEEEEPAVEeppakadVAKEEKKEIVTTSGD--- 363 Neurospora crassa
EDN09345     325 -------ESRKER-EEKLRKMMEDE--DMED-VPEDVPELPPARAPERTDTSQ----------SEEVPKAESKEEARap- 382 Histoplasma cap...
Q2UB13       313 -------ESRKER-EEKLKQMMEDDdeDEDE-EMPDATEPP-EESKPIDQPPP----------KKPELKEEITVQG---- 368 Aspergillus oryzae
XP_756008    313 -------ETRKER-EEKLRKMMEDE--DDDDeEMADVPEPPMEEEKTIDQPP-----------TKEEPREEITVSG---- 367 Aspergillus fum...
CAG31915     315 -------ENQKKK-RKRIKQLESDS--SDEE----DVPASP-TLEEEKAPSPPPLvp----aLKAELEPASTEASAG--- 372 chicken
KIS68186     430 aaptaakRRVRKKRKIgTKKLRSKD-ERGYTVTKTIDEYESYSSDESDtPvvagskrtsgatkkeaPNKPAEARSTSASA 508 Ustilago maydis...
Q6CE56       360 vh-ttttTAKRGKKKV-IKKVQELD-EDGYVTYKKVETWESCDEDEDEsGlkeevk-----rdvkkEVKKEVKKESPEPA 431 Yarrowia lipoly...
EDO32210     413 -------AKRRKRQKV-LHSKTYMN-DEGFMVTEKVYESESTDASDEE------------------PVEVKPAEPKKTSP 465 starlet sea ane...
XP_003447500 357 ------eMKIRKRRRV-MKSHTFVD-DDGCMVTEKGYVSESYSESEDDfK----------------PSKQASRDPIKAKP 412 Nile tilapia
P84798       378 -------ENKRKRKRV-LKSKTFTD-EEGCMVTEKVYESESCTDSEEE-L----------------KMKTSSVHRPPAM- 430 cattle
Q7SAP2       364 -------GRRRGKRRV-MKKKQIMD-DQGYLVTIQEPAWESFSEDEAP-P----------------ADKPKPKVANPAPP 417 Neurospora crassa
EDN09345     383 ------kGRRRGRRQV-MKKTTIKD-AEGYLVTKEEPVWESFSEDEAP-P----------------PVKRKLAVSVNSKS 437 Histoplasma cap...
Q2UB13       369 -------GRRRGRRQV-MKKQVRKD-DEGYLVTVEEPSWESFSEDEPA-P----------------PPKKKPAVS----- 417 Aspergillus oryzae
XP_756008    368 -------GRRRGRRKV-MKKKTVKD-EEGYLVTVEEPTWESFSEDEPA-P----------------PPKKKPALS----- 416 Aspergillus fum...
CAG31915     373 -------GKKRKRKRV-LKSKMFVDeEEGCMVTEKVYESESCTDSEDDfA----------------KTKPPAVPKQPAL- 427 chicken
KIS68186     509 SAipapsaptkptSASNNsgprkpsggttpapAKKGQQSLNSFFtRK 555 Ustilago maydis 521
Q6CE56       432 AG-----------AKKSK--------------KANKQSSLMSFF-KK 452 Yarrowia lipolytica
EDO32210     466 QA-----------NKKALd------------pKSAKQSSLMSFFgKK 489 starlet sea anemone
XP_003447500 413 SS-----------SSKEDekktqkk-asansnKGTKQASIMGFFqKK 447 Nile tilapia
P84798       431 AV-----------KKEPKeerkgpkkgtaamgKANRQVAITGFFqRK 466 cattle
Q7SAP2       418 AA-----------AGKAKk------------pAPKGQGNIMSFFsKK 441 Neurospora crassa
EDN09345     438 TS-----------SNKGS--------------QKMGQGNIMSFFgKR 459 Histoplasma capsulatum NAm1
Q2UB13       418 -------------ALKGKp-------------AGKGQGNIMSFFgKK 438 Aspergillus oryzae
XP_756008    417 -------------APKGKa------------gGKAGQGNIMSFFsKK 438 Aspergillus fumigatus Af293
CAG31915     428 PV-----------KKEPKeerknqkkgaatasRANKQISIMGFCqKK 463 chicken
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