Conserved Protein Domain Family
CDC27

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pfam09507: CDC27 
DNA polymerase subunit Cdc27
This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterized by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.
Statistics
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PSSM-Id: 312868
View PSSM: pfam09507
Aligned: 10 rows
Threshold Bit Score: 246.657
Threshold Setting Gi: 74617202
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam09507 is a member of the superfamily cl25760.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307    16 LSVSYAMLSRKFDIAPKQAREVLTEYVESNK-SD---NSLHVTYCLRGVKRHGVST------------------------ 67
gi 124106280   19 KIVTYKWLSYTLGVHVNQAKQMLYDYVERKR-KEnsgAQLHVTYLVSGSLIQNGHSch---------------------- 75
gi 74617202    17 KVVTYRLLSRALRVHPNVAKQMLYDFHKTQS-SKk-pGTVYATYMLYGIKKSVQnqngnamdidlpssl----------- 83
gi 121801149   19 RTVTFRSLSRALRVHSTLAKQMLYDFHHNEN-NKk-pQSVNATYIITGVQKAPA-Patnghtngednrddvfpssp---- 91
gi 930730171   18 KIVTYKWLSLTLGVHVNTAKQMLYHYLDHKR-KEs-sAQLHATYLVSGKFVDNGQTsh---------------------- 73
gi 156357614   21 RIVTYKWLSRTLTVTANQAKQMLYAFLTAQQeKKn-kPQLSVTYLVGGRILQHGEMcs---------------------- 77
gi 1003743067  19 RIVTYKWLSYTLGVHVNQAKQMLYDYVERKR-KEnsgAQLHVTYLVAGNLVQNGHTch---------------------- 75
gi 758981014   20 KLITYRLLSRELRIHVDEAKQALAAFFDSHK-DK---SQLDATYILIGRSAFRETQpdadkiardkdeqsegdklvgpss 95
gi 146323076   19 RTVTYRSLGRALKVHCNLAKRMLYEFHRTEN-KKk-pQSVNATYIITGIQRPSE-Katnsihaeshddgddimqgsp--- 92
gi 154276124   18 EIVTHRALSRALKVHSNLAKRMLYEFHRLEN-SKk-pQSVNATYLISGTPALAQRHalngcakdgddeimqsspft---- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307    68 ------------------------------IELCDGSEIATKRSEFNEPVSQLIYSVSASPTT-TTILYNMALEASSMgP 116
gi 124106280   76 -----------------------------kVAVVREDKLEAVKSKLAVTASVHVYSIQKAMLKdSGPLFNTDYDILKS-N 125
gi 74617202    84 ---------------pdadpvddeevpsytLVLVQEERLADVLKEYETITSIHVYSVGPHPAKdLTLLVDAAQSALAI-- 146
gi 121801149   92 ----------ylsssmpnqdsapdtvatasVLLVREEDLEGRAPLVSHA----GLDLQQTVLQdLNVLTDVSRETVSN-- 155
gi 930730171   74 -----------------------------kVSVVREDQLEDFKAKMSLVVSVHVYSVQRALLRdSGPLYAVDYDAVKD-N 123
gi 156357614   78 -----------------------------qYVLTTDDRLEETKSQFDPVTSVHIYSIQKQTLKdSNSLYMVDYDISRE-H 127
gi 1003743067  76 -----------------------------kVAVVREDKLEATSSXXXXXXXVHVYSIQKALLKdSGPLYNTDYDIIKT-N 125
gi 758981014   96 msssstaparsfldsrvtqrqtkanverqvIRLVSAADLEKARSSFEQISSCHIYSVSPGRLLdAAQLTAVQHDLHTQ-Q 174
gi 146323076   93 ----------flpssmpnqdaasdevpttsIILAREEDLDGKCLRLARS------NLQPAVLQdLNVLTDVHREMLAA-- 154
gi 154276124   92 ----------ssqaarqedgdgnddipttsITLVREEDLLEAKSRYQTVFSIFIYSVEPTRLQdLNVLGDIGHDIMQH-- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307   117 NKFAIVSELVEGVDLTP-TKPVIKDDS------PPVAAAASKPLITTAPAkkpaakqkpkldffggkkKEAKETTPAKhE 189
gi 124106280  126 LQNCSKFSAIQCAAAVPrAPAESSSSEkleqsdPPVSPEMQASDELTTNGhgpp----------vpkqSSQQPKGIMG-M 194
gi 74617202   147 ------KDDAKKPQPRPiVNSHVRRRErkglglKAAAPAKQESKTKTAPTkt---------------aPAKPSPAPAPaA 205
gi 121801149  156 --HSQEDPLEYGGQWSMiQNKNVKRRTg----sRPPPAPAATKSKPTIPSkr---------------pS-EATSSQIKpE 213
gi 930730171  124 LKNCSRYSAIHCASAVPmSSVELQQARe----vQQAPTPEPENKKTGMNGdtsp----------vlksSAKPPKGIMG-M 188
gi 156357614  128 KHEDNRWSHIYCKEAARlGDGGESRAAag---rSALGKENSHPGLKTANGhskclsnil-icvlicieAGSSTTDVQKnK 203
gi 1003743067 126 LHNCSKFSAIHCADAVPrTPAEVAQARtlarssSQTASDTSTVSTPPVNGhgpt----------aakqSSQPPKGIMG-M 194
gi 758981014  175 KYVDSWQQTHRGAQLGViVNPNIKDNYdpskgiPSLGAPSGPALPVSKDSk------------------TANSSSSSSsS 236
gi 146323076  155 --HAHEDPLEYGKQWGMiQNKDVKRRTg----vRPPPPAPTPAQEAAAPSkr---------------pSQDEATQKVKsE 213
gi 154276124  160 ---QPNDPLEYGKQYGMiLNRNVKRRSg-----lPPAPPAPDPVETVKKQkveka--------neapiTTKPEEPTQPqA 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307   190 KKDDHKEAVKDVKKETTPIKEEkAA-----PVKEERKETKAPKGKSVLDAVKEGKKNEPKPKEPAPKSKKQLEA------ 258
gi 124106280  195 FASKAASKAQDANKETKTEAKE-VM-----NSEKNNENLLLSGYWESMIVLFQAQCINKLKVNLDSEQEVKEEK------ 262
gi 74617202   206 APAKPQEESKSTAPAMEPEAPTaTT-----KKPAPSLKRNTSAASGIMQAFSKAASLPKKAKTSEKSTTAAEE------- 273
gi 121801149  214 PKKEETAASEQASTRESTPSTAsKP-----TEKAAPLKR---EKSNLFSSFAKAKPKQKKE-----ESATPAES------ 274
gi 930730171  189 FANKSAPKSQDNTKEMKPEKKE--------DIDAPKSK--PVAKANPVANFFGTQTSKKPEKPVKKEEAPQSSSr----- 253
gi 156357614  204 APPQKSKKGQLPTMGMFAVKTEkKPepkaePVKPPETKKQDKSNSGGMLSFFGKPTAGQSKKTEAKQEKIEKKS------ 277
gi 1003743067 195 FAAKAASKTQDANKE---PKAKeAP-----SVSAASSK--PSAKANIMNNFFGKAAMNKLKVNSVPEQ-PKEEK------ 257
gi 758981014  237 STVTSALGTRPLSTTTTIAKATtAA-----SSAPVGGRKSGLDWSRAKPKGSDSKPAAAKIKAQSSIQSVPDHKtllgsd 311
gi 146323076  214 SKKAEHAAMTSQTKAEEKPPVK--P-----SEKTAPLKR---EKSDLFSSFAKAKSKQKKDGS-ATPAVSGAES------ 276
gi 154276124  224 KTQTPQASSAASSRPSSGGNNKgGT-----SDKPSSLKR---DSSNIFKAFAKVKPKVKKDDVLERPSGREVES------ 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307   259 ----EEAEKKRQRElEEALF-----------------ADEDEDFDIPV-----------KQPV----------------- 289
gi 124106280  263 ----KVEQPPLSVT-EPKLAapv-----------dlkKSSKKAEPVRMqqkek-krrkqMELS----------------- 308
gi 74617202   274 ----------TPAAlSDDGE-----------------DDDDVPLPKPD-------------------------------- 294
gi 121801149  275 ----AEPSGAEDVFgDDDDA-----------------DEEPEELFPDS-----------GKSA----------------- 305
gi 930730171  254 ----AAQQQHERSKpEEKQEt---------------vAPVEPQKDTKKdsrs---ktkrLEDS----------------- 294
gi 156357614  278 ----QEQKPKKEKIhEKESAtsnekkeqekerkksegKPKPRSEKEKQptrk---rvkkFESSdeeedeqpiksksekks 350
gi 1003743067 258 ----EAVKASVPATePESSPntv------------aeKPGRKTEPAKIqqkdkkskmkrMDKS----------------- 304
gi 758981014  312 dedeDDDDDEDDDKpAKLGYa---------------dEDDHNQDVTKAelvrgtapqgtGKRA----------------- 359
gi 146323076  277 ----AEPSGAEDVVlGDASD-----------------EEEPEELFPDS-------------GK----------------- 305
gi 154276124  290 ----AEHSGPEDVVlDDAS------------------EEEREDLFLDT-------------GT----------------- 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307   290 ------KkEEPEK-ETIKEElQEDLEKAEKDT--LTDAqm-iAGGELDvTTEDVEMGDDD--NG-------NKEDVEMTD 350
gi 124106280  309 ------D-DETKEtENMKKK-RRRIKLPESDS--SEDE----VIPDSP-GAYEAESPSPP--PPspspepvLKTEPEPPP 371
gi 74617202   295 --------AQSTR-KSKKER-EEELRRMMEDD--EDEDm--eETADSP-APEEEEEEEPA--VEeppakadVAKEEKKEI 357
gi 121801149  306 ------SsAAATR-ESRKER-EEKLKQMMEDDdeDEDEem-pDATEPP-EESKPIDQPPP------------KKPELKEE 363
gi 930730171  295 ------DgEEEKM-ET--KK-RRRIKKPEPDS--SDED----VIPDSPqPVVTREPSSPS--P---------KKEVEPDR 347
gi 156357614  351 rkksndNkHEPAG-EKTKQK-RKRAKNVLSDE--STDD-------ESPqASEQSVISETP--V---------AEQQTKPR 408
gi 1003743067 305 ------DnEEEREpENQKRR-RKRIKQLESDS--SDEE----DVPASPiLEEEKAPSPPPlvPA-------LKAELEPAT 364
gi 758981014  360 ------DaRSQTE-AKEAAQ-RKELEAMMDTD--DEDNdv-qIVEPSGvSTSGNNTGQGK--DLd------PDVDMADST 420
gi 146323076  306 ------SsTANNR-ETRKER-EEKLRKMMEDE--DDDDeemaDVPEPPmEEEKTIDQPP-------------TKEEPREE 362
gi 154276124  318 ------RrSNSKR-ESRKER-EEKLRKMMEDE--DMEDvp-eDVPELPpARAPERTDTSQ------------SEEVPKAE 374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307   351 VHM--TNDgedvhttttTAKRGKKKV-----------IKKVQELD-EDGYVTYKKVETWESCDEDEDEsGlkeevkrdvk 416
gi 124106280  372 VKG--SDG---------ENKRKRKRV-----------LKSKTFTD-EEGCMVTEKVYESESCTDSEEE-L---------- 417
gi 74617202   358 VTT--SGD---------GRRRGKRRV-----------MKKKQIMD-DQGYLVTIQEPAWESFSEDEAP-P---------- 403
gi 121801149  364 ITV--QG----------GRRRGRRQV-----------MKKQVRKD-DEGYLVTVEEPSWESFSEDEPA-P---------- 408
gi 930730171  348 HSHpsSSE---------MKIRKRRRV-----------MKSHTFVD-GDGCMVTEKGYVSESYSESEDDfK---------- 396
gi 156357614  409 VSE--S-----------AKRRKRQKV-----------LHSKTYMN-DEGFMVTEKVYESESTDASDEE------------ 451
gi 1003743067 365 TEA--SAG---------GKKRKRKRV-----------LKSKMFVDeEEGCMVTEKVYESESCTDSEDD-F---------- 411
gi 758981014  421 VTD--TMD---------GSEAAPTAAkrrvrkkrkigTKKLRSKD-ERGYTVTKTIDEYESYSSDESD-T---------- 477
gi 146323076  363 ITV--SG----------GRRRGRRKV-----------MKKKTVKD-EEGYLVTVEEPTWESFSEDEPA-P---------- 407
gi 154276124  375 SKE--EARap------kGRRRGRRQV-----------MKKTTIKD-AEGYLVTKEEPVWESFSEDEAP-P---------- 423
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635307   417 kEV----------KKEVKKESP-------------------EPaAGAKK----------SK--------------KANKQ 443
gi 124106280  418 -KM----------KTSSVHRPP-------------------AM-AVKKE----------PKeerkgpkkgtaamgKANRQ 456
gi 74617202   404 -AD----------KPKPKVANP-------------------APpAAAGK----------AKk------------pAPKGQ 431
gi 121801149  409 -PP----------KKKPAVS--------------------------ALK----------GKp-------------AGKGQ 428
gi 930730171  397 -PS----------KQASRDPIK-------------------AKpSSSKEdekktqkkasANs------------nKGAKQ 434
gi 156357614  452 -PV----------EVKPAEPKK-------------------TSpQANKK----------ALd------------pKSAKQ 479
gi 1003743067 412 -AK----------TKPPAVPKQ-------------------PAlPVKKE----------PKeerknqkkgaasagRANKQ 451
gi 758981014  478 -PVvagskrtsgaTKKEAPNKPaearstsasasaipapsapTKpTSASN----------NSgprkpsg-gttpapAKKGQ 545
gi 146323076  408 -PP----------KKKPALS--------------------------APK----------GKa------------gGKAGQ 428
gi 154276124  424 -PV----------KRKLAVSVN-------------------SKsTSSNK----------GS--------------QKMGQ 449
                         650
                  ....*....|
gi 74635307   444 SSLMSFF-KK 452
gi 124106280  457 VAITGFFqRK 466
gi 74617202   432 GNIMSFFsKK 441
gi 121801149  429 GNIMSFFgKK 438
gi 930730171  435 ASIMGFFqKK 444
gi 156357614  480 SSLMSFFgKK 489
gi 1003743067 452 VSIMGFFqKK 461
gi 758981014  546 QSLNSFFtRK 555
gi 146323076  429 GNIMSFFsKK 438
gi 154276124  450 GNIMSFFgKR 459
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