Conserved Protein Domain Family
Cas_DxTHG

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pfam09455: Cas_DxTHG 
CRISPR-associated (Cas) DxTHG family
CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.
Statistics
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PSSM-Id: 401419
Aligned: 62 rows
Threshold Bit Score: 35.9468
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012186553     12 VLAPWGLpT--LwDEVNYViprvsesggklcvrpI------NIewndvDKVKSYTSLAGVLRYitn-------------- 69  Caldivirga m...
Q977C6            4 LVYIAGDvT--SyTTTNYEfe-------------------------gkEFNTFFSAHALAKLL----------------- 39  Sulfurisphae...
Q972U4            7 IVTFWSD-I--NfSNEKFF---------------VfdekgeRTsveqeGLNETLAEAEFLK------------------- 49  Sulfurisphae...
Q4J9G9            5 LISIWTN-L--NnRENKYE---------------IinergeETerevvESKPSLAEVKFLRES----------------- 49  Sulfolobus a...
WP_013775166      4 LFAPIGDpS--GyVNVEYL----------------------VNgegpyNTNASFIAISQALKId---------------- 43  Acidianus ho...
Q59060            5 LIAPWGNfS--SwKKVIYSfn-------------------------gvEKESKSSLSAIYDKI----------------- 40  Methanocaldo...
WP_011839191     10 LIAPWGYpP--SwRDAKYC---------------L-----------------KSVKVGNISLKgccigcsssiavylilk 55  Staphylother...
WP_013275354      4 LIYQIGRldrniiKKQKFT----------------------IEgktrsKQLSSFALKEHlk------------------- 42  Thermosedimi...
Q8R6Z4            3 VIYQIGRfdkgfmKTQEFT----------------------FRqekytEVLTSFVMKKFfq------------------- 41  Caldanaeroba...
jgi:TOPB45_1115   2 LIYQIGRldsgafNPIKFE----------------------VNgkeytAQLSSFALRQSfl------------------- 40 
WP_012186553     70 -agHKGfiDVIIMGLdtlafpdtrsqsgncnvvgilsdftntlrngKVNYRdient------------------------ 124 Caldivirga m...
Q977C6           40 -----DpqKIVALLPdslv------------------------ihdNSTAQdlptlikgykkmiltrsnqlfkdenmkkd 90  Sulfurisphae...
Q972U4           50 ---DNNdvKIVAFLPttlsri-------------------lsdpppDYNQ------------------------------ 77  Sulfurisphae...
Q4J9G9           50 ---EEQvdMLVLLPSflsayl-------------------ktqdlpDSYVE----------------------------- 78  Sulfolobus a...
WP_013775166     44 --------KLVVYAGlslcdt-------------------ncndykCCKDSvtqk------------------------- 71  Acidianus ho...
Q59060           41 -----NpdKVYILVLdtl-------------------------snlESENYgdivkev---------------------- 68  Methanocaldo...
WP_011839191     56 shkKINntRLLVIGTdtviep-------------------inedlrSNVKE----------------------------- 87  Staphylother...
WP_013275354     43 --eNGEqaKV--ILVypvslp-------------------fnrtleNANFGdfs-------------------------- 73  Thermosedimi...
Q8R6Z4           42 --kKNPqeKSMVVLIfpvsli-------------------lnesaiKEVIEsnde------------------------- 75  Caldanaeroba...
jgi:TOPB45_1115  41 --eNGEasKV--ILIypvslf-------------------lnkslsNKNNPqtqnip----------------------- 74 
WP_012186553    125 ---ayslLKNCIsqylggfnskAdKINIev-------------------eiLPGTGTYrag--------------nfNAr 168 Caldivirga m...
Q977C6           91 iedfvnkIDVRV---------------------------------------IPNVGSGqayyvnkegdllaegqrykRIp 131 Sulfurisphae...
Q972U4           78 -------LIQRL----------EaEVKNivkvd--------------yvhiLPSEGTIgnh--------------vhHEg 112 Sulfurisphae...
Q4J9G9           79 -------LKKRI----------QeEVLKrfqgi--------------dvevIPSSGTIdadgf----------mhihDNs 117 Sulfolobus a...
WP_013775166     72 ---vaqkLGNEFdl-----------------------------------liAPNIYGT-------------------RFi 94  Acidianus ho...
Q59060           69 kektenfIKENLnidny------------------------------evivCPGVGTFynkdfekyfkfygnltdyySFa 118 Methanocaldo...
WP_011839191     88 -------WFSTV----------G-EKLLnttscegvikn-newindlhfgiVPGIGEYygy-------------yfkGD- 134 Staphylother...
WP_013275354     74 -----rsLKAVL----------RnPKEEylsnpknffsnmpyssevddfivIHSIGEYaginf----------qgkfNDi 128 Thermosedimi...
Q8R6Z4           76 ---aiekFKEKLerfk---dmvPnTLQEystdpyafysfhphckiaddffvIHSLGGYkifgeyi------efnsdyNDi 143 Caldanaeroba...
jgi:TOPB45_1115  75 -idfkkvIESILy--------nKaERFNylsnpypyfakhphskeadefivIHSIGQYeginf----------satlEEl 135
WP_012186553    169 FMGginnlnftMLY-KLYNK--VRYNkySA------IIIDITHGVNYL--P-MITym----aAQLIAKYLSARdNkdicL 232 Caldivirga m...
Q977C6          132 YYKers--pifIFN-VIYSIfnELNEscDE------IIVDLTHGTNVL----VSA-------TMAVGSIFNCRfVa---- 187 Sulfurisphae...
Q972U4          113 LGNfhflfylkLYE-DLLKE----SP--DV------VLLDLSRTFSYY----QNYaisatqlALDDYVITTNRkNtiliq 175 Sulfurisphae...
Q4J9G9          118 LGNfnfsvyysVYN-ALTRY----NP--DT------VLLDLSETTSYL----TYYtsdaaklAIQDYYITKRKaD----- 175 Sulfolobus a...
WP_013775166     95 QKDrkntlyfnFIYfNSLKI--LEDNkpDE------IYIDITHGINYM--P-LLAtda--irLATYTYIVENN-KngvnL 160 Acidianus ho...
Q59060          119 LYE-------------LSKR--LDGD--LE------VHLDLTHGLNYM--P-VLTyrvikdlLEILAIKNKVR------L 166 Methanocaldo...
WP_011839191    135 ILK--------IFL-ESYRY--IALN--IKdfnpslLILDTTHGLNILtiAvLYA-------TVAASIVYNKR-I----L 189 Staphylother...
WP_013275354    129 VFE--------IAL-DMIER--YNEEi-ER------IYVDISSGLNIY----VSAlleavrfFSIWATLKNW-------L 179 Thermosedimi...
Q8R6Z4          144 VLQ--------IFS-DMAIR--YLNEy-NRdnetmeFYIDISSGHNIY----ISAlleaaryFSVFSGLLNW-------L 200 Caldanaeroba...
jgi:TOPB45_1115 136 ILE--------IFI-DMVKR--YQDEpfSE------LYLDISSGHNIY----TSAlleagrlFLTFYKLQNF-------L 187
WP_012186553    233 ITFNA---------------------------DPISrqktea---------tqerrlNIIEMQNIS-------------- 262 Caldivirga m...
Q977C6          188 --------------------------------APIMga-----------------pgNKVSVVELTeiv----------- 207 Sulfurisphae...
Q972U4          176 ya------------------------ridntlVPLF----------------------VKDFKKVRiydy---------- 199 Sulfurisphae...
Q4J9G9          176 --------------------------------IPLIefstdfan------kiitlkkSTIRNVDISdyl----------- 206 Sulfolobus a...
WP_013775166    161 TIYNS---------------------------EPVTkgnqgpyaiddiysekitvrqALSSILS---------------- 197 Acidianus ho...
Q59060          167 VVYNS---------------------------DPYVg--------------------REKEILNIHtvedviikpsydik 199 Methanocaldo...
WP_011839191    190 TINSEpypsgkgtkycievkkksnksitkeneMPKLni------------------hDISHLQQIIdfl----------- 240 Staphylother...
WP_013275354    180 PEAKRpeiw-------------------itfsDPILdneaaey-------qlhreklEFKAFFASPin------------ 221 Thermosedimi...
Q8R6Z4          201 KKEKRpkif-------------------lafsDPILpgttgmke-----yeihieelRFKTFFSSP-------------- 242 Caldanaeroba...
jgi:TOPB45_1115 188 TKGKElnvf-------------------itfsDPILppyertfk------ihkgfllEVKVFFSYP-------------- 228
WP_012186553    263 ------IEphEFLKELtgrlNKEKIFRIVrtnhdkdkinklNKLNnnyedirrrlnpsrittslEYGFAlyLVTYlrknN 336 Caldivirga m...
Q977C6          208 ----kaMKdsLAITYSiekvDERYFRDYSv-----------------------------------------TLKKlnpsE 242 Sulfurisphae...
Q972U4          200 ---lttN---------------------------------------------------------IKLSKekGFSTqgksE 219 Sulfurisphae...
Q4J9G9          207 ----tsQE--------------------------------------------------------IKLAK--GMPTlsksE 224 Sulfolobus a...
WP_013775166    198 ----------PFLSSEsknvIKNKVFKVIrnkan---------------------------------senvNTSScnadF 234 Acidianus ho...
Q59060          200 gmtldfLDatKFV-------DKKEIGKIKkeinmnpkikelRIMKqninafiasivyalplvysTFFVKkdKIEIylneL 272 Methanocaldo...
WP_011839191    241 ----raLNslRFLNEKq-----------------------------------------------LNRLPrrKMQNkyveL 269 Staphylother...
WP_013275354    222 ------------------keDINNVAKKIyed-------------------------------------drSKKRklssL 246 Thermosedimi...
Q8R6Z4          243 --------------IGeeelDNFNLARRIagk-------------------------------------ekELKNvlqkL 271 Caldanaeroba...
jgi:TOPB45_1115 229 ----------EKPYEYslrqGYMKFAGELake-------------------------------------nrEIKRdlndL 261
WP_012186553    337 LTHVKDLEELSRnisnlc---------------------deiynyMNEavdISinNNEVLIsriydfetsPLLLSMafdv 395 Caldivirga m...
Q977C6          243 FKEMKELIERIKsddp--------------------------nkvISLlknLRngFAIEGVrvmrelenyITGLEN---- 292 Sulfurisphae...
Q972U4          220 IYGLGKSLELGFpliliyllknanklv----ppdefekmiinsmkVNK-------GEKYEIvtnfeahetAPYYFIgyhf 288 Sulfurisphae...
Q4J9G9          225 LFAIGRALQLGFplallyllngieelt----kpedfmqkieesitVSK---KE--QEKEYLvssgvraynTAPYYFmgyh 295 Sulfolobus a...
WP_013775166    235 IYHIVNALSAGIfly----------------------------liLKKdeiNSclNVVENIlgkldfnnfAVQLNFengk 286 Acidianus ho...
Q59060          273 IGAFISNIKINPedkilkrylyfgegfnslvkayfaskiseipqlIKDelsLE--------------------------- 325 Methanocaldo...
WP_011839191    270 IDKIICMVEALRtgligllfgnsklss----dkgipftineiykfMENihkLN--YDMEWF---------KPSLENnivk 334 Staphylother...
WP_013275354    247 LENFLVIFSAIKnniplavylfgyedg----evidetsrtliedmKKKlyds---------------yaaSPNLDKntys 307 Thermosedimi...
Q8R6Z4          272 FENFLICFSAIKnntplvlyhfnfdaw----edvisflkdflemlKRKlsgt---------------wesSPVLFKsdyl 332 Caldanaeroba...
jgi:TOPB45_1115 262 FSYGKFFYSAIKnniplvlytqayhse----erineglqiliklvKDSltqn---------------yqnTPKLNFdlfr 322
WP_012186553    396 vrnrvinvlnldqlmdneggidieyllkipvssvadtilsnEVDSIKRAAELFrdvavnllgmnkgilg----------- 464 Caldivirga m...
Q977C6          293 -----------------------------------------DLNSLSKAYNEWynhsyfekesrivlshfystlrvkdli 331 Sulfurisphae...
Q972U4          289 vnsyk----------------------------kiaeeseiSLESLEKLLELFeepqrkliireieil------------ 328 Sulfurisphae...
Q4J9G9          296 fieay---------------------------kvksetgeyTLDDLLKLIDVYneparslikrelei------------- 335 Sulfolobus a...
WP_013775166    287 viydenipieisy------------ihsllkvsnhiaqgsnKISEIRRMAENYstsds---------------------- 332 Acidianus ho...
Q59060          326 -----------------------------------------EIDELKNtlfkenpnsqy--------------------- 343 Methanocaldo...
WP_011839191    335 yepti---------------------------deniikyapILDFLRNYIEEYsdclktislkefakcl----------- 376 Staphylother...
WP_013275354    308 kgllslafysgia-----------evfwhyqiknhdeddgiDLDELKRIFDDLyslfslkpn------------------ 358 Thermosedimi...
Q8R6Z4          333 ntilslgfyagil-----------evletkgiskydyengiALEEIKQLFASEensiyklfgleth-------------- 387 Caldanaeroba...
jgi:TOPB45_1115 323 kaflmlaiykgi--------------tevlktykiakkeevSISELREKFVEEnkslykyfglv---------------- 372
WP_012186553    465 ------------------------------gyvkygnihdfvnksiIDIGRRsNDIREEIKNYSCDNQDSHDDse----- 509 Caldivirga m...
Q977C6          332 ysgndlevlekildlyikvgyydkaislarelpvafclnsrgggvySDDDKNyTECDNIVTEYLKKSSI----------- 400 Sulfurisphae...
Q972U4          329 --------------------------------kdfsrlmkdeeehlLDYLIRi--------------------------- 349 Sulfurisphae...
Q4J9G9          336 --------------------------------lkrlaglkddgeyiLDYLIRl--------------------------- 356 Sulfolobus a...
WP_013775166    333 -----------------------------------------vkyviLNEISRiEEKKNEIPNSPTLYAKIRGTdspk--- 368 Acidianus ho...
Q59060          344 -----------------------------------ikneisslyniINTKYKeEELSEILGNWTPIYKIRRENid----- 383 Methanocaldo...
WP_011839191    377 ------------------------------enklersgywdrkqiiINETSNlTEIACEIKNDMGIETIDSNLlleywsk 426 Staphylother...
WP_013275354    359 --------------------------------------nvflgneisNTKRImGKINIEDSTWHLLIKFHNKEyeg---- 396 Thermosedimi...
Q8R6Z4          388 ---------------------------------ipilgrevhnlchGGKKKEkSILNQATEEWSKVYNFIDEGks----- 429 Caldanaeroba...
jgi:TOPB45_1115 373 -----------------------------------qnrnylsqeikNNFDRNkDKFEKEYKLLREYIGGESED------- 410
WP_012186553    510 ------------crFNDR----------------------NFIAHAGL 523 Caldivirga maquilingensis
Q977C6          401 --------------VQFR----------------------NALMHGSL 412 Sulfurisphaera tokodaii
Q972U4          350 --------------GNARvidwmkgevsedekeecdvnedEMYSHAGL 383 Sulfurisphaera tokodaii
Q4J9G9          357 --------------GNSRvldwlenvpigeskidceiseyEMISHAGM 390 Sulfolobus acidocaldarius
WP_013775166    369 -----------iclPEKR----------------------NLIAHGGF 383 Acidianus hospitalis
Q59060          384 -------------kFKIR----------------------NFLAHAGF 396 Methanocaldococcus jannaschii DSM 2661
WP_011839191    427 kkgfgnsqgekdklVNPR----------------------NFAAHAAL 452 Staphylothermus marinus
WP_013275354    397 ------------rtPDKR----------------------NFFAHSGL 410 Thermosediminibacter oceani
Q8R6Z4          430 ------------ssFENR----------------------NFLAHSGF 443 Caldanaerobacter subterraneus subsp. tengcon...
jgi:TOPB45_1115 411 --------------FNPR----------------------NFFAHCGF 422
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