Conserved Protein Domain Family
Methyltransf_15

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pfam09445: Methyltransf_15 
RNA cap guanine-N2 methyltransferase
RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.
Statistics
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PSSM-Id: 337417
View PSSM: pfam09445
Aligned: 10 rows
Threshold Bit Score: 173.654
Threshold Setting Gi: 74882952
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8I620        258 ILIYLDPFAGAGGNCNHMNNI---F--TIGCDINFYRIKQCQHNCNFY---NKNVDFILCDFF-N--------------- 313  Plasmodium fa...
Q6FK05        131 AKRILDVFSGGGGNSIQFANV---FdrVYCLDSNLEHLYCSIKNGQSYg-vSNKLWMCKGKWG-E--------------- 190  [Candida] gla...
Q6BUU2         81 CRKVLDICCGGGGNTIQFANY---FpsVGSIDINPSNMKCTLHNARVYg-vEDRIWSKVGDWN-Qfslvladgs------ 149  Debaryomyces ...
Q09814         73 pELIIDAFSGCGGNTIQFAK----YcpVISIEIDPIKIAMAKHNLEIYgipSSRVTFIQGDVL-D--------------- 132  Schizosacchar...
Q7RPD6        212 ITIHLDPFSGAGGNCNTMKNV---F--TIASDINLNRLKQCQHNCKFY---NNNIDYILCDFF-S--------------- 267  Plasmodium yo...
Q12052         98 AERILDVFCGGGGNTIQFAMQ---FpyVYGVDYSIEHIYCTAKNAQSYg-vDDRIWLKRGSWK-K--------------- 157  Saccharomyces...
Q6CRW0        100 GNCIVDVFCGGGGNTIQFARL---FekVYGIDSNIDHLYCAYKNAECYn-sAVKLKLIYGDWE-E--------------- 159  Kluyveromyces...
Q75BX4        119 ATTILDVFCGGGGNVVHFAKV---FqkVYGVELKLEHLYCTYRNAEAYg-vADRVWLKHGDWL-Q--------------- 178  Eremothecium ...
XP_001707121   79 RGYVLDLFGGAGGQAIGFALE---GhsVHSIEYSEQHCALIHNNARVYg-vSHLVFPVCCDVFtQ--------------- 139  Giardia lambl...
XP_011393260   81 kRVLIDLFGGAGGNVIAFALSsgrWdrIIAIEKDRSTLACAQHNAEVYd-vLDKITWVHGDCF-Evmkrfwkttrgtkgm 158  Neurospora cr...
Q8I620        314 ----------------------------LVTHfRKGTI----DVIFFSIPWGGPKYKNKKNFELNTeIMDNISIYKCIE- 360  Plasmodium fa...
Q6FK05        191 ----------------------------HTAK-KFRKLn--iDCIFGSPPWGGPEYIKDEKYDLEK-SLLPFGLYKLLK- 237  [Candida] gla...
Q6BUU2        150 --------------------pnqlwippHLRNvKTPSAi--fDFVFCSPPWGGPSYKDTNGFDV-Y-NMQPFPIDQLCH- 204  Debaryomyces ...
Q09814        133 ----------------------------TFKSlQFAKDy--rSLVFMSPPWGGPSYSGKTVYSL-N-DLNPYAFDVLFK- 179  Schizosacchar...
Q7RPD6        268 ----------------------------IVNHfRENVI----DVVFLSIPXGGPSYKKQNKFDLKN-KEKNLCVYTCLK- 313  Plasmodium yo...
Q12052        158 ----------------------------LVSKqKLSKIk--yDCVFGSPPWGGPEYLRNDVYDLEQ-HLKPMGITKMLK- 205  Saccharomyces...
Q6CRW0        160 ----------------------------SLKKtLVKNLgktpDCIFASPPWGGVDYLRQDTYDLEE-HLQPSPLSKILS- 209  Kluyveromyces...
Q75BX4        179 ----------------------------LAARgRFERVh--vDCVFASPPWGGIDYTKTQAYDLET-QLQPAGLSQLLS- 226  Eremothecium ...
XP_001707121  140 ----------------------------ALRFcTSGATpqkyDCVVLSPPWGGPGYWRNGDLDFCKlRINKYKGSQLVSl 191  Giardia lambl...
XP_011393260  159 emkgrgreggeaankgqeqeddneeldgLLAGlKLEEC-----LVFASPPWGGVSYRDQEVFDL-S-KMEPYNLEQLYK- 230  Neurospora cr...
Q8I620        361 ----V------------SVELTENLV---FYLPRNVCMKELyylygyykelvknkkckrgggkkkkkkkkkkdikltsnd 421  Plasmodium fa...
Q6FK05        238 ----T------------FKIVSDNII---LFLPKNSNLDQL--------------------------------------- 259  [Candida] gla...
Q6BUU2        205 ----Q------------VMQYTQNFG---LFLPRSTNLDQL--------------------------------------- 226  Debaryomyces ...
Q09814        180 ----E------------ATRISPYVA---AFLPRNTDVKEL--------------------------------------- 201  Schizosacchar...
Q7RPD6        314 ----E------------SIKLTKNII---IYLPRNVCINDLyflfktykklctlknkdtk---------------inyie 359  Plasmodium yo...
Q12052        206 ----S------------FLKLSPNVI---MFLPRNSDLNQL--------------------------------------- 227  Saccharomyces...
Q6CRW0        210 ----V------------FFSVCQNVV---LFLPRNSDLDQL--------------------------------------- 231  Kluyveromyces...
Q75BX4        227 ----S------------FLRISANVV---LFLPKNSNLQQL--------------------------------------- 248  Eremothecium ...
XP_001707121  192 mcrlV------------DSGISKRFI---LHLPRNTTTRSI--------------------------------------- 217  Giardia lambl...
XP_011393260  231 ----ActmpqeakeehpSTQKQKHILpqaLFLPRQSDLNQI--------------------------------------- 267  Neurospora cr...
Q8I620        422 tyyyehknklqnrsNNILLELYINRSRCN-----------------YQKKDDNSL-NNFFYFFNEK 469  Plasmodium falciparum 3D7
Q6FK05        260 --------------SETTKEVFGPEAKCK-----------------VLYIKEQGYlKGMLCLWGSA 294  [Candida] glabrata
Q6BUU2        227 --------------RRLTTDIYGQSGKCR-----------------IIFLNINGYcKGLLALFGPS 261  Debaryomyces hansenii
Q09814        202 --------------AAYG-SIHNKPY--------------------ITNFLFEGYaKAICCYFNMK 232  Schizosaccharomyces pombe 9...
Q7RPD6        360 nkkverkkynfskkYDMLIELYVNRNRCT-----------------YKDICENNLmNYYYYYFNKK 408  Plasmodium yoelii yoelii
Q12052        228 --------------SRATRKVLGPFAKCK-----------------VLYVKENGYmKGIFCMWGEC 262  Saccharomyces cerevisiae S288c
Q6CRW0        232 --------------SSITHDLLGPDEKCK-----------------VVYVKDNGYmKGILAFWGRP 266  Kluyveromyces lactis
Q75BX4        249 --------------SEITRSLLGPEAKCK-----------------VLYARENGRdKGLLCFWGEA 283  Eremothecium gossypii
XP_001707121  218 --------------YSVGARVARHISRVAiqelgstkadfltssviVSEMQLNGRvSFLAVYIGCW 269  Giardia lamblia ATCC 50803
XP_011393260  268 --------------AAL---VPEGAPKID-----------------VVQYCQKGAsKALVAYLPGn 299  Neurospora crassa OR74A
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