Conserved Protein Domain Family
Methyltransf_15

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pfam09445: Methyltransf_15 
RNA cap guanine-N2 methyltransferase
RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.
Statistics
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Aligned: 9 rows
Threshold Bit Score: 174.445
Threshold Setting Gi: 74882952
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BUU2    81 CRKVLDICCGGGGNTIQFANY---FPSVGSIDINPSNMKCTLHNARVYGV-EDRIWSKVGDWNQfslvladgs------- 149  Debaryomyces hansenii
Q6FK05   131 AKRILDVFSGGGGNSIQFANV---FDRVYCLDSNLEHLYCSIKNGQSYGV-SNKLWMCKGKWGE---------------- 190  [Candida] glabrata
Q09814    73 pELIIDAFSGCGGNTIQFAK----YCPVISIEIDPIKIAMAKHNLEIYGIpSSRVTFIQGDVLD---------------- 132  Schizosaccharomyce...
ESA44167  81 kRVLIDLFGGAGGNVIAFALSsgrWDRIIAIEKDRSTLACAQHNAEVYDV-LDKITWVHGDCFEvmkrfwkttrgtkgme 159  Neurospora crassa ...
Q7RPD6   212 ITIHLDPFSGAGGNCNTMKNV---F--TIASDINLNRLKQCQHNCKFY---NNNIDYILCDFFS---------------- 267  Plasmodium yoelii ...
EDO79447  79 RGYVLDLFGGAGGQAIGFALE---GHSVHSIEYSEQHCALIHNNARVYGV-SHLVFPVCCDVFTq--------------- 139  Giardia lamblia AT...
Q12052    98 AERILDVFCGGGGNTIQFAMQ---FPYVYGVDYSIEHIYCTAKNAQSYGV-DDRIWLKRGSWKK---------------- 157  Saccharomyces cere...
Q6CRW0   100 GNCIVDVFCGGGGNTIQFARL---FEKVYGIDSNIDHLYCAYKNAECYNS-AVKLKLIYGDWEE---------------- 159  Kluyveromyces lactis
Q75BX4   119 ATTILDVFCGGGGNVVHFAKV---FQKVYGVELKLEHLYCTYRNAEAYGV-ADRVWLKHGDWLQ---------------- 178  Eremothecium gossypii
Q6BUU2   150 -------------------pnqlwippHLRNvKTPSA--IFDFVFCSPPWGGPSYKDTNGFDV-Y-NMQPFPIDQLCHQ- 205  Debaryomyces hansenii
Q6FK05   191 ---------------------------HTAK-KFRKL--NIDCIFGSPPWGGPEYIKDEKYDLeK-SLLPFGLYKLLKT- 238  [Candida] glabrata
Q09814   133 ---------------------------TFKSlQFAKD--YRSLVFMSPPWGGPSYSGKTVYSL-N-DLNPYAFDVLFKE- 180  Schizosaccharomyce...
ESA44167 160 mkgrgreggeaankgqeqeddneeldgLLAGlKLEEC-----LVFASPPWGGVSYRDQEVFDL-S-KMEPYNLEQLYKAc 232  Neurospora crassa ...
Q7RPD6   268 ---------------------------IVNHfRENVI----DVVFLSIPXGGPSYKKQNKFDLkN-KEKNLCVYTCLKE- 314  Plasmodium yoelii ...
EDO79447 140 ---------------------------ALRFcTSGATpqKYDCVVLSPPWGGPGYWRNGDLDFcKlRINKYKGSQLVSLm 192  Giardia lamblia AT...
Q12052   158 ---------------------------LVSKqKLSKI--KYDCVFGSPPWGGPEYLRNDVYDLeQ-HLKPMGITKMLKS- 206  Saccharomyces cere...
Q6CRW0   160 ---------------------------SLKKtLVKNLgkTPDCIFASPPWGGVDYLRQDTYDLeE-HLQPSPLSKILSV- 210  Kluyveromyces lactis
Q75BX4   179 ---------------------------LAARgRFERV--HVDCVFASPPWGGIDYTKTQAYDLeT-QLQPAGLSQLLSS- 227  Eremothecium gossypii
Q6BUU2   206 -----------VMQYTQNFG---LFLPRSTNLDQL--------------------------------------RRLTTDI 233  Debaryomyces hansenii
Q6FK05   239 -----------FKIVSDNII---LFLPKNSNLDQL--------------------------------------SETTKEV 266  [Candida] glabrata
Q09814   181 -----------ATRISPYVA---AFLPRNTDVKEL--------------------------------------AAYG-SI 207  Schizosaccharomyce...
ESA44167 233 tmpqeakeehpSTQKQKHILpqaLFLPRQSDLNQI--------------------------------------AAL---V 271  Neurospora crassa ...
Q7RPD6   315 -----------SIKLTKNII---IYLPRNVCINDLyflfktykklctlknkdtkinyienkkverkkynfskkYDMLIEL 380  Plasmodium yoelii ...
EDO79447 193 cr-------lvDSGISKRFI---LHLPRNTTTRSI--------------------------------------YSVGARV 224  Giardia lamblia AT...
Q12052   207 -----------FLKLSPNVI---MFLPRNSDLNQL--------------------------------------SRATRKV 234  Saccharomyces cere...
Q6CRW0   211 -----------FFSVCQNVV---LFLPRNSDLDQL--------------------------------------SSITHDL 238  Kluyveromyces lactis
Q75BX4   228 -----------FLRISANVV---LFLPKNSNLQQL--------------------------------------SEITRSL 255  Eremothecium gossypii
Q6BUU2   234 YGQSGKCR-----------------IIFLNINGYCKGLLALFGPS 261  Debaryomyces hansenii
Q6FK05   267 FGPEAKCK-----------------VLYIKEQGYLKGMLCLWGSA 294  [Candida] glabrata
Q09814   208 HNKPY--------------------ITNFLFEGYAKAICCYFNMK 232  Schizosaccharomyces pombe 972h-
ESA44167 272 PEGAPKID-----------------VVQYCQKGASKALVAYLPGn 299  Neurospora crassa OR74A
Q7RPD6   381 YVNRNRCT-----------------YKDICENNLMNYYYYYFNKK 408  Plasmodium yoelii yoelii
EDO79447 225 ARHISRVAiqelgstkadfltssviVSEMQLNGRVSFLAVYIGCW 269  Giardia lamblia ATCC 50803
Q12052   235 LGPFAKCK-----------------VLYVKENGYMKGIFCMWGEC 262  Saccharomyces cerevisiae S288C
Q6CRW0   239 LGPDEKCK-----------------VVYVKDNGYMKGILAFWGRP 266  Kluyveromyces lactis
Q75BX4   256 LGPEAKCK-----------------VLYARENGRDKGLLCFWGEA 283  Eremothecium gossypii
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