Conserved Protein Domain Family
PPP4R2

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pfam09184: PPP4R2 
PPP4R2
PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.
Statistics
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Aligned: 29 rows
Threshold Bit Score: 126.059
Threshold Setting Gi: 387514374
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD26948       6 ELNSSIHNMMGIKSRRLYEYLNDILITKKVKLSNSSNEPIPFDLLINdFIPHMIDVTPN---------ESFInsneenie 76  Naumovozyma dai...
EKC35391      10 ALNDFEKKK-GEIPPVLEQYLKTIAKTGETLFPWPRVKPLFVGKLEN-VMSKFNRELPAdhlapcpnvENPK-------- 79  Pacific oyster
4_pfamImport   4 AFQDFEKRGKKETCPALEQFLCHVAKTGQPMIPWLQFKTYFLFKLDK-VMEDFHASAPEerdshnpnvEYIP-------- 74 
1_pfamImport   4 AFRDFEKTGKKETCPELEQFLCHIAKTGQPMISWSQFKTYFAFKLEK-VMDDFHASTPEqrarhnpnvDYVP-------- 74 
2_pfamImport   4 AFQDFEKKGKEEVCPLLEQFLCHVAKTGQPLIPWSQFKMYFMFKLEK-VISDFHDSSPEqrtlrnpnvDYVP-------- 74 
XP_003439001   9 AFQDFEKKGKKETCPLLEQFLCHIAKTGQPMIPWSQFKTYFMFKLEK-VMDDFHAATPEqrgphnpnvEFVP-------- 79  Nile tilapia
A1L1M4         9 ALKDFDKKVKKEASTVLDQFLCHIAKTGETLVSWSQFKTYFVFKLEK-VMEDFHASAPEqrgpanpnvESIP-------- 79  zebrafish
6_pfamImport   4 ALEDFEKKGKKDVSPVLDQFLCHVAKTGETMVSWSQFKSYFLFKLEK-VMEDFRASAPEqrgpanpnvESVP-------- 74 
XP_005814738   9 ALRDFDKKAKKEPIPLLEQFLCHVAKTGQTMVPWSQFKNYFLFKLEN-VMDDFKASTPEqrasanpnvESVP-------- 79  southern platyfish
3_pfamImport   4 ALRDFDKKAKKETCPLLEQFLCHIAKTGETMVQWSQFKNYFLFKLEK-VMDDFRASAPEqrgpvnpnvESIP-------- 74 
CCD26948      77 sirrLKEMGENLIDKFFNNEKLPFTIMRIFELCFDPFKYFKvnELVKYVNALEKCCYVDSCLTLASSSSsSTNTEERRDE 156 Naumovozyma dai...
EKC35391      80 ----FKEMRKRILDSLNKFSDAPFTIQRLCELLTDPKKHYR--RTDKFLRGVEKNMLVVSTVDPFGNKI-VSESREVMVN 152 Pacific oyster
4_pfamImport  75 ----FEEMKNRILKIVDGYNGIPFTIQRLCELLTDPKRNYS--GTDKFLRGLEKNVMVVSYLHPTSEK-----------N 137
1_pfamImport  75 ----FEEMKARILKIVDGYNGIPFTIQRLCELLTDPKRNYT--GIDKFLMGLEKNVMVVSCVGPTSEK-----------N 137
2_pfamImport  75 ----FEEMKRRILKIVDGYSGVPFTIQRLCELLTDPKRNYT--STDKFLRGLEKNVMVVSCLFPTSEK-----------K 137
XP_003439001  80 ----FEEMKTRILKIVDGYNGIPFTIQRLCELLMDPKRNYT--GTDKFLRGLEKNVMVVSCIYPTSEK-----------N 142 Nile tilapia
A1L1M4        80 ----FEEMKERILKIVNEYNGIPFTIQRLCELLTEPKRNYT--GTEKFLRGVEKNVMVVSCIYPTSEK-----------N 142 zebrafish
6_pfamImport  75 ----FEEMKERILKIVNGYNGIPFTIQRLCELLTDPKRNYS--GTEKFLRGVEKNVMVVSCVYPTSEK-----------N 137
XP_005814738  80 ----FEDMKERILKIVKGYNGIPFTIQRLCELLTEPKRNYT--GTDKFLRGVEKNVLVVSCVHPTSEK-----------N 142 southern platyfish
3_pfamImport  75 ----FEDMKERILKIVKGYNGIPFTIQRLCELLTEPKRNYT--GTDKFLRGVEKNVMVVSCVYPTSEK-----------N 137
CCD26948     157 EESNGNTIGE------------------------DGDASLVKIPWitekdmgQLLPIVKEIDVIMNVEFDDDDEDDDEEd 212 Naumovozyma dai...
EKC35391     153 GMEG-SPVNGne--------------------adSSPTTTPNIGPslypgaiPLQQTNWTTDSWAGVGTSQEAARDTTCn 211 Pacific oyster
4_pfamImport 138 GTSTMNRMNGvmflgnpslysessrnvngpslskTLNRPKLS-SSslstnglPECPASKEPDG-------ITETEEQHS- 208
1_pfamImport 138 GASSVNRMNGvmfpgnsslysd-srnvngpdtpkPLNRPKSSLTSslstnglPDCPVSREPI--------TEEVEEHHS- 207
2_pfamImport 138 SQLSLKLFERlllpldvigffs-srnvngpstpkTHNRPKLSLSTslstnglPDCSVSKEPQSA------TEMEEHHTS- 209
XP_003439001 143 GASSINRMNGvmfpgnsslyt--drnvngpgtpkPLNRPKLSLPTslstnglPDCPVSKEPEPA------TEEVEEQGI- 213 Nile tilapia
A1L1M4       143 GCSGVNRMNGvmlsgntsaft--erkvngpgtprPLNRQKHSMSSslatnglPDSTENKDTN--------TPQGHSKTT- 211 zebrafish
6_pfamImport 138 GCSGVNRMNGvmlpgntsvft--erkvngpgtprPLNRPKHT-PSslatnglPDSTENKESN--------STSGHNKPV- 205
XP_005814738 143 GCSTVNRMNGvmlpgnasafi--erkvngpgtprPLNRPKVSLVNslaanglPDSTDNKDLN--------TEQDDNQDT- 211 southern platyfish
3_pfamImport 138 GCNAVNRMNGvmlpgntaaft--erkvngpgtprPLNRPKGSLGSslaanglPDSTDNKDLK--------AEPSDDKDS- 206
CCD26948     213 deehhdvngqgtirerksnkHGGTSTDDISITLQNDKDFIIEEyyeddddddddmnvedtnknlTNTPDDEEEQDDDYVD 292 Naumovozyma dai...
EKC35391     212 edpppg--------agapatDSTPHVSVKEEEKEAPPDSNLET---------------------TDGDQAPSEESPPLKK 262 Pacific oyster
4_pfamImport 209 --------------------SETPPSEDEA---KPKHGIKHKH--------------------------REEDEESDCDK 239
1_pfamImport 208 --------------------GHSSSAEGEEI--TPNSGIKNKH-------------------------PAEEEEDYETGE 240
2_pfamImport 210 --------------------SDASSPEKDT---TLKAGLKSKN---------------------P----PPEEDSGQL-- 239
XP_003439001 214 --------------------SETSLSEGEM---TPNSGIKNKH---------------------------PEEEDSDGDK 243 Nile tilapia
A1L1M4       212 --------------------SDASASGIGG---PLGSSVKNKH---------------------LD---DEEDEGMEEEE 244 zebrafish
6_pfamImport 206 --------------------SDSSVSGLSS---PPSGSVKNKH--------------------------SDEEEDMEEEQ 236
XP_005814738 212 --------------------SNVLPSEG-----SPGSAVKNKH---------------------SDE--EEEEEDMEAEH 243 southern platyfish
3_pfamImport 207 --------------------SEVSASED-----SPGSSVKNKH--------------------------ADAEEDMDADQ 235
CCD26948     293 DNMGDTSGDDDDDDADENDE 312 Naumovozyma dairenensis CBS 421
EKC35391     263 SKLSDEISDEVPELASSKDD 282 Pacific oyster
4_pfamImport 240 QEAKKRKTGEYDDETEREEN 259
1_pfamImport 241 HEVKRLKFDEKEEDERESEE 260
2_pfamImport 240 -AAKRLKIDVNQEKEAASEE 258
XP_003439001 244 QEVKRLKFDETEENETTSEK 263 Nile tilapia
A1L1M4       245 HEVKRLKFSQDGNEDEEDED 264 zebrafish
6_pfamImport 237 QEVKRLKFSEDGGEEEEDGE 256
XP_005814738 244 QEVKRLKFCKDEEEEEQEVE 263 southern platyfish
3_pfamImport 236 QEVKRLKFSEEEEVEYSKEK 255
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