1IYJ


Conserved Protein Domain Family
BRCA-2_OB3
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pfam09104: BRCA-2_OB3 
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BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.
Links
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Statistics
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PSSM-Id: 462679
Aligned: 25 rows
Threshold Bit Score: 160.134
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IYJ_D        646 RELLPFSKLSDPAFQPPCSEVDVVGVVVSVvkpiGLAP-------LVYLS-----DECLHLLVVKFGIDLN----EDI-K 708  Norway rat
EFX81680     1310 RSVIAFSTANQPGFKPMFNELDIVGLVVFV----GLQQrp---fqTAILS-----DGN-TYFGVKCWASLEdyalADIiV 1376
XP_008186509 1263 RDVVSFKSICSGTFLPLFGELDLVGIVVSDvnknNAYD-------EIYVS-----DKEMNIISILFRGNIKeygyDDMmY 1330
XP_008215761 1800 RFCTLIPDITAMSFDPKFCEFDTVGVVVST----GPAPhgmksfeVVNMAypkpnNAGSSYLSILFWNGVSsfgyQSIfS 1875
XP_001863104 1507 RRLTKIVDVDRSSFQPLYNEFDMVGVVVYV----GNSDtkk--fqIAYLA-----DASMNLLGVHFWSGIKeyayEDVvK 1575
ETN60573      966 RSVMPIGDIDGSTFRPAFSEFDTVGVVVYV----GTAEkkk--fqSIYLA-----DTAMDLLCVNFWYGLAeyayDDLiT 1034
XP_022524494 2498 RQFTIFRDLQNSAFSSPCGEVDVVGYVISIldrqGASP-------VLYLV-----DDKFDFVSVRSFSSLVqlalEDLvK 2565
XP_005157420 2596 RECVRFRELQNPHFSSPCGEVDIVGYIVSIegkqGHCP-------VLHLV-----DENFDLVTVRTYSSLEqlavEELvK 2663
EGI61921     1381 RVCTSLDEIANSEFVPPYGEFDTVGLVCSV----GPAPygmrdfdAVHLAycktgSSESSYLSILFWQGIAsygyTEIlT 1456
XP_027136178 2891 RVSTHFVDLQNTEFQSLCGEVDLTGYVISIidgqGFSP-------AFYLA-----DGKLNFVKVRCFSSFAqsglEDLvK 2958 large yellow ...

1IYJ_D        709 PRVLIAASNLQWR---PESTSRVPTLFAGNFSVFSASPKEAHFQERVTNMKHAIE--NIDTFYKEAEKKLIQVLKG 779  Norway rat
EFX81680     1377 VGAFLAFSNLQWRataCRTVSKMQFAFIHEGTLVSSRPALKHLDAALNDLKQSVK--DPAACVAEAEGQVDTLLGS 1450
XP_008186509 1331 PGSIISGINIQFKg--FNQISPIPKLYNTEQSLFTTIPKTEYILNIFNDYKIFMKkhENENFLICCQTKLSEIFNR 1404
XP_008215761 1876 VGALIACTNLEWR---RNTSWNVAVAYCSERTVFTCNPRPQYLNSGLRNLRALIQ--NPVAYAESCVEEITNELSK 1946
XP_001863104 1576 ERSLLCVSNLQWRsfsQQST--IPSSYATEYTTFSEHPKADHFKEELRTLKATLEsiDLEQFYRDCTEKITSAKDK 1649
ETN60573     1035 ERKLLCVANLQWRtisRQST--VPHSFATEYTTFTENPRQPHLRVAWDRFQVQLNaiDQEQFFRRCYERVRELNDN 1108
XP_022524494 2566 PLTLLAISNLQLR----ELSGPVPRLYAGEQALFSVNPKEAHLQEAMAHLKTFVQ--SYENFFSVAEEKLSNLLPS 2635
XP_005157420 2664 PRALVAICNLQVR----VLSGPVPSLYAGEQALFSINPKESYLQEAMAHLKTFAQ--NYEQFFNLAEEKVSDVVPS 2733
EGI61921     1457 VGSIVACSNLEWR---RATSWNVPAAYCTDRSTFTRNPRRNHLYESFENLRNLIM--DPVKYAESCTFELNVELQK 1527
XP_027136178 2959 PRVLLALSNLQLR---GQSASPTPVVYAGDLTVFSTNPKEVHLQESLSQLRNLVQ--GQENFFLTAEEKLSHLVKS 3029 large yellow croaker
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