2CTO


Conserved Protein Domain Family
HMG_box_2

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pfam09011: HMG_box_2 
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HMG-box domain
This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.
Statistics
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Aligned: 10 rows
Threshold Bit Score: 82.4667
Threshold Setting Gi: 121908370
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CTO_A         9 PNR-KASRNAYYFFVQEKIPELRRRg-----LP--VARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPS 79  human
EDV21784      36 PKKpKRARNSYLMYMTDRWNQAKES------GQ--VPEIREFTEESSSNWRNMSEEEKEEYHQRAQIDRNRFSREMMTY 106 Trichoplax adhae...
Q66IB6         6 vNKpKGKTSAYAFFVQTCRDEHKRK------SPdvPVNFSEFSKKCSERWKSLNASDKVKFEDMAKADKVRYDREMKTY 78  zebrafish
EAY13247      26 PPKpKRPPNAYNLYYLEMQPKMKAE------NP--LIGGNDVSKLIGQQWGALSDEQKKPYIEKANEIREQFRRENPNW 96  Trichomonas vagi...
EEN53128       6 KNKpQR--NGFWVYMQEMIPEYKRQg-----YQm-PNGMADVVKLAHPSWKAMPEMEKQEYERQAKELKKSASATAGRL 76  Florida lancelet
Q08D62         2 PNK-KAARNAYFFFALDMIPELRRRg-----LQ--VSGVREAIPLCSEDWALLSADQKEAYAEKARLLKNDPDSTSTYN 72  tropical clawed ...
Q96JY0         2 PNR-KASRNAYYFFVQEKIPELRRRg-----LP--VARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPS 72  human
XP_003938690   6 PKKpKGKMSAYAFFVQTCREEHKKK------NPevPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDY 78  Bolivian squirre...
ESS34112      64 AKRsRAAPSAYFLFAKKEQATIRQQlanesgRE--RIPLGEVQKALSEKWRNISSAEREAYYEEAREKKQEYQQEALWH 140 Toxoplasma gondi...
AFR33808       6 PGKpKGKMSAYAYFVKTCREEHNKK------NPgvTVNFSEFSKKCSERWKTMSPKEKTKFEDLAKQDKARYDQEMMHY 78  grass carp
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