Conserved Protein Domain Family
NRBF2

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pfam08961: NRBF2 
Nuclear receptor-binding factor 2, autophagy regulator
NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.
Statistics
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PSSM-Id: 312498
View PSSM: pfam08961
Aligned: 9 rows
Threshold Bit Score: 232.819
Threshold Setting Gi: 542192110
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0VFU5        92 VAERELSAHLQASYRSAADN-ADSQNtlG--SAGQKSGSNPGKYVQDIPSVLDREPDSLMYLLQRRK----E-PMETCKV 163 tropical clawed...
XP_012429874 108 SADKEAATHLQTSYKPSAED-SDDQN--VlvPVAQKYSSSTEKHSQDIRGVFDRDPDTLLFLLQKKK----E-PVEACIG 179 zebra finch
XP_005997767  92 STDLDMTTHLQSLPKVFAEE-ADGKKvlR--SSNERYSPVKEQYLRKMQYVFDRDPDTLLFLLENRE----V-QTEACQG 163 coelacanth
XP_007478332  89 TPD--GTPHLLTSCKPSAEDgSEGPS--G--PRPQLLSPAPERLSPAVPGVFDRDPDTLLFLLQKRK----D-PTEPCTV 157 gray short-tail...
XP_001510735 148 TTDREAAGPLQASPKAPADD-AEGPA--G--PRIPRRSPSMERRLPEIQGIFDRDPDTLLFLLQKRK----E-PTETCIG 217 platypus
XP_507815     89 NTDKDAAAHLQTSHKPSAED-AEGQS-----PLSQKYSPSTEKCLPEIQGIFDRDPDTLLYLLQQKS----E-PAEPCIG 157 chimpanzee
XP_005471288 112 FSKPPSTGSSRPNASPGASA-AELGS------------------------VGEREYDTLLYQLQTRQtggtQiLTPVCSG 166 Nile tilapia
XP_008112965  95 AMDRDGVTHPQASSKPSAEE-SDDQSvaA--PASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRK----E-PQEACVR 166 green anole
XP_014164349  45 SADKEAAAHLQTSYRPSAED-SDDQNvlV--PVAQKYSSSTEKHSQDIRGVFDRDPDTLLFLLQKKK----E-PVEACIG 116 medium ground-f...
Q0VFU5       164 SKAPKDDKTKLEEQATTIKELNQLVDTLLAENEALRKENKKLRAEVARLQKNP-EKDLDIDTDFVEKSELWNLQQPTGSa 242 tropical clawed...
XP_012429874 180 SKAPKDDKTIIEEQATKIADLKQLIESLVAENERLRRENKQLKAERARLQKSPvDKELDVDTDFVEKSELWGLQQHSES- 258 zebra finch
XP_005997767 164 SKAPKDDKTRIEEQETKIAELKRLVELLLAENERLMKENHRLKGENARLQKVPiEKELDVDADFVEKSELWALPQSSKS- 242 coelacanth
XP_007478332 158 SKAPKDDKTIIEEQATKIADLKRHVEFLVADNERLRRENKQLRAEKARLQKAPlEKELDVDADFVEKSELWSLPPPTET- 236 gray short-tail...
XP_001510735 218 SRAPKDDKTIIEEQATQIEDLKRHVEFLVAENDRLRRENRQLKADKARLQKAPrDKELEGDADFVEKSELWGLQPQSEM- 296 platypus
XP_507815    158 SKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPiEKELDVDADFVETSELWSLPPHSET- 236 chimpanzee
XP_005471288 167 SKTTKDDKTRLEEQQTTIENLRLLVDNLTNENQRLRAENERLRLENMRLHSEA--------ADFVERSELWVLPQAGG-- 236 Nile tilapia
XP_008112965 167 SKTPKDDKTKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPlEKELDVDADFVEKSELWGLQQHSETa 246 green anole
XP_014164349 117 SKAPKDDKTIIEEQATKIADLKQLIESLVAENERLRRENKQLKAERARLQKSPvDKELDVDTDFVEKSELWGLQQHSES- 195 medium ground-f...
Q0VFU5       243 -ANPT-SAWQKF-VAHSGKGTDIPIPNLPPLDIPLPE------LPPLELPEDIQSQL 290 tropical clawed frog
XP_012429874 259 -ASSA-ATWQKF-ATTAGKAKDIPIPNLPPLDIPSPE------LPLLELSDDILKGL 306 zebra finch
XP_005997767 243 -PTSTaPTWQNL-TGEAGKAKDIVVlnlppldiplpdlpplelpediqcdlkelldg 297 coelacanth
XP_007478332 237 -ASSA-SAWPEF-AANTGKAKDIPIPNLPPLDFPSPE------LPLLELPEDILKGL 284 gray short-tailed opossum
XP_001510735 297 -ATAS-STWQKFaAANTGKAKDIPIPNLPPLDFPSPE------LPLLELSEDILKGL 345 platypus
XP_507815    237 -ATAS-STWQKF-AANTGKAKDIPIPNLPPLDFPSPE------LPLMELSEDILKGF 284 chimpanzee
XP_005471288 237 -PMGT-GVGQG--GESKRKGKEIAIPQLPPLEMPAQEdlclddLPPLELPEDIQNEL 289 Nile tilapia
XP_008112965 247 aATSA-SSWQKF-TSSAGKAKDIPIPSLPPLDIPSPE------LPLLELSEDILKGL 295 green anole
XP_014164349 196 -ASSA-ATWQKF-ATTAGKAKDIPIPNLPPLDIPSPE------LPLLELSDDILKGL 243 medium ground-finch
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