5IFE


Conserved Protein Domain Family
SF3b1

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pfam08920: SF3b1 
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Splicing factor 3B subunit 1
This family consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C-terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly.
Statistics
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PSSM-Id: 337259
View PSSM: pfam08920
Aligned: 52 rows
Threshold Bit Score: 91.2472
Threshold Setting Gi: 396472079
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5IFE_C        332 SKRKSRWD------ETPAsqm---------------------------------------ggsTPv------lTP----- 355  human
A0EEP7        151 SARASRWDntnklqATPGragt-------------------------------------vfgeTP--------TPghmei 185  Paramecium te...
Q4UCL9        138 KKKVSRWD------KTPMm------------------------------------------------------------e 151  Theileria ann...
Q4XWD8         69 KKKLSRWD------KTGDgggnninfadn-----------------------gtinsdmnnmkTPivs---gnRYnenmm 116  Plasmodium ch...
Q7RM47        221 KKKISRWD------RTVEnstssnnnnnfgd--------------------gkmassgmnqlkTPiis---gnKYnenmi 271  Plasmodium yo...
CCG81011      308 TTKRSRWD------ETPV----------------------------------------------Pvn----gaSTkrsrw 331  Taphrina defo...
XP_001821689  244 TKKKSRWD------QTPS---------------------------------------------LPvpgaaeeaPKrrsrw 272  Aspergillus o...
XP_014081488  219 PKKRSRWS------PAPE---------------------------------------------DTke----aaAParsrw 243  Bipolaris may...
XP_003839021  223 SSKRSRWSep---ePEPE---------------------------------------------KPae----daAPvrsrw 250  Leptosphaeria...
KMZ80704      265 RKKISRWDkv--geGTTAsaadglaqsdlmktprvvaaggvalggmaaggmaaggatpggllkTPy------lVPgsgnf 336  Plasmodium vi...
5IFE_C        356 GKTPI-------Gtp------------aMNMATPtpg-----------himSMTP-------EQLQAWRWEREIDERNRP 398  human
A0EEP7        186 GDTPYkygetptPnhgekehlwlvnhgfGGGMTPhtpgtvmrtpmtpgqlgNMTP-------DRVYQFRLEKEMEERNKY 258  Paramecium te...
Q4UCL9        152 QQTPMaht------------------gmYGMATP------------------MTPqiv--vpESMLKFNITTSYEDRNRY 193  Theileria ann...
Q4XWD8        117 INTPIv---------------------gTNMMTP------------------MTPylgsiqnNDYIKFKIKNEMDFRNRP 157  Plasmodium ch...
Q7RM47        272 INTPIl---------------------gTNIMTP------------------ITPysgsvqnNDYIKIKIKNEMDYRNRP 312  Plasmodium yo...
CCG81011      332 DQTPA----------------------------Pgsvs----------akqVTAP-------AAVIPTSFGTDVAGRNLP 366  Taphrina defo...
XP_001821689  273 DQAPSitsatpvGn--------------QGLATP------------------MHPsq---vgAALIPTSFGTDISGRNAP 317  Aspergillus o...
XP_014081488  244 DTTAV---------------------------APaatatpap---aangahpIAP-----------TFAFGTDISSRNAP 282  Bipolaris may...
XP_003839021  251 DTTAV---------------------------VPasatpaap--aangahpFMPP-----------TFAFGTDISSRNAP 290  Leptosphaeria...
KMZ80704      337 VNTPYvvnqlgnA---------------PAMFTP-----------------MMTPgvaslatDSIIRMKIKNEMEIRNRP 384  Plasmodium vi...
5IFE_C        399 LSDEELDAMFP---EGYKVLPPPAGYVPIRTPARKLT------ATPT 436  human
A0EEP7        259 MTDEELTSILPgpkDGYEILRAPENYKPLRSSLKKLLnakdsiESPV 305  Paramecium tetraurelia
Q4UCL9        194 LTDEELDELLPv--EGYEIVLPPPDYQPYRKPSSYTY------GTVT 232  Theileria annulata
Q4XWD8        158 LTDEDLDNLLPs--EGYEIVKPPEEYEAIRKNKLKILfknmkdTTTT 202  Plasmodium chabaudi
Q7RM47        313 LTDEDLDNLLPi--DGYEIVKPPEEYETIRKNKLKILfknmndTTTT 357  Plasmodium yoelii yoelii
CCG81011      367 LSDEELDELLPk--tGYKILIPPPGFEPIRAPAKRVQ------VEDA 405  Taphrina deformans PYCC 5710
XP_001821689  318 LSDEELDMMLPgeaDGYKILDPPPGYAPIRNPARKLM------STPA 358  Aspergillus oryzae RIB40
XP_014081488  283 LSDEQLDMMLPgeaEGYKVLEPPPGYEPVRRPV----------GMPA 319  Bipolaris maydis ATCC 48331
XP_003839021  291 LSDEQLDMMLPgeaEGYKVLEAPPGYEPVRRPV----------GMPV 327  Leptosphaeria maculans JN3
KMZ80704      385 LTDEDLDELLPs--EGYEIVQPPEEYEAIRRNKLKAFfktvasAAGT 429  Plasmodium vivax India VII
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