1UIX


Conserved Protein Domain Family
Rho_Binding

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pfam08912: Rho_Binding 
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Rho Binding
Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions.
Statistics
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PSSM-Id: 370184
View PSSM: pfam08912
Aligned: 43 rows
Threshold Bit Score: 47.2046
Threshold Setting Gi: 190579484
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UIX_A                 3 TSDVANLANEKEELNNKLKEAQEQLSRLKd-eEISAAAIKaqfeKQLLTERTLKTQAVNKLAEIXNRKE 70   cattle
EDV19578             144 KNDKYEMALRITQLKAEVRFVEDSEENAIl--SKQIEKLR----ESLSAEQLLKTQAVNKLVETLNCKl 206  Trichoplax adhaerens
KYB27402             942 KKMNEHLSKEREDINRQLKQLQEEFSKKSg-nNEEIDKLK----SKLQTESLLKQQAVNKLHEVLNRKD 1005 red flour beetle
Q29IT7               952 HKKLGQKANEYEDLVQQHKKQQDELGQLRatkDEEITKLL----DKCKTEVLLKQVAVNKLAEVMNRRD 1016 Drosophila pseudo...
WGS:AANI:GJ15785-PA  953 HKKLKQKASEWDELLVQHKKQLDELQQQRaakDEEIAKLG----EKCKNEVLLKQVAVAKLAEVMNRRD 1017 Drosophila virilis
Q179S5               889 NKKLNNKAFELDDLTQQNRKMQDELSVLKs-eQSEMEKLR----TKLKTETMLKQQAVNKLAEIMNRKD 952  yellow fever mosq...
Q7PRV2               937 KKSLGNKEYELEDVLQQSKKQQEELYRLKy-eLGELDKCR----AKLVNETILKQQAVNKLAEIMNRKD 1000 Anopheles gambiae...
ETN67237             883 NKNLTNKSYELDDLMQQCKKLQDELYVLRl-eQGELDKCK----TKLLNETILKQQAVNKLAEIMNRKD 946  Anopheles darlingi
NP_001265264         943 KKNVDQYLKEKEDLNKRFKELQDQLSKAQs-nAEEIEKLS----SKLKTEQLLKQQAVNKLAEIMNRKD 1006 honey bee
XP_016841741         952 KKNCEQYTKEKEELTKRLKEMQEQLNKAQf-nADEIERLS----TKLKTEQLLKHQAINKLTEVLSRKD 1015 jewel wasp
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