5A9Q


Conserved Protein Domain Family
Nucleoporin_N

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pfam08801: Nucleoporin_N 
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Nup133 N terminal like
Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.
Statistics
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PSSM-Id: 337210
View PSSM: pfam08801
Aligned: 54 rows
Threshold Bit Score: 183.357
Threshold Setting Gi: 123478393
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A9Q_A         77 NLPEISSIRRV-PLPPELVEQFGhmqCNCMMGVFPPISRAWLTIDSDIFMWNYEDG--GDLAYFDgLSETILAVG-LVKP 152  human
Q6FTD5        135 AFTPFERQKVV-SIPDDILQEASnteLKSDMGIFPEIDRCWFTIDNRIILWNINDS--TEYQTIDdIKHAILKIQ-LVKP 210  [Candida] gla...
Q5KIY7        185 AYKCCSVTKRT-PLPDALHQELNfkhLTAKMGLFEEIERAWFTVDNKLFLWDYGDGr--DFSRYDeQTDTIQAVG-LVKA 260  Cryptococcus ...
Q38AE7         59 TLPAFLPLTGV-TWPEAVKAVWKtfrANSTVGLFPELSRAWITIDNKLLLWNFGTGr--DFFLFDeVPELIVAVGtPVLP 135  Trypanosoma b...
Q4E149         59 TLPDFIPLVGV-SWPEPVKAVWKtfrANSIVGLFPELSRAWITVDNKLLLWNYGTGr--DFLVYDeIPELIVAVGnPVTP 135  Trypanosoma c...
XP_001645907  137 AFTPFER-QQViNVPDEILKEASkteIKNDTGIFPEINRCWITIDNKLILWNYQDS--TDYQTIDeIKHTILHVA-LVKP 212  Vanderwaltozy...
CAY77705      144 AFTPFEK-QDVfNIPDEILHEFStsqTKTDMGIFPELNRCWITIDNKLILWNINNd--NEYQVVDdMKHTIQKVA-LVRP 219  Saccharomyces...
AJU51511      134 AFTPFQR-QQVtNIPDEVLSQVSnteIKSDMGIFLELNYCWITSDNKLILWNINNS--SEYHCIDeIEHTILKVK-LVKP 209  Saccharomyces...
XP_001569335   56 avPDFFPVGGV-AWPEPLLELWKsmrYSSLTGVFADLSRAWFTVDNRLVIWDYHGGr--EFCIYDeIPELISVVGaPLRP 132  Leishmania br...
XP_001316012   51 kENSIATISDVkKYPTRVYNAATaakYRVFMSSFPKLSTLYCVVDNTLYMWPFNNGenPEVITADgNIITTVTYGi---P 127  Trichomonas v...
5A9Q_A        153 KAGIFQpHVRHLLVLATPVDIVILGLSYANlqtgsgvlndslsGGMQLLPDPLYSLPtdnTY-LLTITSTDNGrIFLAG- 230  human
Q6FTD5        211 KPNTFVsHVKHLLVVATVFDIYILAVSYKKe------------TNELSIFNTGMSVNvqgMNvNNITCYEKTGqIFFSG- 277  [Candida] gla...
Q5KIY7        261 RKDVFVdDITHVLVICTSTKATLLGLSRSLt------------SREILLYHTNLTVDt--PTvMVDIKGTDEGrVFVLG- 325  Cryptococcus ...
Q38AE7        136 IAGVFQaHITYVLPVSTPKAVHLLGLCVFGggp--------lkKAELYVVSLGFSVMa-pALfTKLVGVKELGrIFAAG- 205  Trypanosoma b...
Q4E149        136 VAGVFQpHITLVFPVATPKTIHLLGLCVVGdet--------akKAELCVVNLGFSVLa-pTLfIKLVGLRDLGrVFAVG- 205  Trypanosoma c...
XP_001645907  213 KKDTFVdYIKHLLIVVTPFDIFIFAISYNNk------------NNELSIYNTSMSVSvhgLEvFDVVTYDRTGqIFFAG- 279  Vanderwaltozy...
CAY77705      220 KPNTFVpAVKHLLLISTTMELFMFAISLDKa------------TNELSVFNTHLSVPvqgIDvIDIVSHERSGrIFFAGq 287  Saccharomyces...
AJU51511      210 SPNTFVsSVENLLIVATLFDIYILTISFDDr------------THELNIFNTGLKVNvtgFNvSNIISYERTGqIFFTG- 276  Saccharomyces...
XP_001569335  133 LSGVFQpHVTYIIPVGTTSMMFLLGLCIMGega----------qaEMKVVNLGYSCSt-dTViTKAIGSG--GhVFCAG- 198  Leishmania br...
XP_001316012  128 EPKIFNkNPTYVILIATDRTIKIVP------------------AKPFQIYKDEASQMkisTIf-VSSYISSKGeIFLCS- 187  Trichomonas v...
5A9Q_A        231 KDG--CLYEVAYQAEAGw---FSQRCRKINHSKS---SLSfl--------vpSLLQft--------------fSEDDPIL 280  human
Q6FTD5        278 KSNglNVWELQYTGSDDw---FNSKCTKSCRTQS---TFSsllpt---nilsKLPGsnlvqsm----fddsnsHGQESII 344  [Candida] gla...
Q5KIY7        326 ANK--DLYELDYSSDSSwlfgSSTSVRLKNRTSG---GVSnw--------vpSVVAs----------------KVKAGIE 376  Cryptococcus ...
Q38AE7        206 ADG--CLYEVKYAKEDTa---FLPKLRLVNCSLM---FGSvpvlgavsslisAIKQtw--------------aKERPALR 263  Trypanosoma b...
Q4E149        206 ADG--CLYELKYTKESTp---FIPKVRLINHSII---FAGipilstvsslmsTLKQtw--------------aKQRPALR 263  Trypanosoma c...
XP_001645907  280 KTNgiNIWELQYSGSDDw---YNSKCTKVCMTQS---ALSsllpt---nmlsKIPGssyvqsl----feedskYSQETIM 346  Vanderwaltozy...
CAY77705      288 ASGl-NIWELHYSGSDDw---FNSKCKKVCLTKSallSLLptn------mlsQIPGvdfiqalfednsngnggFSQETIT 357  Saccharomyces...
AJU51511      277 ATDgvNVWELQYNCSENl---FNSKSNKICLTKSnlaNLLptk------lipSIPGgkliqkv----legdagTEEETIS 343  Saccharomyces...
XP_001569335  199 ADG--NVYEVRYMRDNTp---ITPKIRMVSYGYW---LSTapvlgqvtsvvaSVWKsw-------------rgGMHGGLI 257  Leishmania br...
XP_001316012  188 DTG--EVYLVKYKDTKStqeaPGLKLKPLISPLW---FIPman------llkN----------------------PRRTT 234  Trichomonas v...
5A9Q_A        281 QIAIDNSRNILYTRSEKGVIQVYDLGqd-gqGMSRVASVSQN-AIVsaa----gnIARt-IDRSVFKPIVQIAVIENSes 353  human
Q6FTD5        345 QITIDQSRGILYTLSSTSKIHAYIIT-----GKSLEGAISVEpSYIkriigattaRGAp-ILAPKYLKLAKLSPVVQAen 418  [Candida] gla...
Q5KIY7        377 SFAVDSQQKRLYTLHTGGEIEFYDVSa---nRFDLRSKYNRLkHDLn------------rDPRGGAVTIVSISAIGGHes 441  Cryptococcus ...
Q38AE7        264 DVAIEAKRKLLFTLNSESTISLWRIT-----NDGLSQLATVRgGALgg------tNRTsvWSGGAGVELARIFCATSSd- 331  Trypanosoma b...
Q4E149        264 DIAAESKRKLLFTLDAEGKILMWRITee--gLKVLTTVKCTRsSFEhhr----hlESSa-DDATSFVKIFCVSPYDEN-- 334  Trypanosoma c...
XP_001645907  347 QLAIDQSRgIIYSLSSKSIIRAYLISn-----nSLVGPMSIEpAYIkriigtttaRGAa-ILANKYLKISKIVLVSQQen 420  Vanderwaltozy...
CAY77705      358 QLTIDQQRgIIYSLSSKSTIRAYVIT-----EKSLEGPMSIEpAYIsriigtttaRAAp-ILGPKYLKIVKISSVAPEen 431  Saccharomyces...
AJU51511      344 QLEVDQSRgVLHTLSTKSIVRSYLITsngleGPVLIDAAHIRrGINal-----gvKNSp-LLSNRAFKIAKIVSISMCen 417  Saccharomyces...
XP_001569335  258 DLVVDErdGILATLCERSRISLWRLIps--gGMRYILSLRHRpGRLp--------rSHt-TPNGEPAPLVRLFVIETDa- 325  Leishmania br...
XP_001316012  235 SMAVDDTHn-YFAFLVGKTIRFYK-----------YQNEHLYyLSKe--------------KIDYSGNITNIEAIPISds 288  Trichomonas v...
5A9Q_A        354 lDCQLLAVTHAgvrlYFSTCPFrqpLARPnTLtlVHVRLPPgfsas--------------------------------st 401  human
Q6FTD5        419 gNLFLVAITIGgvrlYFNGFVG---RTSIeALrlESIKFPPssvtpeilqkeleqqqleqqkrslpfystlnstesvvlk 495  [Candida] gla...
Q5KIY7        442 kRACLVAIASNgvraYFVSTPS---------FypIILRAPP--------------------------------------- 473  Cryptococcus ...
Q38AE7        332 dSCSLIAVAANgeqyRYVCQDGl--WGGAd----ASLSLREslgsyip-------------------------------- 373  Trypanosoma b...
Q4E149        335 --FSVVVITSNgeqyRYLCQEGm--WDRTdGNl-TLRDWTPscip----------------------------------- 374  Trypanosoma c...
XP_001645907  421 nNLFFVAITIGgvrlYFNGSIGr--S-SIeAIrlESIKFPPssvtpqviqqelqkeqleqqkkslpfysaltssesvllr 497  Vanderwaltozy...
CAY77705      432 nNLFLVALTVGgvrlYFNGSMGr--FN-IeALrlESIKFPPssvtpeviqqellhqqqeqakrsfpffsnlmssepvllk 508  Saccharomyces...
AJU51511      418 nDLFLVVITTTgvrlYFKG-SIs--RRSIgSLklDSVKFPPtsisssleqnkssiig----------hhpsnthdtspls 484  Saccharomyces...
XP_001569335  326 qGCRLMATALNgdqfRYRYINI---FDSVfSAelILQSHTPsyls----------------------------------- 367  Leishmania br...
XP_001316012  289 lLSHFVAFSTNgdrfFFGTFPGl--YRNPdEIhlRRTLPAPevfq----------------------------------- 331  Trichomonas v...
5A9Q_A        402 vekPSKVHRALy------sKGILLMA-AseNE-------------------------D---------------------N 428  human
Q6FTD5        496 fqkKSSVLLETttsaeiisPGIFFSA-V--VKnnennnnanqnkdnttpsdnkftepE---------------------N 551  [Candida] gla...
Q5KIY7        474 ---PLQLGLSVsdqs-iytSGTFIAV-Q--YD-------------------------P---------------------N 500  Cryptococcus ...
Q38AE7        374 qgrevtVCFAS--------EGISVVC-H--AEkseg------------------gysP---------------------D 403  Trypanosoma b...
Q4E149        375 snrEVSVCFTS--------DGVALFC-H--TEkdde------------------nasS---------------------D 404  Trypanosoma c...
XP_001645907  498 fqkKSSVLLETtkastiisPGIFFSS-I--VKtpeqdkknnntt--tnnnsghinqiQ---------------------N 551  Vanderwaltozy...
CAY77705      509 fqkKSSVLLETtkastiisPGIFFSA-V--IK-------------------------S---------------------S 539  Saccharomyces...
AJU51511      485 tqkASSTYINTtcastiisPGIYFTC-V--RK-------------------------RtnsgepskgitnqalleneeeH 536  Saccharomyces...
XP_001569335  368 vnkeISVCYASa------sAFLAAFSdM--ND-------------------------Dra------------------sD 396  Leishmania br...
XP_001316012  332 ---ghtLISGSf------sHGMSSFL-F--KD-------------------------M---------------------F 353  Trichomonas v...
5A9Q_A        429 -----------------------------------DILWCVnhdtf----------pfqkpMMETQMTAGVDGh------ 457  human
Q6FTD5        552 -----------------------------------KLFVSVpdygil---------ktfgkYVENATFLDTVS------- 580  [Candida] gla...
Q5KIY7        501 -----------------------------------APLTQThltfaipqsgrqsalrenyeTLEPPVFQEWTAteivpsq 545  Cryptococcus ...
Q38AE7        404 -----------------------------------SVTVASshkgil---------qphhnCRDIVAQFEPEAt------ 433  Trypanosoma b...
Q4E149        405 -----------------------------------SVAVTTspktvl---------pphhhCRDIVAHFEPSAs------ 434  Trypanosoma c...
XP_001645907  552 -----------------------------------KLFVSVpdygvl---------kqhgkYIENATFLDTTG------- 580  Vanderwaltozy...
CAY77705      540 qqthqqekkenssvtgttatagsktvkqqpvtlqhKLFVSVpdygil---------kthgkYVENATFLETAG------- 603  Saccharomyces...
AJU51511      537 -----------------------------------KLYVSApdygil---------knhgkYVENTALLDTTD------- 565  Saccharomyces...
XP_001569335  397 -----------------------------------EVLAATspatvi---------aphqnVRDIVATFSGSSsr----i 428  Leishmania br...
XP_001316012  354 -----------------------------------AILHPNsnphh-----------mqshLVEDLVTIPLSP------- 380  Trichomonas v...
5A9Q_A        458 SWALsaI--DEL--KvdkiiTplNKDHIP--ITDSPVVVQq---HMlpPKK-FVLLSAQG 507  human
Q6FTD5        581 PVKE--I--KVL--T-----KtfNASNKP--EGYANTFATqy-sSE--ELK-IAVLTNSS 623  [Candida] glabrata
Q5KIY7        546 VWAI--VelSDA--N-----PknSPASLRrsDGLALSALPrqaeAG--PRG-FLVLAASG 593  Cryptococcus neoformans
Q38AE7        434 CMTR--VdaISE--V-----PveGGVSPN--ELCSQVS------CS--PRQ-FVFLHRHG 473  Trypanosoma brucei
Q4E149        435 LMAR--VdaIGE--V-----PvrESVSPN--ELCSQVV------CS--PRQ-FVFVHRHG 474  Trypanosoma cruzi
XP_001645907  581 PVKQ--V--IPL--T-----AsfNATMKQ--EGYANVFATqy-tVE--NLR-IAVLTNTA 623  Vanderwaltozyma polyspora DSM 70294
CAY77705      604 PVQQ--I--IPL--S-----GlfNATTKP--QGFANEFATqy-tSE--TLR-VAVLTSTS 646  Saccharomyces cerevisiae EC1118
AJU51511      566 EIKE--I--VPL--T-----RsfNYTSTP--QGYANVFASqy-sAE--PLK-VAVLTSNA 608  Saccharomyces cerevisiae YJM1402
XP_001569335  429 VRVD--A--IER--M-----PtqGSQNFS--DLCAQV-------CS--PGPtYVVVHRHG 466  Leishmania braziliensis MHOM/BR/7...
XP_001316012  381 ---D--C--LSFfrS-----EhiYKGQNT--SMFHNEYLWqh-iVQ--PTP-GFLQCADG 422  Trichomonas vaginalis G3
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