5KNW,1OWX


Conserved Protein Domain Family
RRM_3

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pfam08777: RRM_3 
Click on image for an interactive view with Cn3D
RNA binding motif
This domain is found in protein La which functions as an RNA chaperone during RNA polymerase III transcription, and can also stimulate translation initiation. It contains a five stranded beta sheet which forms an atypical RNA recognition motif.
Statistics
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PSSM-Id: 370115
View PSSM: pfam08777
Aligned: 13 rows
Threshold Bit Score: 94.3457
Threshold Setting Gi: 74855304
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KNW_A        18 GVIVKII--STEPLPgRKQVRDTLAAIS---EVLYVDLLEGDTECHARFKTPED--AQAVINAYTE-------INKKHCW 83  human
Q54TG6       229 GVILCFKg-VGKGLH-RGDIKEIFSQYG---EVQFVGYNSDEENGSVRYKTAES--CKRAIESLTEtk----kEIGGQIP 297 Dictyostelium d...
Q7ZWE3       429 GVIVKIS--YNQPLPsKRCIKDMLSELS---PVAYVDLLDGDTEGHVRFKSSED--AQKVIKARFEf-------QKKYNW 494 zebrafish
Q4G0J3       454 GVIVKII--STEPLPgRKQVRDTLAAIS---EVLYVDLLEGDTECHARFKTPED--AQAVINAYTEi-------NKKHCW 519 human
2_pfamImport   1 GVIVKIT--DSKALPaRSRIKDALSRLS---PVAYVDVLEGDAEGHVRFHSPED--ARAACEGRAAl-------QKELGW 66 
Q6K6X2       330 G----LSgkANSPIS-REDLKEAFKKFG---TVRYVDFSIGDESGYLRFEDSKA--AEKARMSAVLade-gglIVKDHIV 398 Japanese rice
CAP38874     232 GLILAVDg-IKGESS-VDSIKTFFKQYG---SVGYVAHEVGNATAEVRFNNDSEggAQKAWEKAVEagtdgkvMMNDAEI 306 Caenorhabditis ...
P05455       231 GCLLKFSgdLDDQTC-REDLHILFSNHG---EIKWIDFVRGAKEGIILFKEK----AKEALGKAKDann-gnlQLRNKEV 301 human
1_pfamImport   1 GCLLKFSg-ELEDVS-REDFHELFSGHG---KIKWVDFARGAKEGALLFDGN----AKEAFEKAKEang-gelKIKDCSV 70 
Q7PWI4       261 GACVFMEg-LGKETT-RESIKEAIRALDetlEFAYIDYQKGDASGYVRFNKQDA--GKQLLEKLTDkk----lKIDDAEV 332 Anopheles gambi...
Q17EQ5       250 GACVHLAg-FNKETS-RETIKETILKLDeslEVAFIDYQKTDSEGTVRFAADDA--GKKFMEKLTDsk----iQIDEEEI 321 yellow fever mo...
O01806       230 GLILAVDg-LGPDST-IDSIKTFFKLHG---SVGYVAHENGGKTAEIRFNNDSEg-AQKAWDNAVAagtdgkvILQEAEL 303 Caenorhabditis ...
1OWX_A        18 GCLLKFSgdLDDQTC-REDLHILFSNHG---EIKWIDFVRGAKEGIILFK--EK--AKEALGKAKDann-gnlQLRNKEV 88  human
5KNW_A        84 KLEILSGDHEQRYWQKILVDRQAKL--NQPREKKR 116 human
Q54TG6       298 TYNLLEGEEEKKEWEKIIERKKNAA--KNGGFKKG 330 Dictyostelium discoideum AX4
Q7ZWE3       495 NLELLSGDHERRYWQKILVDRQAKL--NTPREKKR 527 zebrafish
Q4G0J3       520 KLEILSGDHEQRYWQKILVDRQAKL--NQPREKKR 552 human
2_pfamImport  67 RLEVISGEREQRYWQKILVDRQVKL--NRPREKKR 99 
Q6K6X2       399 TLEPVTGEAEKDYWNTIRGIQGKYK--DNRSYKGR 431 Japanese rice
CAP38874     307 TARVLEGEEEEKYWTEFNNRKSQKQ----NFRGGR 337 Caenorhabditis briggsae
P05455       302 TWEVLEGEVEKEALKKIIEDQQESL--NKWKSKGR 334 human
1_pfamImport  71 TWQLLEGDEEKEALKRIIEAQQETQ-----RNKGR 100
Q7PWI4       333 TADLLVDEKETEYLKKIAEEQAKRK--VNAKNKGR 365 Anopheles gambiae str. PEST
Q17EQ5       322 TARLLEGDEEKEFLRKVVKDQQARRqaSNARNKGR 356 yellow fever mosquito
O01806       304 SARVLDGEEEEKYWTEFNARKNQRQggGRGGRGGR 338 Caenorhabditis elegans
1OWX_A        89 TWEVLEGEVEKEALKKIIEDQQESL--NKWKSKGR 121 human
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