3G43


Conserved Protein Domain Family
Ca_chan_IQ

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pfam08763: Ca_chan_IQ 
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Voltage gated calcium channel IQ domain
Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Statistics
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PSSM-Id: 370105
View PSSM: pfam08763
Aligned: 46 rows
Threshold Bit Score: 96.0599
Threshold Setting Gi: 0
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3G43_E           5 STLFALVRTALRIKTEg------NLEQA--NEELRAIIKKIWKRTSMK-LLDQVVP-PAG-DDEVTVGKFYATFLIQEYF 73   human
EDV27941      1366 ATLFALIRTSLKIKV--------REDQHeaDAELCQIIRKIWPQVTSR-TLERILPqVEHgARHLTIGKIYAALIIYEYY 1436 Trichoplax a...
EGD78396      1330 ACLLAIVRNQLHIKTsyl---dgSWEQR--NYDLRKLLEKLYDP--PKeQLDRMLP-PPS-KRNVTIGVLYAVYLLQEIY 1400 Salpingoeca ...
EDO46991      1480 ATLFGLVRTSLSIKRPeg---kgSLEKA--NEEMRAIIMKVWPKTSQE-FLDEIIQ-PPGgDDEVTVGKFYATYLIQEYF 1552 starlet sea ...
EGW06086        15 ATLFALVRTSLKIKTe------gNLDQA--NQELRMVIKKIWKRIKQK-LLDEVIP-PPD-EEEVTVGKFYATFLIQDYF 83   Chinese hamster
CDS29677      1733 ATLFALVRRNLRIKVPeddekekSLDQL--NEELRSVIKKIWKRTSPK-LLDQILP-PKE-LDVVTVGKFYATFLIQNWF 1807 Hymenolepis ...
GAA52227       639 ATLFALVRTNLKIKTeg-----aPIDQL--NEELRTVIKKIWKRTSPK-LLDQVVP-PAGgNDDVTVGKFYATFLIQEWF 709  Clonorchis s...
21_pfamImport    2 ATLFALVRTALKIKTe------dNFFII--KSSVRLII---WCPLCMN-LTSQVIHmEHAsNDEVTVGKFYATFLIQDYF 69  
8_pfamImport     2 ATLFALVRTALKIKTe------gKHSLA--EGQVRMSVFSGWNFKLIE-IXDQVVP-PAG-DDEVTVGKFYATFLIQDYF 70  
XP_021334158  1457 ATLFALVRTSLKIKTd------gPIDQQ--NEELRAIIKKIWKRTKPK-LLDEVIP-PPS-GNEVTAGKFYASFLIQDYF 1525 zebrafish
3G43_E          74 RKF 76   human
EDV27941      1437 KRY 1439 Trichoplax adhaerens
EGD78396      1401 REN 1403 Salpingoeca rosetta
EDO46991      1553 RRF 1555 starlet sea anemone
EGW06086        84 RKF 86   Chinese hamster
CDS29677      1808 REW 1810 Hymenolepis microstoma
GAA52227       710 RRW 712  Clonorchis sinensis
21_pfamImport   70 RKF 72  
8_pfamImport    71 RKF 73  
XP_021334158  1526 KKF 1528 zebrafish
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