2N8Y


Conserved Protein Domain Family
EFhand_Ca_insen

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pfam08726: EFhand_Ca_insen 
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Ca2+ insensitive EF hand
EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition.
Statistics
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Aligned: 19 rows
Threshold Bit Score: 87.3622
Threshold Setting Gi: 74686104
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2N8Y_A         83 DTDTADQVMASFKIL-AGDKNYITMDELRRELPPDQA-EYCIARMAPYTGP----DSVPGALDYMSFSTALY 148  human
XP_004023005  169 NVKSSEEIESAFRALsSEGKPYVTKEELYQNLTREQA-DYCVSHMKPYVDGk--gRELPTAFDYVEFTRSLF 237  sheep
P02549       2350 NIKSSDEIENAFQAL-AEGKSYITKEDMKQALTPEQV-SFCATHMQQYMDPr--gRSHLSGYDYVGFTNSYF 2417 human
Q5AVH3        605 DQNTAEQVFQSFREV-ADGKPYVTELDLRHSLIPDEIiEHLVKTMPQHEGPdlleDRDLPKYDYISFMERMM 675  Aspergillus nidulans
Q0UG56        635 DQNTAEQVFESFKEV-ADGKPYVTELDLRHSLVPDEViDDLLSTMPEHKGPdmqeDRDIPKFDYITYMERYM 705  Parastagonospora nodo...
Q2U7P8        559 DQNTAEQVLQSFREV-ADGKPYVTELDLRHSLIPDEViDHLVQTMPRHEVFdrgeDQNEPKYDYYSFMQKMM 629  Aspergillus oryzae
Q0CDG2        559 DQNTAEQVLQSFHEV-ADGKPYVTEMDLRLSLIPEELiEHLTQTMPKHQGPvksqDRDVPQYDYISFMGKMM 629  Aspergillus terreus N...
Q29EZ8       2344 NVQSYEEIENAFRAItAADRPYVTKEELYCNLTKDMA-DYCVQRMKPFSEPrs-gQPIKDALDYIDFTRTLF 2413 Drosophila pseudoobscura
Q21408       2356 NIQSSEEIEMAFRALsKEFRPYVTAEELYANLTPEQA-EFCIRRMKPYMDAis-gRSIQGGLDYEQFVHALF 2425 Caenorhabditis elegans
XP_018644384  335 NVQSRDEVEEAFRALtKEGKEYITKEELYANLSKEQA-EYCSRVMPPYYTKs--gQAILDAYDYQAFTRQLF 403  Schistosoma mansoni
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