2N8Y


Conserved Protein Domain Family
EFhand_Ca_insen

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pfam08726: EFhand_Ca_insen 
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Ca2+ insensitive EF hand
EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition.
Statistics
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PSSM-Id: 312305
View PSSM: pfam08726
Aligned: 19 rows
Threshold Bit Score: 129.734
Threshold Setting Gi: 308153675
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2N8Y_A         83 DTDTADQVMASFKIL-AGDKNYITMDELRRELPPDQA-EYCIARMAPYTGP----DSVPGALDYMSFSTALY 148
7_pfamImport    1 NVKSSEEIESAFRALsSEGKPYVTKEELYQNLTREQA-DYCVSHMKPYVDGk--gRELPTAFDYVEFTRSLF 69
gi 308153675 2350 NIKSSDEIENAFQAL-AEGKSYITKEDMKQALTPEQV-SFCATHMQQYMDPr--gRSHLSGYDYVGFTNSYF 2417
gi 74680635   605 DQNTAEQVFQSFREV-ADGKPYVTELDLRHSLIPDEIiEHLVKTMPQHEGPdlleDRDLPKYDYISFMERMM 675
gi 121930071  635 DQNTAEQVFESFKEV-ADGKPYVTELDLRHSLVPDEViDDLLSTMPEHKGPdmqeDRDIPKFDYITYMERYM 705
gi 121938368  559 DQNTAEQVLQSFREV-ADGKPYVTELDLRHSLIPDEViDHLVQTMPRHEVFdrgeDQNEPKYDYYSFMQKMM 629
gi 121735122  559 DQNTAEQVLQSFHEV-ADGKPYVTEMDLRLSLIPEELiEHLTQTMPKHQGPvksqDRDVPQYDYISFMGKMM 629
gi 122121399 2344 NVQSYEEIENAFRAItAADRPYVTKEELYCNLTKDMA-DYCVQRMKPFSEPrs-gQPIKDALDYIDFTRTLF 2413
gi 74965328  2356 NIQSSEEIEMAFRALsKEFRPYVTAEELYANLTPEQA-EFCIRRMKPYMDAis-gRSIQGGLDYEQFVHALF 2425
4_pfamImport    1 NVQSRDEVEEAFRALtKEGKEYITKEELYANLSKEQA-EYCSRVMPPYYTKs--gQAILDAYDYQAFTRQLF 69
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