1M1J


Conserved Protein Domain Family
Fib_alpha

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pfam08702: Fib_alpha 
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Fibrinogen alpha/beta chain family
Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).
Statistics
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PSSM-Id: 312286
View PSSM: pfam08702
Aligned: 71 rows
Threshold Bit Score: 149.994
Threshold Setting Gi: 768942638
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1M1J_E         67 AGGCKHPLDELGVLCPTGCELQTTLLKQEKTVKPVLRDLKDRVAKFSDTSTTMYQYVNMIDNKLVKTQKQRKdNDIILSE 146
gi 1018997393  61 qDWPFCTDDDWTYKCPSGCRLKGLIDETSQDFTNRITKLRNLLFEHQRSNKDSSSVTREMLELIRGDLVSGNeNDNLFGQ 140
gi 291401111   50 ADWPFCADDDWNQKCPSGCRMKGLIDEMNQDFTDRMNKLRNSLFDYQKNNKDSSSVVTNIMEYLRGNLATANnYDTTYNQ 129
gi 354474601   49 TDWPFCSDEDWNHKCPSGCRMQGLIDEVNRDFINRINKLKNSLFDFQKNNKDSNSLTRNIMEYLRGDFANANnFDNTYGQ 128
gi 831226582   51 SDWPFCSDDDWNNKCPSGCRMKGLVDEVNQDFTNRINKLRNALFDYQKNNKDSNSLTRNIMEVLRGDFAKANnYDNAYNQ 130
gi 759120615   50 TDWPFCSDEDWSQKCPSGCRMQGLIDEVNLDFTNRINKLKNALLNYQKNNKDSSSVTRNIMEILRGDFASGNhNDNTYNQ 129
gi 965876574   53 TGWPFCADEDWGEKCPSGCRMKGLIDEVNQDFTGRINKLRDSLFNYQKTNKDSNTLTKNIVEILRGDFAKANnNDNTFNQ 132
gi 348582214   50 TGWPFCSDDDWNLRCPSGCRMQGLIDEVNQDFTNRIKKLKDSLFNYQKNNKDSSTY-RNIMEILRGKLSKDNnHDNTYNQ 128
gi 612030903   49 TDWPFCSDDDWTYKCPSGCRIKGLMDETNEDFTNRVTKIRNLLFDHQRNNKDSSSVTRNIMELLRGNMANDNtNNNALNQ 128
gi 395542501   50 ANWPFCSDEDWTYKCPSGCRIQGLIDETNEDFTNRITKIRNSLFDYQKNNKDSSSVSRNIMEILRGNTANDFnNGNSFGQ 129
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
1M1J_E        147 YNTEMElHYNYIKDNLDNNIpSSLRVLRAVIDSLHKKIQKLENAIATQTDYCRSPCVASCNIP 209
gi 1018997393 141 VSEDLRrRIETLKRKVSDQA-QRIINLQSSVRDQLVEMKRLEVDIDIKVRSCKGSCNRAYQYe 202
gi 291401111  130 VSEELRrRIEVLQRKVIEKV-QHIKLLQNNVRAQLIDMKRLEVDIDIKIRSCQGSCNRVLshe 191
gi 354474601  129 VSEELRrRIEVLKRKVVEKA-QQIQVLQNNVRTQLIDMKRLEVDIDIKIRSCKGSCSRGVARE 190
gi 831226582  131 VSEDLRsRIEVLKRKVIEKV-QHIKLLQNNVRSQLVEMKRLEVDIDIKIRSCKGSCSRALVHQ 192
gi 759120615  130 VSEDLRsRIEVLRRKVTEQV-QHIQLLQNNVRAQLVDMKRLEVDIDIKIRSCQGSCSRAVVRQ 191
gi 965876574  133 VSEDLRsRIEILRRKVIEQA-QHINLLQKNVKNQLVDMKRLEVDIDIKIRSCKGSCSRALehk 194
gi 348582214  129 VSEDVRsRIETLRRKVIEKA-QQIQLLQSNVRAQLIDMKRLEVDIDIKIRSCKGSCSRALsre 190
gi 612030903  129 VTEDLRrRIEVLKRKVTEQV-QNIVSLQTNIRNQLVEMKRLEVDIDIKIRSCKGSCSRSLdre 190
gi 395542501  130 VSDDLRrRIETLKVKVIEQV-QKIVSLQNSIRNQLVQMKQLEVDIDIKIRSCKGSCSRSLare 191
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