Conserved Protein Domain Family
Vps51

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pfam08700: Vps51 
Vps51/Vps67
This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.
Statistics
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PSSM-Id: 337162
View PSSM: pfam08700
Aligned: 48 rows
Threshold Bit Score: 41.4981
Threshold Setting Gi: 74606609
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7S488        249 SPDFSAQPYLA-ELLQsSTLAELLKTYARILSEIRALDAEKKALVYDNYSKLISATETIRKMRTSMfdpnaltgDKLDPM 327  Neurospora cr...
Q173I8          7 LLNINVDKLFEq-----NSIAEIDQVHKRLQAELELKREELRTMVGERYRDLLKAADTIGDMRTTA--------SSIIGN 73   yellow fever ...
Q5KJF4        100 WADIEPDEVFRr-----LPVREVKRVEAKMRSEALNKQSELRAMVGARYRDLLTSATQITSLRSSS--------LRLSEN 166  Cryptococcus ...
Q7RZT4         11 TLLSSAQIFSSn-----YPLPHIRAIHKALHAEIDDKQSRLRTQVGGSYRELLGTADTIVQMRGDM--------ESVQAT 77   Neurospora cr...
Q2U987          3 LDGPDPQSLNSwQDAFqYPIPTVRRVEQELRRDIASNKEKLRALVGTRYRELVGTAETIVSMNREM--------QEVDAT 74   Aspergillus o...
Q6C0N6         26 LGLSSWQSTMSk-----YSIADVVIIEQQLRSKKDRRNEELRCLINTTYRDLLGTTDDIQSLSEKM--------TKQHTL 92   Yarrowia lipo...
Q4E335          5 EAVQEVRRIFTn-----NTVEQVRDYLSTITRGIQESDYRLKQIVGQSYRDLIAACDKVVGMEQTC--------RKLLQM 71   Trypanosoma c...
XP_011387543   81 PFGTEPDTLFL-SL----TVKEVEAYERAVRSTALGKQEELRSLVGQRYEDLLGTANTIIDMAGSS--------SGLSHR 147  Ustilago mayd...
XP_003721620    5 EAAQEVRRILCq-----NDVEETLNYLSTVTRCIEDNQHDLRAVIGNSYRDLLGACDGVVGMERDC------------AD 67   Leishmania ma...
XP_001276848    8 NINEDPRLLFEk-----YDVATIKKIKESAQTEIEHKQNVLRQFIGDNYKPVLETPPVLKDIQVIF--------EDTRQT 74   Trichomonas v...
Q7S488        328 ASTLDAVLGKVYE 340  Neurospora crassa
Q173I8         74 VDNITAACRKLND 86   yellow fever mosquito
Q5KJF4        167 LKQIVQSCQNPEP 179  Cryptococcus neoformans
Q7RZT4         78 LGRMGGRCGRQVV 90   Neurospora crassa
Q2U987         75 LADIGRRCNPRLM 87   Aspergillus oryzae
Q6C0N6         93 LSNLSHG----DI 101  Yarrowia lipolytica
Q4E335         72 QKQLHTEQQLTLS 84   Trypanosoma cruzi
XP_011387543  148 LLELLSRVRLAAA 160  Ustilago maydis 521
XP_003721620   68 ILTIEEAMERASA 80   Leishmania major strain Friedlin
XP_001276848   75 LSKITEYSKNFNS 87   Trichomonas vaginalis G3
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