Conserved Protein Domain Family
Coa1

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pfam08695: Coa1 
Cytochrome oxidase complex assembly protein 1
Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence. The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex.
Statistics
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Aligned: 38 rows
Threshold Bit Score: 80.3563
Threshold Setting Gi: 123633103
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS71844            5 VVTV-GMALGSWAVFSLYATNTEKLSSSILKSVISQVKASPLVVDLLDthEPIVLKPELwlankPHIQGSVNMM---QGR 80  Ustilago m...
Q16I65             13 TATYiAIGGITAALLMKSKLEDRVRMQPYYRESLKLLRAHPGAIQLLG--E--PIKEMG-----F-DFGEESKKy-gEGK 81  yellow fev...
jgi:Cyan7425_3418  92 AISF-PLMVISIGASIFFLVMNFISSSAPYEMAVNQVKNNPLVFEQFG--K--PIAIGW-----I-TTGNIETSn-dRGL 159 Cyanothece...
Q09C66             31 PVLM----CGCLGAFVAYFVTSTIKSTDAYQQAVALVTANPEVQEALG--T--PIDFGW-------PRGSVNTTn-gEGR 94  Stigmatell...
Q484Y8             91 GLIL-----LFVVFPLFFTLIGSMLKGEAFDQSMVSISQNTEVIEVVG--E--PIEAGY-----F-VMGSIQTSg-aKGE 154 Colwellia ...
jgi:Acid345_4771   30 LVISiVLFFVLAVVVFVVGIFVLVSNTEPEKLAFAKAANSPAVVERLG--Q--PIKKGM-----F-SSGSINTTg-pSGH 98  Candidatus...
Q7UH60             80 GCLIaVMVCGGVIATGVVGAFALIKSSEPYTESLARAQTNEELQSMIG--D--PVDASI-----F-VQGSIKLNn-dDGN 148 Pirellula sp.
jgi:RoseRS_1044    18 GVTF--IVVVGCVVGIFAGVISLFRNSDVAQEALARAQRDPQVEAALG--R--PLEIGW-----FLPTGSLRTDangGGE 86  Roseiflexu...
XP_017207846       11 MTIFmTVVTGGGCATMYYLMQKNFAKSEYYRQALEQLNSNSTAMASLG---APPLKIHN-----IHLSDRHNRId--HSS 80  zebrafish
Q3T081              8 QVFFaGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALG--T--PLNVHY-----LRLTDKYNFVd--IAD 76  cattle
KIS71844           81 ID-LAFKIHPRNnhtNTATVYFTSIRPHKHAPFHILRFLVIHNh-sAKSVNLLD 132 Ustilago maydis 521
Q16I65             82 IEdFTLPVKGTQ---QRGKLHFWAERKDDQ--WHITRAELELNkdaDRRLVIRK 130 yellow fever mosquito
jgi:Cyan7425_3418 160 AC-LQIPVSGSK---ASGVIYVDAVRQDGE--WKFRQLFVTNEq-tNQPILLFM 206 Cyanothece sp. PCC 7425
Q09C66             95 AS-ISVPLEGPK---ASGTMRVEALAEGET--WTLDLLQVEVPg--RPAIDLLD 140 Stigmatella aurantiaca DW4/3-1
Q484Y8            155 AS-LQYSISGPK---GEADVYVLAYKEMEA--WSLHNVIVHIPe-tDKKIQIVT 201 Colwellia psychrerythraea 34H
jgi:Acid345_4771   99 AE-LKVPISGPK---GEGYIYLTANKSADR--WTFTQLEVAIDg-dEKRIELVE 145 Candidatus Koribacter versatilis Ell...
Q7UH60            149 TD-LNYSVSGPN---GAATVHVTGTKLDGN--WDYSRMDATTEd--GTKIDLLD 194 Pirellula sp.
jgi:RoseRS_1044    87 VD-LTLPISGPR---GSGTLIISGVRTRGV--WEYDRLIVTVDg-tGQRIDLLR 133 Roseiflexus sp. RS-1
XP_017207846       81 AQ-LKIPVTGSK---TGGYLYTTSTRDSLTNRWHLQQVVLKLRk--GDTVEIFN 128 zebrafish
Q3T081             77 AK-LKIPVSGPK---SEGHLYVSSSRDAPFKRWNLQEVFLELKd--GQQIPLFK 124 cattle
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