Conserved Protein Domain Family
Nup153

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pfam08604: Nup153 
Nucleoporin Nup153-like
This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.
Statistics
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PSSM-Id: 312201
View PSSM: pfam08604
Aligned: 9 rows
Threshold Bit Score: 290.744
Threshold Setting Gi: 1351657
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam08604 is a member of the superfamily cl25821.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  113 PSTTSTASNYPDvl-tRPSLHRSH--LNFSMLE--------SPALHCQPSTSSAF----PIg-SSGFSLVKEIKDstSQH 176
gi 1351657    112 PRKPKQKQDYTN----SPTLFKRHdeLSLKSLNsl----hpSSALSKKLGSTSQHqiatPKssASLLNILRSLHD--EQK 181
gi 768933478  104 PTTSRASLNFHEfvlsRPPLNRSH--LHLTPLDaaspslgpSNSLFSPPSTSSAPg---PF--TTGFSLIKEIKDnlSQH 176
gi 597763727  100 PSTSKASLNFQDvl-sRPPLNRSH--LQFPTQDgsps-lgaSNFLFSQPSTSTASfpasPFavASNFSLVKEIKDssSQH 175
gi 688600915   98 PSTSRASLNFQEal-sRPPLNRTH--LQFPSLDgspa-lggSSSLFSQPSTSTAPfsgsPFavTSNFSLVKEIKDssSQH 173
gi 941773953  119 PSTSRASLNFQEyvlsRPPLSRSH--LHFTPLDassptmgaSSSLFSPPSTSSAPg---PF--STGFSLVKEIKDnlSQH 191
gi 612008212   86 PSTSRSALNYPDvl-tRPSLHRSH--LNFSMLE--------SPTMHCQPSTSSAF----PIg-SSGFSFVKEIKDstSQH 149
gi 733881187   81 PSTSRSALNFSVvl-tRPSLHRSH--LNCTVLD--------SAVPPCQPSTSSTL----GIg-NPGLSLVKEIKDstSQH 144
gi 823456424   42 PSTSRSALNFSDvl-tRPSLHRSH--LNCTVLD--------STVPHCQPSTSATL----GIg-SPGLSLVKEIKDstSQH 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  177 DDDNISTTSgfSSRASDKditvskntslpplwSPEAErshslsqhtatsSKKPAFNLSAFGTLSPSLGNSSILKTSQLGD 256
gi 1351657    182 NTLNISSVK--QDRITEA--------------NPTCE------------KRKPSRSPSPMLSKKKSVARASENEPSAKQN 233
gi 768933478  177 EDDNISTTSgfSSRASDKdvptsktaslpqlwSPEMDrshtgpqpsqssLKRPSFNLSVFGTSSNTSFNNTVLNSSQLGD 256
gi 597763727  176 EDDNISTTSgfSSRASDKdvptsk--tapllwSPETDrthsgsqsgqtgLKKPAFNLSVFGTSSSSVMNNSVLNSSQLGD 253
gi 688600915  174 EDDNISTTSgfSSRASDKdvptsk--tvpllwSPETErthsgsqtahsgLKKPAFNLSVFGTSSSSVLNSSVLNSSQLGD 251
gi 941773953  192 EDDNISTTSgfSSRASDKdvptsktaslpqlwSPEMDrtnsgpqqsqssLKKPSFNLSVFGNSSNSTLNSTLLNSSQLGD 271
gi 612008212  150 DDDNISTTSgfSSRASDKdiavskntsgpplwSPEAErshslsqhtatsSKKPAFNLSAFGTLSPSLGNSSILKTSQLGD 229
gi 733881187  145 DDDNISTTSgfSSRASDKdiavsktnsapllwSTEAErshslsqhsassSKKPAFNLSAFGALSPSLGNTSVFKTSQLGD 224
gi 823456424  106 DDDNISTTSgfSSRASDKditvskntsapllwSPEAErshalsqhpassSKKPAFNLSAFGSPSPSLGNTSVFKTRQLGD 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  257 SPFyPGKTTYGGaAAAVRQSKL-Rntpyq-apvrRQMKAKQlsaqsyGVTSSTARR----------ILQSLEKMssPLAD 324
gi 1351657    234 KSF-SGNDSHKS-LTDIRDKENgE----------TEVSAKN------HVPHRSSRRrrrhqrlipiIYETLEQM--DLRK 293
gi 768933478  257 SSFyPGKTTYGG-AAAARSSRN-RpgtpyqppvrRQIKAKPagvqpcGVTSATARR----------ILQSLERMssPLAD 324
gi 597763727  254 SPFyPGKTTYGG-AAAARSGRA-RpgtpyhapvrRQIKAKPagaqpcGVTSATARR----------ILQSLERMssPLAD 321
gi 688600915  252 SPFyPGKTTYGG-ASAMRTARS-RpatpyqppvrRQIKAKPtgaqpcGVTSATARR----------ILQSLERMssPLAD 319
gi 941773953  272 SPFyPGKTTYGG-AAAVRSSRG-RpgtpyqapvrRQIKAKPagaqpcGVTSATARR----------ILQSLERMssPLAD 339
gi 612008212  230 SPFyPGKTTYGG-AAAVRQSKI-Rntpyq-apirRQMKAKQvnsqsyGVTSSTARR----------ILQSLEKMssPLAD 296
gi 733881187  225 SPFyPGKTTYGGaAAAARQTKV-Riapyq-tpvrRQMKAKQanvqsyGVTSSTARR----------ILQSLEKMssPLAD 292
gi 823456424  186 SPFyPGKTSYGGaAAAARQTKV-Qisayq-ppikRQVKAKQanvqsyGVTSSTARR----------ILQTLEKMssPLAD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  325 AKRIPSI--VSSPLNSPLDRSGIDItdfqakrekvdsqyppVQRLMTPKPVSiatnrsvyfKPSLTPSGefrkTNQRIDN 402
gi 1351657    294 PVLVNAEvqTDSNPGNTMFIDKQDI----------------YHRLSTPTSRK---------RQTLEKGHi--kAFSAVDE 346
gi 768933478  325 ARRIPAS--ASSPLSTTLDSMIPDVprsqakkkrmdtnlppVQKLLVPSVAAtarnrsmsfRPTLTPGGgg----rPLDK 398
gi 597763727  322 AKRIPST--VSSPLSTSLNHSDLDVssfqskkkkvepalppVQKLVIPAAASvasnrsmsfRPSLTPGS----VSRVVDK 395
gi 688600915  320 AKRIPST--VSSPLSASLNHTDLDIsnyqakrkrlepsvppVQKLVVPAAAAvsgnrsisfRPSLTPGG----VSRGVEK 393
gi 941773953  340 AKRIPAAtaGSPSRSPSMDILNQDGprhqakkkrmdsnlppVQKLVVPAAASvsgnrsvsfRPTLTPGG----LTRALDR 415
gi 612008212  297 AKRIPAA--ISSPLSSPLDRSGIEIidipakrkkmeshyppVQRLMTPKPISiatsrsvyfKPSLTPSAegikTSQRIDK 374
gi 733881187  293 AKRIPSS--VTSPLSSPVDRSMLDItgfhstrkqmeshhppVQKLVTPKAISlsgsrtqyfKPSLTPSAdsskIHQRVDT 370
gi 823456424  254 AKRIPSS--VSSPLSSPVDRSVLNVtnfqsrqnqvdlqhppVQKLVTPKPISltgsrityfKPSLKSATnsrkIHQRVDT 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  403 KCST---GYE----------KNMTPGQ-----NR----EQRESGFSy---PNFSLPAANGLSSGvgggggkmrrertrfv 457
gi 1351657    347 DLDE---IFA----------CEDDVHYtalpkQN----PKSERILE----PIIASPKDNTSDKG---------------- 389
gi 768933478  399 APAEtptRQSpqlpemsprpS------------------QSTMGYSapayPLSSTPAANSVTFGggkmkrerssarvsmk 460
gi 597763727  396 SNKE----TP----------VRRSPKRpd-apAP----PPSTSGLSy---PLSSTPTTSNTGAGggkmkrersirpsskk 453
gi 688600915  394 TSRE----TP----------VRQSPPIsepaqAP----PPSTSTLSy---PLSSTPAANSAALGggkmkrerairpsskr 452
gi 941773953  416 TPRE---KTP----------TRQSPQLpeatpGP----SQ--RSFSdpvyPLSSTPAASSLSSGggkirrerttarpssk 476
gi 612008212  375 KHNI---GCE----------KNLSPG------QK----EQHESDFSy---PNFSTPATNGLPSGvggggkmrrertrfvp 428
gi 733881187  371 KHKE---VKE----------KSLPEEQ-----RV----EPSESNLTy---PKFSTPASNGLTSGvsggggkmrrergvhy 425
gi 823456424  332 DHQ-----------------DMMEESF-----PAekpvKSSESNLSy---PKLDTPASNGLSSGgrmesacgkmrrerer 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  458 ask----pleeeemevpvlpkislpITSSSLPTFNFSSP------EITTSSPSPINSSQA------------LTN-KVQM 514
gi 1351657    390 -------------------------LLTKSAPTFEELQAsitpkpVKTSPNDTALTLANA------------EDNkTFEH 432
gi 768933478  461 rh------eedgqpelpdlptvslpISTSALPTFSFTSPl----pASVIGNSSSITV-TPgkevltametpaASS----- 524
gi 597763727  454 t--------ddevseapdlpaislpLSNSPLPTFSFSSPp----pTSTLKPNNKPSTLIP------------KEP-AISK 508
gi 688600915  453 p---------ddevaeepdlppaslpSNFTLPTFTFSTPp----pTSSLKSSTAPLITVS------------EEP-AANK 506
gi 941773953  477 ht------eedevaeapvlpsislpINKSSLPTFSFSPSlp---pAISVSSSPSFTSTTP------------AKEtLANK 535
gi 612008212  429 kl-----pdeeeeveapvlpkislpITSTSLPVFSFCSP------LSTSSSLSPINATQT------------LSN-KIQA 484
gi 733881187  426 vsk----sgqeqeveepvlpkislpISTASLAPFNFSFL------TSSTVSSSPSTVSTS------------VMNk---V 480
gi 823456424  387 ysasrpaqkqqlemeqevlpevplpISTASLPTFSFSFP------TSSAVSSSPSIVSKA------------VMN-KVQP 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206729891  515 TSPSSTGSPMF--KFSSPIVKST----EANVLPPSS-IGFT-FSVPVAKTAElSGSSSTlepiisssahhvttvnstncK 586
gi 1351657    433 QPLSKDTEAPKsqFSSSPTKESTtrksEVEPPSPSKeIKSShFSVPEFKFEPkTEATTD--------------------K 492
gi 768933478  525 -------SPSVpfTFSSPIVKAA----PASTP-ISPsAGFT-FSAPVAK-GP-SMSNGKlanskv---------avksaP 580
gi 597763727  509 QAPTVPTTPDApfTFSTPIVKAT----AASPPSFSPsTGFT-FSAPTMKTTP-SASNGKpapaav---------avkpaA 573
gi 688600915  507 QPAAPSTPPSApfTFSSPIVKAT----AASPPSFSPsSGFT-FSAPTMKMGP-SFSNGKivpsva----------pvksv 570
gi 941773953  536 DPPKASTPPCApfTFSSPIVKAT----AASPPSYSPaVGFT-FSAPVAKLAP-SMSNGNltapta--------tavkpiA 601
gi 612008212  485 ASPNKTGSPVF--RFSSPIVKST----EADILPPTS-IGFT-FSVPVVKSSEiSVCSNIsgstissvkd-attlnstsnN 555
gi 733881187  481 QPTSNVGSPVF--RFSSPIVKST----EAEVLPPLS-IGFT-FSVPVVKSAErSGCSDTavtslltrd--tttvnsisnK 550
gi 823456424  448 AS--NVGSPTF--VFSSPIVKST----EVEVLPPLSqIKFT-FSVPVVKSSElSGSTDTpvtsilspg--satvnstsnK 516
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 206729891  587 KTPPEDCEgpFRPAEI-------LKEGSvldiLKSPGFASPK 621
gi 1351657    493 KLNVPKFE--FKPTATadvqtnrLKENE----PKPTFFAQLP 528
gi 768933478  581 CKSTEESDglFKPAKT-------LKQGSvldlLKTPGFTSAV 615
gi 597763727  574 SECKEEFEgpFKPAKV-------LKQGSvldiLKGPGFASPA 608
gi 688600915  571 VIEEKEFEgpFKPAKV-------LKQGSvldiLKGPGFASPS 605
gi 941773953  602 SKSTEEFVgpFKPAKT-------LKQGSvldlLKSPGFASPV 636
gi 612008212  556 KEDGEDYEgpFRPAKT-------LKEGSvldiLKSPGFTSPK 590
gi 733881187  551 KEEKEEYDgpFKPAKV-------LKEGSvldiLRNPGFTSVK 585
gi 823456424  517 KEEEEEYDgfCKPAKF-------LKQGSvldiLKSPGFMSGK 551
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