Conserved Protein Domain Family
eIF3_subunit

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pfam08597: eIF3_subunit 
Translation initiation factor eIF3 subunit
This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein HCR1 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p.
Statistics
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PSSM-Id: 312194
View PSSM: pfam08597
Aligned: 165 rows
Threshold Bit Score: 65.7824
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BJ82           3 WDDEDFdipsnSKQAAA------------------SWEE-EG-----------NDE-PLL------DSWDIDEEEVARKK 45  Debaryomyces ...
8_pfamImport     4 WDASDFe---aEAAEVEek---------------pKWDD-EEpga------aePTTqELVpaskppSKYNDMDREELLQV 58 
91_pfamImport    4 WDDDEF-----EVPSVAentk-----------vsaNWDD-EE-----------EEEeEVA-------------------- 35 
26_pfamImport    4 WDDDEF-----EVPSVTetqk-----------vaaNWDD-EEe----------EEE-PVV-------------------- 35 
106_pfamImport   4 WDDDEF-----EVPPVTqpqi-----------spaTWDD-EEa----------EDE-PVP-------------------- 35 
74_pfamImport    4 WDDDEF-----EVPSVTetqq-----------vaaNWDD-EEe----------EEEkPIV-------------------- 36 
30_pfamImport    4 WEDEEF-----DLPSSVppta-----------vpvSWED-EE-----------EDQ----------EDAGAVAPGLAPKM 45 
15_pfamImport    5 WDDSDD-----------------------------DWDKsDDeldkrlglakiDDEkDAG------PVFNDEEEDLTLQD 49 
13_pfamImport    1 -D---------------------------------EWDVdDDaldqklgmkkvAQNlPTF----------DDEEDLALKE 36 
XP_002175971     4 WEDFLV-----DDKAAEdfsftgaaakskpakatkRFDD-EE-----------EEQ-ENL-------SWED------QVK 52  Schizosacchar...
Q6BJ82          46 KEEEAKKKAEKEAlk----kKQEESKAKKLSKNKgq---------rALLDIDLVDENTRQELLKKAELDADLNNAAD-LF 111 Debaryomyces ...
8_pfamImport    59 IARLEAQGPTqk------kaPKKKKLKQILAEREaaeaaraeelaqAEQELTPEERAAAKIVERRQVEESHMDAAKD-LF 131
91_pfamImport   36 -----APEPSQTSlapkgplKPKQLKKMKLKEMEekrkmdialtkaRLAEQANETEAERKAREKRQMEEADFEAAID-AF 109
26_pfamImport   36 -------SAKPEPavpkgplKPKQLKKMKLKEIEekqkmeialtkaRLAAQADETDDQRRSREKASIEEADFEMAID-AF 107
106_pfamImport  36 ------AVKPELPaatkalpKPKQLKKMKLKEIEekqkmeialakaRLAAQTDETGEQRRAREKASIEEADFEMAID-AF 108
74_pfamImport   37 -------AAKSEPaapkgplKPKQLKKMKLKEIEekqkmeialtkaRLAAQAEETDDQRRAREKASIEEADFEMAID-AF 108
30_pfamImport   46 SAAKAAKTAAEKDariaaelETRLQLGETAEQ--------------------------RRLRERNRVEEADNDLTED-LF 98 
15_pfamImport   50 KAADEKANQALLKtkgsalaKKKAAEKSQKEELEiarkam-emeaeMEANMTPEE----RRQLAREREEADATAMTNdLF 124
13_pfamImport   37 KAAREQAENAELKkkgralaSKKQAEQERLEELEiarkam-eleaeAMANLSPDE---LRRMKQRQVEEADNALTDD-LF 111
XP_002175971    53 SSTSSETHASEKKq-----lSRAERMQQRIHERKlekai---seaeKLAAA--EQQTVSKKEAQAAEIESDLANAMD-LF 121 Schizosacchar...
Q6BJ82         112 GGLgvageggmdinehpreraakaaaaaaaasgpTparLtKDT---PIDTHPLF-QPTDRQEYEKLRKALAPVLTNLAeD 187 Debaryomyces ...
8_pfamImport   132 GGD-----------------------------------E-EEE---EVVLFEAM-QPKTKEDFEKFARAIVKKARKYD-V 170
91_pfamImport  110 ATVtkp-------------------------apvA---PgADG---DAESAISGmRLLSLADHEQLGEVVANRINASNa- 157
26_pfamImport  108 AGAppk--------------------------paA---G-ASD---DADNAISAmRLLSLADHEHLGDVVASRLATSNa- 153
106_pfamImport 109 AGApsk--------------------------paA---G-ATN---DVDDNVSAfRLLSLADHEQFGDVVSTRLAASNs- 154
74_pfamImport  109 AGAppk--------------------------ptV---A-AGD---DADAAVSAlRLLSLADHEHLGDVVSSRLATSNs- 154
30_pfamImport   99 GGGg------------------------------A---R-GQG---AGGGLSGL-ALKNMQDHVKLAIELAERMDS---S 137
15_pfamImport  125 GAVdals------------------------kgtS---AvPGG---VMMSGDKV-VMKDLKDHLRHAKKVGECIQGHGkI 173
13_pfamImport  112 GGVdaka------------------------gkgA---T-GGA---AAAAGDKV-IMKDVKDHLKHARKVAECMQGHGkI 159
XP_002175971   122 DIV-------------------------------D---Q-NTAsghRARAAEAR-ELKTAADFAKFQAEILKKLLNTHtS 165 Schizosacchar...
Q6BJ82         188 SLmNYsSGLAIDLIRDLAQPLSIESIRKVVSTLNVISKEKEKAERQARlkkag---gtatgG-------------AGKKK 251 Debaryomyces ...
8_pfamImport   171 SP-HY-LDFVDALFRDLLENASSEKIRQAIKSVNVLANEKAKTEKN-------------------------------KKT 217
91_pfamImport  158 ---KYaLECIKVIITKGSVNLTADDMKDLTTIINVIKNDKIAAAKP---------------K-------------GKKKK 206
26_pfamImport  154 ---KYaLECIKVILTKASVNLTADDMKEITTIVNVIKNEKITAAKP---------------K-------------GKKKK 202
106_pfamImport 155 ---KYaLECIKVILTKASVNLTADDMKEITTVVNVVKNEKIAAAKP---------------K-------------GKKKK 203
74_pfamImport  155 ---KYaLECIKVILTKASVNLTADDMKEITTIVNVIKNDKIASAKP---------------K-------------GKKKK 203
30_pfamImport  138 KPaHM-TAFLKELVTKLSPKMTADGLTDLVNHTTMFRDEKRQAEERIAsakanktnvianqR-------------ANKKK 203
15_pfamImport  174 ---TLcSAFLTEVIQQCKDVLDDDAITEIIKSCNVIKNEKVQAAKRVKkg---------qaQ-------------KSKKA 228
13_pfamImport  160 ---HLaAAFFKELLQQSKDVLDDDAITEIIKTCNVIKNEKVQAAKRVTkvk-------gqaQ-------------KSKKA 216
XP_002175971   166 K--EY-LKFCQDLIPLLLETLPASEIKNINKSINKLALGKEQEEKARN-------------KprgaraparvsvpASSAA 229 Schizosacchar...
Q6BJ82         252 AKPAVKTN------------------V----NTSFkqDVf-------------------Ddidq---skyDefeedDFM 286 Debaryomyces h...
8_pfamImport   218 KSKPKKAQiqasrgaassvagfldgdGy--gDDYG--DDl------------------------------------DFM 256
91_pfamImport  207 VTGKQGYAnverstggggk------------------------------iinddeeygyDe--------yD-----DFM 242
26_pfamImport  203 QAGKQGYAnve------------------------rsVGnggaggmg----yagfedtyDd--------yD-----DFI 240
106_pfamImport 204 QIGKQGYAnv--------------------------eRGvgssggkafagyedtyedglDd--------yD-----DFM 243
74_pfamImport  204 QTGKQGYAnve------------------------rnVGnggaggks----yagfedtyDd--------yD-----DFM 241
30_pfamImport  204 SIKKKKAHs----------------dVf--gGDFD--GDgidtv----------gmdyeSk--------yD-----DFM 239
15_pfamImport  229 DKQAAKKAm----------------eIh--eDVFGesNQy-------------------DeydemggayeD-----DF- 264
13_pfamImport  217 DKAAEAKAl----------------qKq--vETFG--AN--------------------De--------yD-----EYD 242
XP_002175971   230 KKPAGKPSl----------------nLnakkTAADk-SVy-------------------Edyvadeyddfaddfddfm- 271 Schizosaccharo...
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