Conserved Protein Domain Family
eIF3_subunit

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pfam08597: eIF3_subunit 
Translation initiation factor eIF3 subunit
This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein HCR1 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p.
Statistics
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Aligned: 165 rows
Threshold Bit Score: 70.8223
Threshold Setting Gi: 298712135
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BJ82          3 WDDEDFdip-----snSKQAAA-------SWEE-EG-----------NDE-PLLDSWDIDEEEVARKKKEEEAKKKAEKE 57  Debaryomyces h...
XP_004952075    4 WDAEDFqpaapvviaePLKN---------QWAD-EDv----------EED-DVKDSWEEEDEEKPKPPPV-------EKA 55  foxtail millet
12_pfamImport   4 WDDDEF----------EVPSVAentkvsaNWDD-EE-----------EEEeEVA-------------------APEPSQT 42 
EEY70293        4 WDDDEF----------EVPSVTetqkvaaNWDD-EEe----------EEE-PVV---------------------SAKPE 40  Phytophthora i...
14_pfamImport   4 WDDDEF----------EVPPVTqpqispaTWDD-EEa----------EDE-PVP--------------------AVKPEL 41 
CBJ33014        5 WEDEEF----------DLPSSVpptavpvSWED-EE-----------EDQ----EDAGAVAPGLAPKMSAAKAAKTAAEK 58  Ectocarpus sil...
EED95455        5 WDDSDD-----------------------DWDKsDDeldkrlglakiDDEkDAGPVFNDEEEDLTLQDKAADEKANQALL 61  Thalassiosira ...
EEC45738        9 dD---------------------------EWDVdDDaldqklgmkkvAQNlPTF----DDEEDLALKEKAAREQAENAEL 57  Phaeodactylum ...
XP_002996949    4 WDDDEF----------EVPSVTetqkvaaNWDD-EEe----------EEe-PVV---------------------SAKPE 40  Phytophthora i...
XP_015626133    4 WDSEDFqpavpsakaePLKS---------KWAD-EDv----------EED-DVKESWEEEEEEKPKPPPV-------EKT 55  Japanese rice
Q6BJ82         58 Alk----kKQEESKAKKLSKNKgq---------rALLDIDLVDENTRQELLKKAELDADLNNAAD-LFGGLgvageggmd 123 Debaryomyces h...
XP_004952075   56 AakpsskaPAKKGKQQASTSAE-------------EPDEPPLSPTSEKIRQQRLVEEADFKSTTE-LFAK---------- 111 foxtail millet
12_pfamImport  43 SlapkgplKPKQLKKMKLKEMEekrkmdialtkaRLAEQANETEAERKAREKRQMEEADFEAAID-AFATVtkp------ 115
EEY70293       41 PavpkgplKPKQLKKMKLKEIEekqkmeialtkaRLAAQADETDDQRRSREKASIEEADFEMAID-AFAGAppk------ 113 Phytophthora i...
14_pfamImport  42 PaatkalpKPKQLKKMKLKEIEekqkmeialakaRLAAQTDETGEQRRAREKASIEEADFEMAID-AFAGApsk------ 114
CBJ33014       59 DariaaelETRLQLGETAEQ--------------------------RRLRERNRVEEADNDLTED-LFGGGg-------- 103 Ectocarpus sil...
EED95455       62 KtkgsalaKKKAAEKSQKEELEiarkam-emeaeMEANMTPEE----RRQLAREREEADATAMTNdLFGAVdals----- 131 Thalassiosira ...
EEC45738       58 KkkgralaSKKQAEQERLEELEiarkam-eleaeAMANLSPDE---LRRMKQRQVEEADNALTDD-LFGGVdaka----- 127 Phaeodactylum ...
XP_002996949   41 PavpkgplKPKQLKKMKLKEIEekqkmeialtkaRLAAQADETDDQRRSREKASIEEADFEMAID-AFAGAppk------ 113 Phytophthora i...
XP_015626133   56 ApkpsgkgAAKKGKQQASTSSE------------VVQDEALDDPALEKLRQQRLVEEADFKSTTE-LFGK---------- 112 Japanese rice
Q6BJ82        124 inehpreraakaaaaaaaasgpTparLtKDTPIDTHPLF-QPTDRQEYEKLRKALAPVLTNLAeDSLmNYsSGLAIDLIR 202 Debaryomyces h...
XP_004952075  112 ----------------------------KGGDQKSLDTF-IPKSESDFAEYAELIANKLRPYEkSF--HY-MGLLKNVMR 159 foxtail millet
12_pfamImport 116 -------------------apvA---PgADGDAESAISGmRLLSLADHEQLGEVVANRINASNa----KYaLECIKVIIT 169
EEY70293      114 --------------------paA---G-ASDDADNAISAmRLLSLADHEHLGDVVASRLATSNa----KYaLECIKVILT 165 Phytophthora i...
14_pfamImport 115 --------------------paA---G-ATNDVDDNVSAfRLLSLADHEQFGDVVSTRLAASNs----KYaLECIKVILT 166
CBJ33014      104 ----------------------A---R-GQGAGGGLSGL-ALKNMQDHVKLAIELAERMDS---SKPaHM-TAFLKELVT 152 Ectocarpus sil...
EED95455      132 -------------------kgtS---AvPGGVMMSGDKV-VMKDLKDHLRHAKKVGECIQGHGkI---TLcSAFLTEVIQ 185 Thalassiosira ...
EEC45738      128 -------------------gkgA---T-GGAAAAAGDKV-IMKDVKDHLKHARKVAECMQGHGkI---HLaAAFFKELLQ 180 Phaeodactylum ...
XP_002996949  114 --------------------paA---G-ASDDADNAISAmRLLSLADHEHLGDVVASRLATSNa----KYaLECIKVILT 165 Phytophthora i...
XP_015626133  113 ----------------------------KDGSEKSLDTF-IPKSESDFAEYAELIANKLRPYEkSF--HY-MGLLKNVMR 160 Japanese rice
Q6BJ82        203 DLAQPLSIESIRKVVSTLNVISKEKEKAERQARlkkag---gtatgGAGKKKAKPAVKTN--V--NTSFkqDVf------ 269 Debaryomyces h...
XP_004952075  160 LSMTSLKGADAKDISSSVTAIANEKIKAEKEA--------------AAGKKKQGAKKKQLhiekgdd------------- 212 foxtail millet
12_pfamImport 170 KGSVNLTADDMKDLTTIINVIKNDKIAAAKP---------------KGKKKKVTGKQGYAnverstggggk--------- 225
EEY70293      166 KASVNLTADDMKEITTIVNVIKNEKITAAKP---------------KGKKKKQAGKQGYAnve------rsVGnggaggm 224 Phytophthora i...
14_pfamImport 167 KASVNLTADDMKEITTVVNVVKNEKIAAAKP---------------KGKKKKQIGKQGYAnv--------eRGvgssggk 223
CBJ33014      153 KLSPKMTADGLTDLVNHTTMFRDEKRQAEERIAsakanktnvianqRANKKKSIKKKKAHsdVfgGDFD--GDgidtv-- 228 Ectocarpus sil...
EED95455      186 QCKDVLDDDAITEIIKSCNVIKNEKVQAAKRVKkg---------qaQKSKKADKQAAKKAmeIheDVFGesNQy------ 250 Thalassiosira ...
EEC45738      181 QSKDVLDDDAITEIIKTCNVIKNEKVQAAKRVTkvk-------gqaQKSKKADKAAEAKAlqKqvETFG--AN------- 244 Phaeodactylum ...
XP_002996949  166 KASVNLTADDMKEITTIVNVIKNEKITAAKP---------------KGKKKKQAGKQGYAnve------rsVGnggaggm 224 Phytophthora i...
XP_015626133  161 LSMASLKGADAKDISSSIAAIANEKIKAEKEA--------------AAGKKKQGAKKKQLhienkdd------------- 213 Japanese rice
Q6BJ82        270 -------------Ddidq---skyDefeedDFM 286 Debaryomyces hansenii CBS767
XP_004952075  213 ------dfipgrgGg--------yDdpdeyDFM 231 foxtail millet
12_pfamImport 226 ---iinddeeygyDe--------yD-----DFM 242
EEY70293      225 g----yagfedtyDd--------yD-----DFI 240 Phytophthora infestans T30-4
14_pfamImport 224 afagyedtyedglDd--------yD-----DFM 243
CBJ33014      229 --------gmdyeSk--------yD-----DFM 240 Ectocarpus siliculosus
EED95455      251 -------------DeydemggayeD-----DFf 265 Thalassiosira pseudonana CCMP1335
EEC45738      245 -------------De--------yD-----EYD 251 Phaeodactylum tricornutum CCAP 1055/1
XP_002996949  225 g----yagfedtyDd--------yD-----DFI 240 Phytophthora infestans T30-4
XP_015626133  214 -------dfipgkGn--------fDdpdeyDFM 231 Japanese rice
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