1IQP


Conserved Protein Domain Family
Rep_fac_C

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pfam08542: Rep_fac_C 
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Replication factor C C-terminal domain
This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.
Statistics
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PSSM-Id: 378018
View PSSM: pfam08542
Aligned: 354 rows
Threshold Bit Score: 29.3742
Threshold Setting Gi: 157436099
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IQP_A   234 ARPEDIREMMLLAlK-GNFLKAREKLReILLKQ---GLSGEDVLVQMHKEVFNLpi---eEPKKVLLAdkIGEYNFRLVE 306 Pyrococcus furiosus
EXX60910 237 PDPKYIMEMLKRC-IrYEVKNVFNAVV-KLYGD---GYSALDIVQTMMKLMKSAseneieEDYYNDFLmeIAKTELVIKS 311 Rhizophagus irregul...
CBN80389 245 PQPAKIVEIVDLLrNrGGYVEACKKLR-GLCGKggeGYSPMDILASFFRALSVLdv---rESQRIEIAkvIGLVQNRVAS 320 Ectocarpus siliculosus
EEQ97797 240 PQPGELKQATLDC-VnNDWCSAFDRLD-RITAQ---GYSIGDIVGTLERVIRNLppeelnEAIKIEFLqaIAMCRLRMSE 314 Perkinsus marinus A...
EEA05236 226 PSPEKIKSILDAC-VkSDWRLAHNIAE-ELYSS---GYSPLDIVITMRNVLKRYql---qETLILEYLkeVGRCHFVMLD 297 Cryptosporidium mur...
Q4MZT0   228 PSPDLIQKMLENC-LnGNWRQAHEKVD-QLLEL---GHSPVDILVTMRNVLKTMda---pEHVLLEYIksVALSHMTMVN 299 Theileria parva
ESS29665 254 PPPEAVRSMLMEC-LaGKWREAHDIAA-ELLRR---GYTPMDVVLTTRSVLSRFene-ckEHILLEYLkyVGLAHMTMSA 327 Toxoplasma gondii VEG
Q4XX92   238 PSPERIENLLKHC-IsSEWRKAHDIAY-DMIKE---GHTPFDVALTSSNVLRRYdl--gsEAIQIEFLkiGAMACNTMAS 310 Plasmodium chabaudi
EED43686 213 PNKKQLLKIINSIk--NKNEEELIVNSeKLFSH---KYDYSDIMNGLFKIIKDEd--------NYEYLkiIGEYQYKMND 279 Enterocytozoon bien...
Q5UQ47   225 PDPEDIRKIISLC-LeSNLEKADEIMN-NIIKL---DYCYFDIVTSFIYVLKVYdm---sENLRLRLImiVNETKINISK 296 Acanthamoeba polyph...
1IQP_A   307 GANEIIQLEALLA 319 Pyrococcus furiosus
EXX60910 312 GTDSELQVIGLVS 324 Rhizophagus irregularis DAOM 197198w
CBN80389 321 GASSYLQLAAMLW 333 Ectocarpus siliculosus
EEQ97797 315 GLQSRVQLSGLVA 327 Perkinsus marinus ATCC 50983
EEA05236 298 GCSTELQLDKLLG 310 Cryptosporidium muris RN66
Q4MZT0   300 GLSTQLQLEKLLA 312 Theileria parva
ESS29665 328 GLSTPLQLDKMLA 340 Toxoplasma gondii VEG
Q4XX92   311 GLSSVIQLDKLIA 323 Plasmodium chabaudi
EED43686 280 GIFSKLQFYAMFG 292 Enterocytozoon bieneusi H348
Q5UQ47   297 GLRSKLQLTGMIC 309 Acanthamoeba polyphaga mimivirus
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