1IQP


Conserved Protein Domain Family
Rep_fac_C

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pfam08542: Rep_fac_C 
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Replication factor C C-terminal domain
This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.
Statistics
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PSSM-Id: 337100
View PSSM: pfam08542
Aligned: 353 rows
Threshold Bit Score: 48.207
Threshold Setting Gi: 672271840
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IQP_A       234 ARPEDIREMMllalKGNFLKAREKLReILLKQGLSGEDVLVQMHKEVFNLpi--eEPKKVLLAdkIGEYNFRLVEGANEI 311 Pyrococcus furi...
Q5CVS5       242 PPIKIIERIInsckILGVESILIETa-KLINEGWSVELIFKGLAEFIIMCdk-idDSKKAFLMlrISEADASVIDGSNEY 319 Cryptosporidium...
Q7RI33       236 PDNDVILKIVdsckMKDFKILEKTVq-DIIEDGFDVSYIFKSLNEYFVMCqd-inDSIKYQILmeLSRHDFRLHNGATKY 313 Plasmodium yoel...
Q4N742       239 PPKEVVERIFevckNPE-GDVESVCk-EVVYDGWDISAIFQQISEYVVECdf-igDIEKSKISleLANRDFALLQGGSQY 315 Theileria parva
XP_654775    229 VPSKEITEIIhlcqNGSVNDLYLKAMsLVVEQNFSADSILSQLRDVYIEDcvnltNQERCLFLqlIAQSDATLIDKTDPL 308 Entamoeba histo...
XP_001611428 237 PPKEIVNEIFatckGTT-QDVEELCk-KIIYDGWEVATLFQQISEYVVNSas-ltDVQKATITieLSGRELALIQGGLQY 313 Babesia bovis T2Bo
KFG44179       2 PPARIVTDFLra-cQASPSQASSEVDnVISQ-GWDVCLLLQEMIRQVVVSphlk-dlqKARVIndIAQKEFAVFQGASPY 78  Toxoplasma gond...
XP_002257855 236 PADDIISKIIdackMKDLKNVEKAVq-DIIEDGYDVAYIFKSLNNYFVMNte-yqDSVKSQILleLSRHDYRLHSGATKY 313 Plasmodium know...
XP_001326199 235 NPSDV-ENYFhtclSADWDTIENATt-DLVYAGYDISQIFEILISLIVKSne-ipEAKKPQLIlkIAQADGSIINRADPQ 311 Trichomonas vag...
WP_006054997 245 GHDDKLKEILetarNGEIRDARKTITtLLDDEGYDGQELLRDLLAIadkypeefgEADVMRLHrlAGAVDLDLTEGLDDR 324 Halogeometricum...
1IQP_A       312 IQLEALLA 319 Pyrococcus furiosus
Q5CVS5       320 LTLLNVCS 327 Cryptosporidium parvum
Q7RI33       314 IQLMSFAS 321 Plasmodium yoelii yoelii
Q4N742       316 FQLASACF 323 Theileria parva
XP_654775    309 FTICALLC 316 Entamoeba histolytica HM-1:IMSS
XP_001611428 314 FQLASLCF 321 Babesia bovis T2Bo
KFG44179      79 LQLLSLSL 86  Toxoplasma gondii FOU
XP_002257855 314 IQLMSFAS 321 Plasmodium knowlesi strain H
XP_001326199 312 FQLLGISA 319 Trichomonas vaginalis G3
WP_006054997 325 LHLTHLLS 332 Halogeometricum borinquense
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