3G5C


Conserved Protein Domain Family
ADAM_CR

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pfam08516: ADAM_CR 
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ADAM cysteine-rich
ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity.
Statistics
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PSSM-Id: 337086
View PSSM: pfam08516
Aligned: 381 rows
Threshold Bit Score: 66.0965
Threshold Setting Gi: 675847716
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3G5C_A         299 DGYSCdg-vQGICFGGRCKTRDRQCKYIWG-QKVTASDKYCY-----EKLNIEGTEK-GNCGk------DKDT----WIQ 360
gi 675847668   781 DGKVCqs--nFYCYKGICRTYDRSCQFLWGtKLTKGASLKCYdtnslEGPNQ----TqNNCKfdiv--------knqPIP 846
gi 802779290    41 DGLTCpddeNAICYGGRCGSRLLQCKEIWG-EQARPSADSCYkdgnlCKIPRSEGMF-AGSGeevkvkvTRDH------L 112
gi 675864524   296 NGQMCsn--qEYCYKGKCNSRDLQCSEFWY-PGTKSGNEKCY-----QFTYVKPDDC-FHCDhhep--------tkqNFP 358
gi 675847668   177 NGLMCsg--eHYCYDGGCVTRDRACLAMWS-GGVKASDDVCY-----SMVPPDYDPLlLYCYanma--------tsvIVP 240
gi 675847716   206 DGSMCsn--rDFCINGSCGSRSVACSNIFYnTDTRPAENLCY-----RANRDEQEEAnFNCGydpv--------rksIIP 270
gi 1005954503  471 DGWSCey-gQGHCFNGKCGSYHLSCDKIFE--NSEPAPDTCY------EKNRAGNLV-FNCGppskyfeTFDGn---ATK 537
gi 1005954501  471 DGWSCey-gQGHCFNGKCGSYHLSCDKIFE--NSEPAPDSCY------EKNTVGDEV-FNCGppskyfeIFDGk---ATK 537
gi 1005954499  472 DGWSCey-gEGHCFNGKCGSYHLSCDKIFE--NSEPAPDSCY------EKNAVGTLY-FNCGpptdyfhPFDGk---AKK 538
gi 198415279   517 NGSPCng-nQAACAQGVCLTHDLQCQGIWG-EGAVSGNDICY------------------------------ErvnkLGN 564
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3G5C_A         361 CNKR--------------DVLCGYLLCTNI--GNIPRLGELdgeitSTLVVQQGR-TLNCSGGHVkleeDV---DLG 417
gi 675847668   847 CKKQ--------------NAMCGTLFCDGPd-DKNSMRFGI-----ATIFSSQLPdQSKCVSTFMi--ySPyvdNPS 901
gi 802779290   113 CKEK--------------DKMCGMLRCSVG--DFDEAKGHItg--wHYTFSTKvcvqnhkqkk-------------- 157
gi 675864524   359 CEER--------------NYRCGRLLCSVPgiQYKKPVKHP---------YSAYSdTCVCASYRF----TRgskHMS 408
gi 675847668   241 CNER--------------NKMCGTVFCNRI---KESEMHMNii--pFLTLHNNFNnSVTCTSAFYp--yQDgvrNPG 296
gi 675847716   271 CSEG--------------DELCGKLFCQFGg-VQAPIDGSIfl--fYEFSEQNLS-SITCAAVRMdymeNVp--NLA 327
gi 1005954503  538 CKKK--------------DVKCGRLLCTGSg-TLRNSFLQAyk--wNAFGFKSAP----CLGIYIyrtfQRnatDLG 593
gi 1005954501  538 CKKK--------------DVKCGRLLCTDSg-SFRSTIRQAya--rTVIRSGSAS----CRGVRIsrsfRRnetDLG 593
gi 1005954499  539 CKKE--------------DVKCGRLLCTDSs-RLRNSIKQAyi--nVIIDFESAS----CRGILIprtfKRnatDLG 594
gi 198415279   565 WNGNcgrgtsgfiictkeNSKCGKLQCSGG--ADRPIVARD-----RYAFKNTIDrKYECKTISSdd-nATdvsDPG 633
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