Conserved Protein Domain Family
VIT

?
pfam08487: VIT 
Vault protein inter-alpha-trypsin domain
Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumor metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.
Statistics
?
Aligned: 338 rows
Threshold Bit Score: 62.1545
Threshold Setting Gi: 483494075
Created: 4-Jun-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EFA79297        58 LKSMTINANVTDTCSLTKVEQRYGalhpNDStlKigdDsnfEAVYSLLLPPYAAISSLEVE-YEGKLLVATIKEKETAAN 136  Heterosteliu...
ELW64998        35 FSIYKVQSTITSRMANTIIQSKLV----NNSpqP---Q---NVVFDVQIPKGAFISNFSMT-VDGTTFTSSIKERTVGRA 103  Chinese tree...
XP_001365240    75 LYSYKVKSTVTSRVANTVVQCKVV----NNSpyS---Q---NVELDVQIPRGAFVTNFSMI-VNGVTFTSTIKERTVARG 143  gray short-t...
6_pfamImport     1 LYSYKVHSTVTSRLANTIVQSKVV----NNSprS---Q---NVAFDVQMPRGAFLSNFSMT-VNGVTFTSSIKEKSVARG 69  
XP_015207837    81 IPRYKVEARITSRFAHTSIHSQVI----NSAhhA---Q---SIAFDVQIPKTAFISNFTMN-VNGIVFVGSVKDKTIARN 149  spotted gar
Q5RH28          67 VKSYKVESKITSRFAHTKVKSSVV----NSGlqA---Q---SIGFNVQIPKRAFINNFTMN-VNGITFVGSVKEKTVARN 135  zebrafish
41_pfamImport    1 VQSYQVESRITSRFVHTSVRSAVL----NSAprA---Q---SIGFNVQVPKRAFITNFTMN-VNGIVFVGSVKEKTVARN 69  
38_pfamImport    1 IYSYKVQSTITSRFAHTVICSKVV----NRAavA---Q---SVAFNVQIPKTAFISNFTMN-VNGLTFVGSVKARTEARS 69  
36_pfamImport    1 VNSLAIVGTINGRYAETVVTSIVT----NNAdiG---R---EAEFHILLPSDAYIVNLTMAtANE-TIVGSIETKEKAKK 69  
XP_009859948   706 VETFVVATTIKARFAETVMTSTVY----NDAavS---R---EAQYYVILPVNAFITNFSMT-IDGVVYNGRIEEKARAEA 774  vase tunicate
EFA79297       137 EYNDAIASGNSAFLASKSq--SGQFQVSLgNIDIRSSVVVRFTV 178  Heterostelium album PN500
ELW64998       104 LYSQARAKGKTAGLVRSkaldMENFRTEV-NILPGVKVQFELQY 146  Chinese tree shrew
XP_001365240   144 LYAQARARGKTAGWVSSnsldMENFKTEV-NVLPGSNVQFELHY 186  gray short-tailed opossum
6_pfamImport    70 LYALARAKDKNTGLVRSsgadMENFQTTV-NVPPGAKVQFEIHY 112 
XP_015207837   150 LYSQARARGKAAGIVRTnaqdMETFKCEV-NVPSGSRIEFELHY 192  spotted gar
Q5RH28         136 LYAQARARGKAAGIVRTnsqaMETFRTEV-HVPAGSKVEFELHY 178  zebrafish
41_pfamImport   70 LYAQARARAKAAGIVRTgsldMETFQTEV-HVPPGSNIQFELHY 112 
38_pfamImport   70 LYARARARGRAVGIIRTsaydMENFKGEV-SVPAGSKIYFELHY 112 
36_pfamImport   70 IYKEAKKTGKTAGHVAARdtstRAFKTSL-FVSPREVVTFQFTY 112 
XP_009859948   775 IYTTARERDLTVGHVAARdqssSVFQTST-NLAPRKRVIFQLTY 817  vase tunicate
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap