4DJT,3DPU,2EW1


Conserved Protein Domain Family
Roc

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pfam08477: Roc 
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Ras of Complex, Roc, domain of DAPkinase
Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.
Statistics
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PSSM-Id: 312094
View PSSM: pfam08477
Aligned: 186 rows
Threshold Bit Score: 88.7165
Threshold Setting Gi: 924442917
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DJT_B         13 KICLIGDGGVGKTTYINRVLDGRF--EKN--YNATVGavnhPVTF------L--DdqgNvikFNVWDTAGQEKKAVLKDV 80   Encephalitozo...
XP_012815443 1328 KVLIVGNTGSGKTTLVQQLMKCRRleHGA--EKATVGid--vKDWpilir----gkikKeitLNVWDFAGQEEFYCSHPH 1399 western clawe...
CAG05593     1327 KLIVVGNVASGKTTLIQQLMKLKR--SQL--KSKSTSvgidV-QDwt-----ikDwdrKkmvLNVWDFSGGEEFSGSHPH 1396 spotted green...
NP_001188385 1352 KLMVLGGSGSGKSSLIQQLMRLRR--SQW--R-SDPGvsirDWPVr-------sKd-kRnmmLNVWEFSGGEECSGIHPH 1418 zebrafish
XP_013004740 1401 KLMIVGNTGSGKTTLLQQLMKTKK--SDL--GVQGATvgidVKDWpiqikgKk----kKdlvLNVWDFAGREEFYSTHPH 1472 domestic guin...
XP_008109800 1348 KLMLVGNTGSGKTTLLQQLMKCRR--PDLglQNATIGidvnDWKIpvrg------kvkKdvvLNVWDFAGQEEFYSAHPH 1419 green anole
XP_005755539   60 KMLVIGPPRQGKSALLEALQTGKA--SPF--TPAECSistsVWELdkp-sgGknKkds--viFNVWDIGGQASMSTVNQC 132  Pundamilia ny...
XP_012815033  605 KMIIVGPPRQGKSTLFEVLQSGKV-------SQQMQGdnsiRTTCwelqkpVgtTakvDsvqFHVWDVGGSNAMSAVNQC 677  western clawe...
WP_014444162  267 KVLLVGEGEVGKSSLVDSFQGRPF--ITG--RPTTHGielsTLQLphp-elPdvDi-----tLRFWDFGGQEVYRITHQF 336  Actinoplanes ...
WP_012412722  368 KLILIGEGEVGKSCLLGALRGDEW--EDG--RPTTHGieikSVI-------VtdPdsgTeisLNGWDFGGQRVYRPTHQL 436  Nostoc puncti...
4DJT_B         81 YYIGASGAI----LF----FDv---tSRiTCQNL---AR---WVKEFQ-AVVGnEAPIVVCANKID 128  Encephalitozoon cuniculi GB-M1
XP_012815443 1400 FMTPQALYL----VV----YDlskgvSE-VDAIK----P---WLFNIK-ARAS-SSPVILVGTHLD 1447 western clawed frog
CAG05593     1397 FLTSRALYL----VV----YNlsrgaSQ-VDALK----P---WLFNIK-AAAP-VSPVILVGTHTD 1444 spotted green pufferfish
NP_001188385 1419 FMSSRAVYL----VL----YDls-kgAS-EIHAI---KP---WLFNIK-AVAG-QCPVIVVGTHAD 1466 zebrafish
XP_013004740 1473 FMTQRALYL----AV----FDlskgqAE-VDAMK----P---WLFNIK-ARAS-SSPVILVGTHLD 1520 domestic guinea pig
XP_008109800 1420 FMTQRALYL----AV----YDlsk-geA-EVDAM---KP---WLFNIK-ARAS-SSPVILIGTHLD 1467 green anole
XP_005755539  133 FFTDKALYV----VIwnlaMG-----EE-AVANL---QT---WLLNIE-ARAP-NSAVIVVGTHLD 180  Pundamilia nyererei
XP_012815033  678 FFTDKALYVvvwnLA----LG-----EE-AVANL---QF---WLLNIE-AKAP-NAVVLVVGTHLD 725  western clawed frog
WP_014444162  337 FFSRRSLYL----LV----WK-----PR-QGQEEnaiEF---WLRLIRlRLGR-DAQVMIVATHGD 384  Actinoplanes missouriensis
WP_012412722  437 FFSAPAVYL----VI----WK-----PR-EGPQQ---GFvkeWITLIK-NREP-DAKVLVVATHGG 483  Nostoc punctiforme
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