2EW1,1Z08,1X3S,3DPU,1YZQ,2N1B,2F7S,4DJT,3D6T,2HXS


Conserved Protein Domain Family
Roc

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pfam08477: Roc 
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Ras of Complex, Roc, domain of DAPkinase
Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.
Statistics
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PSSM-Id: 369896
View PSSM: pfam08477
Aligned: 193 rows
Threshold Bit Score: 86.7876
Threshold Setting Gi: 847112135
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EW1_A          28 KIVLIGNAGVGKTCLVRRFTQ--GLF--PPG--QGATIGVDFMI--Kt-vEi-------NGEkvK-----L--QIWDTAG 84   human
21_pfamImport    1 KLMLIGDPRAGKTTLLHSLM---KTR--SRK--RSLISGYSGATpdKevtTlatvgvdvNEWklKhknklYsvSAWDFAG 73  
XP_008109800  1348 KLMLVGNTGSGKTTLLQQLMK--CRR--PDLglQNATIGIDVND--Wkip--------vrgKvkKdv--vL--NVWDFAG 1409 green anole
CAG05593      1327 KLIVVGNVASGKTTLIQQLMK--LKR--SQL--KSKSTSVGIDVqd---wTi-------kDWdrKkm--vL--NVWDFSG 1386 spotted gree...
XP_021326175  1352 KLMVLGGSGSGKSSLIQQLMR--LRR--SQW--R-SDPGVSIRD--Wpv---------rSKd-kRnm--mL--NVWEFSG 1408 zebrafish
XP_013004740  1401 KLMIVGNTGSGKTTLLQQLMK--TKK--SDLgvQGATVGIDVKD--Wp-iQik-------gKkkKdl--vL--NVWDFAG 1462 domestic gui...
XP_015706993  1339 KLMIVGNTGSGKTTLLQQLMKckRTE--LGC--PKATVGIDVKDw-----Iiqg-----kgKmkKel--iL--NVWDFGG 1400 Japanese quail
XP_012815442  1283 KVLIVGNTGSGKTTLVQQLMK--CRRleHGA--EKATVGIDV----KdwpIli------rgKikKei--tL--NVWDFAG 1344 tropical cla...
XP_014347483  1230 KLMIVGNAGSGKTTLLQHLMRc-KHS--DVR--EKATVGIDVKD--Wvip--------vkvKvkKel--iL--NVWDFAG 1290 coelacanth
TDH16768       631 KMLVIGPPRQGKTALLEALQT--GRV--APF--TPAECSISTST--WeldKpng---gkNSKds----vaF--NVWDIGG 693  yellow perch
2EW1_A          85 QERFRSITQSYYRSANALILT----YD-----ITC--E----ESFRClpeWLREIEQYASNKVItVLVGNKID---L 143  human
21_pfamImport   74 QEDFYATHPCFLSERAMYIAV----YD-----ASR--SlkelQTLKP---WLAAVHARASHCPV-LIVGSHAD---R 132 
XP_008109800  1410 QEEFYSAHPHFMTQRALYLAV----YDlsk-geAE--V----DAMKP---WLFNIKARASSSPV-ILIGTHLD---I 1468 green anole
CAG05593      1387 GEEFSGSHPHFLTSRALYLVV----YNlsrgaSQV--D----ALK-P---WLFNIKAAAPVSPV-ILVGTHTD---V 1445 spotted green p...
XP_021326175  1409 GEECSGIHPHFMSSRAVYLVL----YDls-kgASE--I----HAIKP---WLFNIKAVAGQCPV-IVVGTHADlcee 1470 zebrafish
XP_013004740  1463 REEFYSTHPHFMTQRALYLAV----FDls-kgQAE--V----DAMKP---WLFNIKARASSSPV-ILVGTHLD---V 1521 domestic guinea...
XP_015706993  1401 QEEFYSTHPHFMTQRALYLAV----YDlskgqAEV--D----AMK-P---WLFNIKARASTSPV-ILVGTHLDvsdE 1462 Japanese quail
XP_012815442  1345 QEEFYCSHPHFMTPQALYLVV----YDlskgvSEV--D----AIK-P---WLFNIKARASSSPV-ILVGTHLDvsdE 1406 tropical clawed...
XP_014347483  1291 QEEFYSTHPHFMTQRALYLVV----YDls--kGATevD----AI-KP---WLFNIKARASSSPV-ILVGTHLDvsdE 1352 coelacanth
TDH16768       694 QASMSTVNQCFFTDKALYVVIwnlaLG-----EEA--V----ANLQT---WLLNIEARAPNSAV-VVVGTHLD---L 752  yellow perch
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