4DJT,3DPU,2EW1


Conserved Protein Domain Family
Roc

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pfam08477: Roc 
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Ras of Complex, Roc, domain of DAPkinase
Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, and Miro-2) and atypical Rho GTPases. Full-length proteins have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (pfam00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.
Statistics
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PSSM-Id: 312094
View PSSM: pfam08477
Aligned: 186 rows
Threshold Bit Score: 88.7165
Threshold Setting Gi: 924442917
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DJT_B         13 KICLIGDGGVGKTTYINRVLDGRF--EKN--YNATVGavnhPVTF------L--DdqgNvikFNVWDTAGQEKKAVLKDV 80
gi 847114467 1328 KVLIVGNTGSGKTTLVQQLMKCRRleHGA--EKATVGid--vKDWpilir----gkikKeitLNVWDFAGQEEFYCSHPH 1399
gi 47220567  1327 KLIVVGNVASGKTTLIQQLMKLKR--SQL--KSKSTSvgidV-QDwt-----ikDwdrKkmvLNVWDFSGGEEFSGSHPH 1396
gi 924442917 1352 KLMVLGGSGSGKSSLIQQLMRLRR--SQW--R-SDPGvsirDWPVr-------sKd-kRnmmLNVWEFSGGEECSGIHPH 1418
gi 884897779 1401 KLMIVGNTGSGKTTLLQQLMKTKK--SDL--GVQGATvgidVKDWpiqikgKk----kKdlvLNVWDFAGREEFYSTHPH 1472
gi 637305559 1348 KLMLVGNTGSGKTTLLQQLMKCRR--PDLglQNATIGidvnDWKIpvrg------kvkKdvvLNVWDFAGQEEFYSAHPH 1419
gi 548553274   60 KMLVIGPPRQGKSALLEALQTGKA--SPF--TPAECSistsVWELdkp-sgGknKkds--viFNVWDIGGQASMSTVNQC 132
gi 847112135  605 KMIIVGPPRQGKSTLFEVLQSGKV-------SQQMQGdnsiRTTCwelqkpVgtTakvDsvqFHVWDVGGSNAMSAVNQC 677
gi 504257060  267 KVLLVGEGEVGKSSLVDSFQGRPF--ITG--RPTTHGielsTLQLphp-elPdvDi-----tLRFWDFGGQEVYRITHQF 336
gi 501381156  368 KLILIGEGEVGKSCLLGALRGDEW--EDG--RPTTHGieikSVI-------VtdPdsgTeisLNGWDFGGQRVYRPTHQL 436
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
4DJT_B         81 YYIGASGAI----LF----FDv---tSRiTCQNL---AR---WVKEFQ-AVVGnEAPIVVCANKID 128
gi 847114467 1400 FMTPQALYL----VV----YDlskgvSE-VDAIK----P---WLFNIK-ARAS-SSPVILVGTHLD 1447
gi 47220567  1397 FLTSRALYL----VV----YNlsrgaSQ-VDALK----P---WLFNIK-AAAP-VSPVILVGTHTD 1444
gi 924442917 1419 FMSSRAVYL----VL----YDls-kgAS-EIHAI---KP---WLFNIK-AVAG-QCPVIVVGTHAD 1466
gi 884897779 1473 FMTQRALYL----AV----FDlskgqAE-VDAMK----P---WLFNIK-ARAS-SSPVILVGTHLD 1520
gi 637305559 1420 FMTQRALYL----AV----YDlsk-geA-EVDAM---KP---WLFNIK-ARAS-SSPVILIGTHLD 1467
gi 548553274  133 FFTDKALYV----VIwnlaMG-----EE-AVANL---QT---WLLNIE-ARAP-NSAVIVVGTHLD 180
gi 847112135  678 FFTDKALYVvvwnLA----LG-----EE-AVANL---QF---WLLNIE-AKAP-NAVVLVVGTHLD 725
gi 504257060  337 FFSRRSLYL----LV----WK-----PR-QGQEEnaiEF---WLRLIRlRLGR-DAQVMIVATHGD 384
gi 501381156  437 FFSAPAVYL----VI----WK-----PR-EGPQQ---GFvkeWITLIK-NREP-DAKVLVVATHGG 483
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