5NUG,3VKG,4RH7


Conserved Protein Domain Family
DHC_N2

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pfam08393: DHC_N2 
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Dynein heavy chain, N-terminal region 2
Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Statistics
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Aligned: 667 rows
Threshold Bit Score: 59.537
Threshold Setting Gi: 163773822
Created: 27-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NUG_A        1319 VQV--ALEE--L-QDLKGVWSELSKV----WE---QIDQ-----MkeqpwVSV---QPR-KLRQNL---D--ALL-N--- 1368 human
EGD80062      1651 adT--ILEQ--I-DLLTDCWQRMREW----DA---RFEQ-----WmplplAQL---DLE-EMNAFV---S--SFL-N--- 1700 Salpingoeca ...
EGB05234       807 MCA--------L-SSLEQLWRAAESWrsqtTI------------W-----MEArcgDLDpAVLEDVlvtHssAFRtS--- 857  Aureococcus ...
EAY06405       692 FDEtkLFEGrrLsNCLMKLWVSTKEY----SMeneKIAG-----------TQIgliDTE-EISKKF---E--KWVgS--- 747  Trichomonas ...
96_pfamImport    1 LDD--IAEE--M-EPYEQLWKTAREFremsSR------------WlrgnlFELcasEGMqALHQMLtiiA--NVSkIlhl 61  
EEY65913      1057 LDD--IAEE--M-APYERLWKTVREFremnSK------------WlrgnvFELpgnEGMqTLQQMLtvvS--DVSsVlil 1117 Phytophthora...
Q57VL9         750 LRV--------F-DVLEQFWCSVFDStrvkDYyiiPLSAl----------------NSE-KTIDEVqrcR--RLLhS--- 798  Trypanosoma ...
CAM41666       445 MNH--------F-EIIEQFWITVFEStklrELyrtPVSSv----------------NAN-AFIERArewR--RLIhS--- 493  Leishmania b...
EFO86788       630 MRL--FVGE--I-ESLQSLFVATSGY----YK---HVNAffesrR-----TLV---NID-ASRNFI---E--QFTvQ--- 680  Caenorhabdit...
CAP35738       610 MRH--FVGE--I-ESLESLFVATSGY----YK---HVNAffesrR-----TLV---NID-ASRNFI---E--QFTiQ--- 660  Caenorhabdit...
5NUG_A        1369 -----QL---KS--------FP--A-Rlrq---yaSYEFV----QRL--------LK----GYMKINMLVIEL-KSEALK 1409 human
EGD80062      1701 -----AL---ThaqhtlsttFA--KiA--------TYTNK----AAD--------AS----LLL---DISEMV-RSPWFG 1742 Salpingoeca ...
EGB05234       858 ------LhnlS---------------------------------GNEaavsyhgmAE----DFRLVIGLIREL-RSPFLR 893  Aureococcus ...
EAY06405       748 ------I-----------------NdAcdglkefqIPRNI----AIL--------VEsnvkEFKSYIPIINAL-SSIYLR 791  Trichomonas ...
96_pfamImport   62 nsagaAI----------------------------TAEML----KKQ--------LT----DFRENARLVGAI-LNPSMK 96  
EEY65913      1118 nsaaaAI----------------------------TAEAV----RKQ--------MT----DFRENVRFLVAI-QNPAMK 1152 Phytophthora...
Q57VL9         799 -----SV---RN--------LR--GyP--------GLVCL----GRQ--------QEqvlaDFESLQTLLAYL-STPGLR 839  Trypanosoma ...
CAM41666       494 -----TIrnlR-------------GyP--------ALVRL----GRE--------QElalaKFEE-LELFLELiTTPGLR 534  Leishmania b...
EFO86788       681 --------------------LSvfEsSlat---hrAAKHFiayaRNE--------VD----TFKKNFSVAEVMsCRRLL- 724  Caenorhabdit...
CAP35738       661 --------------------LSifEsSltt---hrAAKHFiayaRNE--------VD----SFKKNFSVAEVMsCRRLL- 704  Caenorhabdit...
5NUG_A        1410 DRHWKQLMKRLHvnw-------------------------vvSELTLGQIWDVDLqkN--EAIVKDVLLVAQGEMALEEF 1462 human
EGD80062      1743 QRYVRRTSVLVvlni-------------------------dvnITTYGYLHASKP--PqrVEALEDLFVQAEEEQRREQQ 1795 Salpingoeca ...
EGB05234       894 NRHREAVEDILgfsisaipqrdgaggdlaeappgltkldaarLSVTLGQLIERHA--IkaLPAIKAITTRATHEAILYQS 971  Aureococcus ...
EAY06405       792 NRHWTMINDLFkldh------------------------pldQSATLYYLIDIIV--LnkEKEIMDIVKIAENEYILEDF 845  Trichomonas ...
96_pfamImport   97 DRHLKEVSALLglsl------------------------dpqDPLTLLKVLEGGA--LdhLSKILEISQNATQEKQIEGV 150 
EEY65913      1153 ERHMKAVSGLIgidf------------------------tseEAITLLKLLENGV--FerIGDIVDISCNATQEQQIERA 1206 Phytophthora...
Q57VL9         840 KNHWKEIGRILqlgrkq--------------------stqidSNVTLKQLLENGI--IdhLDEIKLIVDPAFLDFEAEAT 897  Trypanosoma ...
CAM41666       535 KSHWRDIAKLIstqlrdd------------------illvtnMTVTVKRLLDAGL--LdhIVPLAQIVSQARCDYDVENE 594  Leishmania b...
EFO86788       725 DAHWLRMSEIVgfdl------------------------tpyANSSIAQICELGL--EahLQQLKPIAFSAEREATAADQ 778  Caenorhabdit...
CAP35738       705 DAHWLRMSEIVGfdl------------------------tpyANSSIAQICELGL--EahLQQLKPIAFSAEREATAADQ 758  Caenorhabdit...
5NUG_A        1463 LKQIREVWNT----------YE--LDLVN-YQN-----------K-----------------CRLIRG--WDDLFNK--V 1497 human
EGD80062      1796 WKELNEKWDS----------MV--LPIKR-Qg--------------------------------------STLLGRDayL 1824 Salpingoeca ...
EGB05234       972 LDEVRTTWAG----------AE--F--------------------------------------VVLNYngRKDAPTLacI 1001 Aureococcus ...
EAY06405       846 LDGIIASFYDwtfsitlfncSN--F---------------------------------------------IKEGISR--L 876  Trichomonas ...
96_pfamImport  151 LIEIDIEWRE----------LQ--FLFKAaKKPnygss--nlpvSvelqkqrnapdhpsletSTLLQResVEDVTQL--V 214 
EEY65913      1207 LHEIRDEWEA----------IS--FNLVPsRHPitvstalapilStdnge--------petvNIVLEKdcGEQIVSL--M 1264 Phytophthora...
Q57VL9         898 LERMKSDAKK----------TRfvFEVAEgSNDa-----------------------------LILSPrcRTSISSQ--L 936  Trypanosoma ...
CAM41666       595 LEEMRSYAKR----------TH--FALENsAVHd----------Dl----------------NTPPLKgnRHEMVCR--I 634  Leishmania b...
EFO86788       779 LHSIVTFWSQ----------EH--LEMRF-HVQw-----------------------------KLSLAvkLRDLHSR--V 814  Caenorhabdit...
CAP35738       759 LHAIVTFWSQ----------EH--LEMRF-HSQw-----------------------------KLSLAvkLRDLYRR--V 794  Caenorhabdit...
5NUG_A        1498 -------KEHI-------NSVSAMKLSpyykvF-EEDALSWEDKLNRIMALFDVWIDVQRRW-------VYLEGIftg-- 1553 human
EGD80062      1825 lenvsalRDEIvhaemvlLNLSRSDASpe----lKSKARALHEKITTFEQRLSQWEDCERAW-------SRVHAPmtag- 1892 Salpingoeca ...
EGB05234      1002 qvlvddvQKDM-------AALVQLLESphvsyI-REELEGWHASLVKLAMQLDALTEIQSGLtrltfqfRVPESSsvsrv 1073 Aureococcus ...
EAY06405       877 -------QDQM-------RDLRKVKKSnfknlF-LQKIEKHENFVTQMQDFVTLLRKIYNLY-------LYQNDFme--- 931  Trichomonas ...
96_pfamImport  215 -------EEHQ-------VRLHSLLCMqhaipF-FQEISSWLHFTRNIRRLLDALIAVERLW-------KAINPLfsari 272 
EEY65913      1265 -------EDHL-------LRLQSLSCMahagpF-IEEIAFWQTFASEMGQIVEMLVLVEHRW-------RRITPLfaagi 1322 Phytophthora...
Q57VL9         937 -------EAFS-------HELSALRQVehlsqYtISSVMEFDSVVQRMKETLLTWEDVEKEWkevlpfgITLETTtdedf 1002 Trypanosoma ...
CAM41666       635 -------EECM-------LKCRAMRRRpnlgpSvLRAVDEWVDACEKSREVLLAWDNVKMRW-------MRLRACvsslr 693  Leishmania b...
EFO86788       815 -------QTDI-------NTLKHMTNVeq---itDDSLPQWIEWTCRTETILKAWCETQQKW-------MRVANIfvtcr 870  Caenorhabdit...
CAP35738       795 -------QNDI-------NTLKHMTNVeq---itDDSLPQWTEWTARAETILKAWCETQQKW-------MRVANIfvtcr 850  Caenorhabdit...
5NUG_A        1554 --sadIKHLLPVETQ---RFQSISTEFL-A--LMK------------------KV-SK-S----------P---L-VMDv 1591 human
EGD80062      1893 --lnnNSEEFAHAVT---IYKSTMRQWR----ALC------------------QLgYR-Seh------------------ 1926 Salpingoeca ...
EGB05234      1074 -tsfdLGSLIPVAER---VLNDTEPWWR-D--LMT------------------SIsSE------------PsvlRaALLp 1116 Aureococcus ...
EAY06405       932 -----aEDTISHQYSfylTFGDIKSNLT-D--LLS------------------KC-------------------TcCVLs 966  Trichomonas ...
96_pfamImport  273 ------vdidSKETK---LFGTADQLYKgV--VMRiqrq----------plyrEViPRvTqksdpalssiPqs------- 324 
EEY65913      1323 ------vendSKSSR---LFVSAAKLYQsShaTILrnp------------acaEYcQQsNttvdldqtpkSpatSlISD- 1380 Phytophthora...
Q57VL9        1003 --igltPRDLKLLRE---KVSSTSDTFK-S--LAA------------------TLrkaqytlf---------------ta 1041 Trypanosoma ...
CAM41666       694 savseGICSAEEARTitqKLTTASAAFKgMgaILRkpqfsly------------------------------------ta 737  Leishmania b...
EFO86788       871 -dtlqVSFDSNIQQD---LYYLLQKEYE----LLRtcakyf-------ikierNVvKDaTiyrvmqlphlP--------- 926  Caenorhabdit...
CAP35738       851 -dtlqVKNLFNVTQK---SEELFTEGIR----ITEnlcqifpnhreerskrcdHLsSDaTtpfalldrenP--------- 913  Caenorhabdit...
5NUG_A        1592 lniqgVQRS-LERLADLLGKIQKALGE---YLERERSSFP----RFYFVGDEDLLEIIgn-sKN-VA-KL-QKH-FK-K- 1656 human
EGD80062      1927 ----vLRDLcSPEVGQRLAEYHHQFQEcysLLIATVDAYSvtctRLYMLTPPEVLQLVgq-aRS-LH-SI-KPL-IC-K- 1995 Salpingoeca ...
EGB05234      1117 ----aMKQQeLEKHRSGLHMAMNEIRS---HLQSRREAFP----RLYLCADDALLPSIaqtsLGnAA-ALaSPI-IR-S- 1181 Aureococcus ...
EAY06405       967 i---sMTEK-LEVIYDKIRELKEKIYP---YLQNRRKEYY----RLQYLANSELFNYIss-tKN-PE-RF-SEQ-VK-S- 1028 Trichomonas ...
96_pfamImport  325 ----mLAD--LNTCLSLLEEAKDTLRV---GLDGKRSHFP----RFYFLSDLELVSALscrsAS-GDlLL-EASeLW-Ky 388 
EEY65913      1381 ----------LEECHEILETVRADVRV---GFESKQASFS----RFYYLSDLELVTALal-aEV-PSdVSlWKA-LS-R- 1438 Phytophthora...
Q57VL9        1042 mmqenIQDQ-VTLARTILGDVRKILAS---SLDAKREVFP----RFYLMDDESLLSFLsvhnAT----KL-KRH-LT-T- 1105 Trypanosoma ...
CAM41666       738 mmqdtIQDF-LLTIKSEVDDADEVLRG---VTERRRALFP----RFRFLPDSELIEFQsvqsAH-SFvHL-FQY------ 801  Leishmania b...
EFO86788       927 --------CwIEKIRKMVVVIIQGVRG---LLDGMRMINS----RLCLSSELHLLNLFsttsID-TRlQL-----LLkD- 984  Caenorhabdit...
CAP35738       914 ----------------------FNVRG---LLDGMRMINA----RLCLSSELSLLNLFstttID-SRlKL-----LLkD- 957  Caenorhabdit...
5NUG_A        1657 ---MFAGVSSIILnednsVVlGISSR-EGE-EVMFKTPVSI------TehpkinEW----------LTLVEKEM----RV 1711 human
EGD80062      1996 ---CFSDVSDLLLaegrkID-GLLAP-SGE-TIRFAqsivat--------gpthlWlpqlfsemqdFVKFDilsaherld 2061 Salpingoeca ...
EGB05234      1182 ---CFPAVSTFEL--------GIGSKiSKDiLITspdgghisilfdfkmrcaleEW----------LHALNLAMhravAK 1240 Aureococcus ...
EAY06405      1029 ---LFPSLDGMIIen-nkII-GVIGK-NSE-QLRLNpieydi------------------kdvpllLKTIEMKI----EE 1079 Trichomonas ...
96_pfamImport  389 lspCFPGIHRVQVnasreIT-SLVSS-VGE-QFTLGtpiata-------nasviAW----------LGKMETSM----TT 444 
EEY65913      1439 ---CFPGIHSVQTnpaneIT-ALLSS-VGE-PFPLGsaittk-------dtsmpTW----------LTKLETSM----TT 1491 Phytophthora...
Q57VL9        1106 ---LYSRVCDVNLeg-nvVT-SFITT-DGS-VLRtdtpiel-------splpveQW----------MKTFDRTL----RS 1157 Trypanosoma ...
CAM41666       802 ---LYPRITDVEVvd--rIVtAVVAT-DGA-RLPLSSPLALt-----Kdt--pdAW----------IQRFDHAV----RA 853  Leishmania b...
EFO86788       985 ---CFPSLRRLCFnrr--nqlELVDL-LGE-KVTVDltkteie----------------sqepcelIRSIETAF----AS 1037 Caenorhabdit...
CAP35738       958 ---CFPSLRRLCFnrr--nqlELVDL-LGE-KITVDltkaeie----------------nqepcelIRSIETAF----AS 1010 Caenorhabdit...
5NUG_A        1712 TLAKL-LAES 1720 human
EGD80062      2062 rlwsevfasa 2071 Salpingoeca rosetta
EGB05234      1241 GLKPClRLAL 1250 Aureococcus anophagefferens
EAY06405      1080 KLTKTvIDIA 1089 Trichomonas vaginalis G3
96_pfamImport  445 ILQAC-VRAA 453 
EEY65913      1492 ILHAS-IRAA 1500 Phytophthora infestans T30-4
Q57VL9        1158 SLLNE-IKMS 1166 Trypanosoma brucei
CAM41666       854 SLVAA-VKEC 862  Leishmania braziliensis MHOM/BR/75/M2904
EFO86788      1038 KLTDI-ITYE 1046 Caenorhabditis remanei
CAP35738      1011 KLTDI-ITYE 1019 Caenorhabditis briggsae
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