4RH7


Conserved Protein Domain Family
DHC_N2

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pfam08393: DHC_N2 
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Dynein heavy chain, N-terminal region 2
Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Statistics
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PSSM-Id: 337038
View PSSM: pfam08393
Aligned: 660 rows
Threshold Bit Score: 74.1737
Threshold Setting Gi: 167526770
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RH7_A        266 IESCAQIWAFYEEFQQGFQEmanedw-itfrtKTY-LFEEFL---MNWH-DRL---Rkvee---hsvMTVKLQSEVDKYK 333 
XP_003736434 1397 LRRVKQLWDFVRVIESCIVDwhatp---wlliDTD-DMEHEC---KKFT-RDL---RtldkcirdwaPYVYIVGVLRELV 1465 Drosophila ps...
EFX85716     1298 TIMIKQLWDYSYVIRSSVDNwktth---wkeiDVE-RMEIEC---KHFA-KNI---RgldkemrawdAYIGLDASVRDLL 1366 common water ...
XP_011483852  570 ITILRDLWDKVLFFQERVNTwsiik---wrqiNVD-QIDAEV---RKFA-RDL---QkldkdarawdVYTGLELHVRNMQ 638  Japanese medaka
XP_019220092 1272 ITILKELWDIVVYVQSSVENwtmtk---wrqiNVD-QMDAEL---RRLA-KDI---QkldkearswdVYSGLDLYVKNLL 1340 Nile tilapia
CDS25741     1350 MKTIKKMWDLVNTFNNYMASwktqp---wkqvNFE-EIEDVI---RVIS-LEM---RsadkdvkrwpLYKDFEGALKDIS 1418 Hymenolepis m...
CDS41848     1401 MKANKKMWDLVETFKSYVVSwktql---wkqvDFE-AIEDVI---RDIS-LEL---RsmdkdvkkwpVYKGLEAALKDIG 1469 Echinococcus ...
GAA54008     1347 MKVTKRVWDYINMFRSYVTAwktsk---wkeiDFG-AIDEVI---REIS-IEI---RtmdkdvkqwpMFQGLEAELKDIN 1415 Clonorchis si...
XP_001320325 1302 LKLLTNVWETTNRIQTELSNwkntl---wsevDFS-QLQNEC---EQNT-RTI---HriekrakdwgVYTGLDALIKSVS 1370 Trichomonas v...
XP_015223291 1369 VRNLTLMWQAVEVIRKQQSEwktqpwqdidtvQLVsSTSQQLeliKSLArE-VhgwD----------VYAGTLESVNVIQ 1437 spotted gar
4RH7_A        334 IvIPILKYVRGEHLSPDHWLDLFRLL--Gl-----------pRGTSLEKLLFGDLLRVadTIvaK--AADLKDLNSRAQG 398 
XP_003736434 1466 AsLRAITELQNPAItERHWLELMQLTkls----------ykcN----KSTSLAQLLKL--QLqhH--EEDIKNTVDRAIK 1527 Drosophila ps...
EFX85716     1367 TsLKAISELQNPAVrERHWTQLIEATkrktflrdnftvslvtG----IDTTLADLLAL--DLhrY--EDEVRSVVDRAVR 1438 common water ...
XP_011483852  639 TlLRVVSQLQNLAVrERHWVQLTPELkis----------fnvT----DSTTLGELLAL--KLhmF--EEEICKVVEQAVK 700  Japanese medaka
XP_019220092 1341 TsLQAVTQLQNPAIrERHWVQLIRTTqmd----------ftvT----DSTTLENLLAL--QLhlF--EEEVRNIVEKAVK 1402 Nile tilapia
CDS25741     1419 TsISAVSDLQNSAIkDRHWAELMQDTgti----------idiS----NNTDLEELLSL--NLhkF--EDKVHGIVSKALN 1480 Hymenolepis m...
CDS41848     1470 AsMSAVSDLQNPAVkDRHWVELMHGTgav----------idiS----DDTTLEALLSL--NLhkF--EDEVHGIVSKAMN 1531 Echinococcus ...
GAA54008     1416 AaVTAVRDLQNPAVkERHWVELMTDTgrm----------ieiN----DETTLADLLSL--NLhkF--EEEVHGIVSKASN 1477 Clonorchis si...
XP_001320325 1371 StIPIFQQLHNDKLrERHWSKLKQITgvd----------fqkT----VDLKLGDILDK--NLmrY--AEDITEVCDGANN 1432 Trichomonas v...
XP_015223291 1438 LtLPLIEDLLNPAMRTRHWKQLVRVTggQll----------iSPQSLRGMTLGDLLAL--GL--QkhADNVKAIVERASN 1503 spotted gar
4RH7_A        399 EVTIREALRELDLWGVGAVFTLIDYEDsqsRt-mKLIK----------D--WKDIVNQVGDNRCLLQSLKDSPYY-KgFE 464 
XP_003736434 1528 ELTVTKVLDEIKATWAHLEFELEPHQT---RpsiQLLK----------Vs--eELIETLDDNQMQLQNISTSKHI-EyLL 1591 Drosophila ps...
EFX85716     1439 EVSMEKTLRELEATWATLELGKEEHA----RtglTLLK----------As--dELIATLEDNQVQLQTLASSKYV-AhLM 1501 common water ...
XP_011483852  701 EMAIEKIVTEIGQTWASKELLYEEHD----QnsiPLLK----------Cd--eELIEMLEDHQVRLQTVVQSKHV-DnFV 763  Japanese medaka
XP_019220092 1403 EMAIEKVVTEISQTWMSMELSYEDHY----QtsvPLLK----------Cd--eQLIETLEDHQVQLQSVFQNKHI-DhFL 1465 Nile tilapia
CDS25741     1481 EQKIEGDLEKIESTWTNMCFEFEKHE----RtglMLPK----------Qt--eTLIAQLEETQVKILDMMSNRDN-AhSI 1543 Hymenolepis m...
CDS41848     1532 EQKIEADLVKVDSIWRDMYFEYEPHE----RtglLLPK----------Qt--eTLTTFLEETQVKVLDMMANRDN-AySI 1594 Echinococcus ...
GAA54008     1478 EQKIERDLEKIEQVWSEMMFEYETHD----RtglELPK----------Qt--eELTGTLEEIQVKVLDMLGNRDN-TfSI 1540 Clonorchis si...
XP_001320325 1433 EVRMETALADLKKTWSTMEFTYKGMEA---FpdlLVLN----------Vp--eELVQTLEENQVAVQNYLSSKNI-SfFR 1496 Trichomonas v...
XP_015223291 1504 DIAIETGLKNCEEVWLSRIFDLQPHNR---A---MSATregeagvfmlVtnTEAIFEELEHHQMALDTMKDSSEAgT-FL 1576 spotted gar
4RH7_A        465 DKVSIWERKLAELDEYLQNLNHIQRKWVYLEPIFG-------RGALPKEQTRFNRVDEDFRSIMTdikkdnr-vttltth 536 
XP_003736434 1592 DKLGHWQRVLSGIDTLIVNWLEVQRKWIYLECIFIgsa--diRAQLPADAANFERIDADFTALLArvsgvrv-vmqvvlr 1668 Drosophila ps...
EFX85716     1502 TDVLDWQRRLGLADQVLALWCEVQRSWSHLESIFAgsgtddiRQQLPEDSNRFDETNANFKELLGhlllkpn-visvatr 1580 common water ...
XP_011483852  764 VQVRELQNQLSVAESVLIIWMEVQKTWAYLESIFKscd--diCQHLPADLQRFQEVDNEFQVLMVnsartkn-vieatni 840  Japanese medaka
XP_019220092 1466 HQVVELQKQLTVADSVLMVWMEVQRTWAYLESIFKgcd--diCQQLPGDTHRFKAIDAEFQELMLgsamikn-vieatnk 1542 Nile tilapia
CDS25741     1544 DKINHWNKILFTVDKVLTLWFETQKVWSGLEAIFMlcd--diREQLPIDTDLFFEHDKEFRLLIEelakkpkiveattsq 1621 Hymenolepis m...
CDS41848     1595 VKITYWNKALFTADKVLSLWFETQRVWSSLEAIFVlcd--diREQLPKDTDLFFEHDKEFRLLAEeiakkpkvieattsq 1672 Echinococcus ...
GAA54008     1541 DRINYWHKTLSMTDQVLTLWFETQRVWSGLESIFVlcd--diQAQLPDDTALFMDLDKEFRVLIDelqskpkvldattqr 1618 Clonorchis si...
XP_001320325 1497 VTLDEWQEKLKQVDKVMTIWLDVQQHWTHLRPIFIgse--diRKQLPKQSESFEMIDKQMIEFVNkqqankn-vvdtcnq 1573 Trichomonas v...
XP_015223291 1577 DEVTKWQKKLQIIESIVHLMLQVQDKWVNLEEVLTts---svCGDLPMEAAVFASVQQDLCSLMKaaeenpni--lqici 1651 spotted gar
4RH7_A        537 AG-IRNSLLTILDQLQRCQRSLNEFLEEKRSAFPRFYFIGDDDLLEIL-GQsTNpsVIQSHlk-kLFAGINSVCFDek-- 611 
XP_003736434 1669 HEdVLPQLLQLQQRLAICEKALNDYLETKRLAFPRFYFISAADLLDIL-SNgNNpqVIDRHli-kLFDSILRLQYEtn-- 1744 Drosophila ps...
EFX85716     1581 PN-VLDDLHRIDSQLQLCEKALAQYLESKRVDFPRFYFVSTADLLDIL-SNgNSpqLIQRHlt-kLFDALARIKLEpitt 1657 common water ...
XP_011483852  841 PH-LFEKLDNLQKRLALCEQALADYLEAKRIAFPRFYFISSANLLDIL-SKgSHprGVIVHls-kLFDSMSDLEFAqteq 917  Japanese medaka
XP_019220092 1543 PL-LLEKLEDLQKRLALCEKALAEYLETKRLAFPRFYFISSADLLDIL-SKgSRprEVTGHls-kIFDNLSDLEFSkneq 1619 Nile tilapia
CDS25741     1622 PE-MFDNIQAVRNGFAICEKTLAVYLETKRLAFPRFYFVSQADLTDIV-SKgKMpqRVFRHls-kLFDSICNLIVNsdnq 1698 Hymenolepis m...
CDS41848     1673 PE-LFDNIQAVRDGLAICEKTLAVYLETKRLAFPRFYFVSQADLMDIV-SKgKMpeKVFKHls-kLFDSICNL--Etdqs 1747 Echinococcus ...
GAA54008     1619 PE-ILDEIQKIRDGMTICEKALADYLETKRLSFPRFYFVSQVDVTDIV-SNgKVpaKVLRHls-kLFDSICSLTFEkpda 1695 Clonorchis si...
XP_001320325 1574 PD-IMKFMEMLLRELTIVEKSLNDYLETKRRAFPRFYFVSANDLLDIL-SKgRHpqEIEPHfs-kVFDNLVKVQWTg--- 1647 Trichomonas v...
XP_015223291 1652 rqgLQGMLCEMKEKLEKCQHSLLDYLESRRHAFPRLFFLPLQDTLKLIcCAcn--pEVQHHylykVFEHMESLIFVknne 1729 spotted gar
4RH7_A        612 -----sKHITAMKSLEGE-VVPfknkvp------lsnnveTW-LNDLALEMKKTLEQLLKEC 660 
XP_003736434 1745 -----tTHAVGMHSKENDeYVPfvaeqdqpafivcsgrveLW-LRAIIQQMRSTLHELFRRA 1800 Drosophila pseudoobscura pseudo...
EFX85716     1658 tqkdgpYQAVGLWSKDGE-YVPlckpiq------cvgqveGW-LNALADSMRVSLRLLLQDA 1711 common water flea
XP_011483852  918 --mlnpKQAVGMYSKERE-YVPfttecw------cygpveTW-LVSLEESMKKSVRDQLFNA 969  Japanese medaka
XP_019220092 1620 --lsnpKVAVGMYSKERE-FVPfqtecl------crgpveAW-LSRLEESMKECVKGHLSEA 1671 Nile tilapia
CDS25741     1699 --snsnLTALKMEAKDGE-IVDfvnkfa------legqveEW-LSYLLDEMRNTIRMTLSEA 1750 Hymenolepis microstoma
CDS41848     1748 ---nsnLTALKMEAKDGE-IVKfvstft------legqveEW-LNRLIDEMVHTMRATLSEA 1798 Echinococcus multilocularis
GAA54008     1696 --avkhAT--KMIAKDGE-EVKfvksfd------ltgqveEW-LNQLLDEMRHTLRKILADA 1745 Clonorchis sinensis
XP_001320325 1648 -----pESCKAMMSKEGE-VVEfdeelv------ldgpveIW-LQKLLDCARATLKERLAEA 1696 Trichomonas vaginalis G3
XP_015223291 1730 ihearsQRIVAVKSFAGE-QLYlteple-------cgglaEQgLQLLQGRIGSALRSQLHAA 1783 spotted gar
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