4BTA


Conserved Protein Domain Family
P4Ha_N

?
pfam08336: P4Ha_N 
Click on image for an interactive view with Cn3D
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.
Statistics
?
Aligned: 194 rows
Threshold Bit Score: 68.4435
Threshold Setting Gi: 0
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4BTA_A               14 SIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLT----ST--ATKDPEG-----FVGHPVNAFKLMKRLN 82  human
Q29C52                1 MTKVFGYEQKMLQHMQKFVADNQSKLDFLRARLREFEQERTEAQ----HW--GTAYFES-----PLNQYLLSKRLTVDWR 69  Drosophi...
EDV21666             30 ATDDIEKLIYSEYELYHELDNYIKLQQNRLVTLRKLLDEIKSQMhgvhLK--GYEQGKH---------PLAVFLLVRRFL 98  Trichopl...
WGS:AAPP:GF23330-PA  25 SITGLEELLKTEEHLMLQLRSKVNGIKTSLQQLERELSSIEQEH----VS--ASKDTEN-----YLTNPVNVYRLMKRLN 93  Drosophi...
Q9VA64               26 SITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEH----TM--AASDTEN-----YLTNPVNVYRLMKRLH 94  fruit fly
EDW39340             26 SITGLEKLLQTEDFLIKNLRTTVNAVRTSLQRLESEVFAIEQEH----VV--AARDTEN-----YLTNPVNVYRLMKRLH 94  Drosophi...
EDO30487             24 ALTHMRGLIRLEKTLQRKLVEYLNLNPRASEDLRITMEEVKQHT----KN--IRGDVEK-----FLGHPVNAYMLIRRFI 92  starlet ...
EDO30483             21 SLEKMKGLARLESFLPTILEKYLDRQQVIPRVLLDFLDLLKTQT----------RVKNDmgldrFVLHPTNAFKMIRRFL 90  starlet ...
20_pfamImport         1 ---MLTKLYDVQNDHFNVLDNYANLETKRLEELKNYVAAVYEWR----DNikTKKQ--------FLHDHMDVFKVMTQML 65 
EDO36263             13 SMDQLQRLSTVEKNLHETLDLYIMQERKRLEDLKGIYAAKKEEL--------KKRERDD-----EVYHPLDVFRVINRVS 79  starlet ...
4BTA_A               83 TEWSELENLVLKDMSDGfISNLTiqr---qyFPNDE--DQVG------AAKALLRLQDTYNLDTDTISKGNL 143 human
Q29C52               70 RVQNLMYADTGEKPLERlLKLRQrpsm-pdaSELEG--AIDG------LLRLQYVYRLEAKHLAKGILDGVN 132 Drosophila pseud...
EDV21666             99 RNWKELEATAEEEQIFN-DKLLDtfayykrtFPNLQ--DLEG------SAEAILRLQDVYNLKEIDLASGII 161 Trichoplax adhae...
WGS:AAPP:GF23330-PA  94 TDWSLMEGRLQQISEDMnFNVtrgs--yglsFPSQE--DVEG------AALALVRLQSTYKLDVAQVAAGIL 155 Drosophila anana...
Q9VA64               95 TDWSLMEGRVQLMAEEMnFNatre---yglsYPSQE--DVEG------AALALVRLQSTYKLDVAQVAQGIL 155 fruit fly
EDW39340             95 TDWPHLETRVQQIADKMdFNatqg---yglsFPSQE--DVDG------AALALVRLQSTYKLDVAQVAAGIL 155 Drosophila persi...
EDO30487             93 KNWKDVEEYLEKHDDQ--EDLLallrlhkvdFPTSK--DMLG------CVQAIQRIQDVYNITAKRIASGHL 154 starlet sea anemone
EDO30483             91 KHWTELANYLNKGPDNDlKEMLnvn---rpiFPKPS--DLLA------CAEAILRIQDVYNLTAKQIAKGHI 151 starlet sea anemone
20_pfamImport        66 QHYFQIDDLIKNKKSLEaFKDI------------DEhkDLSGehivllAHRALRRLQLFYAIPASDMSAGRF 125
EDO36263             80 SEWSTVEKLVRFNPHKS--EFIQeirnyhasFPSDA--DFDG------TRAAMLRLQKVYNISSQSISSGVI 141 starlet sea anemone
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap