Conserved Protein Domain Family
Sec39

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pfam08314: Sec39 
Secretory pathway protein Sec39
Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).
Statistics
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Aligned: 70 rows
Threshold Bit Score: 326.209
Threshold Setting Gi: 387514722
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS99211              11 VLLAAQFTATGDIASLAS-LAAGHGDALRKKLVLRLLLTYLPSHLTTEEYLPLLQSL--------------ESADYSCFf 75   Sporot...
CCD27183               7 YLLACVFASKADSTNLSQ-ILRHVHYSLD---FIKAACILWPELDDP----MNLISLfptielgnddndnnASANDDGSl 78   Naumov...
CCC72177               7 YLLACLFASRADSENLIR-VLHHVEYSMK---FVKIVCILWPELSDP----LSLRFLfn-----------hQKDAQVKPm 67   Naumov...
Q12745                 7 YLLACIFASRADTRNIKK-LSTRLGSQSK---YLEILCVLWPELDDP----KNLLFLrel--------eeeVQSPEGEEt 70   Saccha...
EJS42638               7 YLLTCIFASRADKDNVKK-LTTRLGSKAD---YLKVICVLWPEFDDP----KHLSFLyer--------eetVQSTEEREi 70   Saccha...
EJT42393               7 YLLACVFASRADTDNIKK-LVTRLGSKSD---YLKVICVLWPELDDP----EKLSFLykg--------geeTPSAKEKEi 70   Saccha...
EDO16615               6 YLLCTIFAARADITNSSL-LYDQANGNFTQE-CFDALCILWPELMDP----NGLSFVfq----------qgPSDDQVQLs 69   Vander...
CCE61847               7 YLLATIFASTADVEKLTI-LKNSFTNSSE---LLDIICVLWPELDDPILLRNFLTNLel-----------nDLNADENPi 71   Tetrap...
WGS:AFWA:PNEG_01189   11 LYIAVQYASAPSLQTLSE-LILKFPYIFSKRVILSI-LNFVPECIDPDEYLSLIFDEky--------------------- 67   Pneumo...
EPB88423             175 IAQAIEYARSENNVALDAiFMHHGSDVLEHRL---FILSQIPETADPSLF-----DL--------------PHVTHDHEd 232  Mucor ...
ERS99211              76 ---------PLQEIDTSSV---QSLSDEQAAKKVRKLRL----------QPlslpgaasslasssEARGEteeAEEpeDP 133  Sporot...
CCD27183              79 sdenlvvklLENNPDLIPL---VEVGNTIVNTRYLSTKYfiesklnglySS--------------NIIPLetsLSSleDL 141  Naumov...
CCC72177              68 tdeelvvslLEKDSMLIPM---VEINNETVSNRRQQLEQfinskwdsltS-------------------IndiDTSssSS 125  Naumov...
Q12745                71 tdedvivelLESDSSLIPL---IESDTTTRSNRYHELQEfiskklnnktL----------------------------EN 119  Saccha...
EJS42638              71 tnedamielLESDSGLIPL---IEIDNTTRSSRYHELQEfindkldnkcL----------------------------EN 119  Saccha...
EJT42393              71 tsedvviglLESDSGLIPL---IEIDNATRSSRYQELREfinskvdnkpL----------------------------EN 119  Saccha...
EDO16615              70 dpndlmmnlLEVDNKLIPI---IELEHDIVHERSEKVKDfvskrilqleQd---------------------sLITfdNI 125  Vander...
CCE61847              72 dednilvslLETGEDLVPI---IEMDVETVSERVSTVKEyinrrlvevtLd---------------------eITSfdDT 127  Tetrap...
WGS:AFWA:PNEG_01189   68 --------eGEDDMDSSQIsktQNINNAALSQKLKKLHI----------YQ--------------DETKTnncISD--EE 113  Pneumo...
EPB88423             233 swleepwrkEKDAVEQDWVqtlIRVQVPEETEYLERL----------------------------KGGIEttpYPTsaSV 284  Mucor ...
ERS99211             134 LAVFLIQRAYAVD---DGSGALPELPALLA-------PFLSR-SYFLRTW---TISVLLPLLRRNCEYYPDAplqqTLAN 199  Sporot...
CCD27183             142 QSLWLQIRILVCNeviPEMTSFYEPLWTHSnf---------hiNKEGKDW---IECIIEPLNYINSRLGSKl----KIKD 205  Naumov...
CCC72177             126 SISWLSKRILLCNdsyPGDVFFYEPLWnll-----ikDGVVSeKDRLFQW---IKGIIIPLHSISIRTHAMt----KIID 193  Naumov...
Q12745               120 FEEWLRERILICNemiPETPLLYSVLWETAksk--------vlSTKFIGW---VEGVLKPLDHLNKRLHLIf----KINE 184  Saccha...
EJS42638             120 LEDWLKERILICNevlPESPLFYSSLWETMdpg--------llSTKFSSW---VDGVIKPLDHLNKRLHVIf----KIKE 184  Saccha...
EJT42393             120 FEDWLRERILICNemlPEAPLFYSQLWETAgpg--------vlSTKFIRW---VDGVIKPLDHLNKRLHVVf----KINE 184  Saccha...
EDO16615             126 LSNWLRRRILVCDefnPNNVLFNEPLW----------ETHSKdDIKFAQW---ISGIIKPLSYLNLRSGSKTl---KIKD 189  Vander...
CCE61847             128 VSSWLRKRILLCDelnPFNVLFNKKLW----------KEIKPiDPEFMGW---VNGILEPLDFINNSSDIRVq--fRIID 192  Tetrap...
WGS:AFWA:PNEG_01189  114 LYAWFISRALQIE---EETGLISFSRKLVL-------TSKYPiPPKVQEWgrgIVSTLESVINRQYNNPLLEfnvpTLRE 183  Pneumo...
EPB88423             285 IASWYLDRAHAAD----SIGLSSSALEICRyarvmgvTGIDE-QVSEYEW---LCKYVY-LAKAKLDQEGAYv---DLKT 352  Mucor ...
ERS99211             200 FEHLPDRLAVARLLSNTgsHEdTLHFVGRDLRGLIGPWLYSDRRWTKRRRGSESsssgavssaetggedkgksaseangl 279  Sporot...
CCD27183             206 FSKMDPIAVFPLILEGG------------DMKKELIPYLQYT-------------------------------------- 235  Naumov...
CCC72177             194 FEKMNATVTFPLILDGK-------------IFHELIPYLDFT-------------------------------------- 222  Naumov...
Q12745               185 WEKMPDSELFKIIFDGVe-DMqGYIGIADVIEDELAPTLSYG-------------------------------------- 225  Saccha...
EJS42638             185 WEKISDVKLFKIIFDGVe-DTqDDGNMRQIIERELIPTLSYG-------------------------------------- 225  Saccha...
EJT42393             185 WKEMPDKKLFNIIVDGA-----EGSNMTEIIEYELIPTLSYA-------------------------------------- 221  Saccha...
EDO16615             190 FENFKPVDIINLILGNIndDEyNLSIDASIIIQELIPYLKYS-------------------------------------- 231  Vander...
CCE61847             193 FEALTPNNVIELLTKNLleNEySFNNKNVQQIDCLISYLNYT-------------------------------------- 234  Tetrap...
WGS:AFWA:PNEG_01189  184 FETLNHKEVIDILLQHL-----ENEEILEEIKSSIIPYISYCQKSSKT-------------------------------- 226  Pneumo...
EPB88423             353 FQRISSYEILEGLLSST-----NAANIVDDMLRLALPWISMANKRKHVNDHNSAkk------------------------ 403  Mucor ...
ERS99211             280 qsslcPGWEEVLQWLTAHAAK--SWRVAARAIEQWDGP----------SDADlggfgtMW--LDDREQEYLEYRYARAAL 345  Sporot...
CCD27183             236 --------KSFTSFL-------------NNFCTVTQFPmdnqenyellDNLId--------iLPSVLPQDEIHTFKTSLL 286  Naumov...
CCC72177             223 --------NLSNEFI-------------ENYFTNENFLlatvqnydifRNIFf--------aFSNETSKSNFDKVCGNVA 273  Naumov...
Q12745               226 --------KKWETFI-------------TEFFNKQQFSlksdtnyqlfIKLY------YSleKGVKDNSEASRKLQSNVV 278  Saccha...
EJS42638             226 --------KKWETFT-------------SEFFNKQQFSlksnanyrlfLETY------YCleNQLKGSNEALRYLQNKVV 278  Saccha...
EJT42393             222 --------NKWETFI-------------GGVFNEQQFSlrsdsnyhwfLKMY------HSleEQLKGDSETLRNLQRKVV 274  Saccha...
EDO16615             232 --------KAYDIFL-------------DIVFNPSVFRfdtavnyynfRQLYs--------lLSNEIPIEFKEKLEELSL 282  Vander...
CCE61847             235 --------NSFTLFL-------------EQKFNTNSFLfkkkqnylvfDAIFt--------kFNESNVMADKENFQKAAL 285  Tetrap...
WGS:AFWA:PNEG_01189  227 -----NIWDSLWSWLLNFSFKqkNLNLI--------------------KLIS----------FNNVISSEKYSEFSKYAI 271  Pneumo...
EPB88423             404 -------eFLLYRWLLDPAVVdaHLDW-CCVVFEHSKPtiavedriikDDLD----------------------LSRLVL 453  Mucor ...
ERS99211             346 ACVYLLPESS---EEAMAAAHAIVGKIIGLLDQD---------PLPA-LP--TDLSLLSPVSTDTdvgtlltpknavYLR 410  Sporot...
CCD27183             287 RIIF---ENSgnlL-KFTTLA----TLSNLVNVT-------------------------------------------ADN 315  Naumov...
CCC72177             274 NILF---ENSsnlL-NFKSLE----ELKNILN---------------------------------------------RIP 300  Naumov...
Q12745               279 DILF---HNSenlF-NLSSLTHKLDELWSILS---------------------------------------------GFP 309  Saccha...
EJS42638             279 DILF---NNSenlF-NLPTLLQKLDELRNILS---------------------------------------------HFP 309  Saccha...
EJT42393             275 YILF---NNSenlF-NLSGLLPKLNELRTILS---------------------------------------------ELP 305  Saccha...
EDO16615             283 KIIY---DNSanmL-NVTSSS----ELEQLLT---------------------------------------------QFS 309  Vander...
CCE61847             286 SIIF---ENSkelM-NIISMD----ELKQLLD---------------------------------------------AFD 312  Tetrap...
WGS:AFWA:PNEG_01189  272 ASCYCLQSTE---EENIHSMKIILQNLKQNLNIE--------------TN--SNTSVLNDIKISSl----------nVFT 322  Pneumo...
EPB88423             454 AIVY-----------SGNGSMEYLVRLFECLPIFddinensndPTDMaAImpKATSPMA--------------------- 501  Mucor ...
ERS99211             411 NDLLSEA-NVLTKPS-RTATKLLHALVLSASLLNKMGASCTIRRAGELA-VLQNE--REQKTEAANAIHWV-ATNGT--- 481  Sporot...
CCD27183             316 SVMLTDY-DNLHYYDlQKYLLFMQNFSKSKD---SF------KDLY-LI-NKGTE--SSQLAHFASICKEElSANANk-- 379  Naumov...
CCC72177             301 KDTPIAK-YDITVADvTEYIRYMEVMLSNY----SL------KEVY-TI-SQEEE--SAQLAHFASSCKEElMAALNnne 365  Naumov...
Q12745               310 DEITIEEqKTITALEmKQFMEFFIKCSTKF----SF------KEIF-AI-TQEEE--SAQLAHFSSLCHEEfNKA----- 370  Saccha...
EJS42638             310 DDITVGDqKNVTVLEmKQFMEFFTRCSTKF----SF------KEIF-AI-TQEEE--SAQLAHFTSLCHEEfNKT----- 370  Saccha...
EJT42393             306 DDISIEEqNNVTVLEmKQFMEFFTKCSTKF----SF------KEIF-AI-TEEEE--SAQLAHFTSLCHEEfSKS----- 366  Saccha...
EDO16615             310 PGTKVKS-TSLTANNlKWFAHYMNLCFQGY----SL------SDIN-AI-CQSSE--QEQLAHFASMVKGKiCNSQSqqt 374  Vander...
CCE61847             313 QNIETA--NGINSKIlLSYIHLISIFLQDY----SL------KEVH-LI-SKENE--ASQLLHYTSMIKAKiMSKGFkts 376  Tetrap...
WGS:AFWA:PNEG_01189  323 PENIQDY-SELITPN-SDSLSLLEIMIKTVLIINSTKEICKITLSEAVCyRNKDK--KSQISLLHKMIPQN-PHFLS--- 394  Pneumo...
EPB88423             502 --IFMEL-QSVGEYGlTQMMDTLQGHLGSAETLARY------NAHVPLRwYLEDQsvEAQRQLCVRMSSQAaGGVESgga 572  Mucor ...
ERS99211             482 -RNDDRYWIKARNEILWLRDWGAddegggtddhAQSTGSGVFGQVKREFIEVEFLKALLTNTRYFLARSLY----EDS-P 555  Sporot...
CCD27183             380 pSINNAKIKDIFDSI------------------VHEDNDMVLSHLTIERKISILLETVLDLGEFDVLEEV---------- 431  Naumov...
CCC72177             366 eSTLSQKLNSLYT--------------------LSNASSSVFNRLSTKIQQSILLETVLDMGQFDILHEF---------- 415  Naumov...
Q12745               371 -NEISSFLQAMYETVL-----------------DISKDDKIFTRISMDEKLYSILEILLQMNEFAYIEAI---------- 422  Saccha...
EJS42638             371 -TDISGFLQSMYETIL-----------------DTNKEDKIFTRINMDGKIYSILEILLQMNEFKYAELI---------- 422  Saccha...
EJT42393             367 -NEISMFLQSLYETVL-----------------DTNKKDKIFTRISANDKIYCILEILLQMNDFRHTEMI---------- 418  Saccha...
EDO16615             375 iDVISNLISE-----------------------SKIKEKQIFTNLTIDKQISIFVEILLELGEFDLLQNF---------- 421  Vander...
CCE61847             377 sSTAVNEILSVITGS------------------ASNSEQIVFTHIPPKRQISVLIDLLLELGEFDLLQDL---------- 428  Tetrap...
WGS:AFWA:PNEG_01189  395 -KLNDSEWIKLRNNIKWLHDVSL-----------------IYKNIPEIEYESFLLYNILRTTKFNLAENIYikrnKGNmP 456  Pneumo...
EPB88423             573 kFDRDDDWRELLDDMIRLNG----------------DGQGIFGKLENAEILEIFFYSLLRCGRFKLAKELI--------- 627  Mucor ...
ERS99211             556 dhpLSNDLVQD------TVLAAALNAYDNASNPNRTRGGLKKCDEIIHTFPLTV-------EKSLPATRRAEALMAATHG 622  Sporot...
CCD27183             432 ------VTQYKekfitkLLLKFFWIYFNNSTNGSKKSLGMTKCRKVLNLLSLEAhtkgrqdLITKEELNSLQTLLDVSDD 505  Naumov...
CCC72177             416 ------MSEYGsnletdLLEKYFWKFFNNATNGSCKRAEMIKSQKTLNLLl----------KQDAKKYERLQSLLDVADE 479  Naumov...
Q12745               423 ---IERFDYSNntqiyeLLVKFFWHFFNNASNGLRKEPEMKKASQTLQIIQKHMs------QRAGTNLTKLEVLLEISDK 493  Saccha...
EJS42638             423 ---IEGFHYDDnaqiyeLLVKFFWHFFNNALNGLRKEPEMKKASQTLQILQRHMt------HQTGEDLTRLEVLIELADK 493  Saccha...
EJT42393             419 ---IERFDYDDdaqmyaLLVKFFWHFFNNASNGLRREREMKKASQTLQILQKHMt------QGVGTDLTRLEVLLDLADK 489  Saccha...
EDO16615             422 ------VTLNNskleenVLEKYFWNFFNNATNGLKSRPEIKKAEKTLQLMd----------VQNSTVYKHLHTLLKVADT 485  Vander...
CCE61847             429 ------MEEQNsqleeaGLEKYFWHFFNNASNGLKSRPEMKKAQKTVKLLl----------EQNEPKFKHLEILLHIADL 492  Tetrap...
WGS:AFWA:PNEG_01189  457 ---LKDVMVEK------ICIEIFLEFFDSSSNGNITKGNMKNAYNLLQTIKQYY-------NSEQ--LESFSYLVKVTNT 518  Pneumo...
EPB88423             628 ---FGSKRIMDmtkaehLVIDAEREFFDNATSGNMNSGSMKQAWDCLKIL-----------PPSTE-IKKEVDLIEATHT 692  Mucor ...
ERS99211             623 L-CDYRLVLKQ---GE---PFTPVVLRVH-TDPLSILGKVLEQNPRSYTNIQALLKIASDIVDA---GLTvrdkagqpal 691  Sporot...
CCD27183             506 L-SKYSMNLGK---GH---IFKPSNILDFeTKETGLISILLESNNSIYKDISVTFEIMKKLNVAmacQCPfinhnql--- 575  Naumov...
CCC72177             480 I-SRYSMNLGR---GI---IFKPSNILDFqEDPYQLISTLLELNSSLYKDILVTFTILKKLYTAlekSSLrs-------- 544  Naumov...
Q12745               494 L-SHYSINLNKshnGArdtAFKPSNILEYrDCPLDIISNLLELNPRLYKDLPTTKSLLFGIYDSlsiNREg--------- 563  Saccha...
EJS42638             494 L-SHYSINLNKtqnGTrdaAFKPSNILEYkNCPLDIISNLLELNPRLYKDLSTTRGLLSGIYESlsiSEGs--------- 563  Saccha...
EJT42393             490 L-SHYSINLSRthtGTrdaAFKPSNILEYkDCPLDIISNLLELNPRLYKDLSSTRGLLSEIYNGlsiSEGc--------- 559  Saccha...
EDO16615             486 L-SRYSINLGK---GI---PFKPCNIFEFkYNPSKLISILLELNRDLYKDVANSMNLIDQLVEAmqiSREhl-------- 550  Vander...
CCE61847             493 L-SYYSINLGK---GV---IFKPSNIFDFkNHPSQIISKLLELNDGLYKDKNTTSLMLKELFEGmnlDITgd-------- 557  Tetrap...
WGS:AFWA:PNEG_01189  519 L-YHYS---------H---KFKPVQIRLH-NNPFEILEDFLSSNPGIYKSIDEVMEICNDLLLStnkNYL---------- 574  Pneumo...
EPB88423             693 LiYEYKVQDHP---GI---TLMPIQIRQS-QNRLELISKLINNRAGMYQRHEQVLELVRKLGYG---------------- 749  Mucor ...
ERS99211             692 tpeqaplQRALAERRVTAMCIDAALTEDDFETAYSYVMSRLanddelpkaqgvnasssYGGAPSa--------------D 757  Sporot...
CCD27183             576 -kpaqkkdVIVAYMRLLTLHIDYSLVNMDFNFAYKLTMELFd---------------kFKTYIGqqsetsgiatderfnL 639  Naumov...
CCC72177             545 ------tnFDYEYDKLLIIHIDHALVNMDFPFAFNMTKELLeremks---------------------------enddlI 591  Naumov...
Q12745               564 -------qTGKVEVDLMVLHIDYALVNLDFGTAYELGKQVFeicqeag------------------------qhmmkalG 612  Saccha...
EJS42638             564 -------qTGKMEVDLMILHIDYALVNLDFNVAYEIGERVFdychkkg------------------------qqmmkalG 612  Saccha...
EJT42393             560 -------qTGKMEVDLMVLHIDHALVNLDFDMAYEMGKRVFefcqemg------------------------pqtmkalG 608  Saccha...
EDO16615             551 -------dRESEYNKILVIHIDHALVNMDFTFAFQKSKELLrr----------------------------------dsV 589  Vander...
CCE61847             558 -------fFVQEQIRVSEFHIDNALANLDFYFAYHESKELLtk----------------------------------seN 596  Tetrap...
WGS:AFWA:PNEG_01189  575 -------YQKEIQAKILCIIAETALSQNEFDFAYDICINHLfslfeavd-----------------------iktrealS 624  Pneumo...
EPB88423             750 -------NDLLAKVKTLAMLASAALVEGDYLESYKLCQITT-------------------TAAVnkdasnhnkkyndevD 803  Mucor ...
ERS99211             758 TWSWRAALEAGKYRRTe--rTVRPTHLgtasaNLQIRHLEQRIECLATALRVAPPDTLQEILNAYRRC------EEELEA 829  Sporot...
CCD27183             640 CDYWLTIYQVGKFIDPnwldNEIPTEI-----------LMQQMKILSKLLYVCPVEEVEPIISYWSGL------ELELSI 702  Naumov...
CCC72177             592 RDHWLTIFQVGKFVDPnwldNEIPTEI-----------LMSQMEVLAELLNVCPVEEIEIITSHWSGL------ELELSA 654  Naumov...
Q12745               613 DEHWLTFYQMGKFVDPnwvdNEIPTEI-----------IVLQMSILGRLLEVCPLEEVEIVTSQWSTL------ELELSA 675  Saccha...
EJS42638             613 DEHWLTFYQMGKFVDPnwvdNEIPTEI-----------IILQMSILGQLLEICPLEEVEIITSQWSTL------ELELSA 675  Saccha...
EJT42393             609 GEHWLTFYQMGKFVNPnwvdNEIPTEI-----------INMQMSILGQLLQICPLEEVEIVTSQWSTL------ELELSA 671  Saccha...
EDO16615             590 STYWATVFQVCKFINPnwidSEVPTEY-----------LILQLELLGDLLSVCPADGLDIVVSQWSGA------ELELST 652  Vander...
CCE61847             597 KTPWATVFQVCKFSDPnwldNETPTEI-----------LVLQFELSSDLLQSCPTEEMEIVISQWSSL------ELELLT 659  Tetrap...
WGS:AFWA:PNEG_01189  625 NIIWKSCLQISKNYET----------------EESLENIKKKMFLLSKVINICPKEYLVEVLNVWKRF------EKEQLS 682  Pneumo...
EPB88423             804 QSAWQICFNLGK--------------------VDAFDDISRRLDVLSMALTLSPAENIGDVLTVWRKLggnsfnQIELAQ 863  Mucor ...
ERS99211             830 A-VKAEDEQETAW 841  Sporothrix schenckii ATCC 58251
CCD27183             703 RdLVNDKYSLEk- 714  Naumovozyma dairenensis CBS 421
CCC72177             655 RdLVKDKYSLAs- 666  Naumovozyma castellii CBS 4309
Q12745               676 RdLVKDKYALDGQ 688  Saccharomyces cerevisiae S288C
EJS42638             676 RdLVKDKYALDEQ 688  Saccharomyces arboricola H-6
EJT42393             672 RdLVRDKYALDGR 684  Saccharomyces kudriavzevii IFO 1802
EDO16615             653 RnLIDDKYSIENM 665  Vanderwaltozyma polyspora DSM 70294
CCE61847             660 RdIINDQYSIgns 672  Tetrapisispora phaffii CBS 4417
WGS:AFWA:PNEG_01189  683 I-RSKKLSEFNDn 694  Pneumocystis murina B123
EPB88423             864 LsASNNNNDqnls 876  Mucor circinelloides f. circinelloides 1006PhL
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