Conserved Protein Domain Family
Inhibitor_I29

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pfam08246: Inhibitor_I29 
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
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PSSM-Id: 336973
View PSSM: pfam08246
Aligned: 60 rows
Threshold Bit Score: 39.9567
Threshold Setting Gi: 74876166
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q75PZ5        55 RLYKRKYNKRD----EEINLEHRRFMTYLKNVKEIEKHNeryERNEETYELAINHLADMLPEEF 114 Brugia malayi
Q9VKY4        37 EKFKNNNNRKY----LRTYDEMRSYKAFEENFKVIEEHNqnyKEGQTSFRLKPNIFADMSTDGY 96  fruit fly
Q7K0S6        39 DDFLRQTGKVY-----SDEERVYRESIFAAKMSLITLSNknaDNGVSGFRLGVNTLADMTRKEI 97  fruit fly
Q17IZ6        32 DTFLGAYQKKY----KAKYRMDRRKRAFKKNMQEIEEHNanyEQGKSTFQMGVNELADMDKSSY 91  yellow fever mosquito
Q4DC63        56 DRFLQEYGKKY-----DAREYVRRRALFEQTLARVRTHN---EAGNHLYVMGINHMSDWTPEEL 111 Trypanosoma cruzi
Q9VNK6        31 DQYKAKYNKQY-----RNRDKYHR-ALYEQRVLAVESHNqlyLQGKVAFKMGLNKFSD-TDQRI 87  fruit fly
XP_004039664  33 DQYISDYSKNYa---KGTREYDQRKIIFESKLQEILSHN---QNTSHTYKRGINAFTDMSHQEF 90  Ichthyophthirius multifiliis
CDP97174      90 KDYVTALGKHY-----DQKETNFRMAIFESNELMTEKINkkyEQGLVSYTTALNDLADLTDEEF 148 Brugia malayi
XP_002901472  41 VDYALDYEKSYrndaNDHDVVQLRFRSFATNLERIQTHNeayERGEHSFTLGLNDLADLADAEY 104 Phytophthora infestans T30-4
XP_001633385 246 DKYVKKHKKNY----KDNKEHHTRREHFKHNLRFIHSKN----RRHAGYYLAMNHLGDRSDKEL 301 starlet sea anemone
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