Conserved Protein Domain Family
RNA_polI_A34

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pfam08208: RNA_polI_A34 
DNA-directed RNA polymerase I subunit RPA34.5
This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription.
Statistics
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Aligned: 79 rows
Threshold Bit Score: 62.3879
Threshold Setting Gi: 74625889
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKM83192      71 DEDVEVWVIRVPESIKPKHLEGLSFDLDEptsspsrRKKRTTA-LigslKRKHNSYDIWSL---------GDdhdedqge 140 Agaricus bispor...
Q6BWD0        42 QNDKEIWLIKTPKGFPLKNLK--TLPVSFta---tsISNGPSR-F----NLNQKNFQVNEE---------Llg------- 95  Debaryomyces ha...
XP_001486103  44 RDNREIWLIKTPKGFPIEKLQ--TLPVSFgltskngLNTSAAT-F----KVENRSFQLYEE---------Sfa------- 100 Meyerozyma guil...
EDK42278      49 DNDKEVWLIKTPKGFPIHKLK--SLPISFk------kSKKAEA-F----EVNDHLFEISEE---------VTagkqa--a 104 Lodderomyces el...
CCE41956      44 AKDKEIWLIKTPKDFPLEKLK--TLPIAFt------kNRVAEP-F----DIVGSTYQVEEE---------LSstsas-ti 100 Candida parapsi...
Q5AP67        45 LKGKEVWLIKTPKGFPLTDLK--KLPISF-------SGKSAES-F----KVNNLSYQVTED---------LGas------ 95  Candida albicans
EER32886      51 LKGKEVWLIKAPKGFPLKDLK--TLSVAK-------KNKGNES-I----KVNKISYKIDED---------FDid------ 101 Candida tropica...
EGG13616      31 qSKDQLWLMKLPKNFDINDLNGLQFTSSI-------NNIKSDG-T----SIGDSKYTITQEkn----------------- 81  Cavenderia fasc...
Q552C9        27 iDGKELWLIKIPRDLPYESLPN-KIQVSD-------LNKVNVKsI----DINKKKFTIHQD---------DT-------- 77  Dictyostelium d...
XP_011273772  27 LDKKEIWLIKTPKGFKFDGLT--KIPINF-------NPNGTSLdF----SKDSKNYNIQEDltnfnsnlsGKs------- 86  Wickerhamomyces...
EKM83192     141 kttEPtslIGGDELkslscLLPRNTKNGKLY-AApKPIARHILVSAQPAQPTTTSTDSDsptemVYTNP-PRENyPPElL 218 Agaricus bispor...
Q6BWD0        96 --tDT---ESSKYA-----VLTNENKKNFKI-VG-QDISRFYNIRESVDIPSIAMDEV------VKPRK-NIKE-IKN-L 154 Debaryomyces ha...
XP_001486103 101 --aES---EAHKYS-----ILGHKGENQLEP-VE-KTIDRFYNISEKIAIPDINYEKV------VIPRK-DVEK-IDG-L 159 Meyerozyma guil...
EDK42278     105 sgdDD---EDKKHT-----IFKAGKSDTFRP-TS-YKISRFYNIRETVKIPEINFEEA------VVPRK-DVPQ-IEG-L 165 Lodderomyces el...
CCE41956     101 ipsTE---INNKHT-----IF-KAKHDSFRP-TD-LKISRFYNIKEVVNIPQIDFDKS------RIPRE-DVPQ-LKR-L 160 Candida parapsi...
Q5AP67        96 --aSD---TNNKHT------IFSSKKRSFRP-LG-EKISRFYSIHEVVDIPEIQLDKV------VVPRQ-NVPK-IKK-L 153 Candida albicans
EER32886     102 -------nDSNNKH-----TLFASKKAGFKP-ID-AKISRFYSIHEVVKIPSIDLDKV------VVPRE-NVQK-VKK-L 158 Candida tropica...
EGG13616      82 --iEE---IQSLVN-----VWYEKGSQGEMK-IG-IPFSKYITVEETIDIPETTATL-------EPTKK-TIQD-LSE-L 139 Cavenderia fasc...
Q552C9        78 ---EQ---IQGLFN-----VWSKNSNNGKMG-LG-KPFTKFIQIDESVNLPKEQ----------VEPKPlPKPKqQHDlL 134 Dictyostelium d...
XP_011273772  87 --eDV---SSKYSL-----LIPKETKNGLKIqNS-LKINKFYNIKESVSIPDINYGKVI-----KKRKN-IR-T-IKG-L 146 Wickerhamomyces...
EKM83192     219 THRFMPYGSLVKTSTDSDNDEDEndtavtsrmdnevvmtevdsnvqsDVAKKEERAIKSSSSKKKDkkveeeedieVEEE 298 Agaricus bispor...
Q6BWD0       155 RMRHFPTGYGAedfde--------------------------akpqgGDVNASDTDSEDDGKIVKK----------AKIE 198 Debaryomyces ha...
XP_001486103 160 VMKHYPTGYGAsdfe----------------------------earaPKRTASHSENGTHKKRKTE----------SESG 201 Meyerozyma guil...
EDK42278     166 RMRHFPTGYGQKDYGLMAESGKRkkneddeke------ekeeeeeedRSRDIEEGKILKRAKVDKD----------EGSP 229 Lodderomyces el...
CCE41956     161 RMRHFPTGYGEKDFKVtyddd----------------------dsdvEEGKAVKRTRKEEPAFDEP----------HKEK 208 Candida parapsi...
Q5AP67       154 RMRHFPTGYGADDYQFDKEEEEEeeees--------------enddvEAGKVLKKAKV------------------EEKE 201 Candida albicans
EER32886     159 RMRHFPTGYGAKDYQIDGAQEEEsed-------------------edVSSGKVLKKARVESKPQAD----------DEED 209 Candida tropica...
EGG13616     140 KGAFRPPGGKYQLNNTIPQDVLEkmnkk--------------kkkstSTSTTSTKKQQPKQQVEEE----------EKSS 195 Cavenderia fasc...
Q552C9       135 KGRYDPPGSS-GFLEKLGKESKNkniki--------------nkptkPTTTTKTTTTTTTTSKTAE----------KENK 189 Dictyostelium d...
XP_011273772 147 KPQHFATGY-DRVEEDVASDAEDveikd--------------eekdqDGDLKIDDDEAKVEAKKEK----------KDK- 200 Wickerhamomyces...
EKM83192     299 RQKEKKEKKKSGRKrkg------------------eegVSPKKSKKS 327 Agaricus bisporus var. burnettii JB137-S8
Q6BWD0       199 EKSKSDKKDKKEKKekkek--------------kekkeKKSKKEKKD 231 Debaryomyces hansenii
XP_001486103 202 EKEKKEKKDKKEKKekkekke-----------kkekkdKKDKKEKKE 237 Meyerozyma guilliermondii ATCC 6260
EDK42278     230 RKDKKERKEKKEKKekke-----------------kkdKKDKKEKEK 259 Lodderomyces elongisporus NRRL YB-4239
CCE41956     209 HSSSKHQKENKDKKekkek--------------kekkeKKEKKEKRE 241 Candida parapsilosis
Q5AP67       202 EKEAKHKKDKKEKKdkkdk--------------kdkkdKKDKKDKKK 234 Candida albicans
EER32886     210 IKEKKTKKDKKEKKdkkdk--------------kdkkdKKDKKEKKK 242 Candida tropicalis MYA-3404
EGG13616     196 KKKKSSKKDDKEKKsskkkeesdeemkevaseeeestkKSNKKDKKK 242 Cavenderia fasciculata
Q552C9       190 KENKKEKENKKEVKkqesesesese---dkkksskndkKSSKKDKKS 233 Dictyostelium discoideum AX4
XP_011273772 201 ------KEKKEKKEkkekke------------kkdkkdKKIkkekk- 228 Wickerhamomyces ciferrii
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