Conserved Protein Domain Family
NUC194

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pfam08163: NUC194 
NUC194 domain
This is domain B in the catalytic subunit of DNA-dependent protein kinases.
Statistics
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Aligned: 21 rows
Threshold Bit Score: 326.977
Threshold Setting Gi: 780185494
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KOF80019      270 RKFVIKKVCLPFLRNMSKIPFVEFLKSNIPAIVNIVEAEITQLSe-dLMEQHLTDKMCCFQILEIMYRSMDVKELNGPGS 348  Octopus bimac...
EDO34281      206 RLAVLDRVSVTLLCNASKAGVSEFFSSHVKEIMEIIEAKQLKTYd-pGFESQLVSKMCAFRMIEVLYSRLGKAELNSPQS 284  starlet sea a...
EDV28309     1748 RRAAIERVCLPMLQKASLKITKDFYVSHIKEIMDIIEAKLVKTAd---LENQLISKLGSYKLMKLMYSKLSKQDVNTAES 1824 Trichoplax ad...
EGD81392     1699 RRGVAQRVLATFLQACKLSMCSAFYIKRLPAIMSLMSQDTPLTSt-----pAIVIKMCTFTLIDILFQRLNTTDLYGKSA 1773 Salpingoeca r...
5_pfamImport    1 RIASLQRFCLPLLQHSNAIAFNNFFLENVKQIMKTLESNEDKNYe-eRLKNQLVSKIGGYQLISVMFNRLNKDHIYGKGS 79  
KMQ98034     1596 RLDVLHRFLLPTFKFCDTIAIERFFERNIRQLHDYAYPFIGATDe-tRTKEIIVSKIGCFQLITIMFATVDMNKIVGVNA 1674 Lasius niger
EFZ21533     1449 RLDILQGFLLPAFQFCDAIAIERFFKKNILDLREMID---KDVHdddAVKQIIVSKIGCFQLIAVMFTRVDENKIDANGT 1525 red fire ant
XP_012056011 1494 RLDILHGFLLPAFKFCDSIAIERFFDRNYKVLYDYYIDFLNIFNnddAIKQKIVTMIGYSQLLTIMFARVDKNKIQANES 1573 Atta cephalotes
KYQ60250      493 RLDILHGFLLPAFKFCDSAAIESFFDYNYKVLYDYYIDFLNISNd-dAIKQKIVTMIGYSQLLTIMFARVDKNKIQANQT 571  Trachymyrmex ...
XP_016659149 1672 REMISNIFLIPIMSCCRKNVITKIYTDIIDFILKTVNENLLANDs-gKARHLLISKIACFKLIEEMFKFFTNIELN-DGC 1749 pea aphid
KOF80019      349 EVNFVYCKAQ--NIEaqkivG-KELTKVITRIAHQTKKE--DMRG-ETLYLELHRQVHCAAYNLLIAIISCTQTDLKFYN 422  Octopus bimac...
EDO34281      285 SINLAYCPND--NT------G-KELTKAITKSAHAAKSE--DMRG-ETVAFELRRQLHCAAYNALLALISCTQTELKFYT 352  starlet sea a...
EDV28309     1825 SIVKAYTGRP--TED-----G-KEITKSITKAAHACKSD--DLRG-ETRSVELHRQCCCAAYNALISVISSTQTEMKFYT 1893 Trichoplax ad...
EGD81392     1774 VINKTYCEAAgePVNd---kG-SNLTTN---TCRALR-D--TVTG-EESLVELRRQASCAAYNALTTVICKTQTQEKFYS 1842 Salpingoeca r...
5_pfamImport   80 ALNQKFCGGI--NCN-----G-NELTKAVISCGNVTRKF--QLCNcSANVVELRRQQNCAAYSMLIDVICCTQTDIKMFN 149 
KMQ98034     1675 TIARNALHQ---IEN-----D-RQLLQNLFKRARDMRAL--RIT--QSGCNELTRLLHCSAYNCSLAIINLNEKE-KTY- 1739 Lasius niger
EFZ21533     1526 ITPNELDQI---LID-----R-NHYKEMFVSVMRNAQKN--LRIT-RPGCQNLVRLLHCCAYNCSLAILSLKKEE-RFYS 1592 red fire ant
XP_012056011 1574 TMQNPGSNLK--ILIk----R-NDYQQ-LVKSTIKIFQK--SIKW--SVHQEFIHQLQCSLYNCLLAIISLKEDE-IFYR 1640 Atta cephalotes
KYQ60250      572 TIQNPGSNTS--ILV-----K-RNDYQQLGQITKKMQMKirKFRW--SVCQKLVRQLQCSLYNCLLAIISLKEDE--YCY 639  Trachymyrmex ...
XP_016659149 1750 TIPYTYIGSQ--SKN-----LiTQFRTSAVKVRYSNV-D--YTKG-SNKIKHLFRQLHCSSYNALITIISNTEDDHNKYT 1818 pea aphid
KOF80019      423 VFLFAENEEKKEFLLDNVIDKEKKYSFPIVFE-MQPKKETIFLTLQK-EIK-------QKVVADASQSASY-HLSSVYLE 492  Octopus bimac...
EDO34281      353 AFLFNENPVKGQFLLDNLIDTDRKYEFEVELS-TPLERKKQMTSIRI-NARvq----sDQVEEALSQGRSVrYLSSQYLA 426  starlet sea a...
EDV28309     1894 VFLFTENVARKQLLWENLIDMEREYAFEIELS-YQDKQKTTFRSLRE------------QSRSSVSMAPSY-HLPSQYLA 1959 Trichoplax ad...
EGD81392     1843 AFCFKEATGKVRDCVFNLIDEKRKYTFTTELPaAMSVRSKCVLALREgEATp-----sTTAAATA---AARrYLPSQILA 1914 Salpingoeca r...
5_pfamImport  150 GFLFNENASKGEIFLDNLIDINKKYQFDLELE-ELFKRKRQFVRVRK-EALehkraemIDADIDNEFPQSVhYVTSQYLY 227 
KMQ98034     1740 GAVFGENSAEDLLIWKNIVDLDKRYQLGQTFK-EHPKTREIAVNIRS-----------TTFSMDGSR-HRYaYVHSYDLS 1806 Lasius niger
EFZ21533     1593 -YAFDK---KKLFNW-KIIDCDVQYNLRQTVK-EYPKTRKITVNIRS------------QVDKNERQTHRYaYVHSYDLS 1654 red fire ant
XP_012056011 1641 VVF-------DTFGWEKIVDCRTQYTFGQSVK-DYPKTREITVNIRS-----------AEIEREE-QTHRYtYIHSYDLS 1700 Atta cephalotes
KYQ60250      640 RIVFSE-----PYVWEDIIDCRTQYELDQIFK-EYPKTHEITVNIRS-----------AEVESEERQTHRYtYVHSYDLS 702  Trachymyrmex ...
XP_016659149 1819 IFLFNERPPK-QFIWRNLVDCTIRYEFPIDFE-KVPQRKKKLINIRT-KSNq--------------NIPEV-YIDLSSHL 1880 pea aphid
KOF80019      493 KSSLSVDIGRY-DYLSSNve------hQ-EIPSISEEEN----------SANSSAISEEKTRGY---------ALEMDEI 545  Octopus bimac...
EDO34281      427 DSSLSEEVSQF-DFSTPV-------------------QV----------NIINYLKRTGKPDQLgedsyeigeDVEMDEL 476  starlet sea a...
EDV28309     1960 DSSLNEEISQF-DFNSSTv--------Q-GYSENNSIKQ-------------IPTRETGDSEKFad------eELELDDL 2010 Trichoplax ad...
EGD81392     1915 DSSLSQDAAQLeALRQGAdvgesqaveD-ASSSSSSPPSsdgptfgldmDASEDSPGAPSNIPVyvv---edsQMEMDEL 1990 Salpingoeca r...
5_pfamImport  228 GSSLSEEVSQF-DFSSSN---------Q-VFIGEKPKTQ-------------IDTSSEEVYEEV---------TLELDEL 274 
KMQ98034     1807 ASTLCEDINAY-DFNRSV-----------LLPFNRHHPA-----------SARNLGDSHGATSV---------VLENDDF 1854 Lasius niger
EFZ21533     1655 ACTLSEDINAY-DLNKCVvl------pS-NFRHSASTTN-------------SDSLRTHDTTSF---------LNNDEHF 1704 red fire ant
XP_012056011 1701 SCTLSEDINAY-DLNKCVvl------pA-DFRRSTPIMN----------SADSDSLHTHHATSI---------TLTNNDF 1753 Atta cephalotes
KYQ60250      703 ACTLSEDINAY-DLNKCVvl------pA-DFHRSASTMN----------SADSDPLRTHNATSI---------TLTSNDF 755  Trachymyrmex ...
XP_016659149 1881 KNTLVEDLGSY-DYNNSYl--------RsNFVEDCSSPN---------------SQSLHKMFSV---------ELEMDSF 1927 pea aphid
KOF80019      546 NQSECMLPVVAVLKHMYQQNITPKEN----------AEMPPWMYYLHKKFTASSTH-LNIKLFIAKLIVNT-AEIFEKYA 613  Octopus bimac...
EDO34281      477 NSHECLTKICSLLTHMKESNISPQPDkga-----lpKDMPSWMSALHKKLTNFETH-LNIQLFIAKVIINQ-SQVFEPYA 549  starlet sea a...
EDV28309     2011 NKHECMEALLTLLDHMAVNKINPAIEkdt-----tpSEMPSWMVALRKKASDHTTN-RNIKLFIAKLIINR-PKIFRPYA 2083 Trichoplax ad...
EGD81392     1991 NSHESMVSLMGLIQRIQAVHAESKPQrnedglilpsSTMPSWMSNLLKSFESTSTS-HNVRLFIAKLITNM-PDAFQPWS 2068 Salpingoeca r...
5_pfamImport  275 NKHECMATMNALLRHLYTSNMISNTE-----------QLPTCVQKLVNKLKCNVTH-ENVKLFVIKLILNN-SKIFEPFA 341 
KMQ98034     1855 NEHECMPYICVLLRRIREICVs-------------sNELPECMKLFCNAMPN---H-PNITLFLLRIVWNTaDDVFKPYA 1917 Lasius niger
EFZ21533     1705 NEHECMPYICVFLRHIRKVFKl-------------sDKEPEWLTNFLDVIQLDN---QNIQLFMLKVILNTaDDVFKPYA 1768 red fire ant
XP_012056011 1754 DKHECMPYICVLLRHIRKIFGSTN------------TEIPKWLEYFLNTIQHNNLH-ANIQLFMLKIISNTaDEVFKPYA 1820 Atta cephalotes
KYQ60250      756 DKHECMPYICVILRHIRKVFVSTNTE-------------PKWLTCFLNAMQRDNLH-ANIQLFMLKIISNTaDEVFKPYA 821  Trachymyrmex ...
XP_016659149 1928 NNHECMAHLCAVIKYLSSENMIGSAMkp-------nVDMPDWMNNLKLVFCDKATDtINSKILLIKLIINC-ETNFEPYA 1999 pea aphid
KOF80019      614 SFWVLPLSEFII--CGNFEe--kGINYFVLDIIVMILSWGENSIP 654  Octopus bimaculoides
EDO34281      550 RFWLSPLMELILklIEEEGenkrGLNYFVVDLLVTILSWATTAIP 594  starlet sea anemone
EDV28309     2084 KFWLVPLIQLII--EGKESd---GIHYFIVDLMIVLLSWADVAIP 2123 Trichoplax adhaerens
EGD81392     2069 SRWLRPIMLLIL--KFQDEpetpGFNYFVTDLCLLLLTWADTAVP 2111 Salpingoeca rosetta
5_pfamImport  342 KFLLEPLMQMII--NGVTGg---rLNYMTNDVLVMILRWAQITIP 381 
KMQ98034     1918 KFMLTPIVKTVA--NYLERy---dLNYIITDILEILMDWHDVAVP 1957 Lasius niger
EFZ21533     1769 RFALTKIIKAVA--KYLQQy---hLNYIITDILVILMDWHDVAVP 1808 red fire ant
XP_012056011 1821 RFALTKIIKTIA--NYLQGn--nNLNYIITDVLEILMNWHDIAIP 1861 Atta cephalotes
KYQ60250      822 KFALTRIIKTIA--NYLQGn---NLNYIITDILEILMDWHNVAIP 861  Trachymyrmex zeteki
XP_016659149 2000 KHWLCPLMEFVL--DKHLGn---NLNYVITDVVSMLVSWHNIAVP 2039 pea aphid
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