Conserved Protein Domain Family
NUC194

?
pfam08163: NUC194 
NUC194 domain
This is domain B in the catalytic subunit of DNA-dependent protein kinases.
Statistics
?
PSSM-Id: 336943
View PSSM: pfam08163
Aligned: 33 rows
Threshold Bit Score: 268.808
Threshold Setting Gi: 674587886
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
A0CIS1       1692 VRIALGNKLLIPLLS--NSNLLLE-FYSEFTPYLLQQLNVtwdd--nwkNMLFQ----------LQWRGLIFDLFGIAYK 1756 Paramecium te...
Q54UC0       1981 LKITLIDKFCVPLIShmKENILVQ-IFSQHLSSLMSIIQPlqp---kylSDSQErk------ssIIEKICCFHLIEALYQ 2050 Dictyostelium...
EFA79656     1821 LKITLIDKFCVPLIGhmKQQVLIQ-LFAQHLSSLMSIIQPlap---kylATAIErk------ssVVEKICCFKLTQQFYE 1890 Polysphondyli...
XP_004350354  796 LKITLVDKFCTPLIAkmTQPSLIH-LFTLHLTSLMSIIQPlvp---kymTNSGErk------ssIIEKICCFHVIEAFYE 865  Dictyostelium...
XP_009009260   23 hRKSIFYKIFYPTLEsaTEEALLEdYFIAHVLDIMSTLNKkip---yhlDVKLDs--------hFLNKICCLDLITLFYS 91   Helobdella ro...
XP_002680550 1956 IRRQIIQWVCLTCLThmPERGLVQ-FFEDNIQKLMKSIAKptalsetisNPNIEeleadsvralFVTRTCCYNLLEAMYR 2034 Naegleria gru...
XP_001765725 1860 LRRAVVEVIFEAFVNssSMEFVTV-WYSQHISDLFYVLKQsssm--lsaEREFEd---------LFKKICHYELLELLYS 1927 Physcomitrell...
XP_016659149 1671 rREMISNIFLIPIMSccRKNVITK-IYTDIIDFILKTVNEnll---andSGKARh--------lLISKIACFKLIEEMFK 1738 pea aphid
EFN85096     1308 eKLDILHEFLLPAFDhcDAPTTER-FFERNIRELHAISRRnis---dsiNSELD----------LVSKIGCYQLMAIMCT 1373 Jerdon's jump...
EPB89690     1808 ihkkNITKVLLVLLKgaNEGHVIA-FFKEHLGYILGVVSQp-------vDRDTDsl------ddLHMKANCLCFMQAYCN 1873 Mucor circine...
A0CIS1       1757 RMSTEQIKK-------QLHQNLKf--------QADNEITKKLIVDCNKASKfkfekinilninqkeilSQ---VNY--LK 1816 Paramecium te...
Q54UC0       2051 SLPSAIIKE-------KINPFFYdk-----pdGKGTELTAAIMKAAHSAKSekl-----------tsdDK---YVT--RS 2102 Dictyostelium...
EFA79656     1891 SLPATVIRD-------QVNPYFTgdk----hdAKGTELTAAIMKAAHLAKSekl-----------atdEQ---HVT--RV 1943 Polysphondyli...
XP_004350354  866 AMPSTTIKD-------NVNRYFYdk-----pdAKGTELTAAIMRAAHSAKSekl-----------asdDK---HVT--RP 917  Dictyostelium...
XP_009009260   92 RLSKDSLHSlt----sKVNSEYCkhfc--vtdIKGKELTTSIIRTAKDFKSddyhski----nshkttPS---SPLddFE 158  Helobdella ro...
XP_002680550 2035 LLPASAVKE-------YINNKYCekqssgsgqLTGKELTEKVMRSSFAARSwk-------------psDQeykVLG--YE 2092 Naegleria gru...
XP_001765725 1928 KADNVSITK-------TIAPVFT-----------SSDLMRQAGDTCHGKLDpe-------------ykLY---PEN--LS 1971 Physcomitrell...
XP_016659149 1739 FFTNIELNDg-----cTIPYTYIg--------sQSKNLITQFRTSAVKVRYsnvd----------ytkGS---NKI--KH 1790 pea aphid
EFN85096     1374 RLEESKIVDan----gTIVRNAGld-----nvQDGRELVQSLFKDALNVRKlk---------------iQ---IRC--RD 1424 Jerdon's jump...
EPB89690     1874 LIPTEVIGHggeldnvWVNCKENkg-----htAVRQEMSK-VMKGLHAAIKhdi------------trLT---PER--RE 1930 Mucor circine...
A0CIS1       1817 IVEDYQSSAFITYIYVLMKTQTKENIFYAHLFKKERDIS--Y--WDNFINKEWQF-NFQVETNFE---EKPLYTEVKKqQ 1888 Paramecium te...
Q54UC0       2103 LCTKYHGAAFSALASVIVSTQTKENFFHVFFFKENKDKNeyL--WENIIDTDQVF-NFQPETNFLv-sYSTPQSLFAN-D 2177 Dictyostelium...
EFA79656     1944 LATKYHGAAYSALASVVATTQTKETFFHVFFFKENKEKN--EylWENIIDLEQQY-NFEPETNFq--iSSQLSSAV---- 2014 Polysphondyli...
XP_004350354  918 LCTLYHGSAYSCLASVIAATQSRENFFHTFFFKENIEKN--EylWENIIDTEKVY-NFEPETNFTv-nSKVDMNSIARrn 993  Dictyostelium...
XP_009009260  159 MQRLLNCSSFNTLSHVLMRTQTDVKFYTAFLFTENLAKG--EiiWENLIDTKRLY-KFSIEITDAe-aRKMKYKTLRKqI 234  Helobdella ro...
XP_002680550 2093 LLLDFRTSAFNVLAGGVKCTQTQEKFYTGFLFKE---KE--EdlWENIIDTNREY-KFEIETNFAf-hRK-AVDELRIdS 2164 Naegleria gru...
XP_001765725 1972 TWRELHAAAYNCLAAVILCTQIDEKWFNAFLFSE---KS--RplWQHLVDLTKVYdDMSVETSQSs-iISQTVKGMRAdL 2045 Physcomitrell...
XP_016659149 1791 LFRQLHCSSYNALITIISNTEDDHNKYTIFLFNERPPK---QfiWRNLVDCTIRY-EFPIDFEKVp-qRKKKLINIRTkS 1865 pea aphid
EFN85096     1425 IVRLLHCSAYNLTLAITS-LKEDEQFYN-IVFAENRDRG--MfiWKNIIDCEKHY-QLSQICGNSkshCRETTVNIKSsV 1499 Jerdon's jump...
EPB89690     1931 AIINFHREAVNAFGTFVMRVVNKEKLYEAVF---RMGST--DfiWDALIDPEE---PIYLDMLFAqplLKKKLDAFFNsK 2002 Mucor circine...
A0CIS1       1889 ----Q----DY-----------F-------------------------Qek-----------------ivKN-YLYTASL 1906 Paramecium te...
Q54UC0       2178 ----L----RY-----------L-------------------------S---------------------SQ-YLVDSSL 2191 Dictyostelium...
EFA79656     2015 ----------------------Ansq-------------------srdLky-----------------lsSQ-YLQDSSL 2035 Polysphondyli...
XP_004350354  994 l---------------------------------------------qdIky-----------------lsSQ-YLQDSSL 1010 Dictyostelium...
XP_009009260  235 ----R----IHtqgkpgvdaedEeed-------------------ndnVqy---------------------lsTLDSSV 266  Helobdella ro...
XP_002680550 2165 ----N----QPtsd-----ngkRkag-------------------elrIgylssqylsdsslsssmpfagSF-FIPGSKY 2211 Naegleria gru...
XP_001765725 2046 ----KarrtRG-----------Kgsl-------------------sqtAst-----------------isSQ-YMHSASL 2073 Physcomitrell...
XP_016659149 1866 ----N----QN-----------IpevyidlsshlkntlvedlgsydynNsy-----------------lrSN-FVEDCSS 1908 pea aphid
EFN85096     1500 idggR----EG-----------Qass-------------------qhrYsh-----------------ihSY-DLLTCSL 1527 Jerdon's jump...
EPB89690     2003 ----E----RKn----------Nkae-------------------rpsIyy-----------------mdSIdIMGSRYL 2028 Mucor circine...
A0CIS1       1907 --SVE-------QVtETTmeieeenENLQS------------------T------------------------------- 1928 Paramecium te...
Q54UC0       2192 --SQDfiaknflEGdNNS-------TTNNNngddgiimqgqsqsgdneN------------------------------- 2231 Dictyostelium...
EFA79656     2036 --SQS-------------------------------------------L------------------------------- 2039 Polysphondyli...
XP_004350354 1011 --SQD-------------------------------------------A------------------------------- 1014 Dictyostelium...
XP_009009260  267 --SADltqlipksn-------------------------hfsvnksvpH------------------------------- 288  Helobdella ro...
XP_002680550 2212 --SEE-------------------------------------------Vtkssedesk---------------------- 2224 Naegleria gru...
XP_001765725 2074 --SQE-------------------------------------------Pavirtfvggirkeetsaagvgagllldeesp 2108 Physcomitrell...
XP_016659149 1909 pnSQSl-----------------------------------------hK------------------------------- 1916 pea aphid
EFN85096     1528 --NEEinaydfnksvll--------------------pasaaipcgrsA------------------------------- 1554 Jerdon's jump...
EPB89690     2029 --EED-------------------------------------------I------------------------------- 2032 Mucor circine...
A0CIS1       1929 -----------------V---------------------------------E---------------------------- 1930 Paramecium te...
Q54UC0       2232 -----------------Q---------------------------------I---------------------------- 2233 Dictyostelium...
EFA79656     2040 -----------------Dvdtsssttststtt------tsnnnnlkivasaM---------------------------- 2068 Polysphondyli...
XP_004350354 1015 -----------------S---------------------------------Isgrgafiapapvghplatfddimyqqqq 1044 Dictyostelium...
XP_009009260  289 -----------------Q---------------------------------S---------------------------- 290  Helobdella ro...
XP_002680550 2225 ---------esektpnvD---------------------------------N---------------------------- 2234 Naegleria gru...
XP_001765725 2109 stetnietaeqepaeeiI---------------------------------E---------------------------- 2127 Physcomitrell...
XP_016659149 1917 -----------------M---------------------------------F---------------------------- 1918 pea aphid
EFN85096     1555 -----------------T---------------------------------I---------------------------- 1556 Jerdon's jump...
EPB89690     2033 -----------------DmegnatieanqtgntdntnstndtnntnntnstE---------------------------- 2067 Mucor circine...
A0CIS1       1931 ------VQKIEMDEVNKHKLMIPMLSLIDFMANKQNFQQQIAGQQqtqqtq--qqeeeMPSWMTAIKQVFNDd-S-LY-- 1998 Paramecium te...
Q54UC0       2234 ------SNDIEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFgqqsqqpkptvgdMPKWMFEIYQKLQQ--G-VH-- 2302 Dictyostelium...
EFA79656     2069 ------NMPIELDKINSNPSMQPMLKIIDIYQERFRESIDQSpn-------------dMPKWMNELYLKVKNd-TnLH-- 2126 Polysphondyli...
XP_004350354 1045 rkyaklNENMEMDEINSNPSMLPMLHIIDIYQDKFKLDSNSn---------------eMPKWMTELYNKAKDs------- 1102 Dictyostelium...
XP_009009260  291 ------TPTLDFDEMNCHESMQTLMTIIHHINENIAPFQSSPTSAa------------aPTWLSCIIEKISSp-S-TR-- 348  Helobdella ro...
XP_002680550 2235 ------SSTLEMDEVNTNPCMASILRTVDHMVSIFKYPVGSDKAAan---------saMPSWMAEMHKKLNNd-E-TH-- 2295 Naegleria gru...
XP_001765725 2128 ------TTALDRDDFDQHECMPVILRLAEHVHVKFGANYQpg---------------vMPDWMKSLHATLDNa-A-TH-- 2182 Physcomitrell...
XP_016659149 1919 ------SVELEMDSFNNHECMAHLCAVIKYLSSENMIGSAMKPNVd------------MPDWMNNLKLVFCDkaT-DT-- 1977 pea aphid
EFN85096     1557 ------NVILESDDFNEHECMPNICGILQRFSSLKKPEKMTK----------------LAECLNYFVLGLQKd---VP-- 1609 Jerdon's jump...
EPB89690     2068 ------DINLEIDQLNDNSFMPVFTEMIKKLSEFQDKKQDNDMEIdne-------nkpMPSWMVGLRYAFNHy-Q-TPqy 2132 Mucor circine...
A0CIS1       1999 ----LSLKIFMLKLIINKS-DIFNRYASGWIGVLLDYCTKENKinG--------GKG--FHYFLRDVIVVLIKFSQKLEV 2063 Paramecium te...
Q54UC0       2303 ----PNIVIFMIKIIINRP-QYFERFHELWIPILMDYVVSEGN--G--------GNG--LHYFVRDVCFILLKWPNIYKS 2365 Dictyostelium...
EFA79656     2127 ----PNILIFILKVIINRQ-QYFYRYHKQWTPILIEYVISNQT--G--------GQG--IHYFIRDIAMLLLSWPNIYQD 2189 Polysphondyli...
XP_004350354 1103 -------------LLINRP-QYFEKYHRQWIPLLIDYVISPAT--G--------GKG--FHYFIRDVCLIILKWPNIYsl 1156 Dictyostelium...
XP_009009260  349 ----WNVVIFLVKVIVNCQ-QILKYFASFLIGPLLKVAQDCRL--Y--------EHG--SNTISNDVVVMLLLWSDAAKP 411  Helobdella ro...
XP_002680550 2296 ----RNIKLFLCKIITNRP-TIFEPFSKYFFEPIIKFIMKEED--DqkknedlsSKG--ITYFIRDLIILLLKWKDVSps 2366 Naegleria gru...
XP_001765725 2183 ----INVRLFLAKVITKTR-KIFAPHAADWIRPYVQTILIDPR--K--------SGGlkFHYMLRDICVTILQWNVASAP 2247 Physcomitrell...
XP_016659149 1978 ----INSKILLIKLIINCE-TNFEPYAKHWLCPLMEFVLDKHL-----------GNN--LNYVITDVVSMLVSWHNIAVP 2039 pea aphid
EFN85096     1610 ----RNIQLFMLKIVDNTAnTVFKPYAKFMLPGIAQAVANY-L--K--------AND--LNYIITNVLNILISWRDKIND 1672 Jerdon's jump...
EPB89690     2133 dkakYTRQVYIARLIVNYP-QAFENYAHEWIVPLLKFVVKGHL--F--------GET--MNYLVHDICIILGVWGETTFN 2199 Mucor circine...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap