Conserved Protein Domain Family
TMPIT

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pfam07851: TMPIT 
TMPIT-like protein
A number of members of this family are annotated as being transmembrane proteins induced by tumor necrosis factor alpha, but no literature was found to support this.
Statistics
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Aligned: 45 rows
Threshold Bit Score: 307.209
Threshold Setting Gi: 1091662024
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5FWV6        10 VRDWGELQENYQDIQETHrlykq-kleelAKLQTRCSGTIARQKKKLKELSVELKKYKSSVKnv-----------eEEEE 77  tropical clawed...
EFC40706       9 NEDWSECSTDQEKIESSFdklikekradlFYSESDVKKKAEKQKKRLRSCVAMIESVEKAg--------------sSNEE 74  Naegleria gruberi
EGG16102      16 KKELEELEKSQNGVKEKGlkfke-qiavgFKSLDEICNTLDKQEKESSKLLQRITLLQSGGGd-------------KSND 81  Cavenderia fasc...
Q54IK2        34 KNEVFELKKSHEQCKEKGikvkk-dindvFKHADDITNTLAKHEKESSQLISRIKHLNAKe---------------KQLD 97  Dictyostelium d...
EGC34020      31 KNEILELKRSNLSCQEKGikikk-eindvYKQVDDIAGTLAKHEKESSHLQSRLKQILTKe---------------KQID 94  Dictyostelium p...
EDQ51854      23 EDRVASLAKSCRSLKEAA-----------SAHSSRWQHEADTLSKQAINHVSTLKKLQVDVGsase-------kdeIDQQ 84  Physcomitrella ...
ERN08213      11 LEEVSHLLDRAKELQDSA-----------SSFLSKMKHEEQSILQRVSALQSDLKKLQACVAsasa-------setLDKR 72  Amborella trich...
EEF43500      14 EEEVERVVEQAKQVQEAA-----------ASLISRSTNDEQSLRQRALSLESSIRRCRSLFDslls-------rnlIHPK 75  castor bean
ETO09627      10 MKSIDEISNELKAVSETFetstq-qlnqkFKQIDQCISKTKTKTKMYNDLWSEWQEMNVQVGngse------nersKYEK 82  Reticulomyxa fi...
XP_018674989   8 LEEAARLAEAARELQEAA-----------AILISRTRNEEQSLRQRAVALESDLRRLQSSLDstvrkkgqsatgggVDPK 76  wild Malaysian ...
Q5FWV6        78 --QISVLNNQIRIREKTFF--EMESFLPKK-NGLYLSLVLG-NVNVTLLSKQS-KFAYKDEYEKFKLYLTMILMVLSFIC 150 tropical clawed...
EFC40706      75 --LIKDLQEKKLKIKHYIKklDVINKQTLNtGGKFVELFLGkESSAVLVGDDSkKFNFKKEYESFKYKCTVWNIPFTLLL 152 Naegleria gruberi
EGG16102      82 --AVVEMKQKIQSIKTSIK--QSKKTFTPEtGGVFVRLFLG-QVNVKHYREGE-RFRLKTEYEKFKFKTNPQFILFVALL 155 Cavenderia fasc...
Q54IK2        98 --ITKELSAHLDQIKVNVK--RAKVSFTPEtGSIFVRLFLG-QVNVKHMRENE-KFRLKQEYEKFKKKTNPQFILFVVLL 171 Dictyostelium d...
EGC34020      95 nnIIKELTDDLEQIKMNVK--RSKGLFTPEtGSIFVRLFLG-QVNVKHLRENE-KFRLKTEYEKFKKKTNPQFIIFVVLL 170 Dictyostelium p...
EDQ51854      85 --TADKLEEELYRARTMLYngEVSSLLPAKaNGVFLRMLLG-PTNVRATLKDG-RYKVKEEYNAYRDRTALMFLAFPVIL 160 Physcomitrella ...
ERN08213      73 --EAEKLEEELSRAKCMIAdgDVSSLLPSKsNGKFLRMFLG-PISVRATRKDV-QLKVKEEYNNYRDRTAVMFLLFPFAL 148 Amborella trich...
EEF43500      76 --LADKLDEDLQRARCMMVdgDAAAFLPSKaQGGFLKMFLG-PINVRASRKDV-QLKVKEEYNSYRDRTALLFLLFPSLL 151 castor bean
ETO09627      83 --QMEEMKKDLELTKKISE--SISSY--EQnRSYFLIGLMG-NAPMKLWNEID-RAKFKTEYNRFKQHTLWVFLLFPLLQ 154 Reticulomyxa fi...
XP_018674989  77 --IAEKVDEELCRARCVINdgDVASLLLSKtHGRFLKMFLG-PVNVRATRKEV-QLKVKEEYNSYRDRTAFLFLLFPSTL 152 wild Malaysian ...
Q5FWV6       151 RFVLNSR---VTDA----VFNFLLVWYYCTLTIRESILINNGSRIKGWWVLNHYISTFLSGVMLTW-----PDGLMYQMF 218 tropical clawed...
EFC40706     153 YFFIQSR---AIDT----LYQLYLTYFYLTLALRENILAVNGSNIKAWWIRHHYLSIFLVITMLTW-----PETAFYQAY 220 Naegleria gruberi
EGG16102     156 FMFPSNS---FITT----SWQIWLLYYYVTLALRENILLVNGSSIRPWWIMHHYLSIAGALTNLLW-----PLSTSFTDL 223 Cavenderia fasc...
Q54IK2       172 LLYPQSS---FVTT----SWQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLF-----PLSESFSYF 239 Dictyostelium d...
EGC34020     171 LLYPHSS---FVTT----SWQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLF-----PFSEAFTYF 238 Dictyostelium p...
EDQ51854     161 LVLKNKIwngCFPAlpvqVYQAWLLFFYTSLALRENILRVNGSDIRPWWVYHHYCAMVMALVSLTWg---hPSCIRKQQG 237 Physcomitrella ...
ERN08213     149 LILRYAIwkgCFPAwavqLYQAWLLFLYTSLALRENILRINGSDIRPWWIYHHYCAMMMALVSLTWeikgqPDCYQKQRG 228 Amborella trich...
EEF43500     152 LILRSWLwdgCLPAfpvqLYQAWLLFLYTGLALRENILRSNGSDIRPWWIYHHYCAMVMALVSLTWeikgqPNCAQKQRG 231 castor bean
ETO09627     155 LYFHFNI---FLHQ----IHSLYLFYYYTSLAIRENILKQNGSRIDYWWIVHHYITLFVSLLFLVNltpthPAVVTGGVY 227 Reticulomyxa fi...
XP_018674989 153 LLLRSWVwdaCLPAlpvqLYQVWLLYLYTTLALRENILRVNGSDIRPWWICHHYCAMLMALISLTWeikrqPDCAYKQRG 232 wild Malaysian ...
Q5FWV6       219 RNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHNMDLTveg-----fqsWM----WRG-LTFLLPFLFFGQFWQLYN 288 tropical clawed...
EFC40706     221 RPYFLLYALYASIVQVLQYKYQKERLYVRTAIGKSNMMDVAnsd------ssQVvvesSLA-LVFLLPFIFIGQIFQVYN 293 Naegleria gruberi
EGG16102     224 LPMMTMFSGAQGIVQILTNRYQQGQLYRMVAIGKANIMDVTsenmi--sdpgW-----TPS-ALFLLPFLLFVHCFQMYN 295 Cavenderia fasc...
Q54IK2       240 LPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTgesegwgndpgW-----TPS-ALFLFPFLLFVQFFQLYN 313 Dictyostelium d...
EGC34020     239 LPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTgesegwnndpgW-----TPS-AMFLLPFLLFVQFFQLYN 312 Dictyostelium p...
EDQ51854     238 VQLFLGWAVMQGVAMLLQNRYQRRRLYTRIALGKAGRMDVV-----------WGetagVKGqLGILYPLLFILQGFQFFI 306 Physcomitrella ...
ERN08213     229 IELFLTWAMMQGVAMLLQNRYQRQRLYTRIALGKANRMDVV-----------WGetasVEGqLWLLYPVLFILQGFEAYI 297 Amborella trich...
EEF43500     232 VQLFLQWAMMQGVAMLLQNRYQRQRLYTRIALGKAKRMDVV-----------WGetagVDGqLWLLCPILFILQGFEAYV 300 castor bean
ETO09627     228 LIDY--FMLWQGIVIVLQMRYQEKRHYVRKALAKKNAMDVRt---------tEViderPHGdFEFLVPALYITYFFQLII 296 Reticulomyxa fi...
XP_018674989 233 VQLFLMWAMMQGVSMLLQNRYQRQRLYTRIALGKAKRMDVV-----------WGetagVEGqLWLLCPILFILQGFEAYV 301 wild Malaysian ...
Q5FWV6       289 AITLFKLARHp-ECK-----EWQVIMCGLPFLVHFLGNFFTTLRVVHQKFQKQ 335 tropical clawed frog
EFC40706     294 AYKLFDWGLLhpESFggitvEWQVYANGLLFLILALGNFVTTTEVLVKKVKRV 346 Naegleria gruberi
EGG16102     296 GFVFLTYSYFkyHTYy---iEWQVIACGLILVSLGIGNLVTTSNIYLNKWKSY 345 Cavenderia fasciculata
Q54IK2       314 SFSFFAFAYQrsGYV-----EWQVFSCGFIFLCLGLGNLLTTLSVYYQKWKNF 361 Dictyostelium discoideum
EGC34020     313 SFSFFYFAYQrdGNV-----EWQVYMCGLIFLLLGFGNLFTTISVYYQKWKNI 360 Dictyostelium purpureum
EDQ51854     307 GILLLKTAIVe-DKS-----EWQIVVCGLLLVLMACGNFINTVATLVAKAKIK 353 Physcomitrella patens
ERN08213     298 GILLLMTAVTs-SVS-----EWQVVVCGGLLVIMASGNFANTVQTLSAKLRFK 344 Amborella trichopoda
EEF43500     301 GLQLLRTAFVr-VVS-----EWQVIFCGMLLVFMAVGNFFNTVQTLMVKSRFK 347 castor bean
ETO09627     297 AFYFAYVCCAq-EFScf-ydRAQMGLLAMCWTILPIGNLSTLVKVLYRKRvih 347 Reticulomyxa filosa
XP_018674989 302 GLLLLRTAFVg-VIC-----EWQVIACGILLVLMAIGNFANTMQTLIAKSRFK 348 wild Malaysian banana
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