Conserved Protein Domain Family
CCDC90-like
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pfam07798: CCDC90-like 
Coiled-coil domain-containing protein 90-like
This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.
Links
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Statistics
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PSSM-Id: 462268
Aligned: 89 rows
Threshold Bit Score: 118.77
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCF49413      307 FDTHGFVKRLES----GGWIsnaakaqrlaasskpgkgkqaqnesgsqelglqiaqrHDPAEAIMEGVRHLITTRGRQLA 382 
EHK41366       34 FDTYSLVKQLHE----GGYS-------------------------------------SDQATTMMKAVRALLAHNLDMAQ 72  
CCT66261      162 FDTYSLVKQLQE----GGYT-------------------------------------QEQATTSMKAIRTLLAENLEIAQ 200 
KJK77411      194 FDSYSLVKQLEE----GGYS-------------------------------------REQAVTSMKAIRKILGQNLDVAQ 232 
XP_006667070  229 FDSYSLVKHLEVe---GGYT-------------------------------------TQQAIMSMKAIRKLLAKNLHVAQ 268 
XP_001908096  244 FDSYSLVKHLSSpdqpPKYT-------------------------------------LPQSIALMKAIRALLAHNLDSAQ 286 
XP_003655476  222 FDSYTLVKQLTA----GGYT-------------------------------------LPQAILAMKAIRTLLASHLDVAQ 260 
XP_002143025  183 FNTYQVFDELKE----GGFD-------------------------------------DEQAHQMVGIIGDMVKYKIGDIL 221 
EEQ38631      110 IDTYEVYKQLTR----AGFT-------------------------------------AEQSNEIIDLLVYQLNTKLSKLS 148 
XP_001528547  167 LDTYSVFSKLKE----AGFT-------------------------------------DAQADSIIYLLIYQLNSKLSKLS 205 

CCF49413      383 HACLNKSDVENQTYLFKAALSEIRTEVQVRGRNDAAGLRSITTLLQREVDALEQKMKEDVERLKHDIQVDMNNRKAESKE 462 
EHK41366       73 EKLVSKSDVENESYLFSAACSELSAEIKNNRRAQDEQIRQQRTHLQHEVDILTQTLNQELLTLNDNVRGAFNDRKMTVRE 152 
CCT66261      201 STLVSKSDVENETYLFTAACSELSTEIKNNRRLEEEQLRQQRTHLQHEVDILTQSLNQEVHTLNDNVRGSFNDRKMAVRE 280 
KJK77411      233 KSLVSKSDVENETYLFQAACSELSTEIKNNRRLQEEEMRQQRTHLQHEVDILTQSLNQELLTLNDAVRGLFNDRNMAVRE 312 
XP_006667070  269 QSLVSKSDVENETYLFSAACSELNTEVKNNRRIAEEELRQQRTHLQHEVDILTQSLNQEVATLNDTVKGMYNDRKQAVRE 348 
XP_001908096  287 SGLVSRSDVDNETYLFRAACSELSTEVRKNRRVADEQLRQQRTHLQHEVDILTQRLNQDLLTLTDSVRGMFNDRKMAVRE 366 
XP_003655476  261 AGLVSKADMENESYLFRAACSELSAEVRNNRRVADEQLRQQRTLLQHEVDILAQRLNQELLTLNDSVRGMFNDRRMAVRE 340 
XP_002143025  222 ENYFPMLDSDNEAYLFEAACSELRTEVQKMREADVNERQLEIDSFQKDMEEFEQDVNSLLIDMRNNIDILLSERKNENDE 301 
EEQ38631      149 TKYSQIYELENEQYLFESAQQELRVDITRNREQHINDAVTKINALETDYEVISDELNNHFIQMKNDVQVAINDQKSDNTL 228 
XP_001528547  206 TIYAQQYELESEQYLFESAQQEIRVDITRSREQHINELITLVNILERDFNIITDELNNDYLKLKNDSQVAINEQKSENTL 285 

CCF49413      463 EQNNLEQEIQDLNNRFTISL-SDLKTEIEqNVKWDATRRSL-FLVFGIAAIVAAN---LA 517 
EHK41366      153 EQKGADSAIQQITYKISIMLsSDSKSEIE-GVRWILIRRSV-VGILFMAIVTLGT---IR 207 
CCT66261      281 EQKSVESSIQQINYKISIVLsSDAKSEIE-AVRWILIRRSV-LGILFMAVLTLGT---LR 335 
KJK77411      313 EQKSVESAIQKINYKMSILLsSDSKSEIE-GVRWVLIRRSV-VGLVFLAILTLGM---IR 367 
XP_006667070  349 EQKAMDSAIQKISYKISIDLtSDAKTEIE-GVRWVLIWRSV-LGIVVMAFLTLGT---LR 403 
XP_001908096  367 EQKAVESRIQQINYKISVMLnSDSKSEIE-EVRWVLIRRSV-LGILFMAVLTLGT---LR 421 
XP_003655476  341 EQKAVESRIQQINYKISVTLnSDAKSDIE-ALRWVLIRRSV-LGIIFMAVLTLGM---LR 395 
XP_002143025  302 VLKHTDIRIQEVNNSIVVDAnHRMKPVIE-EFRWVLMRNGL-FLIFSVAVMLLGTl-yLW 358 
EEQ38631      229 KSKKIMLRIQETNHKITTELnMAMRSEIE-SLRWHLSRWGLiAIMASVCASSVTIyvyRI 287 
XP_001528547  286 NVKKLFLRIQETNHKITTELdSAIRSEIE-SLRWYLSRWGL-----------ITLlvsLF 333
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