Conserved Protein Domain Family
Cas1_AcylT

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pfam07779: Cas1_AcylT 
10 TM Acyl Transferase domain found in Cas1p
Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.
Statistics
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PSSM-Id: 462263
Aligned: 18 rows
Threshold Bit Score: 580.036
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002411502  303 MNYNDGTCCSSS-EPVTMLQIITFSAFGVIsILALAMIVHRHLQLRRARAF---------RA--DDVQCLVNGEFSLhrp 370 
XP_009029734  252 MNFDDGSCCTSP-ENPTTVQIAMAAFFATSlAAAVLIATCRRLNGRSNKNN---------KNnnKTNNNNNNQSKNM--- 318 
XP_006636227  349 LKPIDGSCCHPR-PPLNIVQKLTAGVFAS----AIMSFLVLNLLCYSKHRR---------SRhvTDLENAEEKRPAAat- 413 
XP_519208     431 LKPVDGSCCQPR-PPVTLIQKLAACFFTL----SIIGYLIFYIIHRNAHRK---------NKpcTDLESGEEKKNIInt- 495 
XP_006011687  297 LRPNDASCCLPK-PSFTVIQKLTACFFGI----SIIGFLIFSYLFRNNHKK---------SKpcTDVESGEEK-PTTat- 360 
2_pfamImport    1 TPTVDGTCCKKP-DPVTVVQIILATFGSLWfVYHFCFVVVNLVQKHVQRPS---------PGteEENKKNNIRTTi---- 66  
KJE94275      462 DRPDDVTCCAPY-PALTGLQYVFFAV--------VLFALVCWLGGSYAARH---------HTggAVASGAESAFGATara 523 
Q6CDI8        309 VYPFSDTCCIHYkQPRTMGQVLLLGVI-------CAILPIIYLGQRYTRSDyyprfvryvSWpvPSIQDE---------- 371  Yarrowia lipo...
EKC31313      299 MNHNDGTCCRVP-DSITSIQIITAAFFLVClLSAIAMFLYRRRIRRNGSKA---------RAadNGIRNGRSYVTSTek- 367 
XP_002127948  288 THATDGTCCRKP-DPLTIVQIIMAVLG--F-IF--ILLAVGIRIQRIGKPT---------PTneDEVAKNKDSIHN---- 348  vase tunicate
XP_002411502  371 aiifgklslFYDltCFNFSTLQLGLIMGYFFLCDRTNFFMKENKYYTHLNFFLPVAYVFALGLFFTEE-TQHTQVLHRDQ 449 
XP_009029734  319 ---------DCP--TLISCIAKLGLILLYFFICDRTTFFMKENKYYTHVNFFLPFTYLMILGLFFTES-TKQVQVLNRCQ 386 
XP_006636227  414 --------sMASlkVPFQSVCKLGLIMVYFYLCDRADIFMKEQKFYTHSTFFIPLIYIFVLGVFYTEN-GKETKVLNREQ 484 
XP_519208     496 --------pVSSleILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNEN-TKETKVLNREQ 566 
XP_006011687  361 -------paPANteILLQSLCKLGLIMAYFYLCDRANLFMKEHKFYTNSTFFVPLIFILMLGVFCNEN-AKESKLLNRDQ 432 
2_pfamImport   67 -------------vELVSAAAKMSLILLYFYICDRTDVFMKANKHYTNTRFFLPLLYIVFLGVFGIDA-AEKPVFLNRNQ 132 
KJE94275      524 r----hmlsSPNllSVAMPVAQLGLVLVFAFLCDRTHIFPKERKIYTHFDLIASIGVMFVAGWCTLTHvKTAPTFLSRDQ 599 
Q6CDI8        372 --------------TLLTACVVIAASLAYSFFCDRTQFFGKSSKQFEASEFWVLILLFLVATGYSFEPqNDNS-FLNRHQ 436  Yarrowia lipo...
EKC31313      368 -------twPDTlyEIMLCLAKLGLIMAYTFLCDRTNFFMKENKYYTHVNFLLPFAYLMILGFFFTEN-TDQTKVLHRDQ 439 
XP_002127948  349 -----------IiaELTYAAAKMSLILFYFYICDRTDVFMKSNKHYTNTRFFLPLLYIVFLGIFGIDS-TKQPVFLNRDQ 416  vase tunicate
XP_002411502  450 TNEWKGWMQLIILIYHTTGASQVLPIYMHVRVLVTSYLFLTGYGHFTYFWHNGDFGLYRLWQMLFRMNLLVVVLCLSMNR 529 
XP_009029734  387 TDEWKGWMQIVILIYHLTGASKVLSIYMHIRVMVSAYLFLSAYGHFVYFFNKNDFSFHRLCTVLVRFNLLVVLLCLSMNR 466 
XP_006636227  485 TDEWKGWMQLVILIYHISGASAFIPVYMHVRVLVAAYLFQTGYGHFSFFWLKGDFGLNRVCQVLFRLNFLVVVLCLVMDR 564 
XP_519208     567 TDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIHRVCQVLFRLNFLVVVLCIVMDR 646 
XP_006011687  433 TDEWKGWMQLVILLYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWIKDDLGLYRLCQILFRLNFLVVVLCLVMDR 512 
2_pfamImport  133 TDEWKGWMQLIILIYHMTGASVNVPIYMHIRLLVSMYLFMTGYGHFSYFWNKGDFGLHRVFGVMFRLNFLTIMLCLTMDR 212 
KJE94275      600 TDEWKGWMQIVFLIYHFLGGSSVLPLYMLVRVFVASYLFLTGFGHFTFFYTKKQFGITRIIQVLTRLNVLTIGLCMVMDK 679 
Q6CDI8        437 TEEWKGWMQIIILIYHITGASKILPIYKFVRVLVAAYLFMTGFGHATFFIKRGDFSLKRATSVLFRMNFLSILLAYVMDT 516  Yarrowia lipo...
EKC31313      440 TDEWKGWMQLVIMIYHLTGASKVLPIYMHIRVLVSAYLFLTGYGHFSYFWNKSDFSVQRYCQVMFRLNFLVVVLCFVMNR 519 
XP_002127948  417 TDEWKGWMQLVILIYHVTGASVNVPIYMHVRLLVAMYLFMTGYGHFSYFWNKGDFGVHRVFGVMFRLNFLTVMLCLTMDR 496  vase tunicate
XP_002411502  530 PYQFYYFVPLVSFWFVVVFVTMTSI--PQvvaASAEAN------------PLQYLYIVLKFVGLFSVVTILYMS-EV--- 591 
XP_009029734  467 PYQFYYFVPLVTFWFIVIFIVMALP--PR---SSSSMS------------ISSFFWIFLKIVGLAVVVTLLYSS-EV--- 525 
XP_006636227  565 PYQFYYFVPLVTFWFAVIYVTLAIW--PQilqKKANGS------------GIWHLGLLLKLLALLLFICFLTYS-RG--- 626 
XP_519208     647 PYQFYYFVPLVTVWFMVIYVTLALW--PQiiqKKANGN------------CFWHFGLLLKLGFLLLFICFLAYS-QG--- 708 
XP_006011687  513 PYQFYYFVPLVTFWFVVIYVVFALW--PPivnRTASGS------------CFWNLSLLLRLGLLLTCICILAYF-QS--- 574 
2_pfamImport  213 PYQFYYFVPMCSFWYLVLYLTMAMW--PRayiSSPTNE------------NTAVFKMILKLSFLFFLIVVVFIS-QN--- 274 
KJE94275      680 PYQFYYFVPLSSFWFLVVYAIMAFPsiPAvqkRF------------------PGLDAPARILALFTICSIVWLP-FSgny 740 
Q6CDI8        517 DYLFYYFAPLVSFWFCVVWITFRVL--PSwnsIDTSVG------------P-----VLAKISASAVILNILVRF-QL--- 573  Yarrowia lipo...
EKC31313      520 PYQFYYFVPLVSFWFTVVYLTMAIW--PRisdASCEAS------------NLHYLYMIIKFIILTTVITLFFMS-EV--- 581 
XP_002127948  497 SYQFYYFVPMCSFWFLVLYLFMALW--PRaymVATNKEttlsdgetkevtFTSPIFVMCAKLSLLLFTIVLVFLsQE--- 571  vase tunicate
XP_002411502  592 ---------FFEKIFVTRPWKALFVTTDDSIKEWWFRWKIDRYSVASGMLFAFAHYLLKQYRVVDDNH------------ 650 
XP_009029734  526 ---------FFDQLFLSTSLKPLFVTSDESIHDWRFRWNLDRYSSIYGLLFALALVMAKRFKLIDDSV------------ 584 
XP_006636227  627 ---------VFNSIFSIWPISKLF-ELHGSSHEWWFRWKLDRFAVFHGMLFAFVYLVLQKCQVLSEGK------------ 684 
XP_519208     709 ---------AFEKIFSLWPLSKCF-ELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGK------------ 766 
XP_006011687  575 ---------TFEAVFATWPVSKLF-ELQGSVHEWWFRWKLDRFAVFHGMMFAFLYLTLQKWQVFSEGN------------ 632 
2_pfamImport  275 ---------LFESMFSWWPVIRLFELPSGMVREWWFRCHLDRFAVLHGSLFAFSYIMLKRLSVVDDSR------------ 333 
KJE94275      741 kstsaddfpIFQFLFDWWPIKELF-SVSDSLYEWRFRSGLDCFIVAHGMLIAYAYQIAKSHGVIHDNQpavrpgttpppp 819 
Q6CDI8        574 ---------PFQIVFAV--LKYLF-NIQWNLREWRFRLILDIYIVYIGMFAAVATLRYKQGNFPLK-------------- 627  Yarrowia lipo...
EKC31313      582 ---------LFEKVFLMRPIKALFVRSDDSLHEWRFRWTLDRYSVVYGMVFAFGYHLLLKKGIIADNH------------ 640 
XP_002127948  572 ---------LFESMFSWWPVIRLFELPPGMVREWWFRCHLDRFAMLHGAVFAFGYIILKRLSIVDDSR------------ 630  vase tunicate
XP_002411502  651 ----HGNLFSR-ENGSSCTAVAhgvLLAFQFYTTFALVCRAKPDCNEIHAYvsfvPIISYIILRNISGLLRTRYSTFFAW 725 
XP_009029734  585 ----SDLVASR-KVNMLSMALS---ICGLVGYAVFTSLCNSKEQCNNNNNK----KILSYICLRNMMGCARRKFSAFFAW 652 
XP_006636227  685 ----GEPLFSN-RVSNCLLFIS---VVSFLTYSIWASSCKDKTECNELHPYisvvQILAFVLIRNIPGYARSLYSSFFAW 756 
XP_519208     767 ----GEPLFSN-KISNFLLFIS---VVSFLTYSIWASSCKNKAECNELHPSvsvvQILAFILIRNIPGYARSVYSSFFAW 838 
XP_006011687  633 ----GEPLFSH-MVSYCLLFVS---VVSFLSYSIWAANCKIKAECNEWHPYisviQILAFVLIRNIPGYARSVYSTFFAW 704 
2_pfamImport  334 ----QGCLFST-KVSLIAVTTS---IICTLLYSIWAMHCTDKQSCNEVHSFasliPISAFILIRNIPGYLRAGYSAFFAW 405 
KJE94275      820 gpllSGLLFNT-ATSAILSIVS---IGIFCWYIMFTRSCTDKAYCNYIHTFsspfLVAAFAFLRNLTGRSRAVYSRFFAY 895 
Q6CDI8        628 ---------NLvTNRLVLGVVA---LITFIVYIAVAASFGIKQNYNQAHPYiswmPIVAFVILRNITVRFRSHYSTWMSF 695  Yarrowia lipo...
EKC31313      641 ----TKSLFST-GVSLSLTILS---FIGLGSYAIFSFLCKNKTECNDTHSYlvalPLISYVTVRNVLGWVRTRYSSFFAW 712 
XP_002127948  631 ----QGCLLST-KVSLIAVTAS---ILCTLFYSVWALQCSDKQSCNEVHSFasliPISAFILIRNIPGYLRAGYSSFFAW 702  vase tunicate
XP_002411502  726 FGKISLELFIAQYHIWLAADTHGVLVLV-PG----Y-----PVLNVIVTSFIFVCISHEIHLLTGKLVVFAIPADWRYMV 795 
XP_009029734  653 FGKMSLELFIAQYHIWLAADTHGILVLI-PS----Y-----PVMNLIVTSFVFVCVAHEIKLLTSLLTPVLVPRSRLKLA 722 
XP_006636227  757 FGKISLELFICQYHIWLAADTKGILVLV-PG----Y-----PMLNIVISTFIFVCVAHEISQITNDLAQVAIPKDSSALV 826 
XP_519208     839 FGKISLELFICQYHIWLAADTRGILVLI-PG----N-----PMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLL 908 
XP_006011687  705 FGKISLELFICQYHIWLAADTRGILVLI-PG----N-----PVLNIIISTFIFVCIAHEISKITNDLVQIAIPKDDTALL 774 
2_pfamImport  406 FGKISLELFIGQYHIWLAADTKGILVLTsPD----W-----PMLNLLITTFIFVCVAHEIFSLTGVFAKHLVGSPKSADS 476 
KJE94275      896 IGQLSLELFLLQFHIWLAADTKGILVLI-PGtsgfW-----RLLNAAFTTGLFVAVSEVASDSSALIVSLLAPGDNTRAV 969 
Q6CDI8        696 IGTCSLETFTLQFHFFLAADTKGRLYILnTPtssgVlgmlqKYLNFGLVTVIFIIVSHAVAEQSNALTKLFVGNQDQQLP 775  Yarrowia lipo...
EKC31313      713 FGKISLELFIAQYHIWLAADTYGVLVLM-PT----Y-----PVLNVILTSFIFICASHEISKITGILTNYLVPKEGKALL 782 
XP_002127948  703 FGKISLELFIGQYHIWLAADTKGILVITsPQ----W-----PMLNLLVSTFVFVCVAHEISALTGTFAKYLVGPAKTADT 773  vase tunicate
XP_002411502  796 RNLS 799 
XP_009029734  723 RNVL 726 
XP_006636227  827 KRLL 830 
XP_519208     909 KRLA 912 
XP_006011687  775 KRLL 778 
2_pfamImport  477 KTLC 480 
KJE94275      970 ISRF 973 
Q6CDI8        776 EHVT 779  Yarrowia lipolytica
EKC31313      783 RNAI 786 
XP_002127948  774 KTVC 777  vase tunicate
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