Conserved Protein Domain Family
DUF1620

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pfam07774: DUF1620 
Protein of unknown function (DUF1620)
These sequences are mainly derived from predicted eukaryotic proteins. The region in question lies towards the C-terminus of these large proteins and is approximately 300 amino acid residues long.
Statistics
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PSSM-Id: 311630
View PSSM: pfam07774
Aligned: 168 rows
Threshold Bit Score: 110.655
Threshold Setting Gi: 74777681
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74780791   360 SENWLVYSYYNDKARRTEMTSIELY---------EGKTQtnstvwss------------------ldapplpMV--ERQS 410
gi 74832084   598 VEHAVLYHFMDVEKMRHSLGVWEMF---------ETEVG---------------------------------PVlfKDTG 635
gi 74777681   734 FQNIILITSFHSNYKVPVILILELF---------QFIKDetstginmldkfiflv--sskknvkeskiysekHVhvQETT 802
gi 124461151  116 DDHKVFVTYQNQAKMIFEIWTVEIY---------HMKRSvhlqkcqsiiislkiqqiniimkqntilfsnskyidfLQQV 186
gi 124465929  666 DEHQVFVTYYNKAQMMFEIWTVEIY---------HAKIEvsfikmlenyyft-------ktpiitnyykadfEAffLQQV 729
gi 121983596  775 DENGVFVSYYNPVYSIFQIWTVELF---------SKKMEnnfvsmlqnyyfses----gakyedfnylnenmDIiaLEQK 841
gi 294897196  574 FDNSAIVYYHNDKANRNELLVVDLFkdrddhgfwETMKMsqkaredgaiegn--------strvsayalempIA--AAQQ 643
gi 407411708  447 VEHAVLYYYMDMEKVRHCIGVWEMF---------EEEPGrvlrkd---------------------agatipQV--IA-S 493
gi 339899177  594 VEHAIVYYYLDAKKMRYCFGVWELF---------EDENS---------------------------------PVvfKTAG 631
gi 672567752 1076 YDNVVMAHYWNLQQARYELHFVELQ---------DAQKDegplsiifsaar---------hivprltgfelpPPtgISQT 1137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74780791   411 YIL------------PMAVA------------A---------------------------------LKETITEKGITSKH 433
gi 74832084   636 ATP------------PQVIS------------SffsrhkrvfssratwppvvvgsvlgmhgggvakMSVTTSFGAIARKS 691
gi 74777681   803 FLYn----------yELPID------------Y---------------------------------SLLSKTSESLASKI 827
gi 124461151  187 YGF------------PLGIK------------Y---------------------------------LGITRTRKSLTKKN 209
gi 124465929  730 YGY------------PLGIK------------Y---------------------------------LGMSRTQKSLTKKN 752
gi 121983596  842 YGY------------SLGIK------------K---------------------------------MAVVTTKLSLTKRN 864
gi 294897196  644 FVV------------PQAVI------------S---------------------------------MGVSTTQKGITPRS 666
gi 407411708  494 FFSrfkrtfssratrPPVVTvavlgvyggnlaT---------------------------------MGVTTSFNGISRKS 540
gi 339899177  632 ATI------------PQIIA------------SffvntkrefssratrppivvvstlgsfggpladMGVTTSYNAIARKS 687
gi 672567752 1138 YIL------------PTGVR------------A---------------------------------FGVTATLQGITTRA 1160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74780791   434 IL-IGLTTGAV--AE-MTW--ALLDPRRPVts-------------peKA------RE-EG---IVPympelplpHEILIN 484
gi 74832084   692 LL-FVFTSGRV--AS-VGLnrLLAGGQVSL-----------------GD------GAgQLthvIIP--------STAIVT 736
gi 74777681   828 IL-FGSEKSNV--FEcIPE--RLFSTLRPN-------------------------KSkKK---NLIhnsn-lpfYQSILS 873
gi 124461151  210 LL-IITTFSQM--YQ-LDR--NLVSARRREnsd------------ldHPfvql------------------tyrLFNMNS 253
gi 124465929  753 LL-IITTSGQL--HS-LDR--NLVSTRRREka--------------dQPile-ysLQsAE---LPPyqyqlpinFLNMLS 808
gi 121983596  865 LM-IITPNNQI--HS-LDR--DILSTRRAVklp------------kdNQlqnafsFEsTT---LPPynymvpidRLSIIS 923
gi 294897196  667 VF-LGLASGKV--LA-VNKd-TVLNPRRQTnhpvsgrssrlqnvasdKD------HD-AS---LPAyaplipvkATDVVT 731
gi 407411708  541 VV-LAFDSGRIatVE-LNR--LLAGGQLPLddk------------gtQA------Thvi-------------ipSTSLAS 585
gi 339899177  688 LV-LAYATGRV--VV-VELrhLLAGNQMPLp----------------GA------KDrQMshlLLP--------SFLFAS 733
gi 672567752 1161 ILlATSSSHQI--YT-MST--RLANARRPRlvderglp--lkeagpaQQ------QQeEG---VLPyhpllpllPHDCIS 1224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74780791   485 YNQTVTHIR--------GIHTAPS---------GLESTCLVLVHGLDLFVTR-VSPSKTFDLLKEDFDYFLITVVLVVLT 546
gi 74832084   737 HRYRAARPT--------LIATRPT---------NLESSCHVLVSGMDLFYVR-TSSGKEFDLLNSDFNKTLLIALTCSFG 798
gi 74777681   874 E-----RIKfstkfnskKIFSFPHe--------TYESKSKLLSVGFNSLEVFeIYPNTSFDLLPYDFNYYNIINTVFLIL 940
gi 124461151  254 LF-IF-KVC--------QLTIKHSiskgfqqnlQIQNPMPFLSF---MVLTI-ITPYKSYDMVQKNFNYDAVILTTVLIT 319
gi 124465929  809 YHQTF-DIE--------KFSIEST---------NLESSALLLVYGSDIFFTR-IAPDKTYDMLLDNFNYNALIVTTVLIV 869
gi 121983596  924 YHANLNDIK--------EIYFSGS---------NLESTILFVAYGNDVFMSS-IAPDRTYDMINEDFNYILVTLSIIICF 985
gi 294897196  732 YSNQVEGLK--------FIRTTPT---------HFESTSLLVLFGLDMYMIP-TNTAQRYDLLGPDFDYPLLTISIAVVL 793
gi 407411708  586 HKLRVAKPS--------LIATTPT---------NLESSCHVLVSGLDIFYVR-ASSGKAFDLLNSDFNKNLLITLTCGFG 647
gi 339899177  734 HKYRVAFPR--------KITTEPT---------LLESSCHVVVSGLDLFYVR-SSSGKPFDLLNSDFNKPLLITLVCGFA 795
gi 672567752 1225 YYNQVFHVR--------GIAAHHT---------LRESTSSTFAFGLDLFFSP-VQPAKGYDVLSSQFNYGLLAAAMVTLL 1286
                         330
                  ....*....|....*....
gi 74780791   547 TTSFVVKQLASKKLVKQAW 565
gi 74832084   799 VLSLVARYFAMRKGVRQLW 817
gi 74777681   941 TITAISIYFSKRNQLK-KW 958
gi 124461151  320 LTIQVSQKLIKSSKQVKQF 338
gi 124465929  870 VATKVLSKLVKSSKQVKQF 888
gi 121983596  986 VGVFIAKKYASQSNLH-RL 1003
gi 294897196  794 ATILITTRMASRKALENRW 812
gi 407411708  648 VLTFAARYFVRRKALNLLW 666
gi 339899177  796 ALSVMARYFVNRKALNSAW 814
gi 672567752 1287 VLVVLTRWRAKEADLAAKW 1305
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