3I4U,3KX2,6ID1,6QIE,5AOR,5LQW,5N8R


Conserved Protein Domain Family
OB_NTP_bind

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pfam07717: OB_NTP_bind 
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Oligonucleotide/oligosaccharide-binding (OB)-fold
This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure Structure 3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Statistics
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PSSM-Id: 369483
View PSSM: pfam07717
Aligned: 65 rows
Threshold Bit Score: 48.8178
Threshold Setting Gi: 74644973
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3I4U_A    169 VQKAICSGFFRNAA-----------------KKDP----------QE-G------YRTL--ID------------QQVVY 200  human
F4IDQ6    919 LRAVIAVGLYPMLG-----------------RMCP----------LSkNrtrsviETIA----------------GAKVR 955  thale cress
F4INY4    895 LRAVLAVGLYPMVG-----------------RLCP----------AFgNnrrtivETAS----------------GAKVR 931  thale cress
EAA31814 1221 LRALTASAFSPQIAriqfpdkkfaasmtgavELDP----------EAkT------IKFF--SQe-----------NGRVF 1271 Neurospora crassa...
O94536   1158 LSTLIAAALSPNVVkcvypdkkfvasfsgslEMEQ----------EArLtk---fYDQN----------------NQRLF 1208 Schizosaccharomyc...
CDH93106  543 VRVIIAAGLYPNFS-----------------ILDP----------VNkYgygqemFTHT--RL------------KPFTQ 581  Caenorhabditis el...
Q9DBV3    800 LKLVLGRGLYPQLA-----------------VPDAf--------nSGrKdsdqifHTQA----------------KQGTV 838  house mouse
Q20644   1023 IQAVIAAGCYPFIG------------------VSA----------SEsNlkkvqtFN------------------DKPAF 1056 Caenorhabditis el...
Q869Z1   1315 IRAIICSGLFPNIA------------------RQR----------KKrE------FKTL----------------SENTF 1344 Dictyostelium dis...
Q06698   1205 LRAILTGAFYPHIArvqlpdvkylstssgavEKDPeakmikywirSEeYqdkleeYKTKisQEtqkvdledlplpATRAF 1284 Saccharomyces cer...
3I4U_A    201 IHPSSALFNR------Q-----PE-----------------------WVVYHE--LVLTTK-EYMREVTTIDPR-WLVEF 242  human
F4IDQ6    956 VPSLSNNVDM------SstkfdEA-----------------------LIVFDE--ITRGDWgVVIRSCTVLPTI-PVLLF 1003 thale cress
F4INY4    932 VHSLSNNFNL------SskkydES-----------------------LLVFDE--ITRGDGgMHIRNCTVARDL-PLLLI 979  thale cress
EAA31814 1272 IHPSSTLFDS------QgftgnAS-----------------------FMSYFT--KIATSK-IFIRDLTPFNAY-TLLLF 1318 Neurospora crassa...
O94536   1209 IHPSSTMFVN------SpnasrCT-----------------------FVAYEQ--KVETTK-PFLRNCTPINTY-GMILL 1255 Schizosaccharomyc...
CDH93106  582 IHPNSSIAQY------HpetidPRqgsdgf------------srlhqIPFYGL--LLETTK-PYICNVMPVPAVyTLLV- 639  Caenorhabditis el...
Q9DBV3    839 LHPTCVFANSpevlhtQgqeasGQegsqdgrd--------qmsckhqLLAFVS--LLETNK-PYLVNCVRIPALqSLLLF 907  house mouse
Q20644   1057 LHPSSMVKKQivkmgkSeksprVE-----------------------YVAFQEmcQMPSDRsLSMKTVTVIPSM-TALLF 1112 Caenorhabditis el...
Q869Z1   1345 LHPSSIVYNLf-----QelnpkEN-----------------------WVIFEE--KFKTKL-TFIKTITRIPEI-SLLLF 1392 Dictyostelium dis...
Q06698   1285 IHPSSVLFST------NsvnleDAkllsevdgpisrqskiptvvkypFVLFTT--SQVTNK-LYLRDLTPTTTL-SLLLF 1354 Saccharomyces cer...
3I4U_A    243 APA 245  human
F4IDQ6   1004 SRE 1006 thale cress
F4INY4    980 STe 982  thale cress
EAA31814 1319 SGA 1321 Neurospora crassa OR74A
O94536   1256 GAN 1258 Schizosaccharomyces pombe 972h-
CDH93106  640 AQK 642  Caenorhabditis elegans
Q9DBV3    908 SRS 910  house mouse
Q20644   1113 TGP 1115 Caenorhabditis elegans
Q869Z1   1393 GST 1395 Dictyostelium discoideum
Q06698   1355 GGA 1357 Saccharomyces cerevisiae S288C
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