3I4U


Conserved Protein Domain Family
OB_NTP_bind

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pfam07717: OB_NTP_bind 
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Oligonucleotide/oligosaccharide-binding (OB)-fold
This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure Structure 3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Statistics
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PSSM-Id: 336780
View PSSM: pfam07717
Aligned: 59 rows
Threshold Bit Score: 47.6616
Threshold Setting Gi: 74644973
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3I4U_A        169 VQKAICSGFFRNAA-----------------KKDP----------QE-G------YRTL--ID------------QQVVY 200  human
F4IDQ6        919 LRAVIAVGLYPMLG-----------------RMCP----------LSkNrtrsviETIA----------------GAKVR 955  thale cress
F4INY4        895 LRAVLAVGLYPMVG-----------------RLCP----------AFgNnrrtivETAS----------------GAKVR 931  thale cress
O94536       1158 LSTLIAAALSPNVVkcvypdkkfvasfsgslEMEQ----------EArLtk---fYDQN----------------NQRLF 1208 Schizosacchar...
Q9DBV3        800 LKLVLGRGLYPQLA-----------------VPDAf--------nSGrKdsdqifHTQA----------------KQGTV 838  house mouse
Q9VWI5        786 LKLLLGSGFYPQLA-----------------ISDEf--------nYCkGggqqffHTRL----------------KPFVL 824  fruit fly
Q20644       1023 IQAVIAAGCYPFIG------------------VSA----------SEsNlkkvqtFN------------------DKPAF 1056 Caenorhabditi...
Q869Z1       1315 IRAIICSGLFPNIA------------------RQR----------KKrE------FKTL----------------SENTF 1344 Dictyostelium...
Q06698       1205 LRAILTGAFYPHIArvqlpdvkylstssgavEKDPeakmikywirSEeYqdkleeYKTKisQEtqkvdledlplpATRAF 1284 Saccharomyces...
XP_003349625 1230 LRALTASAFSPQIAriqfpdkkfaasmtgavELDP----------EAkT------IKFF--SQe-----------NGRVF 1280 Sordaria macr...
3I4U_A        201 IHPSSALFNR------Q-----PE-----------------------WVVYHE--LVLTTK-EYMREVTTIDPR-WLVEF 242  human
F4IDQ6        956 VPSLSNNVDM------SstkfdEA-----------------------LIVFDE--ITRGDWgVVIRSCTVLPTI-PVLLF 1003 thale cress
F4INY4        932 VHSLSNNFNL------SskkydES-----------------------LLVFDE--ITRGDGgMHIRNCTVARDL-PLLLI 979  thale cress
O94536       1209 IHPSSTMFVN------SpnasrCT-----------------------FVAYEQ--KVETTK-PFLRNCTPINTY-GMILL 1255 Schizosacchar...
Q9DBV3        839 LHPTCVFANSpevlhtQgqeasGQegsqdgrd--------qmsckhqLLAFVS--LLETNK-PYLVNCVRIPALqSLLLF 907  house mouse
Q9VWI5        825 QHPNSQFAKHfellklTesdllPKpdfytpkl--------plskrhqLLCYQS--LLETAK-PYLINCIRLPAAqTLLLF 893  fruit fly
Q20644       1057 LHPSSMVKKQivkmgkSeksprVE-----------------------YVAFQEmcQMPSDRsLSMKTVTVIPSM-TALLF 1112 Caenorhabditi...
Q869Z1       1345 LHPSSIVYNLf-----QelnpkEN-----------------------WVIFEE--KFKTKL-TFIKTITRIPEI-SLLLF 1392 Dictyostelium...
Q06698       1285 IHPSSVLFST------NsvnleDAkllsevdgpisrqskiptvvkypFVLFTT--SQVTNK-LYLRDLTPTTTL-SLLLF 1354 Saccharomyces...
XP_003349625 1281 IHPSSTLFDS------QgftgnAS-----------------------FMSYFT--KIATSK-IFIRDLTPFNAY-TLLLF 1327 Sordaria macr...
3I4U_A        243 APA 245  human
F4IDQ6       1004 SRE 1006 thale cress
F4INY4        980 STe 982  thale cress
O94536       1256 GAN 1258 Schizosaccharomyces pombe 972h-
Q9DBV3        908 SRS 910  house mouse
Q9VWI5        894 SFA 896  fruit fly
Q20644       1113 TGP 1115 Caenorhabditis elegans
Q869Z1       1393 GST 1395 Dictyostelium discoideum
Q06698       1355 GGA 1357 Saccharomyces cerevisiae S288c
XP_003349625 1328 SGA 1330 Sordaria macrospora k-hell
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