4L01,5UT1,3D7U,1IEP,1SM2,3SXR,3KMM,6CZ2,4UXL,1LUF,3ZZW,3F66,5UI0,3ZFX,4P4C,3KUL,5F1Z,4QT1,4K2R,5WNO,2R4B,3LMG,3RCD,1U4D


Conserved Protein Domain Family
Pkinase_Tyr

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pfam07714: Pkinase_Tyr 
Click on image for an interactive view with Cn3D
Protein tyrosine kinase
Statistics
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PSSM-Id: 400179
View PSSM: pfam07714
Aligned: 120 rows
Threshold Bit Score: 210.817
Threshold Setting Gi: 73920239
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4L01_B         27 LVQGEHLGRGTRTHIYSGTLMdykddeg---tseekkIKVILKVL--DPSHRDI---SLAFFEAASMMRQVSHKHIVYLY 98   human
XP_002054634  716 LHLLERIGQGRFGTVHRALWH----------------GDVAVKLL--NEDYLQDehmLESFRNEVANFKKTRHENLVLFM 777  Drosophila vi...
P18160       2115 LEFGQTIGKGFFGEVKRGYWRe---------------TDVAIKIIyrDQFKTKSs--LVMFQNEVGILSKLRHPNVVQFL 2177 Dictyostelium...
P18161        853 IQFIQKVGEGAFSEVWEGWWKg---------------IHVAIKKL--KIIGDEEq-fKERFIREVQNLKKGNHQNIVMFI 914  Dictyostelium...
Q54I36       1057 VAIVEKVGAGSFANVFLGIWNg---------------YKVAIKIL--KNESISN---DEKFIKEVSSLIKSHHPNVVTFM 1116 Dictyostelium...
O12990        580 IVQGEHLGRGTRTNIYAGILKpksddedd-lggysqeVKVVLKVL----GSGHRd-iSLAFFETASMMRQISHKHTALLY 653  zebrafish
Q63272        517 LEWHENLGHGSFTKIFHGHRRevvdg-------ethdTEVLLKVM----DSRHQn-cMESFLEAASLMSQVSYPHLVLLH 584  Norway rat
5UT1_A         10 LIFNESLGQGTFTKIFKGVRRevgdy------gqlheTEVLLKVL----DKAHRn-ySESFFEAASMMSKLSHKHLVLNY 78   human
XP_009293332  509 lQTTEGLGQGTFTQVFRGIRRevgdy------gevhkMEVVMKIL--DKSHRNY---TESFFESASMMSQLSHKHLLLNY 577  zebrafish
CAG11593      586 iEQEEHLGRGTRTNIYSGTLRvkseededagyssfqeVKVVLKLL--SYGHRDI---SLAFFETASMMRQVSHKHIVLLY 660  spotted green...
4L01_B         99 GVCF--RDVENIMVEEFVEGGPLDLFMHRK-----SDVLTTPWKFKVAKQLASALSYLEDKD--LVHGNVCTKNLLLAre 169  human
XP_002054634  778 GACM--NPPYLAIVTALCKGNTLYTYIHQR-----REKFAMNRTLLIAQQIAQGMGYLHARD--IIHKDLRTKNIFIE-- 846  Drosophila vi...
P18160       2178 GACTagGEDHHCIVTEWMGGGSLRQFLTDHf---nLLEQNPHIRLKLALDIAKGMNYLHGWTppILHRDLSSRNILLDhn 2254 Dictyostelium...
P18161        915 GACY----KPACIITEYMAGGSLYNILHNPnsstpKVKYSFPLVLKMATDMALGLLHLHSIT--IVHRDLTSQNILLDe- 987  Dictyostelium...
Q54I36       1117 GACI----DPPCIFTEYLQGGSLYDVLHIQ-----KIKLNPLMMYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLDe- 1184 Dictyostelium...
O12990        654 GVCVr-HQEN-IMVEEFVQYGPLDLFMRRQ-----TTPLSTAWKFQVAKQLASALSYLEDKK--MVHGYVCSKNILVArd 724  zebrafish
Q63272        585 GVCM--AGDS-IMVQEFVYLGAIDTYLRKR-----GHLVPASWKLQVTKQLAYALNYLEDKG--LPHGNVSARKVLLAre 654  Norway rat
5UT1_A         79 GVCVc-GDEN-ILVQEFVKFGSLDTYLKKN-----KNCINILWKLEVAKQLAAAMHFLEENT--LIHGNVCAKNILLIre 149  human
XP_009293332  578 GICV--CADEHIMVQEYVRFGSLDTYLKRN-----RNTINITWKLEVAKQLAWALHHLEEKS--LTHGNVCARNVLVTre 648  zebrafish
CAG11593      661 GVCV--HHQENIMVEEFVQLGPLDVFMRRQ-----QNPLSIPWKFQVAKQLASALSYLEDKK--LVHGFVCAKNILLArd 731  spotted green...
4L01_B        170 gi------dsecGP-FIKLSDPGIPITV------LSRQECIERIPWI---APECVEDSKn---------LSVAADKWSFG 224  human
XP_002054634  847 ------------NG-KVIITDFGLFSSTkl---lYCDMGLGVPQNWLcylAPELIRALQpckppgecleFTSYSDVYSFG 910  Drosophila vi...
P18160       2255 idpknpvvssrqDI-KCKISDFGLSRLKme--qaSQMTQSVGCIPYM---APEVFKGDS----------NSEKSDVYSYG 2318 Dictyostelium...
P18161        988 ------------LG-NIKISDFGLSREKsregsmTMTNGGICNPRWR---PPELTKNLGh---------YSEKVDVYCFS 1042 Dictyostelium...
Q54I36       1185 ------------FK-NIKIADFGLATTLs----dDMTLSGITNPRWR---SPELTKGLV----------YNEKVDVYSFG 1234 Dictyostelium...
O12990        725 gl-------dgeGGpFIKLSDPGIPITV------LSREECVDRIPWI---APECVKDTAn---------LTIAADKWSFG 779  zebrafish
Q63272        655 g--------vdgNPpFIKLSDPGVSPTV------LSLEMLTDRIPWV---APECLQEAGt---------LNLEADKWGFG 708  Norway rat
5UT1_A        150 ed------rktgNPpFIKLSDPGISITV------LPKDILQERIPWV---PPECIENPKn---------LNLATDKWSFG 205  human
XP_009293332  649 edr-----ktgtPP-FIKLSDPGISITV------QPREILLERIPWV---PPECVKDSRn---------LSLAADKWSFG 704  zebrafish
CAG11593      732 gmg-----tdegGP-FIKLSDPGIPITVl----tRE--ECVHRIPWI---APECVKNVSa---------LSVAADKWGFG 787  spotted green...
4L01_B        225 TTLWEICYnGEIPLKDK-TLIEKERFY-ESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDI 289  human
XP_002054634  911 TVWYELIC-GEFTFKDQ-PAESIIWQVgRGMKQSLANLqsGRDVKDLLMLCWTYEKEHRPDFARLLSLL 977  Drosophila virilis
P18160       2319 MVLFELLT-SDEPQQDM-KPMKMAHLAaYESYRPPIPLttSSKWKEILTQCWDSNPDSRPTFKQIIVHL 2385 Dictyostelium discoideum
P18161       1043 LVVWEILT-GEIPFSDL-DGSQASAQVaYAGLRPPIPEycDPELKLLLTQCWEADPNDRPPFTYIVNKL 1109 Dictyostelium discoideum
Q54I36       1235 LVVYEIYT-GKIPFEGLdGTASAAKAA-FENYRPAIPPdcPVSLRKLITKCWASDPSQRPSFTEILTEL 1301 Dictyostelium discoideum
O12990        780 TTLWEICYnGEIPLKDK-KLSE-KERFyAAQCQLATPD--CDELAKLMTHCMTYDPRQRLFFRAIVRDI 844  zebrafish
Q63272        709 ATTWEVFSgAPMHITSL-EPAK-KLKFyEDRGQLPALK--WTELEGLIAQCMAYDPGRRPSFRAILRDL 773  Norway rat
5UT1_A        206 TTLWEICSgGDKPLSAL-DSQR-KLQFyEDRHQLPAPK--AAELANLINNCMDYEPDHRPSFRAIIRDL 270  human
XP_009293332  705 TTLWEIYCgGEQPLAAY-DTAKKLLFY-EDKHQLPAPK--WTELASVINSCMDYEPLHRPSFRALIRDL 769  zebrafish
CAG11593      788 TTLWEICYdGEVPLKEK-KLTEKERFY-ETECQLATPD--CTELAELMTHCMNYDPKKRPFFRAIVRDi 852  spotted green pufferfish
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