3ZFX,4K33,2QOH,3BYS,3KUL,3SXR,4ANS,2WD1,3PXK,4OT5,5AMN,3ZBF,1LUF,5TO8,3MIY,3ZZW,2OO8,3PLS,3QUP,5D7V,1BYG,1U46,1U59,4E4L,5TQ5,4GVJ,4RIY,4PX6,4HVD,4FVP,4L00


Conserved Protein Domain Family
Pkinase_Tyr

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pfam07714: Pkinase_Tyr 
Click on image for an interactive view with Cn3D
Protein tyrosine kinase
Statistics
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PSSM-Id: 336778
View PSSM: pfam07714
Aligned: 153 rows
Threshold Bit Score: 211.202
Threshold Setting Gi: 73920239
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZFX_A     21 VKIEEVIGAGEFGEVYKGRLK----------LP------GKREIYVAIKTLkaGYSEKq-RRDFLSEASIMGQF-DHPNI 82   human
P10676     16 FEIYEEIAQGVNAKVFRAKEL-------------------DNDRIVALKIQ--HYDEEh-QVSIEEEYRTLRDYcDHPNL 73   fruit fly
P23458    583 LVQGEHLGRGTRTHIYSGTLMdykd---degTS------EEKKIKVILKVLdpSHRDI--SLAFFEAASMMRQV-SHKHI 650  human
O12990    580 IVQGEHLGRGTRTNIYAGILKpksdd-eddlGG------YSQEVKVVLKVL--GSGHRdiSLAFFETASMMRQI-SHKHT 649  zebrafish
O60674    545 LIFNESLGQGTFTKIFKGVRRev------gdYG------QLHETEVLLKVL--DKAHRnySESFFEAASMMSKL-SHKHL 609  human
Q63272    517 LEWHENLGHGSFTKIFHGHRRev-------vDG------ETHDTEVLLKVM--DSRHQncMESFLEAASLMSQV-SYPHL 580  Norway rat
AAQ82054  368 lQTTEGLGQGTFTQVFRGIRRev------gdYG------EVHKMEVVMKILdkSHRNY--TESFFESASMMSQL-SHKHL 432  zebrafish
CAG11593  586 iEQEEHLGRGTRTNIYSGTLRvkseededagYS------SFQEVKVVLKLLsyGHRDI--SLAFFETASMMRQV-SHKHI 656  spotted green puf...
4FVP_A     10 LIFNESLGQGTFTKIFKGVRRev------gdYG------QLHETEVLLKVLd-KAHRNy-SESFFEAASMMSKL-SHKHL 74   human
4L00_A     27 LVQGEHLGRGTRTHIYSGTLMd---------YKddegtsEEKKIKVILKVLdpSHRDIs-L-AFFEAASMMRQV-SHKHI 94   human
3ZFX_A     83 IRLEGVVT-Ksr-----pVMIITEFMENG---ALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNIL 153  human
P10676     74 PEFYGVYK-LskpngpdeIWFVMEYCAGGtavDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRNHVLHRDIRGDNIL 152  fruit fly
P23458    651 VYLYGVCV-Rdv-----eNIMVEEFVEGG---PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL 721  human
O12990    650 ALLYGVCVrHqe------nIMVEEFVQYG---PLDLFMRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNIL 720  zebrafish
O60674    610 VLNYGVCVcGde------nILVQEFVKFG---SLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNIL 680  human
Q63272    581 VLLHGVCM-Agd------sIMVQEFVYLG---AIDTYLRKRGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVL 650  Norway rat
AAQ82054  433 LLNYGICV-Cad-----eHIMVQEYVRFG---SLDTYLKRNRNTINITWKLEVAKQLAWALHHLEEKSLTHGNVCARNVL 503  zebrafish
CAG11593  657 VLLYGVCV-Hhq-----eNIMVEEFVQLG---PLDVFMRRQQNPLSIPWKFQVAKQLASALSYLEDKKLVHGFVCAKNIL 727  spotted green puf...
4FVP_A     75 VLNYGVCV-Cgd-----eNILVQEFVKFG---SLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNIL 145  human
4L00_A     95 VYLYGVCV-Rdv-----eNIMVEEFVEGG---PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL 165  human
3ZFX_A    154 V--------NS--------NL-VCKVSDFGLSRYLQDdtsDPTYTSSLGGKIPVRWTAPEAIAYRK-----FTSASDVWS 211  human
P10676    153 L--------TK--------NG-RVKLCDFGLSRQV-----DSTLGKRGTCIGSPCWMAPEVVSAMEsrepdITVRADVWA 210  fruit fly
P23458    722 L--------ARegid-secGP-FIKLSDPGIPITV---------LSRQECIERIPWIAPECVEDSKn----LSVAADKWS 778  human
O12990    721 V--------ARdgl--dgeGGpFIKLSDPGIPITV---------LSREECVDRIPWIAPECVKDTAn----LTIAADKWS 777  zebrafish
O60674    681 L--------IReedr-ktgNPpFIKLSDPGISITV---------LPKDILQERIPWVPPECIENPKn----LNLATDKWS 738  human
Q63272    651 L--------ARegv---dgNPpFIKLSDPGVSPTV---------LSLEMLTDRIPWVAPECLQEAGt----LNLEADKWG 706  Norway rat
AAQ82054  504 V--------TReedrktgtPP-FIKLSDPGISITV---------QPREILLERIPWVPPECVKDSRn----LSLAADKWS 561  zebrafish
CAG11593  728 L--------ARdgmgtdegGP-FIKLSDPGIPITV-------LTRE--ECVHRIPWIAPECVKNVSa----LSVAADKWG 785  spotted green puf...
4FVP_A    146 LireedrktGN--------PP-FIKLSDPGISITVLP---KD------ILQERIPWVPPECIENPKn----LNLATDKWS 203  human
4L00_A    166 L--------ARegid-secGP-FIKLSDPGIPITV---------LSRQECIERIPWIAPECVEDSKn----LSVAADKWS 222  human
3ZFX_A    212 YGIVMWEVMSFGERPywdmSNQDVINAI-EQDYR--LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI--VNTL 280  human
P10676    211 LGITTIELAD-GKPPfadmHPTRAMFQI-IRNPPptLMRPTNWSQQINDFISESLEKNAENRPMMVEMveHPFL 282  fruit fly
P23458    779 FGTTLWEICYNGEIPlkdkTLIEKERFY-ESRCR--PVTPS--CKELADLMTRCMNYDPNQRPFFRAI--MRDI 845  human
O12990    778 FGTTLWEICYNGEIPlkdkKLSE-KERFyAAQCQ--LATPD--CDELAKLMTHCMTYDPRQRLFFRAI--VRDI 844  zebrafish
O60674    739 FGTTLWEICSGGDKPlsalDSQR-KLQFyEDRHQ--LPAPK--WAELANLINNCMDYEPDFRPSFRAI--IRDL 805  human
Q63272    707 FGATTWEVFSGAPMHitslEPAK-KLKFyEDRGQ--LPALK--WTELEGLIAQCMAYDPGRRPSFRAI--LRDL 773  Norway rat
AAQ82054  562 FGTTLWEIYCGGEQPlaayDTAKKLLFY-EDKHQ--LPAPK--WTELASVINSCMDYEPLHRPSFRAL--IRDL 628  zebrafish
CAG11593  786 FGTTLWEICYDGEVPlkekKLTEKERFY-ETECQ--LATPD--CTELAELMTHCMNYDPKKRPFFRAI--VRDi 852  spotted green pufferfish
4FVP_A    204 FGTTLWEICSGGDKPlsalDSQRKLQFY-EDRHQ--LPAPKAA--ELANLINNCMDYEPDHRPSFRAI--IRDL 270  human
4L00_A    223 FGTTLWEICYNGEIPlkdkTLIEKERFY-ESRCR--PVTP--SCKELADLMTRCMNYDPNQRPFFRAI--MRDI 289  human
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