4L00,5UT1,5WNO,2R4B,3LMG,3RCD,4K2R,3LXP,4QT1,1U4D,3ZFX,3FXX,3KUL,3D7U,1IEP,1SM2,3SXS,3ACK,6CZ2,4UXL,1LUF,6TU9,3ZZW,4KNB,6TUA,5UI0


Conserved Protein Domain Family
Pkinase_Tyr

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pfam07714: Pkinase_Tyr 
Click on image for an interactive view with Cn3D
Protein tyrosine kinase
Statistics
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PSSM-Id: 429616
Aligned: 119 rows
Threshold Bit Score: -1
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4L00_A         27 LVQGEHLGRGTRTHIYSGTLMdykdd---egtseEKKIKVILKVL--DPSHRDI---SLAFFEAASMMRQVSHKHIVYLY 98   human
XP_002054634  716 LHLLERIGQGRFGTVHRALWH----------------GDVAVKLL--NEDYLQDehmLESFRNEVANFKKTRHENLVLFM 777  Drosophila vi...
P18160       2115 LEFGQTIGKGFFGEVKRGYWR---------------ETDVAIKIIyrDQFKTKSs--LVMFQNEVGILSKLRHPNVVQFL 2177 Dictyostelium...
P18161        853 IQFIQKVGEGAFSEVWEGWWK---------------GIHVAIKKL--KIIGDEEq-fKERFIREVQNLKKGNHQNIVMFI 914  Dictyostelium...
Q54I36       1057 VAIVEKVGAGSFANVFLGIWN---------------GYKVAIKIL--KNESISN---DEKFIKEVSSLIKSHHPNVVTFM 1116 Dictyostelium...
O12990        580 IVQGEHLGRGTRTNIYAGILKpksdde-ddlggySQEVKVVLKVL----GSGHRd-iSLAFFETASMMRQISHKHTALLY 653  zebrafish
2_pfamImport    1 IEQEEHLGRGTRTNIYSGTLRvkseededagyssFQEVKVVLKLL--SYGHRDI---SLAFFETASMMRQVSHKHIVLLY 75  
Q63272        517 LEWHENLGHGSFTKIFHGHRRevv-------dgeTHDTEVLLKVM----DSRHQn-cMESFLEAASLMSQVSYPHLVLLH 584  Norway rat
5UT1_A         10 LIFNESLGQGTFTKIFKGVRRevgd------ygqLHETEVLLKVL----DKAHRn-ySESFFEAASMMSKLSHKHLVLNY 78   human
XP_009293332  509 LQTTEGLGQGTFTQVFRGIRRevgd------ygeVHKMEVVMKIL--DKSHRNY---TESFFESASMMSQLSHKHLLLNY 577  zebrafish
XP_002054634  716 LHLLERIGQGRFGTVHRALWH----------------GDVAVKLL--NEDYLQDehmLESFRNEVANFKKTRHENLVLFM 777  Drosophila vi...
P18160       2115 LEFGQTIGKGFFGEVKRGYWR---------------ETDVAIKIIyrDQFKTKSs--LVMFQNEVGILSKLRHPNVVQFL 2177 Dictyostelium...
P18161        853 IQFIQKVGEGAFSEVWEGWWK---------------GIHVAIKKL--KIIGDEEq-fKERFIREVQNLKKGNHQNIVMFI 914  Dictyostelium...
Q54I36       1057 VAIVEKVGAGSFANVFLGIWN---------------GYKVAIKIL--KNESISN---DEKFIKEVSSLIKSHHPNVVTFM 1116 Dictyostelium...
O12990        580 IVQGEHLGRGTRTNIYAGILKpksdde-ddlggySQEVKVVLKVL----GSGHRd-iSLAFFETASMMRQISHKHTALLY 653  zebrafish
2_pfamImport    1 IEQEEHLGRGTRTNIYSGTLRvkseededagyssFQEVKVVLKLL--SYGHRDI---SLAFFETASMMRQVSHKHIVLLY 75  
Q63272        517 LEWHENLGHGSFTKIFHGHRRevv-------dgeTHDTEVLLKVM----DSRHQn-cMESFLEAASLMSQVSYPHLVLLH 584  Norway rat
5UT1_A         10 LIFNESLGQGTFTKIFKGVRRevgd------ygqLHETEVLLKVL----DKAHRn-ySESFFEAASMMSKLSHKHLVLNY 78   human
XP_009293332  509 LQTTEGLGQGTFTQVFRGIRRevgd------ygeVHKMEVVMKIL--DKSHRNY---TESFFESASMMSQLSHKHLLLNY 577  zebrafish
4L00_A         99 GVCV--RDVENIMVEEFVEGGPLDLFMHRK-----SDVLTTPWKFKVAKQLASALSYLEDKD--LVHGNVCTKNLLLARe 169  human
XP_002054634  778 GACM--NPPYLAIVTALCKGNTLYTYIHQR-----REKFAMNRTLLIAQQIAQGMGYLHARD--IIHKDLRTKNIFIE-- 846  Drosophila vi...
P18160       2178 GACTagGEDHHCIVTEWMGGGSLRQFLTDHf---nLLEQNPHIRLKLALDIAKGMNYLHGWTppILHRDLSSRNILLDHn 2254 Dictyostelium...
P18161        915 GACY----KPACIITEYMAGGSLYNILHNPnsstpKVKYSFPLVLKMATDMALGLLHLHSIT--IVHRDLTSQNILLDE- 987  Dictyostelium...
Q54I36       1117 GACI----DPPCIFTEYLQGGSLYDVLHIQ-----KIKLNPLMMYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLDE- 1184 Dictyostelium...
O12990        654 GVCVr-HQEN-IMVEEFVQYGPLDLFMRRQ-----TTPLSTAWKFQVAKQLASALSYLEDKK--MVHGYVCSKNILVARd 724  zebrafish
2_pfamImport   76 GVCV--HHQENIMVEEFVQLGPLDVFMRRQ-----QNPLSIPWKFQVAKQLASALSYLEDKK--LVHGFVCAKNILLARd 146 
Q63272        585 GVCM--AGDS-IMVQEFVYLGAIDTYLRKR-----GHLVPASWKLQVTKQLAYALNYLEDKG--LPHGNVSARKVLLARe 654  Norway rat
5UT1_A         79 GVCVc-GDEN-ILVQEFVKFGSLDTYLKKN-----KNCINILWKLEVAKQLAAAMHFLEENT--LIHGNVCAKNILLIRe 149  human
XP_009293332  578 GICV--CADEHIMVQEYVRFGSLDTYLKRN-----RNTINITWKLEVAKQLAWALHHLEEKS--LTHGNVCARNVLVTRe 648  zebrafish
XP_002054634  778 GACM--NPPYLAIVTALCKGNTLYTYIHQR-----REKFAMNRTLLIAQQIAQGMGYLHARD--IIHKDLRTKNIFIE-- 846  Drosophila vi...
P18160       2178 GACTagGEDHHCIVTEWMGGGSLRQFLTDHf---nLLEQNPHIRLKLALDIAKGMNYLHGWTppILHRDLSSRNILLDHn 2254 Dictyostelium...
P18161        915 GACY----KPACIITEYMAGGSLYNILHNPnsstpKVKYSFPLVLKMATDMALGLLHLHSIT--IVHRDLTSQNILLDE- 987  Dictyostelium...
Q54I36       1117 GACI----DPPCIFTEYLQGGSLYDVLHIQ-----KIKLNPLMMYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLDE- 1184 Dictyostelium...
O12990        654 GVCVr-HQEN-IMVEEFVQYGPLDLFMRRQ-----TTPLSTAWKFQVAKQLASALSYLEDKK--MVHGYVCSKNILVARd 724  zebrafish
2_pfamImport   76 GVCV--HHQENIMVEEFVQLGPLDVFMRRQ-----QNPLSIPWKFQVAKQLASALSYLEDKK--LVHGFVCAKNILLARd 146 
Q63272        585 GVCM--AGDS-IMVQEFVYLGAIDTYLRKR-----GHLVPASWKLQVTKQLAYALNYLEDKG--LPHGNVSARKVLLARe 654  Norway rat
5UT1_A         79 GVCVc-GDEN-ILVQEFVKFGSLDTYLKKN-----KNCINILWKLEVAKQLAAAMHFLEENT--LIHGNVCAKNILLIRe 149  human
XP_009293332  578 GICV--CADEHIMVQEYVRFGSLDTYLKRN-----RNTINITWKLEVAKQLAWALHHLEEKS--LTHGNVCARNVLVTRe 648  zebrafish
4L00_A        170 gid------secGP-FIKLSDPGIPITV------LSRQECIERIPWI---APECVEDSKn---------LSVAADKWSFG 224  human
XP_002054634  847 ------------NG-KVIITDFGLFSSTkl---lYCDMGLGVPQNWLcylAPELIRALQpckppgecleFTSYSDVYSFG 910  Drosophila vi...
P18160       2255 idpknpvvssrqDI-KCKISDFGLSRLKme--qaSQMTQSVGCIPYM---APEVFKGDS----------NSEKSDVYSYG 2318 Dictyostelium...
P18161        988 ------------LG-NIKISDFGLSREKsregsmTMTNGGICNPRWR---PPELTKNLGh---------YSEKVDVYCFS 1042 Dictyostelium...
Q54I36       1185 ------------FK-NIKIADFGLATTLs----dDMTLSGITNPRWR---SPELTKGLV----------YNEKVDVYSFG 1234 Dictyostelium...
O12990        725 gl-------dgeGGpFIKLSDPGIPITV------LSREECVDRIPWI---APECVKDTAn---------LTIAADKWSFG 779  zebrafish
2_pfamImport  147 gmg-----tdegGP-FIKLSDPGIPITVl----tREDAECVHRIPWI---APECVKNVSa---------LSVAADKWGFG 204 
Q63272        655 gv--------dgNPpFIKLSDPGVSPTV------LSLEMLTDRIPWV---APECLQEAGt---------LNLEADKWGFG 708  Norway rat
5UT1_A        150 edr------ktgNPpFIKLSDPGISITV------LPKDILQERIPWV---PPECIENPKn---------LNLATDKWSFG 205  human
XP_009293332  649 edr-----ktgtPP-FIKLSDPGISITV------QPREILLERIPWV---PPECVKDSRn---------LSLAADKWSFG 704  zebrafish
XP_002054634  847 ------------NG-KVIITDFGLFSSTkl---lYCDMGLGVPQNWLcylAPELIRALQpckppgecleFTSYSDVYSFG 910  Drosophila vi...
P18160       2255 idpknpvvssrqDI-KCKISDFGLSRLKme--qaSQMTQSVGCIPYM---APEVFKGDS----------NSEKSDVYSYG 2318 Dictyostelium...
P18161        988 ------------LG-NIKISDFGLSREKsregsmTMTNGGICNPRWR---PPELTKNLGh---------YSEKVDVYCFS 1042 Dictyostelium...
Q54I36       1185 ------------FK-NIKIADFGLATTLs----dDMTLSGITNPRWR---SPELTKGLV----------YNEKVDVYSFG 1234 Dictyostelium...
O12990        725 gl-------dgeGGpFIKLSDPGIPITV------LSREECVDRIPWI---APECVKDTAn---------LTIAADKWSFG 779  zebrafish
2_pfamImport  147 gmg-----tdegGP-FIKLSDPGIPITVl----tREDAECVHRIPWI---APECVKNVSa---------LSVAADKWGFG 204 
Q63272        655 gv--------dgNPpFIKLSDPGVSPTV------LSLEMLTDRIPWV---APECLQEAGt---------LNLEADKWGFG 708  Norway rat
5UT1_A        150 edr------ktgNPpFIKLSDPGISITV------LPKDILQERIPWV---PPECIENPKn---------LNLATDKWSFG 205  human
XP_009293332  649 edr-----ktgtPP-FIKLSDPGISITV------QPREILLERIPWV---PPECVKDSRn---------LSLAADKWSFG 704  zebrafish
4L00_A        225 TTLWEICYNGEIPLKDK-TLIEKERFY-ESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDI 289  human
XP_002054634  911 TVWYELIC-GEFTFKDQ-PAESIIWQVgRGMKQSLANLqsGRDVKDLLMLCWTYEKEHRPDFARLLSLL 977  Drosophila virilis
P18160       2319 MVLFELLT-SDEPQQDM-KPMKMAHLAaYESYRPPIPLttSSKWKEILTQCWDSNPDSRPTFKQIIVHL 2385 Dictyostelium discoideum
P18161       1043 LVVWEILT-GEIPFSDL-DGSQASAQVaYAGLRPPIPEycDPELKLLLTQCWEADPNDRPPFTYIVNKL 1109 Dictyostelium discoideum
Q54I36       1235 LVVYEIYT-GKIPFEGLdGTASAAKAA-FENYRPAIPPdcPVSLRKLITKCWASDPSQRPSFTEILTEL 1301 Dictyostelium discoideum
O12990        780 TTLWEICYNGEIPLKDK-KLSE-KERFyAAQCQLATPD--CDELAKLMTHCMTYDPRQRLFFRAIVRDI 844  zebrafish
2_pfamImport  205 TTLWEICYDGEVPLKEK-KLTEKERFY-ETECQLATPD--CTELAELMTHCMNYDPKKRPFFRAIVRDI 269 
Q63272        709 ATTWEVFSGAPMHITSL-EPAK-KLKFyEDRGQLPALK--WTELEGLIAQCMAYDPGRRPSFRAILRDL 773  Norway rat
5UT1_A        206 TTLWEICSGGDKPLSAL-DSQR-KLQFyEDRHQLPAPK--AAELANLINNCMDYEPDHRPSFRAIIRDL 270  human
XP_009293332  705 TTLWEIYCGGEQPLAAY-DTAKKLLFY-EDKHQLPAPK--WTELASVINSCMDYEPLHRPSFRALIRDL 769  zebrafish
XP_002054634  911 TVWYELIC-GEFTFKDQ-PAESIIWQVgRGMKQSLANLqsGRDVKDLLMLCWTYEKEHRPDFARLLSLL 977  Drosophila virilis
P18160       2319 MVLFELLT-SDEPQQDM-KPMKMAHLAaYESYRPPIPLttSSKWKEILTQCWDSNPDSRPTFKQIIVHL 2385 Dictyostelium discoideum
P18161       1043 LVVWEILT-GEIPFSDL-DGSQASAQVaYAGLRPPIPEycDPELKLLLTQCWEADPNDRPPFTYIVNKL 1109 Dictyostelium discoideum
Q54I36       1235 LVVYEIYT-GKIPFEGLdGTASAAKAA-FENYRPAIPPdcPVSLRKLITKCWASDPSQRPSFTEILTEL 1301 Dictyostelium discoideum
O12990        780 TTLWEICYNGEIPLKDK-KLSE-KERFyAAQCQLATPD--CDELAKLMTHCMTYDPRQRLFFRAIVRDI 844  zebrafish
2_pfamImport  205 TTLWEICYDGEVPLKEK-KLTEKERFY-ETECQLATPD--CTELAELMTHCMNYDPKKRPFFRAIVRDI 269 
Q63272        709 ATTWEVFSGAPMHITSL-EPAK-KLKFyEDRGQLPALK--WTELEGLIAQCMAYDPGRRPSFRAILRDL 773  Norway rat
5UT1_A        206 TTLWEICSGGDKPLSAL-DSQR-KLQFyEDRHQLPAPK--AAELANLINNCMDYEPDHRPSFRAIIRDL 270  human
XP_009293332  705 TTLWEIYCGGEQPLAAY-DTAKKLLFY-EDKHQLPAPK--WTELASVINSCMDYEPLHRPSFRALIRDL 769  zebrafish
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