3ZFX,4K33,2QOH,3BYS,3KUL,3SXR,4GU9,4ANS,5UAB,6FEK,4OT5,3ZBF,1LUF,3MIY,5TO8,3ZZW,2OO8,3PLS,3QUP,5D7V,1BYG,4HZR,1U59,6C7Y,4GVJ,5TQ5,5WNO,4RIY,4PX6,4RIO,5WIJ,4L00


Conserved Protein Domain Family
Pkinase_Tyr

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pfam07714: Pkinase_Tyr 
Click on image for an interactive view with Cn3D
Protein tyrosine kinase
Statistics
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Aligned: 152 rows
Threshold Bit Score: 210.044
Threshold Setting Gi: 73920239
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZFX_A                21 VKIEEVIGAGEFGEVYKGRLK----------LPGKREIYVAIKTL--KAGYSEKQ--RRDFLSEASIMGQF-DHPNIIRL 85   human
WGS:AANI:GJ24562-PA  716 LHLLERIGQGRFGTVHRALWH----------------GDVAVKLL--NEDYLQDEhmLESFRNEVANFKKT-RHENLVLF 776  Drosop...
P18160              2115 LEFGQTIGKGFFGEVKRGYWR---------------ETDVAIKIIyrDQFKTKSS--LVMFQNEVGILSKL-RHPNVVQF 2176 Dictyo...
P18161               853 IQFIQKVGEGAFSEVWEGWWK---------------GIHVAIKKL--KIIGDEEQf-KERFIREVQNLKKG-NHQNIVMF 913  Dictyo...
P10676                16 FEIYEEIAQGVNAKVFRAKEL-------------DNDRIVALKIQ----HYDEEH--QVSIEEEYRTLRDYcDHPNLPEF 76   fruit fly
Q63272               517 LEWHENLGHGSFTKIFHGHRRev-------vDGETHDTEVLLKVM----DSRHQNc-MESFLEAASLMSQV-SYPHLVLL 583  Norway...
O60674               545 LIFNESLGQGTFTKIFKGVRRev------gdYGQLHETEVLLKVL----DKAHRNy-SESFFEAASMMSKL-SHKHLVLN 612  human
XP_009293332         509 lQTTEGLGQGTFTQVFRGIRRev------gdYGEVHKMEVVMKIL--DKSHRNY---TESFFESASMMSQL-SHKHLLLN 576  zebrafish
CAG11593             586 iEQEEHLGRGTRTNIYSGTLRvkseededagYSSFQEVKVVLKLL--SYGHRDI---SLAFFETASMMRQV-SHKHIVLL 659  spotte...
5WIJ_A                10 LIFNESLGQGTFTKIFKGVRRev------gdYGQLHETEVLLKVL---DKAHRNY--SESFFEAASMMSKL-SHKHLVLN 77   human
3ZFX_A                86 EGVVT--KSRP-----VMIITEFMENG---ALDSFLRQN-----DGQFTVIQLVGMLRGIAAGMKYLAEMN--YVHRDLA 148  human
WGS:AANI:GJ24562-PA  777 MGACM--NPPY-----LAIVTALCKGN---TLYTYIHQR-----REKFAMNRTLLIAQQIAQGMGYLHARD--IIHKDLR 839  Drosop...
P18160              2177 LGACTagGEDH-----HCIVTEWMGGG---SLRQFLTDHf---nLLEQNPHIRLKLALDIAKGMNYLHGWTppILHRDLS 2245 Dictyo...
P18161               914 IGACY----KP-----ACIITEYMAGG---SLYNILHNPnsstpKVKYSFPLVLKMATDMALGLLHLHSIT--IVHRDLT 979  Dictyo...
P10676                77 YGVYK--LSKPngpdeIWFVMEYCAGGtavDMVNKLLKL-----DRRMREEHIAYIIRETCRAAIELNRNH--VLHRDIR 147  fruit fly
Q63272               584 HGVCM--AGDS------IMVQEFVYLG---AIDTYLRKR-----GHLVPASWKLQVTKQLAYALNYLEDKG--LPHGNVS 645  Norway...
O60674               613 YGVCVc-GDEN------ILVQEFVKFG---SLDTYLKKN-----KNCINILWKLEVAKQLAWAMHFLEENT--LIHGNVC 675  human
XP_009293332         577 YGICV--CADE-----HIMVQEYVRFG---SLDTYLKRN-----RNTINITWKLEVAKQLAWALHHLEEKS--LTHGNVC 639  zebrafish
CAG11593             660 YGVCV--HHQE-----NIMVEEFVQLG---PLDVFMRRQ-----QNPLSIPWKFQVAKQLASALSYLEDKK--LVHGFVC 722  spotte...
5WIJ_A                78 YGVCV--CGDE-----NILVQEFVKFG---SLDTYLKKN-----KNCINILWKLEVAKQLAAAMHFLEENT--LIHGNVC 140  human
3ZFX_A               149 ARNILV--------NS-------------NL-VCKVSDFGLSRYLQDdtsDPTYTSSLGGKIPVRWT---APEAIAYRK- 202  human
WGS:AANI:GJ24562-PA  840 TKNIFI--------E--------------NG-KVIITDFGLFSST------KLLYCDMGLGVPQNWLcylAPELIRALQp 890  Drosop...
P18160              2246 SRNILL--------DHnidpknpvvssrqDI-KCKISDFGLSRLK-----MEQASQMTQSVGCIPYM---APEVFKGDS- 2307 Dictyo...
P18161               980 SQNILL--------DE-------------LG-NIKISDFGLSREKSR---EGSMTMTNGGICNPRWR---PPELTKNLGh 1031 Dictyo...
P10676               148 GDNILL--------TK-------------NG-RVKLCDFGLSRQV-----DSTLGKRGTCIGSPCWM---APEVVSAMEs 197  fruit fly
Q63272               646 ARKVLL--------ARegv--------dgNPpFIKLSDPGVSPTV---------LSLEMLTDRIPWV---APECLQEAGt 697  Norway...
O60674               676 AKNILL--------IReedr------ktgNPpFIKLSDPGISITV---------LPKDILQERIPWV---PPECIENPKn 729  human
XP_009293332         640 ARNVLV--------TReedr-----ktgtPP-FIKLSDPGISITV---------QPREILLERIPWV---PPECVKDSRn 693  zebrafish
CAG11593             723 AKNILL--------ARdgmg-----tdegGP-FIKLSDPGIPITV-------LTRE--ECVHRIPWI---APECVKNVSa 776  spotte...
5WIJ_A               141 AKNILLireedrktGN-------------PP-FIKLSDPGISITVLP---KD------ILQERIPWV---PPECIENPKn 194  human
3ZFX_A               203 ---------FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYR--LPPPMDCPAALHQLMLDCWQKDRNSR 270  human
WGS:AANI:GJ24562-PA  891 ckppgecleFTSYSDVYSFGTVWYELIC-GEFTFKDQPAESIIWQVgRGMKQ--SLANLQSGRDVKDLLMLCWTYEKEHR 967  Drosop...
P18160              2308 ---------NSEKSDVYSYGMVLFELLT-SDEPQQDMKPMKMAHLAaYESYR--PPIPLTTSSKWKEILTQCWDSNPDSR 2375 Dictyo...
P18161              1032 ---------YSEKVDVYCFSLVVWEILT-GEIPFSDLDGSQASAQVaYAGLR--PPIPEYCDPELKLLLTQCWEADPNDR 1099 Dictyo...
P10676               198 re-----pdITVRADVWALGITTIELAD-GKPPFADMHPTRAMFQI-IRNPPptLMRPTNWSQQINDFISESLEKNAENR 270  fruit fly
Q63272               698 ---------LNLEADKWGFGATTWEVFSGAPMHITSLEPAK-KLKFyEDRGQ--LPALK--WTELEGLIAQCMAYDPGRR 763  Norway...
O60674               730 ---------LNLATDKWSFGTTLWEICSGGDKPLSALDSQR-KLQFyEDRHQ--LPAPK--WAELANLINNCMDYEPDFR 795  human
XP_009293332         694 ---------LSLAADKWSFGTTLWEIYCGGEQPLAAYDTAKKLLFY-EDKHQ--LPAPK--WTELASVINSCMDYEPLHR 759  zebrafish
CAG11593             777 ---------LSVAADKWGFGTTLWEICYDGEVPLKEKKLTEKERFY-ETECQ--LATPD--CTELAELMTHCMNYDPKKR 842  spotte...
5WIJ_A               195 ---------LNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFY-EDRHQ--LPAPKAA--ELANLINNCMDYEPDHR 260  human
3ZFX_A               271 PRFAEI--VNTL 280  human
WGS:AANI:GJ24562-PA  968 PDFARL--LSLL 977  Drosophila virilis
P18160              2376 PTFKQI--IVHL 2385 Dictyostelium discoideum
P18161              1100 PPFTYI--VNKL 1109 Dictyostelium discoideum
P10676               271 PMMVEMveHPFL 282  fruit fly
Q63272               764 PSFRAI--LRDL 773  Norway rat
O60674               796 PSFRAI--IRDL 805  human
XP_009293332         760 PSFRAL--IRDL 769  zebrafish
CAG11593             843 PFFRAI--VRDi 852  spotted green pufferfish
5WIJ_A               261 PSFRAI--IRDL 270  human
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