5FMF,5IY6


Conserved Protein Domain Family
TFIIS_M

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pfam07500: TFIIS_M 
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Transcription factor S-II (TFIIS), central domain
Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.
Statistics
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PSSM-Id: 336713
View PSSM: pfam07500
Aligned: 317 rows
Threshold Bit Score: 46.7826
Threshold Setting Gi: 122100556
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FMF_2         12 KLRDQVLKALYDVLAKES---------------------EH--------------PpQ--SILHTAKA-----------I 43
gi 124457636  236 EVREKFFSVIFYGIEELKdmyqrdptsitqlekeiinnsDTa------------lF-Q--YIKNLALD-----------I 289
gi 121969694  309 EVREKFFEYLIYGLIEFE---------------------ENesilneeekkillqD-SyeIARKLAVE-----------I 355
gi 82011147    15 EIRQKARDMLDVVVKDPK------------------------------------------VSRYLEMAswnhtmdickkL 52
gi 74777125     4 SMQTELRNALEQGLVENKtfk-------------------------------------nvDIYSLSKS-----------I 35
gi 749162183    3 SIATKFREIFRRGLCEYA---------------------VEkgrlp-----agtdV-EgtSVEVVQAA-----------L 44
gi 221056290 1056 KVIDKIKHALDKEdtsgadv----------------------------------ggekaiDTKELSER-----------I 1090
gi 156082744   35 TYGKKLEECLIRGLEEIQ---------------------NDspd---------vdM-SecDVKILTNN-----------I 72
gi 471225551  315 EVREKFFEFIIYGLIEFE---------------------VYenelteeekkvltqD-IyeIARKFAVE-----------I 361
gi 514696436  113 QKRDGMRSVIIRRIVSLN---------------------PG--------------R-SqkSVADVACK-----------V 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FMF_2         44 ESE---M--NKvnncd-------------------tneaaYKARYRIIYSNVisKNNPDLKHKIANGDITPEFLATCDAK 99
gi 124457636  290 EVYthiK--FNtqykt-------------------kleplYVERCKLIYLHMkdDKNLELRRKVISKEFQAQDLSTRDER 348
gi 121969694  356 ESN---L--FNinnshnk----------------yalkeqYKNRCKILFVHLkdPQNFNFRRKILNKQMKPIQLCTINEQ 414
gi 82011147    53 GHD---Lkwdnf-----------------------tfrnrYTQKILSVRYNIglR--QDLLDKMKTGETSIKNFVNSKPW 104
gi 74777125    36 EED------FLkvmag-------------------kdsriIRQRRFELMSNLkrPNNLDLRRRILAGEMSVREFVTCPVS 90
gi 749162183   45 EGE------EYlgkgavdaplyiscvvvdaleqanedrlwIRQKGYEIYQNLkrDHSVRHRVRIISGDLSVAALVSMDAK 118
gi 221056290 1091 VKEvieK--FNdk-------------------------meIKMKLFSICSNLmrKDNAELRKKILHGTIHATDLAHMDSS 1143
gi 156082744   73 CDVchdYygYDrr--------------------------rFKQRMFEIYVNLkrENNQDLRRKILTKAMSVLDLVEADTI 126
gi 471225551  362 EQT---I--FNinnksnk----------------yqlnenYKQRCKMLFSNLkdSLNFSLRRKIITKTLKAQQLCTVQEN 420
gi 514696436  146 EEA---I--FNkfrn---------------------dgdpYKKECRSRANYL---KN-EILDKLIAGELTPEQFATQAEQ 195
                         170       180
                  ....*....|....*....|...
5FMF_2        100 DLAPAPLKQKIE-EIAKQNLYNA 121
gi 124457636  349 DLYNPEKRKQTQ-EIAMRVIEln 370
gi 121969694  415 EMFNPFKLQEIE-NQKikllnrd 436
gi 82011147   105 EVCPEKWEKAFE-DAAKKALRFT 126
gi 74777125    91 ELAPDSVKQQRL-EEQKRYFKEe 112
gi 749162183  119 ELAPESVKRRRR-EEEQKYLKEq 140
gi 221056290 1144 DLAPISLKNKRK-EHERKYFYEn 1165
gi 156082744  127 QLAPEELKHKRQiEVERHYIRNV 149
gi 471225551  421 ELYNPQKQKEIE-EQKQKLfnrd 442
gi 514696436  196 KLVSEEDRRETE-QHLEQALRDk 217
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