4Z0R,5OFB,5OF9,2L7P


Conserved Protein Domain Family
zf-CW

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pfam07496: zf-CW 
Click on image for an interactive view with Cn3D
CW-type Zinc Finger
This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found.
Statistics
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Aligned: 195 rows
Threshold Bit Score: 33.0406
Threshold Setting Gi: 0
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4Z0R_A         10 VWVQCEneNCLKWRLLSSEDs-AKVDH-DePWYCFMNT---D--SRYNN--CSISEED 58  human
EGV95567      138 YWVQCTkpECGKWRQLTKEIq-LTPHMaR-TYRCGIKlntiT--KTDIPdhCSLPEDL 191 Chinese hamster
XP_006011444  147 YWVQCIkpECRKWRQLTKEIq-LTSVLaK-TYRCGMKlnnnV--KNEGPdqCSFPEDM 200 coelacanth
OCA31260      138 YWVQCTklECGKWRQLTKEIq-LTTQMaK-TYKCGMKmnnsV--KTEGSdqCSMPEDL 191 tropical clawed frog
EEC20158       67 FWAQCT--RCHKWRRLPKGDd-LTPEVvE-TFTCSDIPtyddseskiED--CDIPEDp 118 black-legged tick
66_pfamImport   1 YWLQCV--SCKKWRKLPGETe-INYDFiT-KFKCNQme-egS--KKK-SncCSVPEDK 50 
EJW82033      117 FWLQCK--VCKKFRHLPTAVssISREDvE-KFVCGSqt-eaD--RDNTNdsCDIKEEe 168 Wuchereria bancrofti
XP_022527712  168 YWVQCTkpDCGKWRQLTKDIq-LTASLaA-SYRCGMKln-nV--KTEGPdqCSQPEDM 220 Mexican tetra
XP_005452898  160 YWVQCTkpDCRKWRQLTKEIq-LTASLaA-TYRCGMKfn-nI--KSEEPdqCSQPEDL 212 Nile tilapia
XP_023352089  140 YWVQCTkpDCGKWRQLTKEIq-LTSQMaQ-TYRCGTKpntsV--KVEGSdqCSQPEDL 193 Tasmanian devil
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