1KKL,1KO7,1KNX


Conserved Protein Domain Family
Hpr_kinase_C

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pfam07475: Hpr_kinase_C 
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HPr Serine kinase C-terminal domain
This family represents the C terminal kinase domain of Hpr Serine/threonine kinase PtsK. This kinase is the sensor in a multicomponent phosphorelay system in control of carbon catabolic repression in bacteria. This kinase in unusual in that it recognizes the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating enzymes. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller.
Statistics
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Aligned: 61 rows
Threshold Bit Score: 225.432
Threshold Setting Gi: 123593379
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KKL_A         18 QLAErrsmHGVLVDIYGLGVLITGDSGVGKSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGII 97  Lactobacillus ...
Q2YCY0        148 VLAPscsrHGVLLDVLGLGVMITGESSVGKSELALELVSRGHGLVADDVVELYRIAPETLEGRCPPMLRDFLEVRGLGML 227 Nitrosospira m...
A1K2R3        132 QLAEkislHGVFMDVLGIGVFITGNSGAGKSELALELISRGHGLVADDIVEFSRTAPTVLEGRCPELLKDFIEVRGLGIL 211 Azoarcus sp. BH72
CAL62998      135 KLAQritmHGVFMDVLGVGVLITGESGLGKSELGLELISRNHGLVADDAVEFARIAPHMIEGRCPPLLQNLLEVRGLGLL 214 Herminiimonas ...
jgi:Pnuc_1914 142 IGAPqitmHGVFMDILGLGVLLTGESGLGKSELGLELISRGHGLVADDAVDFARLGPDYIEGRCPVILRNLLEVRGLGLL 221 Polynucleobact...
Q122P8        138 HFADrtsmHGVFMDILGMGVMITGESGLGKSELGLELISRGHGLVADDAVDLYRINQTTIEGRCPELLQNLLEVRGIGLL 217 Polaromonas sp...
Q7NST5        133 ALAVstvlHGVFLDVFEIGVLIMGDSAMGKSELALELISRGHGMVADDAVELYRIGPDTLEGRCPPLLRDFLEVRGLGIL 212 Chromobacteriu...
Q5F9S6        133 TLAAssvkHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGIL 212 Neisseria gono...
Q8EL04        130 KLAPeiavHGVCMNVLGIGILIRGESGVGKSELAHTLLGRGHRLVADDIVVLKRLSHKTILGTHNDKNKEFLALRSVGLL 209 Oceanobacillus...
Q3SLD2        133 QLAEtvsvHGVFLEVLGTGILIKGDAGVGKSELALELITRGHRLVADDVVELKHVAPETLEGSCPPLIRDFLEVRGLGIL 212 Thiobacillus d...
1KKL_A         98 DVMNLFGAGAVREDTTISLIVHLENWtp--dKTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSM 175 Lactobacillus ...
Q2YCY0        228 NIRTIFGEAAVRRKKNMKLIVHLQKPnsadlNAMERLPINDVTENILDVNIRKVIIPVAAGRNLAVLVEAAVRNYVLQLR 307 Nitrosospira m...
A1K2R3        212 NIRTIFGETACRRKMRLRLVCHLERRqp-gqDDPNRLPVQQEQQVILGVSTPRVTLPVAAGRNLAVLLEAAVRSTILQLR 290 Azoarcus sp. BH72
CAL62998      215 DIRTIFGETAVRRKMRLKLIVHLVRRst-leENYERLPLPSQSEEILGLSIRKVVIPVEAGRNLAVLLEAAVRNTILQLR 293 Herminiimonas ...
jgi:Pnuc_1914 222 DIRTIFGETAVRRKLKLRLIVQLVRRt---dGEFERLPLEAQHIDVLGIPIRTVKIQVAAGRNLAVLVEAAVRNTILQLR 298 Polynucleobact...
Q122P8        218 DIKAIFGETAVRRKMRLKMIVHLVRRet-leRDYERIPYEPLTQDVLGIPVRKVIIQVEAGRNIAVLVEAAVRNAILQLR 296 Polaromonas sp...
Q7NST5        213 NIRTIFGETAVRPKKVLKLIIHLVKAndqamQALDRLNIQSETQDIIGVTVRKVVLPVAAGRNLAVLVEAAVRNYILQLR 292 Chromobacteriu...
Q5F9S6        213 NIRHIFGETSIRPKKILQLIINLVEAddeymKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLR 292 Neisseria gono...
Q8EL04        210 NVVRAYGSRAFQDETRISLDIKLSKWek--dSLHNELEFETQYRDYMGVSVPSIEIQLQPGRDVAGLIEAAANNWYLQQQ 287 Oceanobacillus...
Q3SLD2        213 NIRFLFGEMAVKPHQNLRLIVELVHPeeigeVGLNRLDMVASTQTILGVAIPKVRVPVAAGRNLAVLVEVAVRNHILKTR 292 Thiobacillus d...
1KKL_A        176 GYDATKTFEKNL 187 Lactobacillus casei
Q2YCY0        308 GIDSGQEFFARH 319 Nitrosospira multiformis ATCC 25196
A1K2R3        291 GVDSTQEFIDRQ 302 Azoarcus sp. BH72
CAL62998      294 GIDTLKDFMIRq 305 Herminiimonas arsenicoxydans
jgi:Pnuc_1914 299 GIDTLKEFIERQ 310 Polynucleobacter asymbioticus QLW-P1DMWA-1
Q122P8        297 GINTYQEFVERH 308 Polaromonas sp. JS666
Q7NST5        293 GIDSTREFIERH 304 Chromobacterium violaceum ATCC 12472
Q5F9S6        293 GKDSTREFLERh 304 Neisseria gonorrhoeae FA 1090
Q8EL04        288 GYSAAEDFMNRI 299 Oceanobacillus iheyensis HTE831
Q3SLD2        293 GINPVEQFIKRQ 304 Thiobacillus denitrificans ATCC 25259
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