Conserved Protein Domain Family
DGCR6

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pfam07324: DGCR6 
DiGeorge syndrome critical region 6 (DGCR6) protein
This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.
Statistics
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PSSM-Id: 462145
Aligned: 10 rows
Threshold Bit Score: 252.421
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q17NK5              263 DDEGLSQDS--QAESQEsttdlalveepyqsqefLQRKLYFLLEQLKKMHA-TLPEQFQLRISYELLAGLANSLLNDTIF 339 yellow f...
XP_011416515         29 EELTVRKEE--IVRREN-----------------QQKRHYFYQNELQNMAR-ELPGKYQQRLPYDLLSSLANSLLDGTVF 88 
WGS:AAQB:GK15388-PA   8 SSTASITET--AADSESq---------------cLQRKIYFLVDNLRSYHA-ELPVTLQTRISYELLTELAHCVLNEGIF 69 
2_pfamImport          1 ERYPGAFEE--AADGAR-----------------QQERHYQLPSALQRAAQvHDRGSCQRRLSYTTLSDLALALLDGSVF 61 
O35347                2 DRYAAAGDE--AADRAR-----------------QQERHYQLLSALQSLVK-ELPSSFQQRLSYTTLSDLALALLDGTVF 61  house mouse
O73770                2 ERFGGAGYEvaAAELSR-----------------QQERHYRLLSELQELVK-ALPSSCQQRLSYTTLSDLALALLDGTVF 63  chicken
XP_014340653          5 DDCLGMYEE--PADTTK-----------------QQERHYYLLSELQNLIK-SLPSSCQQRLSYTMLSDLALALIDGTVF 64  coelacanth
XP_002932120          2 AGYMGMYEE--PRDITQ-----------------QQERHYYLLSELQSLVK-DLPSSCQQRMSHTILSDLALALIDGTVF 61  tropical...
CAF93131              2 ERYPGAV----SGDSTK-----------------QQERHYYLLSELQALVK-DLPSSFQQRLSYSTLGDLALALIDGTVY 59  spotted ...
XP_001353153          2 TDITVSNEG--PTNGSEpvavaedp-fqqpspefLQRKIYFLVDQLRTMHA-ELPENLQTRISYDLLTELANCVLNDSIF 77  Drosophi...
Q17NK5              340 EIVKGLMEIQHVTEKHLMQVREKVENDHQLEV----------KQWESKIQDPEE----LEHIIALMKIKHSKNM------ 399 yellow f...
XP_011416515         89 EIVRSLQEVQQLEERHLHTQRVKLVNDHKAQR----------HELQKRHKELLQgcqtKPHNLPIVEVQIEREKetmekr 158
WGS:AAQB:GK15388-PA  70 EIVKALLELQHATEKHLLQMRLQVENEYEIEV----------TEWCSKIKDPKE----LAHLLDLLKAKHVNKL------ 129
2_pfamImport         62 EIVQGLLETQHLTEKRLYSQRLRLQDGHRVLR----------QALRQKHEEAQEa--cQPHNLPLLQEAALRCTrsgrqw 129
O35347               62 EIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLR----------QTLRQKHLEAQQs--cRPHNLPVLQAAQQRELeamehr 129 house mouse
O73770               64 EIVQGLLEIQHLTEKNLYSQRLKLHSEHRGLK----------QELFHRHKEAQQc--cRPHNLPLLRAAQQREMeaveqr 131 chicken
XP_014340653         65 EIVQGLLEIQHLTEKNLYNQRLKLHSEHRGLKldllrkqkeaQQSC------------KSHNLSLLKTAQQRELealeqr 132 coelacanth
XP_002932120         62 EIVQGLLEIQHLTEKNLYNQRLKLHAEHRGLK----------QDLLRKHREAQQs--cKAHNFQVLKATQQRELesleqr 129 tropical...
CAF93131             60 EIVQGLLDIQHLTEKNLYNQRQKLHCEHQALK----------QELTKKHKDALQt--cKSHNLALLKTNQQAEVealeir 127 spotted ...
XP_001353153         78 VIVKALMELQHETERHLIKMRMQVENEYEIEV----------SDWRAKIKDPEE----LLHILGLMKLKHSKKL------ 137 Drosophi...
Q17NK5              400 -----KETDMKLVLHLDQKVKDQQSTLEKAGVPGFYVSDNPMEIKIQMYLLDFILRLSRlkfEPNK 460 yellow fever mosquito
XP_011416515        159 ceeevKKKDMKIIMELDQKVMDQQVMLEKAGVPGFYVTNKSIDVRIQMYLLDFITRLGH---MQPP 221
WGS:AAQB:GK15388-PA 130 -----KDADKKIIEVLDQKVNDQQSTLHMAGVPGFYATQNAKEIKIQMFLLDFILRLSRlkyKPNK 190
2_pfamImport        130 iheeqQTMDKKIILELDQMVADQQSTLEKAGVTGFYITTNLQELTLQMNLLKLIRKLQQrdcQMGK 195
O35347              130 ireeqQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQrscQVGK 195 house mouse
O73770              132 ireeqRMMDEKIVLELDQKVIDQQSTLEKAGVSGFYITTNPQELTLQMNLLELIRKLQQkesESEK 197 chicken
XP_014340653        133 ikdeqRMMDEKIVLELDQKVIDQQSTLEKAGVPGFYVTTNFQELTLQMNLLELILKLQQketHLGG 198 coelacanth
XP_002932120        130 ikeeqRMMDEKIVLELDQKVIDQQTTLEKAGVSGFYITKNPQELMLQMNILELIQKLQQkesLSNK 195 tropical clawed frog
CAF93131            128 vreeqRMMDKKIVAEMDQKVVDQQNTLEKAGVPGFYITTNPQELTMQMNLLELILKLQQk------ 187 spotted green pufferfish
XP_001353153        138 -----VESDKKIIEILDQKVNDQQSTLQKAGVPGFYVTENPKEIKIQMFLLDFILRLSRlnyEPNK 198 Drosophila pseudoobscu...
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