4A15


Conserved Protein Domain Family
HBB
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pfam06777: HBB 
Helical and beta-bridge domain
HBB is the domain on DEAD-box eukaryotic DNA repair helicases (EC:3.6.1.-) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping architecture. This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).
Links
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Statistics
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PSSM-Id: 462008
Aligned: 39 rows
Threshold Bit Score: 117.481
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4A15_A               236 ADREAQAYGDPELSQKIHVsdLIEMIRSALQSMVsERCGKGDv---RIRFQEFMEYMRIMNKRSEREIRSLLNYLYLFGE 312 Thermop...
mbrcrk:TON_1040      263 AIKEADEYREHEIANFLSI--FGKGLEMLYEEKL-RERDVHEv---PIQPELVFAHVVDILNLDGRYLVKTLNEMVAVGD 336
UBO_LM2E:TERMP_01136 238 AVKEAEEYNEHEIANFLSI--FLKGLENLYNERL-KDREVEEi---PILPESIFSHVFDILNISERLLVRILREIVEVGD 311
WP_015849486         238 AIKEADEYKEHEIANFLSI--FLKGLENLYQEKL-RDLKIDEv---PIIPESIFYHVFDVLKINEKQLIRILDQMVKAGD 311 Thermoc...
WP_013905033         238 AVKEAQEYGEGDIESFLLI--LLRGLELLYEERL-KNYEAYEv---PIRPEDIFRHVIEVTGYLGRAIVRMLNDMVEVGD 311 Pyrococ...
Q8U2A6               240 AIKEAEEYGEKDIENFLSI--LLRGLEILYKEKL-ENYESEEv---PIRPEEVFLHVASVLGWSGREIGMMLEDMIEVGD 313 Pyrococ...
WP_013748813         238 AIKEAEEYGEKDIANFLSI--FLRGLEILYREKL-ENYEIQEv---PLSPMEIFSHVASILGFETRDILMVLNDMVEIGD 311 Pyrococ...
Q9UZ12               238 AIKEANEYGEKDIENFLSI--FLRGLEIIYKEKL-ENYEISEv---PLSPASIFEHVSSILGLRERDLLRFLQEMVEVGD 311 Pyrococ...
licsiro:TALC_00787   264 ALDECMAFNKPPVSSTMTLddFVRAVRRVVKGLA-SKKIPLGekeaMLEPREFETALASESGTDVTGLRSIVEKLTELGE 342
CIDAM:MMALV_08560    243 ALDEAGLFKKPEVCDGVTIdaFIRSVRAAMRDIG-SKYLGFNekekVIPADSLENSVCTALNIDRMQLTAAINRTIELGE 321

4A15_A               313 YVeNEKEKVGKVPFSYCSSVAsriiafsdqdeek-yaailspedggymQAACLDpSGILEVLKES-KTIHMSGTLDPFDF 390 Thermop...
mbrcrk:TON_1040      337 SIrEDKIEKGKPPRSYIGRVGefllfwlsligredylflmsrdkglslELVALDpSKALSFVKNVqSAIFMSGTLTPLEA 416
UBO_LM2E:TERMP_01136 312 AIrEDKIEKNKPPRSYVGRVGefllnwlsvigredylfimskdrgfslELVALDpSKALDFINDIqSAIFMSGTLTPLEA 391
WP_015849486         312 AIrEDKIERSLPPRSYVGRVGeflllwfaligkedylflmsrekgfslELVALDpSKALSFVKNVqSAIFMSGTMTPLEA 391 Thermoc...
WP_013905033         312 AIrEDRIERNLPPRSYIGRVGeflltwlslansedylhlmsrekglslEIVALDpSRALDFVEEVhSAIFMSGTLSPLEA 391 Pyrococ...
Q8U2A6               314 AIrEDRIERNLPPRSYVGRVGeflwnwlalreredylhlftkerglalELVALDpSVALEFLEEVhSAIFMSGTLSPLEA 393 Pyrococ...
WP_013748813         312 AIrEDRIERNLPPRSYIGRTGefllnwlslmdrsdyihlfskergpalELVALDpSIALDFLNDVhSAIFMSGTLTPLEA 391 Pyrococ...
Q9UZ12               312 AIrEDKIERNLPPRSYVGRVGeflwnwisladrsdylhvftrekglalEIVALDpSVALEFLEDVhSAILMSGTLSPLEA 391 Pyrococ...
licsiro:TALC_00787   343 KR-QEAIADTDSPDSPLLDFAillgkwvkspedryikvvrtneegefiQASCIDpADVPAFLRKLpGAVHMSGTLQPLAQ 421
CIDAM:MMALV_08560    322 KR-EEAIADTDAPSSPVLEFGrlmeawvkspadryvravrsnedgeylTASCIDpTDIVRFMNALpGAVHMSGTLQPLAQ 400

4A15_A               391 YSDItgfeipfkk--igeifppeNRYIAYYDGVSSKYDT 427 Thermoplasma acidophilum
mbrcrk:TON_1040      417 FRDVmgienaklk-kfprmvkreNAQVLVAKDVSTRGEE 454
UBO_LM2E:TERMP_01136 392 FKDImgienaklk-kfprmvkkeNALVLVAKDVSTRGEE 429
WP_015849486         392 FADImgiegklkk--fprivkkeNAIVLVAKDVSTRGDE 428 Thermococcus sibiricus
WP_013905033         392 FRDIigveaelkk--fprivkreNALVLVARDVSTRGEE 428 Pyrococcus yayanosii
Q8U2A6               394 FRDIigvkaelkk--fprmikreNAIVLVARDVSTRGIE 430 Pyrococcus furiosus
WP_013748813         392 FRDIigvqaklkk--fprivkseNAIVLVARDVSTRGEE 428 Pyrococcus sp. NA2
Q9UZ12               392 FRDIigvnarlkk--fprmvkseNAIVLVARDVSTRGEE 428 Pyrococcus abyssi
licsiro:TALC_00787   422 YARVmglpdntlprkypspfpkeNKKVVYATDVTSEFKT 460
CIDAM:MMALV_08560    401 YARVmglpsnsvprtypspfpaeNKLVVYAKDVTTNYND 439
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