Conserved Protein Domain Family
Ins_allergen_rp

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pfam06757: Ins_allergen_rp 
Insect allergen related repeat, nitrile-specifier detoxification
This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defense mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.
Statistics
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PSSM-Id: 336496
View PSSM: pfam06757
Aligned: 83 rows
Threshold Bit Score: 119.19
Threshold Setting Gi: 122000602
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q29PK9       154 GLTNLIRVARPMLPAAELRNIFANAVE-DPQVRDLLKLLKSNPFKEQVALLRSTKQHQMLQDYICrrlkldp-------- 224 Drosophila pseu...
XP_001983994  38 DLGKELMDIFAMVQLKPMNKMFARYLLnDGQFQAFVRIMNSNAGFMARWRLLSQPEVIMLRQWVNqqlmtskgkfe-iee 116 Drosophila grim...
XP_002068290  49 TLLQDLEEIIRLIQFKPIKQLVLRYLLnDAEFQAFVRIINSQSGFTARWRLLSQPELIQFLQWVDqqlvasgggsfefee 128 Drosophila will...
XP_002008174  35 NLAQDLTDIYGQIQFKPMQKLFVRYLLnDGQFQAFVRILNSNAGFTAYWRLLAQPEVLLFRQWVDqqllassgqfe-lep 113 Drosophila moja...
XP_017863486  43 NFYLELRSVMRNVPYKQIEHLVQAYLLnDAEFQAVIREINSLPAYRLRMQLLNQPELRQFLQWLSqqlils--------- 113 Drosophila ariz...
XP_002062120  40 NFALELVAIIRSIPRKQIQHLVQAYLLnDEEFQAVVRDINSMSGYRLQQQVLRQPELRQLFIWLNqqlila--------- 110 Drosophila will...
XP_001985097  33 nfylNLKSILRNVPQKQIEHLVQAYLLnDAEFQAVVREINSLTTYRLGLQLLNQPEFRQLLQWTSqqlilaggsikvfee 112 Drosophila grim...
XP_002009131  43 nfylELRSVMRNVPYKQIEHLVQAYLLnDAEFQALIREINSLPTYRLRMQLLNQPELRQFLQWLSqqlilsggslkvfed 122 Drosophila moja...
XP_002035150  46 TLSQDLEEIQRLIQSKPLNQLLVRYLInDAQFQAFVRIINSNAAVTARWRLLSQPELVLFLQWTDqqllasggsfe-lee 124 Drosophila sech...
XP_017861100  35 NLAQDLTDIYGQIQFKPMQKLFVRYLLnDGQFQAFVRILNSNAGFTAYWRLLAQPEVLLFRQWVDqqllassgkfe-lep 113 Drosophila ariz...
Q29PK9       225 -ayyfdyVRIFL---NIHTTEAPTSPLPNRRKGIRGLLQDVRDVLPRTALRDLYLRMYASDAELSNAVRLVRSleFRRLL 300 Drosophila pseu...
XP_001983994 117 memcvtlFNRYP---YMSGSV----------FGWQGFLNELEMYFPTYAIGATIQTKVQMQGIFAQFWTRVQA--LQVVY 181 Drosophila grim...
XP_002068290 129 nelgislWNRYP---YWSGSVL----------GWRGFLSELQLYFPQYAIRGLIEAKVLQRGIFSQFWTRMQA--LQGVY 193 Drosophila will...
XP_002008174 114 vevctslLNRYP---YLSGTV----------FGWQGFLNELEMYFPLYAINAQVQLKVQQGGIFAQFYQRLSA--LKVVY 178 Drosophila moja...
XP_017863486 114 -ggslkvFEDLE---LEIKVLNKYPHWAQSVNGIGGFEQEFSFIYPLAAIRNLLETSAQQSAVFGEFWQRVVG--LKPVY 187 Drosophila ariz...
XP_002062120 111 -gssikiFEDLE---LEIKVFNKYPYWSQMVGGINGFENDFNFIYPLEAIRSQIEQSAQRSPLVAELWRRVVA--LKPLY 184 Drosophila will...
XP_001985097 113 leleikvLNKHPhwaQS-------------VNGINGFEQEFSYLYPVAAIRKLLESSAQQSPVFGEFWRRVVA--LKPTY 177 Drosophila grim...
XP_002009131 123 leleikvLNKYPhwaQS-------------VNGIGGFEQEFSFIYPLAAIRNLLETSAQQSAVFGEFWQRVVG--LKPVY 187 Drosophila moja...
XP_002035150 125 qrlkvslLNQFPywsGT-------------VFGWQGFLNEVQLYFPLYAIRAHIDAKVLQQGIFAQFWSRLQA--LRVMY 189 Drosophila sech...
XP_017861100 114 vevctslLNRYPylsGT-------------VFGWQGFLNELEMYFPLYAINAQVQLKVQQGGIFAQFYQRLSA--LKVVY 178 Drosophila ariz...
Q29PK9       301 QDVRSLKEYRGLTGDLEKAGVPLRQIQ 327 Drosophila pseudoobscura
XP_001983994 182 ERWLAMPGTQTVLNQLQAEGIDNAQLD 208 Drosophila grimshawi
XP_002068290 194 ERWLTWPDTISVLDQLHAAGIDKNQLD 220 Drosophila willistoni
XP_002008174 179 ERWLATPSTQTVFNQLQAEGIDTVQLD 205 Drosophila mojavensis
XP_017863486 188 ERFLATTQAQAFANRLRTLGVDVAGLD 214 Drosophila arizonae
XP_002062120 185 ERLLATPQAKVLVNQLQSRGVNVsavd 211 Drosophila willistoni
XP_001985097 178 ERFLATPQATGLANRLRALGVDVNNwd 204 Drosophila grimshawi
XP_002009131 188 ERFLATTQAKAFANRLRTLGVDVAGld 214 Drosophila mojavensis
XP_002035150 190 ERWLNTVETTQVLAELQKAGIDTVQLD 216 Drosophila sechellia
XP_017861100 179 ERWLATPSTQTVFNQLQAEGIDTVQLd 205 Drosophila arizonae
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