Conserved Protein Domain Family
ITI_HC_C

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pfam06668: ITI_HC_C 
Inter-alpha-trypsin inhibitor heavy chain C-terminus
This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix. All family members contain the pfam00092 domain.
Statistics
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PSSM-Id: 310930
View PSSM: pfam06668
Aligned: 60 rows
Threshold Bit Score: 162.719
Threshold Setting Gi: 762092110
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75570815   762 HSGVTVNGALIGAP-ApaGSHKQQRTYFSTITIV--Ad---KP--KRSYIEVTTQKVILDGRDRMILPTSSSISIETANL 833
gi 637255058  974 ITGLSVNGHLMGAPlRp-GHEERPRTYFDAITIV--VgellPL--PGYVINITRKGITLHGEHILVLPFTQRATIHKPQL 1048
gi 620975527 1126 TAGLRVNGHLVGAPpKv-GHEDRSRTYFDMISVVvqY----PR--VSYALNITRDSISLkGEDSLVVPWSRPAFIQKPRL 1198
gi 557008833  961 QSGVEVTGHLLGAPpKt-AHENFLRNYFDLITIT--V----RRpaGNYLINVTMRNVTVQGEGLHTLSCYRTASLHLPGL 1033
gi 301620566  971 IAGITVNGHLMKAPlKv-GFESRIRTYLDVITVV--Id--rPR--SKYVVSISLQNLTLtGEKQQTFAISLPVFLQKPSL 1043
gi 542216187  987 ERNIIVDGHLMGAP-SkdGAEDRLRNYFDQLTIS--Vvt-gNS--GDIMITLTLDAVVVEGEGRDTLPINQQGSVTRQGV 1060
gi 768915166   81 drGIIVDGHLMGAP-PknGVEERSRTYFDLLTIS--Tdt-gGP--GDISITLSLDAVVVEGEGRDILPINQQGSVRRQGV 154
gi 344246215  786 KAGLHVSGKLLGAP-PrpGHEDQTRTYFQIITIT--Sd---KP--WAYTVTIGLSSISVQGEGTLNLPWDQPALVKKPQL 857
gi 334348381  805 DSGVTVNGELIGAP-AppNGHKKYRTYFRTITIL--In---KP--ERSYLEITPNRIVLDGGDRLVLPCNQSVVVGSQGL 876
gi 620951383  673 GSGVTVNGELIGAP-AppGGHKKQRTYFSTITIL--In---RP--RRWYLEVTPSRIVLDGGDRLVLLCNQSVAVGGWGL 744
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75570815   834 AVVLIANTNLTVTIQGSIQFVILFHHYKNPAAFQRDHLGFYIAKSKGLSKDTHGLLGQFLYEDIGLT----QIPGNfstt 909
gi 637255058 1049 VISMWPEANVTVQIGHELEFLVLLHRYSHPTALQLDHLGFYMVNGKGLSPSACGLLGQFQNSGIQLS-------SG---- 1117
gi 620975527 1199 ALKVSPSANVTLWIGTDIEFLILLHRYSHPTYLQLAHLGFYIVNGKGLSSSAQGLLGQFQHADIQVN----RE------- 1267
gi 557008833 1034 TLSVSHRANVSIQIGNSLDFLVLLHHFHHPTYLQLDHVGFYVVNGKGFSPSAHGILDQFLYADINVT----RTAGD---- 1105
gi 301620566 1044 AIRVVPSTNVTIWIGRNVELLIIFHHYQHPSYLQLDHLGFYIVNAEGLSSSSGGLLGQFQNChMEVT----NQKL----- 1114
gi 542216187 1061 TVTVDNHQSCWIELAEGVQFLVLFHHYKHPSYLQSAHLGFYITDGRGLSDSTQGLLGQFQHADINIT----VVKDHvdeg 1136
gi 768915166  155 TVTVDNHRSCWVELAKDVQFLILFHEYQLPTYLQKAHLGFYITDGRGLSASTQGLLGQFQHADISVT----VVEDPvde- 229
gi 344246215  858 ELHVASAAHLTLQLGPHLNFLILRHQYRHPSTLQLPHLGFYVASDSGLSPSARGLMGQFQHTDIRLV----TGPTG---- 929
gi 334348381  877 ELSVSANANITVTIQGTITFVILIHLYKNPAPYQRNHLGFYISNSKGLSTNCHGLLGQFLNQDPKLT----KEPVGlgsn 952
gi 620951383  745 AVSVSANANVTVTIQDTITFVILFHRYKNPAPYQRNHLGFYISDGHGLSAGCHGLLGQFLNQDAKLIqgraPDPAs---- 820
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75570815   910 gangtqetlgkNFTLP-------SFHFLKVKDRSVAVMKKSRRIYSGK----QTVDCWFAKN 960
gi 637255058 1118 -----------AVDGE-------PATWLWRGASKIPVTEVTKILKDSpq-raHEAPCWLVKR 1160
gi 620975527 1268 -----------QGTRA-------QTGVLRSEAATLPVVWVEKLLKDSAlq-pHKTHCWLVKR 1310
gi 557008833 1106 -----------VTQETcpdcrrpVTGVLRISGWNIPVTLVTKNIKDSYlk-pHEGPCWQVgk 1155
gi 301620566 1115 -----------SHDLT-------LSGTVIRNKQTAPTTLVEKTVKDSTaq-vHVAKCWLVKH 1157
gi 542216187 1137 l------hrvrKEEIL-------ARGILRWGSEQMPVTLQDKTLKDSVqk-rHRGSCWVVPK 1184
gi 768915166  230 --------gahQRAAS-------ARGMLRWGSQHMPVTLQDKTLKDSVrk-hHAGKCWVVPK 275
gi 344246215  930 ------------------------SYLQKHRGPGVPVVLGKKLLKESPrlhpRWTSCWLVKR 967
gi 334348381  953 rnh--tepsvsQADLS-------SETILKVKGHRVPVIWKQRKIYNGQ----EQIDCWFARn 1001
gi 620951383  821 ----------pQGGPG-------PEPILQVKGHRVPVVWKQRKIYNGE----EQVDCWFAKN 861
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