Conserved Protein Domain Family
DIRP

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pfam06584: DIRP 
DIRP
DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.
Statistics
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PSSM-Id: 310884
View PSSM: pfam06584
Aligned: 54 rows
Threshold Bit Score: 109.174
Threshold Setting Gi: 353231515
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124463465  162 YSHLDYTYFSLNEFQQMLTKASIPlGSKS--IAEWRIIKMAVGQPRRFSFYFLQQEMSKLTKYRSVIRNYLFDqnypIHR 239
gi 955346084  626 YSAIDYPWFAKREFMEYLNHVGLG-NIPRltRVEWSVIKSSLGKPRRFSEHFLCEERQKLEQYRESVRKHYt-----ELR 699
gi 552845196  257 YSALDRPFFMFNPLAGLLAQLGLG-EGARltRREWCLIRSSLGKPRRLSLKFLKEERVRLERWRDGCRQQYQS----GAA 331
gi 695043786  594 YSAIDYPWFAKNDYVEYLNHARLS-HIPRfrRAEWSIIRRSLGKARRFSNKFLSEERMKVEQYRESVRTHYTE-----LL 667
gi 731416351  662 YSAIDYPWFVKKEFVEYLDHVGLG-HIQRlsRVEWDVIRSSLGKPRRFSERFLHEEKEKLKQYRKSVRTHYTE-----LR 735
gi 685383578  613 YSAIDHPWFAKMVFVDYLNHVGLG-HVPRltRLEWSVIKSSLGRARRFSERFLQEEREKLKQYRESVRKHYTE-----LR 686
gi 670429734  504 YSAVDYPWFSSNEFVHYLDHAKLS-HLSRltIPEWGTIRSSLGIPRRFSNYFLAVEKENLEDYREKVRKIYAQ-----LS 577
gi 326502138  509 YSAVDYPWFMDNEFVNYLNFAKLS-HLSRltRSEWSTIRSSLGKPRRFSNHFLEAEKEKLEDYRQNVRKYYAE-----LS 582
gi 944225352  498 YSAIDFPWFMDNEFVKYMNHPYLR-HISRlaRSEWSIIRSYRGKPRRFSDNFLVMERKQLEDYRKEVRTYYAQ-----LS 571
gi 302801462  373 YSAIDLPWFARNEFVEYLNHAGLG-HVSKltRTEWTVIRSSLGKPRRLSQKFLQVEREKLEAYRDTVRAHYHD----IRN 447
                          90       100
                  ....*....|....*....|....*...
gi 124463465  240 DiRNLDLIHDivRLAPFNVDQTVYAVHP 267
gi 955346084  700 TgIRDGLPTD--LAKPLYVGQHVIALHP 725
gi 552845196  332 AvAHPKVADH--LPLPLGVGQRVVARHP 357
gi 695043786  668 AgTTKGLSRD--LAIPLSVGQHVIACHP 693
gi 731416351  736 TgAREGLPRD--LARPLSVGQRVIALHP 761
gi 685383578  687 TgAREGLPTD--LARPLAVGNRVIAIHP 712
gi 670429734  578 DgSRDFLPAD--LARPFSIGQQVIVRHP 603
gi 326502138  583 DgLRDSLPTD--LAQPFSVGQHVIVRHP 608
gi 944225352  572 DgSLDSLPAD--VARPFSIGQQVIVRHP 597
gi 302801462  448 DkSGCCLPPD--LARPLTVGQRVIARHP 473
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