Conserved Protein Domain Family
FtsH_ext

?
pfam06480: FtsH_ext 
FtsH Extracellular
This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes. It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni FtsH is involved in protection against environmental stress, and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.
Statistics
?
PSSM-Id: 377663
View PSSM: pfam06480
Aligned: 157 rows
Threshold Bit Score: 31.8053
Threshold Setting Gi: 123725332
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q9SLX5            160 WLFQLLLAGGIFYALNSGEgnd------------ssGSGTG--------------------MRREINFqqfvrdllepgl 207  Cyanidios...
Q5KKS9             87 PLTPFQARVAELEIKAHANkedpdaqleflrqlsegGEFAGlvayyegmalaedtsgsqalLRNDEAWaifmdalarsgr 166  Cryptococ...
Q9RVK7             24 GLLTLHLLTLPVLVQGTAAattahvtasanapttpaPQPPTwtpnk----------gnprlMPENYTVnr---------f 84   Deinococc...
Q3Z9G3             13 TIIYIVMLVAIIAIFSFLVpn--------------------------------------sqKPEEVPLsq---------i 45   Dehalococ...
Q1GSR0             16 VMIWSGILLAMLLVASMFGgaa-------------------------------------qpVGNPLAYse---------f 49   Sphingopy...
A1TZE0             25 SFLWLSAAIFLMFLWLQGNnq---------------------------------------qQQQELAYse---------f 56   Marinobac...
EAW31928           36 VLTWVLVVSSLMYLWTNVTt----------------------------------------qPYHSIPYsd---------f 66   marine ga...
jgi:Franean1_1984  39 FLIPVGLLVTVMLLIAPSLfa---------------------------------------tQPDSLTYsd---------f 70   Frankia s...
A0LR74             28 WLLPIGLLVSLVLLFTFPMrp---------------------------------------sSGKTLTYse---------f 59   Acidother...
EDL57558           35 PWLIILLILVIGSLMLMK------------------TSPEN--------------------TGSKVDYsf---------f 67   Gimesia m...
Q9SLX5            208 VDHLEIVNRQTAYVYvkqtyqgepskRSAGSrqtaedvvldtgvdqpqrdalwetsaqpqltgedysgsesppaairrpr 287  Cyanidios...
Q5KKS9            167 LGDIVTKVRRRDQLLasiganggsss---------------------------------------------saplvsnpt 201  Cryptococ...
Q9RVK7             85 FADLQAGKVERVKLDga--------------------------------------------------------------- 101  Deinococc...
Q3Z9G3             46 ITLSQEHKIAEITVD----------------------------------------------------------------- 60   Dehalococ...
Q1GSR0             50 RQKVEEGSVKEVILS----------------------------------------------------------------- 64   Sphingopy...
A1TZE0             57 KQAVISGQVAEVTLRteeisgs-----------------------------------------------------ftdsg 83   Marinobac...
EAW31928           67 KQELISDNIEQISVKeseing-------------------------------------------------------sfri 91   marine ga...
jgi:Franean1_1984  71 VGRVDSGVVRSVTIDdr--------------------------------------------------------------- 87   Frankia s...
A0LR74             60 LTALHHHDIKTITIHsd--------------------------------------------------------------- 76   Acidother...
EDL57558           68 ISELKRGNVDSVDFH-----------GDILTgkwk-------------------------------------------tk 93   Gimesia m...
Q9SLX5            288 gdGVS-DSKRLNRPTVMYYFTLGSVesferkLEQAEKSLGIDPIPVVF 334  Cyanidioschyzon merolae
Q5KKS9            202 psSVS-ANNSSTSTPSVSSPGPSLTssllsrAVSPTSLANASNASTSQ 248  Cryptococcus neoformans
Q9RVK7            102 gnTQV-FFKEPAGGPNPRWLLLPPDaatlarLRGSGVTMQVTPGGSRF 148  Deinococcus radiodurans
Q3Z9G3             61 --SENiEVTTTDGTKLSTVKEYIASiydiegLDLTDVKVNIQPAGGLD 106  Dehalococcoides mccartyi 195
Q1GSR0             65 ---ED-RVTGTLSNGDRFTANVVRDpdllkmLNDNGVKYDGQPAETPN 108  Sphingopyxis alaskensis
A1TZE0             84 asRFA-NDSRPPSSSFITLRPQVEDpellplLERQEVLVRGSRSGRPW 130  Marinobacter hydrocarbonoclasticus VT8
EAW31928           92 giSDE-DKPANIHQRFRTIVPSFGDtelltlLESKQVAIQSIAATTPL 138  marine gamma proteobacterium HTCC2143
jgi:Franean1_1984  88 -gGVD-GTLTDGTDFTTQIPTALDTtalerqLAAKKVQITATRTGTSF 133  Frankia sp. EAN1pec
A0LR74             77 -gEAS-GQFADGRPYSTTIPIGLAGsqllneLENNGVQISARPPGPSL 122  Acidothermus cellulolyticus 11B
EDL57558           94 peNPD-KEKKDEKLAEEFNTVLPSHpvedrnLIPELEKQGVTFKAEST 140  Gimesia maris DSM 8797
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap