Conserved Protein Domain Family
FtsH_ext

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pfam06480: FtsH_ext 
FtsH Extracellular
This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes. It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni FtsH is involved in protection against environmental stress, and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.
Statistics
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PSSM-Id: 336420
View PSSM: pfam06480
Aligned: 157 rows
Threshold Bit Score: 31.8046
Threshold Setting Gi: 123725332
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75337398   160 WLFQLLLAGGIFYALNSGEgnd------------ssGSGTG--------------------MRREINFqqfvrdllepgl 207
gi 310943126    7 ISFYIIIFILILVIITF-------------------FTATD--------------------NPPKMSYse---------l 38
gi 74686505    87 PLTPFQARVAELEIKAHANkedpdaqleflrqlsegGEFAGlvayyegmalaedtsgsqalLRNDEAWaifmdalarsgr 166
gi 123758745    8 LVLWTLPALVIGFFFWQGTfaga----------padMSKNA--------------------ANTRMTYgr---------f 48
gi 14423723     4 LWIWSLPLIVLAFIGWQELa----------------NQMPV--------------------ATSRMTYgr---------l 38
gi 1043319474   8 VFFVLIIMMVVLIIAYNY------------------ENNAG--------------------ATKDISYsd---------f 40
gi 489627339   10 LLLYLGIPIVIIIIIVL-------------------VIGNM--------------------PQKTMKYse---------i 41
gi 501108671    8 ASFYILLFLVLLIIVQQF------------------GSQPQ--------------------QTVDVEFsr---------l 40
gi 500597822   10 SFVYLIILVAALALFINYFn----------------NAQGQ--------------------QEERGIYqv---------- 43
gi 500265865    8 ATIYILIALVILLLVDILSggls----------ynqLWNMS--------------------EKRNVIYse---------l 48
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75337398   208 VDHLE--IVNRQTAYVYvkqtyqgepskRSAGSrqtaedvvldtgvdqpqrdalwetsaqpqltgedysgsesppaairr 285
gi 310943126   39 LTEMK--AGNVKSIglqt-------------------------------------------------------------- 54
gi 74686505   167 LGDIV--TKVRRRDQLLasiganggsss---------------------------------------------saplvsn 199
gi 123758745   49 LEYVD--AGRVTSVDLY-----------EGGRTa---------------------------------------------- 69
gi 14423723    39 LEYMQ--MGWVKRIDVY-----------DRTAL----------------------------------------------- 58
gi 1043319474  41 LNMLEpvEGKKPLGKLY-----------KGNVDkynkiqiek----------------------------------dvie 75
gi 489627339   42 LNYFE--TQQVTEFDLD-----------LGSGAmvlt------------------------------------------- 65
gi 501108671   41 YRALL--AEDVHEIYMV-----------DRSIE----------------------------------------------- 60
gi 500597822   44 lADAK--AGRVEKIEAQ-----------SGNSE----------------------------------------------- 63
gi 500265865   49 INDIN--DGKVSRIILS-----------YNNVS----------------------------------------------- 68
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 75337398   286 prgdGVSDSKRLNRPTVMYYFTLGSVesferkLEQAEKSLGIDPIPVVF 334
gi 310943126   55 dtatIELKKPKENNRTKFVVIVPPDVtsaserFTAALDNKLIEDFHVTQ 103
gi 74686505   200 ptpsSVSANNSSTSTPSVSSPGPSLTssllsrAVSPTSLANASNASTSQ 248
gi 123758745   70 ---iVEAQDQDIENRVQRWRVD---LpvsapeLISKLKEKKVSFDAHPA 112
gi 14423723    59 ------IEASSPETGWQWIRVD---LpanssdWLEQAKTLHIDVDVHAV 98
gi 1043319474  76 gyyiPSEYADSKTAKPVKFRTT---VapldkdLISSLRRANVSFDARSA 121
gi 489627339   66 -lndGDESKKKEPTQIQYSVPN---VtilyedIKPYIEEYNKDHPDAKM 110
gi 501108671   61 ----GVMTIDNAKVNFKSFIPEVFNEneftelIDAQIKSGTLELKAASP 105
gi 500597822   64 ----ILVTYRDTRAKVRSRIESNDSItmllvqAGVPLDAVNVEVRAAPA 108
gi 500265865   69 ------GQYKDGTKFDNVFVPS---PdkfldqIQPAIESKQIEIVTKEP 108
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