1GXL


Conserved Protein Domain Family
SMC_hinge

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pfam06470: SMC_hinge 
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SMC proteins Flexible Hinge Domain
This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction.
Statistics
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Aligned: 99 rows
Threshold Bit Score: 39.1669
Threshold Setting Gi: 81760300
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GXL_A             41 FPgLVDVVSNLIEVDEKYSLAVSVLLGGTAQNIVVRNVDTAKAIVEFLKQNEAGRVTILPL----DL----IDGsfNRIS 112  Thermotog...
Q2S457            518 lfdDLYTVADVLGCDDDVRVALDAALGALASCVVVPTVDDARAAVARLRDAEKGQTSFLVL----DR----LPD--APPS 587  Salinibac...
Q3ATI3            532 NNsTSRCLADMIEVDERYRAALGSALGDHLNCYLCPTLSDAHHSIALLQKAQKGKLLFLVQ----EL----AAS--ASLP 601  Chlorobiu...
jgi:Clim_1986     519 SEaDQGCLADMISLDPAYRKAVHAALGEALSYYVCRSITEAKQSMQQLRLSKKGKLHFLVL----DH----IAR--ISDN 588  Chlorobiu...
jgi:Cphamn1_0498  519 GKtgHGCLSDLLSLEDVHRKAINAVLGESLGYYVCSSLPEAKTGIRSLAEAGKGKVTFLVL----DM----LKT--PEMD 588  Chlorobiu...
Q8NNW5            501 VV-DYPQLATLIRPQRNVDKALAAALGAHAEALAGEAAEGLVE--KLIDAG-VARTIIVDG----TQ----AGG--AWRL 566  Corynebac...
BAW14010          512 GAgLFGSIAQLVKVLSGYEAALAAALGPAADALAVDGLTAAGSAVSALKQADGGRAVLVLS----DW----PAP--QAPQ 581  Mycobacte...
Q0S2D5            509 QHgIRGPIGGLITVEKGYEGAVAAAMGPAADAVVAESLDAARSAVGALKETDSGRASLFIG-----------SD--HVAR 575  Rhodococc...
WP_009778200      512 GHgIVGTVASLLQVTGGHEGAVAAALGWASEALAVGSAQQAARAVDHLRQDDQGQATLLVG----DT----ARA--SNPS 581  Janibacte...
Q82JU6            511 LGgLLGPAAELLSVTPGYEVPLAAAFGVAADAIAVSTPASAAEAIRLLRKQDAGRAALLLGgapdDVpapePEH--ARRP 588  Streptomy...
1GXL_A            113 GLENERG-------FVGYAVDLVKFPSD-LEVLGGFLFGNSVVVETLDDAIRM 157  Thermotoga maritima
Q2S457            588 VSAPE---------GAVPLRDVVRTTDPaYAPLADTLLRDCFLVDTLAAAEAL 631  Salinibacter ruber DSM 13855
Q3ATI3            602 TLPTIE--------GAEPLANLVSVPPA-WQHALRLLLGTTFVVANAEQAEAL 645  Chlorobium chlorochromatii CaD3
jgi:Clim_1986     589 ETPVRE--------GGRRMMDIIGYPEA-LSAALNNLLFRYYLVDTLDTAENM 632  Chlorobium limicola DSM 245
jgi:Cphamn1_0498  589 ASPAIN--------GTIKINSILSFPKS-LSKAITALTEGCYLVDTFSTAETL 632  Chlorobium phaeobacteroides BS1
Q8NNW5            567 DANIPA--------GASWLLDHVDLDPA-IAGPVNRLLADVVLVDDPSLGRQA 610  Corynebacterium glutamicum
BAW14010          582 SASGEMLp-----sGAQWALDLVESPPQlVGAMI-AMLSGVAVVNDLTEAMGL 628  Mycobacterium tuberculosis
Q0S2D5            576 DGGHLDS-------GARWAVDVIDCPAE-LRTGLAALLGGVVVVDSLDDAVET 620  Rhodococcus jostii RHA1
WP_009778200      582 TWPDLDG-------SGVWARDVVSAPAD-VLPAVEQLLDRVALVATTEHALAL 626  Janibacter sp. HTCC2649
Q82JU6            589 GAAHTDVppaehrgGPPYAADLVRGPAE-LMPAVRRLLRGIVVVGTLEDAEDL 640  Streptomyces avermitilis
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